Taiwanese Journal of Obstetrics & Gynecology最新文献

{"title":"Impact of mismatch repair genes deficiency on survival outcomes and establishment of a novel prognostic prediction model for stage I-II endometrial carcinoma","authors":"Wenhui Wang ,&nbsp;Zihan Yan ,&nbsp;Yuanyuan Chen ,&nbsp;Kang Ren ,&nbsp;Xiaorong Hou ,&nbsp;Ke Hu ,&nbsp;Fuquan Zhang","doi":"10.1016/j.tjog.2025.08.004","DOIUrl":"10.1016/j.tjog.2025.08.004","url":null,"abstract":"<div><h3>Objective</h3><div>Pathological characteristics and MMR status can be determined from microscopic indicators and immunohistochemical (IHC) staining of surgical specimens, and these approaches are more cost-effective and convenient than genome profiling tests. We aimed to evaluate the impact of MMR deficiency on survival outcomes and build a new prognostic model for early-stage endometrial carcinoma (EC) patients.</div></div><div><h3>Materials and methods</h3><div>Patients with stage I to II EC who underwent hysterectomy followed by adjuvant radiotherapy from Oct. 2017 to Dec. 2020 at our institution were retrospectively reviewed. Tumor MMR status was routinely tested by IHC. According to MMR status, they were classified into intact MMR (MMRp) group and defective MMR (MMRd) group.</div></div><div><h3>Results</h3><div>Patients were classified into MMRp group (n = 207) and MMRd group (n = 69). Compared with those in the MMRp group, patients in the MMRd group were more likely to have high-grade disease, LVSI, and high-intermediate risk (HIR)-to-high risk (HR) classifications. The 3-year CSS, DFS, and DMFS rates were significantly lower in the MMRd group. When patients were stratified by risk group, DFS and DMFS were significantly worse among MMRd patients in the HIR-to-HR group. Regarding failure patterns, MMRd patients were more likely to experience distant failure. Among 276 patients, multivariate Cox analysis revealed that ER or PR status, myometrial invasion (MI), MMR status, and LVSI were independent prognostic factors for DFS, whereas ER or PR status, MMR status, and MI were significant predictors of DMFS. A prediction model combining the MMR status and the significant prognostic predictors mentioned above in the multivariate analysis was built through nomogram models.</div></div><div><h3>Conclusion</h3><div>Among early-stage EC patients, MMRd group had poorer survivals. Combination of MMR status and other clinicopathological factors could establish a new prognostic model. Prospective studies with full molecular sequencing to determine the prognostic significance of MMR status are needed.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 81-88"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal diagnosis of a 2.61-Mb de novo 22q11.21 microduplication encompassing TBX1 in a pregnancy associated with no apparently phenotypic abnormality in the fetus","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.007","DOIUrl":"10.1016/j.tjog.2025.11.007","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 134-135"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mosaic 17q24.3q25.3 duplication at amniocentesis in a pregnancy associated with a favorable fetal outcome in a male fetus","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.018","DOIUrl":"10.1016/j.tjog.2025.11.018","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 164-166"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of Hirschsprung disease of total intestinal aganglionosis with intestinal dilatation and peristalsis on prenatal ultrasound","authors":"Yumi Shimizu,&nbsp;Yuri Hamada,&nbsp;Takeshi Murakoshi","doi":"10.1016/j.tjog.2025.08.006","DOIUrl":"10.1016/j.tjog.2025.08.006","url":null,"abstract":"<div><h3>Objective</h3><div>To present a case of total intestinal aganglionosis (TIA), which is the rarest form of Hirschsprung disease (HD) and is difficult to diagnose prenatally owing to nonspecific prenatal ultrasound findings.</div></div><div><h3>Case report</h3><div>In a 34-year-old primipara with a history of HD (total colonic aganglionosis), intestinal dilatation with intestinal movement like peristalsis was observed in the fetus starting at 36 weeks of gestation. By 38 weeks of gestation, the fetal abdominal circumference had increased, prompting cesarean section delivery. Prenatal ultrasound and postnatal barium enema findings suggested small intestinal obstruction, and the infant underwent laparotomy. However, HD was suspected based on the small intestinal dilatation associated with caliber changes. A full-layer biopsy from the dilated small intestine to the stomach revealed no ganglion cells, leading to a diagnosis of TIA.</div></div><div><h3>Conclusion</h3><div>Prenatal ultrasonography may reveal fetal intestinal dilatation with intestinal movement like peristalsis in HD, even in the aganglionic portion.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 123-125"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mosaic distal 11q deletion or 46,XY,del(11)(q23)/46, XY at amniocentesis and cordocentesis in a pregnancy associated with perinatal progressive decrease of the aneuploid cell line and a favorable fetal outcome","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.005","DOIUrl":"10.1016/j.tjog.2025.11.005","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 129-130"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mosaicism for 47,XXX or 47,XXX/46,XX at amniocentesis in a pregnancy with a favorable outcome and no prominent perinatal decrease of the 47,XXX cell line","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.006","DOIUrl":"10.1016/j.tjog.2025.11.006","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 131-133"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular cytogenetic characterization of a de novo small supernumerary marker chromosome detected by amniocentesis and derived from the acrocentric chromosome 14/22","authors":"Chih-Ping Chen ,&nbsp;Ming Chen ,&nbsp;Gwo-Chin Ma ,&nbsp;Shun-Ping Chang ,&nbsp;Wayseen Wang","doi":"10.1016/j.tjog.2025.11.009","DOIUrl":"10.1016/j.tjog.2025.11.009","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 140-142"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of secondary cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for treating recurrent ovarian cancer","authors":"Peng-Hui Wang ,&nbsp;Brahmana Askandar Tjokroprawiro ,&nbsp;Jae-Weon Kim","doi":"10.1016/j.tjog.2025.10.001","DOIUrl":"10.1016/j.tjog.2025.10.001","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 1-3"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-level mosaic trisomy 9 at amniocentesis in a pregnancy associated with intrauterine growth restriction, a positive non-invasive prenatal testing for trisomy 9, cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the trisomy 9 cell line, a heterozygous missense mutation of the PIEZO2 gene and an adverse fetal outcome","authors":"Chih-Ping Chen ,&nbsp;Shin-Yu Lin ,&nbsp;Fang-Tzu Wu ,&nbsp;Yen-Ting Pan ,&nbsp;Wayseen Wang","doi":"10.1016/j.tjog.2025.09.011","DOIUrl":"10.1016/j.tjog.2025.09.011","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 1106-1111"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ascites after assistance reproductive technology","authors":"Szu-Ting Yang,&nbsp;Wen-Hsun Chang,&nbsp;Peng-Hui Wang","doi":"10.1016/j.tjog.2025.09.020","DOIUrl":"10.1016/j.tjog.2025.09.020","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 944-946"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}