Anthony D. Burtman, John Heusinkveld, Chaur-Dong Hsu, Ravi Goyal
{"title":"Falloposcope for early screening of high-grade serous ovarian carcinoma","authors":"Anthony D. Burtman, John Heusinkveld, Chaur-Dong Hsu, Ravi Goyal","doi":"10.1016/j.tjog.2025.03.014","DOIUrl":"10.1016/j.tjog.2025.03.014","url":null,"abstract":"<div><div>High-grade serous carcinoma (HGSC) of the ovary is the most common and lethal subtype of ovarian cancer, representing the deadliest gynecological malignancy. Due to nonspecific symptoms and the absence of an effective screening tool for average-risk patients, most cases are diagnosed at advanced stages. As a result, fewer than 50 % of patients survive beyond five years post-diagnosis. Current screening methods, such as transvaginal ultrasound and CA-125 blood tests, are inadequate for early detection in the general as well as high-risk population. A promising innovation, the falloposcope, is being developed for routine screening, to detect ovarian cancer earlier, improve treatment outcomes, and enhancing survival rates.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 625-628"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low-level mosaic trisomy 21 at amniocentesis in a pregnancy with a favorable fetal outcome and a normal karyotype at birth","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.05.011","DOIUrl":"10.1016/j.tjog.2025.05.011","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 741-744"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cervical cancer in Taiwan","authors":"Szu-Ting Yang, Peng-Hui Wang, Chyong-Huey Lai","doi":"10.1016/j.tjog.2025.04.004","DOIUrl":"10.1016/j.tjog.2025.04.004","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 592-595"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Detection of mosaic 1q21.1 microdeletion in a fetus associated with megacystis and arthrogryposis of bilateral hands","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.05.002","DOIUrl":"10.1016/j.tjog.2025.05.002","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 716-717"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chia-Chen Lee, Kuan-Sheng Lee, Christine Shan-Chi Chiu, Robert Kuo-Kuang Lee, Ming-Huei Lin
{"title":"Better pregnancy outcomes in women with day 2 or day 3 fresh embryo transfer when progesterone supplementation for luteal phase support is initiated on the day of oocyte retrieval","authors":"Chia-Chen Lee, Kuan-Sheng Lee, Christine Shan-Chi Chiu, Robert Kuo-Kuang Lee, Ming-Huei Lin","doi":"10.1016/j.tjog.2023.12.006","DOIUrl":"10.1016/j.tjog.2023.12.006","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the pregnancy outcomes in women undergoing fresh embryo transfer (ET) with the initiation of luteal phase support (LPS) on the day of oocyte retrieval (OR) compared with LPS 1 day after OR.</div></div><div><h3>Materials and Methods</h3><div>Overall, 872 patients underwent fresh ET at Mackay Memorial Hospital between January 2017 and August 2021. Eligible patients were divided into two cleavage-stage (day 2 or day 3) ET and day 5 elective single ET (e-SET) groups. Pregnancy outcomes were analyzed with the initiation of LPS on the OR day and 1 day after OR. The subgroup with diminished ovarian reserve (DOR) (anti-Mullerian hormone ≤1.1 ng/mL) on cleavage-stage ET group was analyzed between the two LPS initiation time points.</div></div><div><h3>Results</h3><div>The cleavage-stage ET group that received LPS on the OR day showed significantly higher implantation (27.8 % vs. 17.6 %, <em>p</em> = 0.002), clinical pregnancy (46.3 % vs. 34.4 %, <em>p</em> = 0.022), and livebirth (33.7 % vs. 23.6 %, <em>p</em> = 0.037) rates. In the subgroup analysis of DOR in the cleavage-stage ET group, LPS initiated on the OR day led to significantly higher rates of implantation (30.7 % vs. 16.2 %, <em>p</em> = 0.048), clinical pregnancy (50.0 % vs. 26.5 %, <em>p</em> = 0.023), and nonstatistically significant but higher livebirth (38.6 % vs. 20.6 %, <em>p</em> = 0.067). In the day 5 e-SET group, no significant differences in clinical pregnancy (51 % vs. 59.4 %, <em>p</em> = 0.294) and livebirth (41 % vs. 44.4 %, <em>p</em> = 0.665) rates were found between the two LPS initiation time points.</div></div><div><h3>Conclusion</h3><div>Women undergoing day 2 or day 3 ET appear to have better pregnancy outcomes including clinical pregnancy, livebirth, and implantation rates when LPS was initiated on the OR day than those undergoing LPS initiated 1 day after OR, particularly for women with DOR. However, in the day 5 e-SET group, clinical outcomes are comparable between the two initiation time points.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 637-642"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"OHVIRA syndrome: A case report treated with delayed diagnosis and multidisciplinary approaches","authors":"Emrullah Akay, Alime Dilayda Uzun Gül","doi":"10.1016/j.tjog.2024.08.014","DOIUrl":"10.1016/j.tjog.2024.08.014","url":null,"abstract":"<div><h3>Objective</h3><div>OHVIRA syndrome is a rare condition involving genitourinary anomalies, where early diagnosis and intervention can reduce the need for complex treatment processes and surgical interventions.