Taiwanese Journal of Obstetrics & Gynecology最新文献

{"title":"Prenatal diagnosis of a familial Xp22.12 duplication in a pregnancy with a favorable fetal outcome","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.017","DOIUrl":"10.1016/j.tjog.2025.11.017","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 161-163"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Arteriovenous malformation-related headache and seizures in pregnancy masquerading as eclampsia: A case report”","authors":"Sivalakshmi Ramu, Rinchen Zangmo, Sathiya Seelan","doi":"10.1016/j.tjog.2024.09.027","DOIUrl":"10.1016/j.tjog.2024.09.027","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Page 167"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apigenin modulates cell survival pathways and restores olaparib sensitivity in high-grade serous ovarian cancer cells","authors":"Jenn-Jhy Tseng ,&nbsp;Yeun-Ting Hsieh ,&nbsp;Chien-Hsing Lu","doi":"10.1016/j.tjog.2025.05.020","DOIUrl":"10.1016/j.tjog.2025.05.020","url":null,"abstract":"<div><h3>Objective</h3><div>High-grade serous ovarian cancer (HGSOC) presents significant therapeutic challenges, particularly due to acquired resistance to poly (ADP-ribose) polymerase inhibitors (PARPi) such as olaparib. This study examines the potential of apigenin (API), a naturally occurring flavonoid, to modulate survival pathways and restore olaparib sensitivity in HGSOC cell lines.</div></div><div><h3>Materials and methods</h3><div>Four human HGSOC cell lines (TYK-nu, Kuramochi, CAOV3, and OVCAR3) and their olaparib-resistant derivatives were used. Olaparib resistance was induced by gradually exposing cells to increasing concentrations of olaparib. Cells were treated with API, and cell viability, apoptosis, and cell cycle distribution were assessed using MTT assays and flow cytometry. Western blotting was performed to analyze STAT3 and AKT phosphorylation, apoptotic markers, and cell cycle regulators, while immunofluorescence was used to evaluate STAT3 subcellular localization.</div></div><div><h3>Results</h3><div>API reduced cell viability in all HGSOC cell lines in a dose-dependent manner, exhibiting differential sensitivity. It induced cell death in TYK-nu and OVCAR3, while causing G2/M phase arrest in Kuramochi and CAOV3. API selectively inhibited pSTAT3 (Y705) and pAKT (S308) without altering total protein levels or STAT3 nuclear localization. Additionally, it downregulated key cell cycle regulators, including p53, p27, p21, and p16 across all lines. Cyclin B1 levels decreased universally, while CDC2 (CDK1) downregulation was specific to Kuramochi and CAOV3, correlating with G2/M arrest. Notably, API restored olaparib sensitivity in resistant Kuramochi and CAOV3 cells by reducing pSTAT3 (Y705) levels, indicating that STAT3 modulation may be a potential mechanism for overcoming resistance.</div></div><div><h3>Conclusion</h3><div>API suppresses HGSOC progression by inducing apoptosis, arresting the cell cycle, and modulating survival pathways. It also restores olaparib sensitivity in resistant cells, supporting its potential as an adjuvant therapy to enhance olaparib efficacy in combination treatments.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 34-43"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of niraparib on reducing the platelet count in patients with ovarian cancer","authors":"Mika Mizuno,&nbsp;Mai Nakazono,&nbsp;Mika Fukuda,&nbsp;Shintaro Yanazume,&nbsp;Shinichi Togami,&nbsp;Hiroaki Kobayashi","doi":"10.1016/j.tjog.2025.04.024","DOIUrl":"10.1016/j.tjog.2025.04.024","url":null,"abstract":"<div><h3>Objective</h3><div>Niraparib (NIRA) is a poly(ADP-ribose) polymerase inhibitor used as maintenance therapy for ovarian carcinomas. Thrombocytopenia is a common adverse event associated with NIRA. This study aimed to evaluate the frequency of NIRA-induced thrombocytopenia and the associated risk factors in clinical practice.</div></div><div><h3>Materials and methods</h3><div>Data from 30 patients who received NIRA as a first-line or recurrent treatment at our institution were retrospectively analyzed to assess reductions in platelet count (PLT).