Xiao-Xiao Hu, Liu Liu, Li-Juan Zhao, Hong-Fei Jiang, Song-Ying Zhang
{"title":"The timing for embryo transfer after antibiotic therapy for chronic endometritis","authors":"Xiao-Xiao Hu, Liu Liu, Li-Juan Zhao, Hong-Fei Jiang, Song-Ying Zhang","doi":"10.1016/j.tjog.2024.02.005","DOIUrl":"https://doi.org/10.1016/j.tjog.2024.02.005","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the optimal timing of embryo transfer after the first round treatment of chronic endometritis (CE) in vitro.</p></div><div><h3>Materials and methods</h3><p>A total of 184 patients were recruited from a retrospective analysis of a large university-affiliated reproduction center in 2021. Some people chose to undergo embryo transfer in the same menstrual cycle with the first round of antibiotic treatment (Group 1, n = 29). Others received embryo transfer in the next cycle after the first round of treatment (Group 2, n = 69) or even one cycle later (Group 3,n = 96).</p></div><div><h3>Results</h3><p>Patients in Group 1 got significantly lower biochemical pregnancy rate and clinical pregnancy rate and live birth rate than Group 2 (p < 0.05) and also Group 3 (p < 0.05). Then after comparing the influence factors, we found embryo transfer in the next cycle after antibiotic treatment had a higher clinical pregnancy rate than group 1 (OR = 3.2 p < 0.05) and group 3(OR = 2.5, p < 0.05). The live birth rate in group 2 was higher than group 1(OR = 3.5, p < 0.05).</p></div><div><h3>Conclusion</h3><p>These findings illustrate that embryo transfer in the next menstrual cycle is the optimal time. Embryo transfer in the same menstrual cycle with the first round of treatment reduces the pregnancy rate.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924000731/pdfft?md5=8e95967852edb19cfbd401fe39bdaef4&pid=1-s2.0-S1028455924000731-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141097463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prenatal diagnosis of familial 17q11.2 duplication encompassing NF1 in a pregnancy associated with asymptomatic carrier parent","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2024.03.012","DOIUrl":"https://doi.org/10.1016/j.tjog.2024.03.012","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924000895/pdfft?md5=eb486d7a3e392c8d62dfcb77af007b6d&pid=1-s2.0-S1028455924000895-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141097677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patricia Nga Ping Ip , Long Nguyen-Hoang , Piya Chaemsaithong , Jun Guo , Xueqin Wang , Daljit Singh Sahota , Jacqueline Pui Wah Chung , Liona Chiu Yee Poon
{"title":"Ultrasonographic placental parameters at 11–13+6 weeks’ gestation in the prediction of complications in pregnancy after assisted reproductive technology","authors":"Patricia Nga Ping Ip , Long Nguyen-Hoang , Piya Chaemsaithong , Jun Guo , Xueqin Wang , Daljit Singh Sahota , Jacqueline Pui Wah Chung , Liona Chiu Yee Poon","doi":"10.1016/j.tjog.2023.09.023","DOIUrl":"https://doi.org/10.1016/j.tjog.2023.09.023","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the performance of maternal factors, biophysical and biochemical markers at 11–13 + 6 weeks’ gestation in the prediction of gestational diabetes mellitus with or without large for gestational age (GDM ± LGA) fetus and great obstetrical syndromes (GOS) among singleton pregnancy following in-vitro fertilisation (IVF)/embryo transfer (ET).</p></div><div><h3>Materials and methods</h3><p>A prospective cohort study was conducted between December 2017 and January 2020 including patients who underwent IVF/ET. Maternal mean arterial pressure (MAP), ultrasound markers including placental volume, vascularisation index (VI), flow index (FI) and vascularisation flow index (VFI), mean uterine artery pulsatility index (mUtPI) and biochemical markers including placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) were measured at 11–13 + 6 weeks’ gestation. Logistic regression analysis was performed to determine the significant predictors of complications.