Taiwanese Journal of Obstetrics & Gynecology最新文献_第2页

Cervical cancer: Part II the landscape of treatment for persistent, recurrent and metastatic diseases (I) 宫颈癌：第二部分：顽固性、复发性和转移性疾病的治疗前景（I）

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2024-09-01 DOI: 10.1016/j.tjog.2024.08.001

{"title":"Cervical cancer: Part II the landscape of treatment for persistent, recurrent and metastatic diseases (I)","authors":"","doi":"10.1016/j.tjog.2024.08.001","DOIUrl":"10.1016/j.tjog.2024.08.001","url":null,"abstract":"<div><p>The WHO (World Health Organization) conducted an elimination of cervical cancer program using triple pillar intervention strategy to target 90%-70%-90% of women before the year 2030, including (1) a full vaccination of HPV (human papillomavirus) vaccine to 90% of girls <15 years of age; (2) a high-performance screening procedure to 70% of women during the reproductive age (at the age of 35 and 45 years of age); and (3) an appropriate and adequate treatment to 90% of women with confirmed diagnosis of cervical lesions. Among the aforementioned three pillars, a full HPV vaccination has been introduced in our previous review, of which we have discussed the policy and strategy of HPV vaccination in the world and also reviewed the efficacy of HPV vaccination, with a successful reduction of over 90% of HPV-associated neoplasms. The aims of the current review will target another pillar-an appropriate and adequate treatment to 90% of women with confirmed diagnosis of cervical lesions. Since the early-stage cervical cancer has a favorable outcome and the treatment recommendation has been established, therefore, the current review focuses on women with persistent, recurrent and metastatic cervical cancers (advanced cervical cancers), which are still a biggest challenge based on its extremely worse outcomes before the introduction of immune checkpoint inhibitors (ICIs). Integration of ICIs into conventional chemotherapy (paclitaxel-cisplatin) has become the new standard therapy for those patients with advanced cervical cancers. The recent clinical trials, such as KENOTE 826 and KENOTE A18 showing a dramatical improvement of both progression free survival and overall survival have approved the therapeutic efficacy of this combination as ICI plus paclitaxel-platinum (cisplatin or carboplatin) with/without bevacizumab to women with persistent, recurrent and metastatic cervical cancers.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924002080/pdfft?md5=966e644d10ea36b47e8cf6136eb212bb&pid=1-s2.0-S1028455924002080-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Besides the front-line maintenance therapy, is any positive impact of poly (ADP-ribose) polymerase (PARP) inhibitors on recurrent high-grade ovarian cancer? 除了一线维持治疗外，多聚（ADP-核糖）聚合酶（PARP）抑制剂对复发性高级别卵巢癌是否有积极影响？

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2024-09-01 DOI: 10.1016/j.tjog.2024.07.013

引用次数: 0

Risk and protective factors for postpartum depressive symptoms among women in postpartum nursing center 产后护理中心妇女产后抑郁症状的风险和保护因素

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2024-09-01 DOI: 10.1016/j.tjog.2024.05.021

{"title":"Risk and protective factors for postpartum depressive symptoms among women in postpartum nursing center","authors":"","doi":"10.1016/j.tjog.2024.05.021","DOIUrl":"10.1016/j.tjog.2024.05.021","url":null,"abstract":"<div><h3>Objectives</h3><p>In Taiwan, many women receive postpartum care at postpartum nursing centers for one month. However, limited research has examined the postpartum depressive symptoms in women residing in postpartum nursing center. The objectives of this study were to investigate the prevalence of postpartum depressive symptoms and to identify the risk factors and protective factors for postpartum depressive symptoms in postpartum nursing center.</p></div><div><h3>Materials and methods</h3><p>This was an observational study. Postpartum women who were over 20 years old and able to speak Mandarin Chinese or Taiwanese, and had delivered singleton, live infants at term were recruited between January 2020 and June 2020 from a postpartum nursing center in central Taiwan. A questionnaire including sociodemographic characteristics, the Edinburgh Postnatal Depression Scale, and a pain scale was administered at first week and last week in the postpartum nursing center.</p></div><div><h3>Results</h3><p>A total of 60 postpartum women participated in the study. The prevalence rates of postpartum depressive symptoms after admission and before discharge from a postpartum nursing center were 13% and 8%, respectively. The postpartum depressive symptoms and postpartum pain intensity (including perineum pain and postoperative pain after caesarean delivery) scores were significantly decreased after staying at the postpartum nursing center. The risk factors for postpartum depressive symptoms were previous abortion experience and postpartum pain, while the protective factors were having child care arrangements after return home and having 8–11 h of sleep per day.</p></div><div><h3>Conclusions</h3><p>There is a need for the early detection and management of postpartum depressive symptoms in postpartum nursing center.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924001748/pdfft?md5=4dc9037e444d0b5f1d6374800ac847fc&pid=1-s2.0-S1028455924001748-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on “Loeys-Dietz syndrome with a novel in-frame SMAD3 deletion diagnosed as a result of postpartum aortic dissection” 关于 "因产后主动脉夹层而被诊断患有新型框架内 SMAD3 缺失的 Loeys-Dietz 综合征 "的评论