</div></div><div><h3>Results</h3><div>The median participant age was 59 (range: 39–75) years, and the median weight was 50 (range: 36–80) kg. NIRA was initiated at a median of 4 (range: 3–8) weeks after the last chemotherapy dose. The prevalence of grade ≥3 thrombocytopenia was 23.3 %, dose interruptions occurred in 53.3 % and dose reductions occurred in 40 %. The median follow-up time was 20 (range: 2–166) months after resumption. Due to thrombocytopenia, one patient discontinued treatment 2 weeks after administration (nadir PLT: 1 × 10⁹/L), and 2 others discontinued treatment after resumption. For the non-interruption and interruption groups, the median nadir PLTs were 194 (91–318) and 57 (1–89) × 10⁹/L (p &lt; 0.001), respectively, the median baseline PLTs were 215 vs. 120 × 10⁹/L (p &lt; 0.001), respectively, and the nadir PLTs during prior chemotherapy were 175 vs. 73 × 10⁹/L (p = 0.007), respectively. Lower baseline PLTs were significantly associated with an increased risk of thrombocytopenia (OR 0.793, 95 % CI 0.654–0.964; p = 0.019).</div></div><div><h3>Conclusions</h3><div>Our real-world data reaffirmed that thrombocytopenia is a significant adverse event that affects the continuation of NIRA and requires careful monitoring. Adjusting the start time to ensure an adequate baseline PLT may help mitigate this risk, but larger-scale studies are needed to validate these findings.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 75-80"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral endometrioma of ovary in a 25-year-old woman with unilateral autoamputation and contralateral torsion of ovary: A case report","authors":"Chia-Wei Chang","doi":"10.1016/j.tjog.2024.08.019","DOIUrl":"10.1016/j.tjog.2024.08.019","url":null,"abstract":"<div><h3>Objective</h3><div>We report a unique case of bilateral ovarian endometrioma in a young woman with suspected torsion. To the best of our knowledge, no previous cases of unilateral torsion with contralateral autoamputation of an ovarian endometrioma have been reported. This case underscores the importance of laparoscopic management and its potential benefits for preserving fertility.</div></div><div><h3>Case report</h3><div>A 25-year-old woman with no history of acute abdominal pain was initially diagnosed with bilateral ovarian endometrioma and torsion. During emergent laparoscopic surgery, an autoamputation of the left ovarian endometrioma with reimplantation into the great omentum was discovered incidentally after adhesiolysis. The amputated tumor had blood supply from the left lower quadrant of the great omentum, and concurrent torsion of the right ovarian endometrioma was noted. A cutting notch was identified over the left infundibulopelvic ligament, despite the absence of prior surgical history. This finding supported the diagnosis of autoamputation of the left adnexa due to a previous asymptomatic torsion of the ovarian endometrioma. All masses were removed laparoscopically.</div></div><div><h3>Conclusion</h3><div>Clinicians should consider spontaneous autoamputation of the adnexa as a potential condition in women presenting with adnexal masses even in the absence of prior abdominal pain. Before undertaking destructive procedures such as adnexectomy or enucleation, a thorough evaluation of the bilateral ovaries should be performed to preserve future fertility.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 107-109"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and diagnostic challenges in a nullipara with spontaneous uterine rupture during vaginal delivery","authors":"I-Ning Cheng ,&nbsp;Tsung-Hsuan Lai","doi":"10.1016/j.tjog.2025.07.029","DOIUrl":"10.1016/j.tjog.2025.07.029","url":null,"abstract":"<div><h3>Objective</h3><div>To present a rare case of uterine rupture after vaginal delivery under epidural anesthesia in a nulliparous woman without prior uterine surgery.</div></div><div><h3>Case report</h3><div>A 38-year-old primiparous woman with a history of infertility conceived through in vitro fertilization. At 39 weeks of gestation, she was admitted due to spontaneous premature rupture of membranes. Oxytocin was administered for labor augmentation, and fundal pressure was applied for maternal exhaustion, leading to the delivery of a healthy infant. Secondary laceration of perineum was found but no cervical laceration was detected just after vaginal delivery. Primary repair was performed layers by layers smoothly. Shortly after delivery, the patient developed hypotension, tachycardia, nausea, and poor uterine tone, but without abdominal pain, likely due to epidural anesthesia masking symptoms. Abdominal ultrasound revealed intrauterine clots and some fluid in the cul-de-sac, suggesting uterine rupture. An emergent laparotomy identified a 10 cm posterior uterine laceration, which was successfully repaired.