</p></div><div><h3>Results</h3><p>Among 123 included pregnancies, 38 (30.9%) had GDM ± LGA fetus and 28 (22.8%) had GOS. The median maternal height and body mass index were significantly higher in women with GDM ± LGA fetus. Multivariate logistic regression analysis demonstrated that in the prediction of GDM ± LGA fetus and GOS, there were significant independent contributions from FI MoM (area under curve (AUROC) of 0.610, 95% CI 0.492–0.727; p = 0.062) and MAP MoM (AUROC of 0.645, 95% CI 0.510–0.779; p = 0.026), respectively.</p></div><div><h3>Conclusion</h3><p>FI and MAP are independent predictors for GDM ± LGA fetus and GOS, respectively. However, they have low predictive value. There is a need to identify more specific novel biomarkers in differentiating IVF/ET pregnancies that are at a higher risk of developing complications.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924000743/pdfft?md5=547eec5e97675273fb9182a093230b08&pid=1-s2.0-S1028455924000743-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141097466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vu Viet Ha Vuong , Phuoc-Dung Nguyen , Nha Nguyen Thi , Phuong Le Thi , Dang Thi Minh Nguyet , Manh Ha Nguyen , Hai Anh Tran , Nhat-Minh Dang-Tran , The-Hung Bui , Thinh Huy Tran , Thanh Van Ta , Van-Khanh Tran
{"title":"Application of short tandem repeats (STRs) in the preimplantation genetic diagnosis (PGD) of α-thalassemia","authors":"Vu Viet Ha Vuong , Phuoc-Dung Nguyen , Nha Nguyen Thi , Phuong Le Thi , Dang Thi Minh Nguyet , Manh Ha Nguyen , Hai Anh Tran , Nhat-Minh Dang-Tran , The-Hung Bui , Thinh Huy Tran , Thanh Van Ta , Van-Khanh Tran","doi":"10.1016/j.tjog.2023.09.024","DOIUrl":"https://doi.org/10.1016/j.tjog.2023.09.024","url":null,"abstract":"<div><h3>Objectives</h3><p>α-thalassemia is an autosomal recessive monogenic blood disorder, affecting up to 5% of the world's population. The occurrence rate of the disease in Vietnam varies up to up to 51.5%, with high rate of mutation carriers, of couples consisting of two carriers at risk of bearing a child with fetal Hb Bart, which can develop into hydrops fetalis syndrome, threatening the well-being of the mother and the child. Our study aims to facilitate birth of healthy/asymptomatic children of α-thalassemia carrier couples who received reproductive service at our centre during the period of 2019–2022.</p></div><div><h3>Materials and methods</h3><p>89 couples at risks of having α-thalassemia offsprings requested IVF procedures and PGD at Post Hospital during 2019–2022 were recruited for investigation. Couple and additional family members’ peripheral blood samples of couples and additional family members were subjected to haemoglobin electrophoresis, DNA extraction for α-thalassemia gene mutation detection and STRs linkage analysis. Data were observed and analysed on GeneMarker software.</p></div><div><h3>Results</h3><p>91 cycles of PGD for α-thalassemia were carried out for 89 couples. α-thalassemia large deletion (--<sup>SEA</sup>/αα) was the most common mutation identified in 88 couples, in which 4 cases also carried β-thalassemia point mutations. Combining results of PGS and PGD, 278/424 amplified embryos were transferable (HBA-mutation free or carriers of single heterozygous HBA mutation, without chromosomal abnormality). 64/89 couples have been transferred with the embryos (prioritizing mutation free ones over carriers), resulting in the birth of 36 α-thalassemia disease-free children, 17 ongoing pregnancies, and 11 with miscarriages.</p></div><div><h3>Conclusion</h3><p>Successful application of microsatellite-based method in PGD facilitated the birth of 36 healthy children and 17 ongoing pregnancies for 53/64 couples with embryo-transferred. All resulted clinical births displayed confirmation results in line with the PGD results, thus demonstrating the feasibility and credibility of the use of STR markers in PGD.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924000780/pdfft?md5=117edf4650ae6d1b2a207656e20ba81a&pid=1-s2.0-S1028455924000780-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141097645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical course and genetic analysis of a case of the amniocentesis showing chromosome 6 trisomy mosaicism","authors":"Naoya Kitamura , Yuki Ito , Tomoko Kawai , Hiromi Kamura , Michihiro Yamamura , Haruna Okubo , Akihiro Hasegawa , Momoko Inoue , Ken Takahashi , Michiko Miya , Hiroshi Kawame , Osamu Samura , Aikou Okamoto","doi":"10.1016/j.tjog.2024.03.009","DOIUrl":"https://doi.org/10.1016/j.tjog.2024.03.009","url":null,"abstract":"<div><h3>Objective</h3><p>Herein, we present a case of mosaic trisomy 6 detected by amniocentesis.