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2024-09-01 DOI: 10.1016/j.tjog.2024.06.008

引用次数: 0

A case with rare complication of chronic puerperal uterine inversion and underwent operation reduction 一例罕见的慢性产褥期子宫内翻并发症患者接受了手术减胎术

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2024-09-01 DOI: 10.1016/j.tjog.2024.04.018

引用次数: 0

Single incision mini sling for the treatment of urodynamic stress incontinence: Surgical outcomes and preoperative predictors of failure 治疗尿动力性压力性尿失禁的单切口微型吊带：手术效果和术前失败预测因素

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2024-09-01 DOI: 10.1016/j.tjog.2024.03.020

{"title":"Single incision mini sling for the treatment of urodynamic stress incontinence: Surgical outcomes and preoperative predictors of failure","authors":"","doi":"10.1016/j.tjog.2024.03.020","DOIUrl":"10.1016/j.tjog.2024.03.020","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the surgical outcomes and predictors of failure of Single Incision Mini Sling (Ophira) in women with urodynamic stress incontinence.</p></div><div><h3>Materials and methods</h3><p>Records of 115 women underwent anti-incontinence procedure using Ophira Mini Sling from June 2019 to September 2020 reviewed. Subjective evaluation was assessed using validated IIQ-7, UDI-6, POPDI-6 and PISQ-12 questionnaires. Multichannel urodynamics, 1-h pad test and 72-h voiding diary was performed as objective evaluation. Primary outcome was the objective cure rate of negative urine leak on provocative filling cystometry and 1-h pad test weight <2 g, and subjective cure rate was negative response to question 3 of UDI-6. Secondary outcome was to identify risk factors associated with failure for Ophira.</p></div><div><h3>Results</h3><p>Total of 108 women were evaluated. The objective cure rate was 91.7% with subjective cure rate of 86.1%. Comparison of clinical outcome shows significant improvement of USI post-operatively (p < 0.001) and reflected in 1-h pad test (p < 0.001). Improvement in all subjective evaluation parameters is seen except for POPDI-6. Failure of Ophira correlate significantly in women age >66 years, presence of asthma, pre-operative Intrinsic Sphincter Deficiency (ISD), and Maximum Urethral Closure Pressure (MUCP) value < 40 cmH20.</p></div><div><h3>Conclusion</h3><p>Ophira Single Incision Mini Sling is safe and effective treatment option for USI, showing high objective and subjective cure rates with low incidence of complications. Non-modifiable risks of age ≥66 years, asthma status, pre-operative intrinsic sphincteric deficiency and low maximal urethral closure pressure were the factors of failure for Ophira.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924001773/pdfft?md5=7671175e207a8b46a40b0a7ccb1c2600&pid=1-s2.0-S1028455924001773-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of maternal and neonatal morbidity in transvaginal versus transabdominal cerclage patients: A retrospective study from two tertiary hospitals 经阴道与经腹部宫颈环扎术患者的产妇和新生儿发病率比较：两家三级医院的回顾性研究

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2024-09-01 DOI: 10.1016/j.tjog.2024.05.023