</div></div><div><h3>Conclusion</h3><div>This case highlights the importance of promptly recognizing atypical or subtle signs of uterine rupture particularly when classical symptoms are masked by epidural anesthesia. Clinicians should maintain a highly suspicion and closely monitor for alternative indicators, such as hemodynamic instability or abnormal fetal heart rate patterns. In addition, fundal pressure should be applied with caution, especially in patients with risk factors for uterine rupture such as myomectomy, to minimize the risk of adverse maternal outcomes.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 119-122"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal and postnatal determinants of clinical outcomes in congenital heart diseases: A 15-year retrospective cohort study","authors":"Jenn-Jhy Tseng ,&nbsp;Shen-Ling Jan ,&nbsp;Chia-Jung Hsieh ,&nbsp;Li-Ling Lin ,&nbsp;Hsien-Wen Peng","doi":"10.1016/j.tjog.2025.06.005","DOIUrl":"10.1016/j.tjog.2025.06.005","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;Congenital heart diseases (CHDs), the most common congenital anomalies, significantly impact pediatric morbidity and mortality. This 15-year retrospective study investigates prenatal features and postnatal outcomes in CHD cases, focusing on factors influencing surgical intervention, mortality, and long-term care.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;div&gt;We retrospectively reviewed 170 perinatally diagnosed CHD cases at Taichung Veterans General Hospital between January 2008 and October 2023. Diagnosis was primarily based on two-dimensional grayscale and Doppler echocardiography, with speckle tracking echocardiography (STE) employed in several cases. Among these, 119 ongoing pregnancies continued to delivery, 32 ended in termination of pregnancy (TOP) or intrauterine fetal demise (IUFD), and 19 were lost to follow-up. CHDs were categorized using two classification systems based on anatomical, physiological, and locational criteria. Maternal and fetal characteristics and echocardiographic findings were analyzed.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Prenatal diagnosis was achieved in 93.5 % of cases, with a median gestational age of 22 weeks at diagnosis. Genetic abnormalities were detected in 3.4 % of cases for karyotypes and 9.3 % for gene dosage changes. CHD subtype distributions varied significantly among outcome groups. In classification-1, left-to-right shunts and arrhythmias predominated in the delivery group, cyanotic CHDs were most common in the TOP/IUFD group, and obstructive lesions/miscellaneous conditions were more frequent in the lost to follow-up group (&lt;em&gt;P&lt;/em&gt; = 0.012). In classification-2, right- and left-sided disorders were most frequent in the delivery group, while mixed or unclassified disorders dominated the TOP/IUFD group (&lt;em&gt;P&lt;/em&gt; = 0.003). Isolated CHDs accounted for 71.2 % of cases but were significantly less frequent in the TOP/IUFD group (&lt;em&gt;P&lt;/em&gt; = 0.001). A higher number of coexistent intracardiac anomalies increased the risk of TOP/IUFD (&lt;em&gt;P&lt;/em&gt; &lt; 0.001). Significant group differences were also noted for isolated ventricular septal defect (&lt;em&gt;P&lt;/em&gt; = 0.009) and right aortic arch (&lt;em&gt;P&lt;/em&gt; = 0.003). Among the 119 deliveries, 24.4 % required early postnatal interventions. Predictive factors included cyanotic CHDs, obstructive lesions, and arrhythmias (&lt;em&gt;P&lt;/em&gt; &lt; 0.001). Neonatal mortality was strongly associated with a 5-min Apgar score &lt;7 (adjusted odds ratio [aOR] 6.63, &lt;em&gt;P&lt;/em&gt; = 0.037). Coexistent intracardiac anomalies increased the risk of hospital readmission (aOR 1.71, &lt;em&gt;P&lt;/em&gt; = 0.034) and post-neonatal surgery (adjusted hazard ratio [aHR] 1.63, &lt;em&gt;P&lt;/em&gt; &lt; 0.001). Both STE and conventional echocardiography provided important insights into myocardial function and hemodynamics in severe cases.