</p></div><div><h3>Case report</h3><p>Amniocentesis (G-banding) was performed at 17 weeks of gestation; the results were 47,XY,+6[3]/46,XY[12]. Fetal screening ultrasonography showed no morphological abnormalities, and the parents desired to continue the pregnancy. The infant was delivered vaginally at 39 weeks' gestation. The male infant weighed 3002 g at birth with no morphological abnormalities. G-banding karyotype analysis performed on the infant's peripheral blood revealed 46,XY[20]. FISH analysis revealed trisomy signals on chromosome 6 in 1–4 out of 100 cells from the placenta. The single nucleotide polymorphism microarray of the umbilical cord blood revealed no abnormalities. Methylation analysis of umbilical cord blood revealed no abnormalities in <em>PLAGL1</em>. No disorders were observed at one year of age.</p></div><div><h3>Conclusion</h3><p>When amniocentesis reveals chromosomal mosaicism, it is essential to provide a thorough fetal ultrasound examination and careful genetic counseling to support the couples’ decision-making.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S102845592400086X/pdfft?md5=5542ff4a9fc752b8108ceaf4907fc6c9&pid=1-s2.0-S102845592400086X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141097648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ping-Ping Zhang , Gui-Chun Ding , Chen-Yue Tao , Lei Zhang , Yi-Xiong Wang , Qiu-Yue Yuan , Sheng-Min Zhang , Li-Ping Wang
{"title":"Levels of trace metals and their impact on oocyte: A review","authors":"Ping-Ping Zhang , Gui-Chun Ding , Chen-Yue Tao , Lei Zhang , Yi-Xiong Wang , Qiu-Yue Yuan , Sheng-Min Zhang , Li-Ping Wang","doi":"10.1016/j.tjog.2024.02.003","DOIUrl":"https://doi.org/10.1016/j.tjog.2024.02.003","url":null,"abstract":"<div><p>Trace metals play a vital role in a variety of biological processes, but excessive amounts can be toxic and are receiving increasing attention. Trace metals in the environment are released from natural sources, such as rock weathering, volcanic eruptions, and other human activities, such as industrial emissions, mineral extraction, and vehicle exhaust. Lifestyle, dietary habits and environmental quality are the main sources of human exposure to trace metals, which play an important role in inducing human reproductive infertility. The purpose of this review is to summarize the distribution of various trace metals in oocyte and to identify the trace metals that may cause oocyte used in the design and execution of toxicological studies.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924000706/pdfft?md5=cbd0d46ea931994703d31d9d9f4b1cdc&pid=1-s2.0-S1028455924000706-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141097773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endometriosis, pregnancy and delivery complications: Evidence from the US nationwide inpatient sample 2005–2018","authors":"Kuan-Lin Chiu , I-Te Wang","doi":"10.1016/j.tjog.2023.06.005","DOIUrl":"https://doi.org/10.1016/j.tjog.2023.06.005","url":null,"abstract":"<div><h3>Objective</h3><p>Endometriosis is associated with higher risk of ectopic pregnancy, premature delivery, miscarriage, and other adverse maternal and fetal complications. This study aimed to assess the impact of endometriosis on maternal and fetal outcomes of singleton pregnancies in a large nationally representative database.</p></div><div><h3>Materials and methods</h3><p>This population-based, retrospective observational study extracted the data of women aged 20–49 years with singleton, spontaneously conceived pregnancies from the US Nationwide Inpatient Sample (NIS) database from 2005 to 2018. Included subjects were divided into those with ICD codes for endometriosis and those without (non-endometriosis group). Data of maternal and fetal outcomes were compared between groups and analyzed using regression analysis.