{"title":"Comparison of maternal and neonatal morbidity in transvaginal versus transabdominal cerclage patients: A retrospective study from two tertiary hospitals","authors":"","doi":"10.1016/j.tjog.2024.05.023","DOIUrl":"10.1016/j.tjog.2024.05.023","url":null,"abstract":"<div><h3>Objective</h3><p>To compare the maternal and neonatal morbidity in patients with transvaginal (TVC) versus transabdominal (TAC) cerclage.</p></div><div><h3>Materials and methods</h3><p>Retrospective analysis of patients who received cervical cerclage and terminated the pregnancy in the second trimester or third trimester in two tertiary hospitals. Data on basic clinical characteristics, predelivery maternal morbidity, intrapartum morbidity, postpartum morbidity and neonatal morbidity of TVC patients and TAC patients were analysed and compared.</p></div><div><h3>Results</h3><p>Seventy-two TVC patients and 120 TAC patients were included. The rates of abnormal fetal presentation and placental disorders were significantly higher in TAC patients than that in TVC patients (21.67% vs 5.56% and 18.33% vs 4.17%, respectively). The rates of premature rupture of membranes and intrauterine infection were significantly higher in TVC patients than that in TAC patients (25.00% vs 2.50% and 11.23% vs 3.33%, respectively). Compared with TVC patients, the rates of estimated intrapartum hemorrhage ≥500 ml, uterine rupture and cesarean delivery in the third trimester were significantly higher in TAC patients than in TVC patients. Gestational age at delivery and neonatal morbidity were comparable between TVC patients and TAC patients.</p></div><div><h3>Conclusion</h3><p>Compared with TVC patients, TAC patients were associated with a significantly higher incidence of maternal morbidity in placental disorders, abnormal fetal presentation, intrapartum hemorrhage ≥500 ml and uterine rupture.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924001839/pdfft?md5=124b2eeb50c67c5db5aa8d457d89d531&pid=1-s2.0-S1028455924001839-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic counseling of mosaic and non-mosaic tetrasomy 9p at prenatal diagnosis 产前诊断中镶嵌型和非镶嵌型 9p 四体综合征的遗传咨询

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2024-09-01 DOI: 10.1016/j.tjog.2024.07.004

引用次数: 0

Glycosylation of FSH and cancer FSH 的糖基化与癌症

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2024-09-01 DOI: 10.1016/j.tjog.2024.06.006

引用次数: 0

Efficacy and safety of rucaparib in patients with recurrent high-grade ovarian carcinoma: A systematic review and meta-analysis 鲁卡帕利对复发性高级别卵巢癌患者的疗效和安全性：系统综述和荟萃分析

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2024-09-01 DOI: 10.1016/j.tjog.2024.05.020

{"title":"Efficacy and safety of rucaparib in patients with recurrent high-grade ovarian carcinoma: A systematic review and meta-analysis","authors":"","doi":"10.1016/j.tjog.2024.05.020","DOIUrl":"10.1016/j.tjog.2024.05.020","url":null,"abstract":"<div><p>Ovarian cancer stands as the third most prevalent gynecological malignancy. The advent of PARP inhibitors, particularly rucaparib, has revolutionized the landscape of advanced ovarian cancer treatment, demonstrating notable efficacy with minimal toxicity, especially in patients not previously exposed to PARP inhibitors. Rucaparib's precision-driven approach, targeting specific genetic mutations, disrupts DNA repair mechanisms, resulting in cytotoxic effects on neoplastic cells. This comprehensive review delves into the clinical efficacy and safety profile of rucaparib in recurrent ovarian cancer, showcasing its promising therapeutic approach. A systematic search of studies reporting rucaparib efficacy and safety, up to September 2023, was conducted across various reputable databases and sources. The meta-analysis of seven articles revealed a pooled objective response rate (ORR) of 0.331 (95% CI, 0.221–0.449; I2 = 92.4%), underscoring rucaparib's efficacy, particularly evident in the BRCA-mutated cohort. Rucaparib consistently outperformed controls in progression-free survival (PFS) and overall survival (OS). Safety evaluations indicated that 98.7% of patients experienced treatment-emergent adverse events (TEAEs), with 61% being grade ≥3. Notable TEAEs included nausea (69.0%), fatigue (66.8%), vomiting (37.3%), and constipation (32.1%). Hematological concerns comprised anemia (47.9%), thrombocytopenia, elevated AST/ALT (37.3%), and serum creatinine levels (19.7%). Despite favourable outcomes, the rucaparib group recorded higher event rates across various metrics than controls. The findings underscore the need for meticulous monitoring and dose adjustments to optimize therapeutic outcomes and mitigate the increased risks associated with adverse events. International Prospective Register of Systematic Review Identifier: CRD42023459646.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924001670/pdfft?md5=b0f48a9228d4ad22ccf40dcef71bfd28&pid=1-s2.0-S1028455924001670-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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