Taiwanese Journal of Obstetrics & Gynecology最新文献

Prenatal diagnosis of a de novo 16p11.2 microduplication of 16p11.2 BP4-5 copy number variants in a fetus with apparently normal phenotype 胎儿16p11.2 BP4-5拷贝数变异的新生儿16p11.2微重复的产前诊断

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-05-01 DOI: 10.1016/j.tjog.2025.03.004

Chih-Ping Chen

引用次数: 0

Comments on “The timing for embryo transfer after antibiotic therapy for chronic endometritis” 关于“慢性子宫内膜炎抗生素治疗后胚胎移植时机”的评论

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-05-01 DOI: 10.1016/j.tjog.2024.12.028

Zhe Gao, Juan Du

引用次数: 0

Exploration of immune-related diagnostic biomarkers in unexplained infertility by bioinformatics analysis and machine learning 利用生物信息学分析和机器学习探索不明原因不孕症的免疫相关诊断生物标志物

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-05-01 DOI: 10.1016/j.tjog.2025.01.004

Ran Ma , Jituan Qin , Sugai Wang , Sufen Guan , Fangjuan Jia , YingYing Deng , Jing Bai , Saili Wang

{"title":"Exploration of immune-related diagnostic biomarkers in unexplained infertility by bioinformatics analysis and machine learning","authors":"Ran Ma , Jituan Qin , Sugai Wang , Sufen Guan , Fangjuan Jia , YingYing Deng , Jing Bai , Saili Wang","doi":"10.1016/j.tjog.2025.01.004","DOIUrl":"10.1016/j.tjog.2025.01.004","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to discover the biomarkers associated with UI and their correlation with immune cell infiltration.</div></div><div><h3>Materials and methods</h3><div>The GSE165004 data set was extracted from the Gene Expression Omnibus and IRGs were obtained from Immport and InnateDB databases. Differential expression analysis, WGCNA, and three machine learning algorithms (LASSO, SVM, and random forest) were used to determine the immune-related hub biomarkers for UI. The diagnostic performance of these markers was evaluated in GSE165004 and validation set (GSE16532). Furthermore, single-sample GSEA was employed to analyze the infiltration level of immune cells and Spearman analysis was conducted to assess the correlation between biomarker and immune cells. The functional enrichment and potential drugs for each biomarker were explored. The biomarker genes were validated in clinical samples by real time PCR assay.</div></div><div><h3>Results</h3><div>Six shared genes (ANXA2, CD300E, IL27RA, SEMA3F, GIPR, and WFDC2) were identified as diagnostic biomarkers by integration analysis. ROC analysis revealed that these markers had diagnostic value for UI both in training and validation sets. Moreover, these biomarkers are closely associated with immune cells, such as natural killer T cells and effector memory CD8 T cells. GSEA analysis showed that these genes were mainly involved in chromosome and mitochondria-related biological functions. Drug prediction indicated that all genes targeted Benzo(a)pyrene. All the biomarker genes, expect for GIPR were differentially expressed in endometrium tissues of UI patients, compared with controls.</div></div><div><h3>Conclusion</h3><div>This study identified immune-related diagnostic biomarkers in UI, providing new insights into understanding the molecular mechanisms and therapeutic targets of UI.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 3","pages":"Pages 438-449"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uterine artery blockage 子宫动脉阻塞

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-05-01 DOI: 10.1016/j.tjog.2024.03.031

I-Gung Li, Hung-Hsien Liu, Peng-Hui Wang

引用次数: 0

The frontiers in gynecologic cancer management: Exploring the new hope to manage women with endometrial cancer by immunochemotherapy 妇科肿瘤治疗的前沿：探索免疫化疗治疗女性子宫内膜癌的新希望

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-05-01 DOI: 10.1016/j.tjog.2025.03.001

Peng-Hui Wang , Szu-Ting Yang , Byoung-Gie Kim

引用次数: 0

Complex tumor microenvironment of endometrial cancer 子宫内膜癌复杂的肿瘤微环境

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-05-01 DOI: 10.1016/j.tjog.2024.03.033

Szu-Ting Yang, Che-Wei Chang, Peng-Hui Wang

引用次数: 0

Spontaneous rupture of left common iliac artery after cesarean section: A rare case of hypovolemic shock in Obstetrics 剖宫产后自发性左髂总动脉破裂：产科低血容量性休克一例

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-05-01 DOI: 10.1016/j.tjog.2024.11.011