</div></div><div><h3>Case report</h3><div>A 42-year-old female patient was diagnosed with OHVIRA syndrome and treated with antibiotic therapy and vaginal septectomy; however, due to elevated CRP levels and severe abdominal pain, a hysterectomy was performed. Post-surgery, the patient showed improvement and was discharged.</div></div><div><h3>Conclusion</h3><div>OHVIRA syndrome is a rare congenital anomaly that manifests with symptoms during adolescence. The diagnostic and treatment process can be challenging and may involve various complications. Early diagnosis and minimally invasive surgery alleviate symptoms and preserve reproductive potential. This case report highlights the multidisciplinary management of OHVIRA syndrome and the complexities of the treatment processes.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 693-699"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hao Lin , Chen-Hsuan Wu , Hung-Chun Fu , Yu-Che Ou
{"title":"Recent advances in cervical cancer treatment: Innovations from early-stage to advanced disease","authors":"Hao Lin , Chen-Hsuan Wu , Hung-Chun Fu , Yu-Che Ou","doi":"10.1016/j.tjog.2025.04.006","DOIUrl":"10.1016/j.tjog.2025.04.006","url":null,"abstract":"<div><div>This article provides a comprehensive review of recent advancements in cervical cancer treatment, highlighting significant breakthroughs in managing the disease at various stages. Traditional treatments, such as radical surgery for early-stage disease and concurrent chemoradiation (CCRT) for advanced stages, have dominated clinical practice for decades. However, recent phase III studies have challenged these norms, leading to new treatment paradigms. For early-stage cervical cancer, the LACC trial revealed that minimally invasive surgery results in poorer outcomes compared to open surgery, prompting updates in clinical guidelines. Additionally, the SHAPE trial suggested that simple hysterectomy might be sufficient for low-risk cases, offering comparable oncological outcomes with fewer complications than radical hysterectomy. In locally advanced diseases, the INTERLACE study demonstrated the benefits of adding short-course induction chemotherapy before CCRT, improving progression-free and overall survival rates. Immunotherapy has also emerged as a promising treatment, with trials like KEYNOTE-A18 showing that pembrolizumab combined with CCRT enhances progression-free survival in high-risk cases. For recurrent or metastatic cervical cancer, the KEYNOTE-826 trial highlighted the efficacy of pembrolizumab with chemotherapy, showing significant survival benefits across various patient subgroups. The antibody–drug conjugates tisotumab vedotin and trastuzumab deruxtecan also showed promising results, even if patients have progressed after multiple lines of treatment including immunotherapy. These advances represent a shift towards more personalized and effective treatments for cervical cancer, improving outcomes for patients across different disease statuses.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 608-615"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Abnormal methylation of ST8SIA4 in low-motility sperm: A genome-wide identification approach","authors":"Chia-Ching Chang , Li-Chun Liu , Yu-Ting Chou , Chia-Wei Chen , Chih-Chi Guo , Chying-Chyuan Chan , Ta-Jen Lin , Ching-Hui Chen , Ming-Tzeung Chung","doi":"10.1016/j.tjog.2025.02.005","DOIUrl":"10.1016/j.tjog.2025.02.005","url":null,"abstract":"<div><h3>Objective</h3><div>To identify abnormally methylated genes associated with low motility sperm and to validate the DNA methylation level of our candidate gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (ST8SIA4) in low-motility sperm.</div></div><div><h3>Materials and methods</h3><div>The MethylationEPIC Array which can measure methylation at >850,000 CpG sites and a pooled DNA strategy were used to investigate the genome-wide methylation profiles in sperm with different motility. A total of seventy semen samples, including 52 normozoospermic controls and 18 asthenozoospermic samples, were used to examine the quantitative DNA methylation level of ST8SIA4 gene.</div></div><div><h3>Results</h3><div>Using the gene function classification in the DAVID Bioinformatics Resources, we found that the abnormally methylated genes in the asthenozoospermia samples were predominantly associated with transcription regulation, metal binding, microtubules, meiosis, palmitate, zinc, and developmental proteins. Interestingly, these glycosyltransferase-associated genes were all hypomethylated in asthenozoospermia, except for ST8SIA4.</div></div><div><h3>Conclusion</h3><div>The promoter methylation level of ST8SIA4 was significantly higher in sperm samples with low motility compared with normal control samples.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 650-654"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Detection of a rare maternal 6q27 microduplication in a fetus with no phenotypic abnormalities","authors":"Ji Wu , Weihua Tian , Tou Tou , Shuqin Xu","doi":"10.1016/j.tjog.2024.11.013","DOIUrl":"10.1016/j.tjog.2024.11.013","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 745-746"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}