</p></div><div><h3>Results</h3><p>After excluding 17,124 women who conceived with assisted reproductive technology (ART), 162,155 women with multiple pregnancies, and 27,847 with abnormal trend weight values (TRENDWT), a total of 8,584,269 women were eligible. After propensity score matching (PMS) case–control 1:4 by age, 45,560 remained (9112 (0.1%) with endometriosis, 36,448 without) and were included in the analysis. The mean age of women before matching was 28.7 years, and 30.5 years after matching. The most common comorbidity was chronic pulmonary disease (3.6%). Smoking frequency was higher in women with endometriosis compared to those without (4.8% vs. 2.4%). Multivariable analysis adjusted for confounders revealed that endometriosis was associated with significantly higher risk of maternal complications, including pre-eclampsia and eclampsia, antepartum hemorrhage, placenta previa, Cesarean delivery, post-partum hemorrhage, disseminated intravascular coagulation (DIC), transfusion, hemoperitoneum, and hospital stays ≥6 days. For fetal outcomes, endometriosis was associated with higher risk of intrauterine growth restriction (IUGR), premature birth, birth defects and abortion.</p></div><div><h3>Conclusion</h3><p>Endometriosis during pregnancy is associated with maternal and fetal complications. Study findings may serve as a benchmark for expanding medical assistance for endometriosis-affected pregnant women.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924000755/pdfft?md5=289ba2bf06dcad76b86ca1d8e11a38e5&pid=1-s2.0-S1028455924000755-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141097467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chih-Ping Chen , Fang-Tzu Wu , Yen-Ting Pan , Peih-Shan Wu , Chen-Chi Lee , Chien-Ling Chiu , Wayseen Wang
{"title":"Low-level mosaic trisomy 21 at amniocentesis in a pregnancy associated with cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the trisomy 21 cell line and a favorable fetal outcome","authors":"Chih-Ping Chen , Fang-Tzu Wu , Yen-Ting Pan , Peih-Shan Wu , Chen-Chi Lee , Chien-Ling Chiu , Wayseen Wang","doi":"10.1016/j.tjog.2024.03.007","DOIUrl":"https://doi.org/10.1016/j.tjog.2024.03.007","url":null,"abstract":"<div><h3>Objective</h3><p>We present low-level mosaic trisomy 21 at amniocentesis in a pregnancy with a favorable fetal outcome.</p></div><div><h3>Case Report</h3><p>A 38-year-old, gravida 2, para 1, woman underwent amniocentesis at 17 weeks of gestation because of advanced maternal age. Amniocentesis revealed a karyotype of 47,XY,+21[4]/46,XY[34]. Prenatal ultrasound findings were normal. At 27 weeks of gestation, she was referred for genetic counseling, and the cultured amniocytes had a karyotype of 47,XY,+21[2]/46,XY[26]. Quantitative fluorescent polymerase chain reaction (QF-PCR) analysis on the DNA extracted from uncultured amniocytes and parental bloods excluded uniparental disomy (UPD) 21. Interphase fluorescence <em>in situ</em> hybridization (FISH) analysis on uncultured amniocytes revealed 30% (30/100 cells) mosaicism for trisomy 21. Array comparative genomic hybridization (aCGH) analysis on the DNA extracted from uncultured amniocytes revealed the result of arr 21q11.2q22.3 × 2.25, consistent with 20%–30% mosaicism for trisomy 21. The parental karyotypes were normal. The woman was advised to continue the pregnancy, and a 3510-g phenotypically normal male baby was delivered at 39 weeks of gestation. Cytogenetic analysis of the cord blood, umbilical cord and placenta revealed the karyotypes of 47,XY,+21[1]/46,XY[39], 47,XY,+21[2]/46,XY[38] and 46,XY in 40/40 cells, respectively. When follow-up at age 1 year and 2 months, the neonate was normal in phenotype and development. The peripheral blood had a karyotype of 46,XY in 40/40 cells, and interphase FISH analysis on uncultured buccal mucosal cells showed 6.4% (7/109 cells) mosaicism for trisomy 21.</p></div><div><h3>Conclusion</h3><p>Low-level mosaic trisomy 21 at amniocentesis can be associated with cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the trisomy 21 cell line and a favorable fetal outcome.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924000822/pdfft?md5=5441a01195ee540a0d880b2afabdf012&pid=1-s2.0-S1028455924000822-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141097501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}