FengXiang Yao, LinLin Wang, Li Wang, LiangLiang Xiao, YanQing Qi

引用次数: 0

Prenatal diagnosis of geleophysic dysplasia with ADAMTSL2 mutations 伴有ADAMTSL2突变的肾小球物理发育不良的产前诊断

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-05-01 DOI: 10.1016/j.tjog.2024.10.021

Yu-Ting Jiang , Shao-Bin Lin , Cai-Xin Huang , Liu Du , Hong-Ning Xie

{"title":"Prenatal diagnosis of geleophysic dysplasia with ADAMTSL2 mutations","authors":"Yu-Ting Jiang , Shao-Bin Lin , Cai-Xin Huang , Liu Du , Hong-Ning Xie","doi":"10.1016/j.tjog.2024.10.021","DOIUrl":"10.1016/j.tjog.2024.10.021","url":null,"abstract":"<div><h3>Objectives</h3><div>We present prenatal diagnosis of Geleophysic dysplasia (GD) at 22 weeks gestation with prenatal ultrasound findings, molecular genetic analysis and postmortem examination.</div></div><div><h3>Case report</h3><div>A 27-year-old primigravida was referred at 22 + 4 weeks gestation for detailed anomaly scanning due to routine ultrasound detection of short limbs. Chorionic villus sampling followed by family-based whole-exome sequencing identified two missense ADAMTSL2 variants, both classified as variants of uncertain significance. Detailed ultrasound screening showed short limbs, small hands and feet, typical facial appearance, cardiac and pulmonary anomalies. The association of phenotype and genotype support the diagnosis of GD. Postmortem examination confirmed the prenatal ultrasound findings and the diagnosis of GD.</div></div><div><h3>Conclusion</h3><div>Two missense ADAMTSL2 variants in this case may add new evidence to the molecular diagnosis of GD. Prenatal ultrasound assessment of the fetal phenotype helps us to better interpret fetal genotype, and find the potential causative variants.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 3","pages":"Pages 528-530"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the enigma of shoulder pain post laparoscopic surgery: exploring influencing factors and recovery trajectories 揭示腹腔镜手术后肩痛之谜：探讨影响因素和恢复轨迹

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-05-01 DOI: 10.1016/j.tjog.2024.06.016

Pei-Shan Lee , Chyi-Long Lee

{"title":"Unveiling the enigma of shoulder pain post laparoscopic surgery: exploring influencing factors and recovery trajectories","authors":"Pei-Shan Lee , Chyi-Long Lee","doi":"10.1016/j.tjog.2024.06.016","DOIUrl":"10.1016/j.tjog.2024.06.016","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate the recovery trajectories of shoulder pain after gynecological laparoscopic surgery and identify the factors influencing its occurrence.</div></div><div><h3>Materials and methods</h3><div>A longitudinal research design with repeated tests was employed using self-administered questionnaires and visual analogue scales of pain. In a tertiary center, a total of 97 participants who underwent gynecological laparoscopic benign surgery were recruited. The data were analyzed using independent t-tests, chi-squared tests, and generalized estimating equations (GEE) in SPSS for Windows Version 15.0. A two-tailed p-value <.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>The prevalence of shoulder pain after gynecological laparoscopic surgery was 77.3 %, with a higher incidence of pain reported on the right side (58.7 %). Several factors were found to influence shoulder pain after gynecological laparoscopic surgery, including the operation time and use of analgesic (p = .01). Furthermore, postoperative shoulder pain demonstrated a significant negative correlation with pain satisfaction (p < .01) and a significant positive correlation with the use of analgesic injections (p = .05). The shoulder pain score decreased at 24 h after surgery and reached its lowest point at 36 h after surgery (P < .01).</div></div><div><h3>Conclusions</h3><div>Following gynecological laparoscopic surgery, 77.3 % of patients suffered from shoulder pain, correlating with longer operation times and increased analgesic use. Shoulder pain tended to peak at 12 h post-surgery. Effective pain relief strategies can significantly improve pain management for minimally invasive therapy, enhancing patient satisfaction and recovery outcomes.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 3","pages":"Pages 482-486"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal diagnosis of SRY(+) 45,X male and the confirmation of high-level mosaicism for 45,X in 45,X/46,X,del(Y) (q11.222) in a fetus with a favorable fetal outcome and perinatal progressive decrease of the 45,X cell line 产前诊断SRY(+) 45，X雄性，确认45，X in 45,X/46，X,del(Y) （q11.222）在胎儿中具有高水平嵌合，胎儿结局良好，围产期45，X细胞系逐渐减少

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-05-01 DOI: 10.1016/j.tjog.2025.03.006

Chih-Ping Chen

引用次数: 0