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;CHD type, complexity, and coexisting conditions, along with key prenatal and postnatal factors, significantly in","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 44-54"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical impact of glandular involvement in high-grade squamous intraepithelial lesions of the cervix","authors":"Szu-Ting Yang ,&nbsp;Che-Wei Chang ,&nbsp;Peng-Hui Wang","doi":"10.1016/j.tjog.2025.12.002","DOIUrl":"10.1016/j.tjog.2025.12.002","url":null,"abstract":"<div><h3>Objective</h3><div>The prognostic significance of glandular involvement in high-grade squamous intraepithelial lesions (HSIL) following cervical conization remains unclear. This research aimed to evaluate the clinical impact of glandular involvement on surgical outcomes.</div></div><div><h3>Materials and methods</h3><div>Between December 2019 and December 2020, 119 patients who underwent cervical conization were retrospectively observed. Patient characteristics, such as human papillomavirus (HPV) status, cytology results, glandular involvement, conization specimen depth and volume, margin status, and recurrence were collected and analyzed.</div></div><div><h3>Results</h3><div>Glandular involvement was significantly associated with positive endocervical margins (22.0 % <em>vs</em>. 6.5 %, <em>p</em> = 0.017), higher prevalence of preceding HSIL or CIN (cervical intraepithelial neoplasm)2/CIN3 cytology (60.4 % <em>vs</em>. 42.0 %), and increased HPV16 infection among high-risk HPV positive patients (69.2 % <em>vs</em>. 34.8 %, <em>p</em> = 0.050). No significant differences were observed in recurrence rates among patients with HSIL with or without glandular involvement. Multivariable analysis identified that margin status is the only independent predictor of recurrence (positive margin: OR [odds ratio] 26.85, 95 % CI [confidence interval] 2.59–277.86, <em>p</em> = 0.006 or uncertain margins: OR 29.90, 95 % CI 1.09–818.17, <em>p</em> = 0.044).</div></div><div><h3>Conclusion</h3><div>While glandular involvement in HSIL is associated with positive endocervical margins, abnormal preceding cytology, and higher risk of HPV16 infection, it does not independently predict recurrence following conization. Instead, positive surgical margins are the primary factor of recurrence, highlighting the value of achieving complete excision to optimize patient outcomes.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 64-69"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conservative management of early-onset cerebral venous thrombosis in pregnancy resulting in full-term delivery: A case report","authors":"Xiaoqian Pan ,&nbsp;Xiaoli Zhang ,&nbsp;Rui Qin ,&nbsp;Heyun Ruan","doi":"10.1016/j.tjog.2025.09.022","DOIUrl":"10.1016/j.tjog.2025.09.022","url":null,"abstract":"<div><h3>Objective</h3><div>Cerebral venous thrombosis is a rare disease with a high mortality rate. Pregnancy can increase the risk of intracranial venous sinus thrombosis formation, and this condition in turn elevates the maternal mortality rate. Therefore, early diagnosis and appropriate treatment of intracranial venous sinus thrombosis during pregnancy are crucial for the prognosis of pregnant women.</div></div><div><h3>Case Report</h3><div>We present a case of 30-year-old woman who had a spontaneous conception, thrombophilia occurring in the early stages of pregnancy, which was further aggravated by cerebral venous thrombosis. However, with appropriate medical intervention, a successful full-term delivery occurred.</div></div><div><h3>Conclusion</h3><div>The management of cerebral venous thrombosis during pregnancy is of great importance. When the patient's condition permits, conservative treatment can be adopted, leading to a favorable prognosis for both the mother and the fetus.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 99-102"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-level mosaicism for 45,X in 45,X/46,XX at amniocentesis associated with postnatal progressive decrease of the 45,X cell line and a favorable fetal outcome in a twin pregnancy","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.012","DOIUrl":"10.1016/j.tjog.2025.11.012","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 149-150"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}