Taiwanese Journal of Obstetrics & Gynecology最新文献_第8页

Low-level mosaic trisomy 21 at amniocentesis in a pregnancy associated with an abnormal first-trimester maternal serum screening result, a favorable fetal outcome and postnatal decrease of the aneuploid cell line 妊娠期羊膜穿刺术中低水平镶嵌21三体与妊娠早期母体血清筛查结果异常、有利的胎儿结局和出生后非整倍体细胞系减少有关

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2025.05.009

Chih-Ping Chen

引用次数: 0

PHLDA2 expression and promoter methylation in placental trophoblasts: Associations with preeclampsia development 胎盘滋养细胞PHLDA2表达和启动子甲基化：与子痫前期发展的关系

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2025.01.006

Jie Chen, Youhong Zheng, Lilin Hang, Huiyan Wang

{"title":"PHLDA2 expression and promoter methylation in placental trophoblasts: Associations with preeclampsia development","authors":"Jie Chen, Youhong Zheng, Lilin Hang, Huiyan Wang","doi":"10.1016/j.tjog.2025.01.006","DOIUrl":"10.1016/j.tjog.2025.01.006","url":null,"abstract":"<div><h3>Objective</h3><div>Preeclampsia (PE) is an idiopathic and life-threatening pregnancy-related disease. Alterations to DNA methylation in imprinted genes may play a crucial role in the dysfunction of trophoblast cells and PE.</div></div><div><h3>Materials and methods</h3><div>Herein, we sought to elucidate the characteristics of PHLDA2 in placental trophoblasts and its underlying mechanisms in pregnant women with PE. Between January 2019 and December 2021, the clinical data and placental tissue samples from 15 PE cases and 15 control women who underwent obstetric examination were collected. Immunohistochemistry, qRT-PCR, WB and pyrosequencing were used to detect and compare the expression and methylation status of imprinted gene PHLDA2 in placental tissues of the two groups.</div></div><div><h3>Results</h3><div>The expression levels of PHLDA2 mRNA and protein were significantly higher in the placental tissue of PE patients than those of healthy controls during the third trimester (<em>P = 0.001)</em>. Additionally, PHLDA2 expression levels were evaluated in four trophoblast cell lines, with the JEG-3 line showing the lowest expression of PHLDA2. Notably, the JEG-3 line demonstrated a significantly faster rate of proliferation compared to the other three cell lines. When the PHLDA2 was overexpressed in JEG-3 cells, the proliferative proteins were significantly reduced, while the expression levels of apoptosis-related proteins p27 and cleaved-caspase3 were significantly increased. In addition, pyrosequencing showed that the methylation levels of the <em>PHLDA2</em> promoter region were significantly lower in PE placentas than in controls.</div></div><div><h3>Conclusion</h3><div>The hypomethylation status of the <em>PHLDA2</em> promoter is associated with its altered expression in PE placentas, suggesting a potential role in the condition's pathogenesis.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 662-670"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of motor imagery focused pelvic floor exercises and relaxation exercises for treating dysmenorrhea: A randomized controlled study 运动意象集中盆底练习和放松练习治疗痛经的比较：一项随机对照研究

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2024.12.029

Selda Koçoğlu , Ömer Şevgin , Beyzanur Dikmen Hoşbaş

{"title":"Comparison of motor imagery focused pelvic floor exercises and relaxation exercises for treating dysmenorrhea: A randomized controlled study","authors":"Selda Koçoğlu , Ömer Şevgin , Beyzanur Dikmen Hoşbaş","doi":"10.1016/j.tjog.2024.12.029","DOIUrl":"10.1016/j.tjog.2024.12.029","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the impact of integrating motor imagery-focused pelvic floor exercises (MOPEXE) and relaxation exercise (RE) on pain and menstrual symptoms in the management of dysmenorrhea.</div></div><div><h3>Materials and methods</h3><div>60 participants with dysmenorrhea were randomly allocated to MOPEXE, RE, and a combination group that included both exercises. Participants were instructed to perform the relevant exercise program 3-d per week for eight weeks. The Menstruation Attitude Questionnaire (MAQ), Functional and Emotional Dysmenorrhea Scale (FEDS), and Short-Form McGill Pain Questionnaire (SF-MPQ) were used to assess pre- and post-treatment participant-reported outcomes.</div></div><div><h3>Results</h3><div>Combination therapy revealed a significant decrease in VAS and FEDS (emotional) and an increase in MAQ (deliberating event, natural event, anticipation, and denial parameters) compared to MOPEXE. MOPEXE group demonstrated a significant increase in menstruation as a bothersome event and a decrease in FEDS (functional). In comparison with the RE group, MAQ scores were significantly higher in the combination group. A significant reduction in VAS and an increase in the denial parameter of MAQ were observed in the RE group.</div></div><div><h3>Conclusion</h3><div>Physical therapy with pelvic floor and relaxation exercises centered on motor imagery is an effective measure to reduce painful symptoms and to relieve dysmenorrhea both in terms of functional and emotional aspects.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 671-677"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for failed induction of labor: A retrospective study in a single, tertiary, perinatal-care center 引产失败的危险因素：在一个单一的，三级，围产期护理中心的回顾性研究

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2025.04.010

Maika Nariai, Osamu Wada-Hiraike, Takayuki Iriyama, Takahiro Seyama, Keiichi Kumasawa, Yasushi Hirota, Yutaka Osuga

{"title":"Risk factors for failed induction of labor: A retrospective study in a single, tertiary, perinatal-care center","authors":"Maika Nariai, Osamu Wada-Hiraike, Takayuki Iriyama, Takahiro Seyama, Keiichi Kumasawa, Yasushi Hirota, Yutaka Osuga","doi":"10.1016/j.tjog.2025.04.010","DOIUrl":"10.1016/j.tjog.2025.04.010","url":null,"abstract":"<div><h3>Objective</h3><div>To estimate the incidence and associated risk factors of failed induction of labor (IOL).</div></div><div><h3>Materials and methods</h3><div>A retrospective, case–control study was conducted on a cohort of women who underwent IOL from January 2020 to December 2023 and delivered after 34 weeks of gestation at our hospital (n = 1541). Failed IOL was defined as delivering with a cesarean section for any reason. The control group consisted of successful vaginal deliveries, including forceps and vacuum deliveries after IOL. Both primiparous and multiparous women were included in the study. We identified associated risk factors of failed IOL via multivariable logistic regression analysis.</div></div><div><h3>Results</h3><div>During the study period, 1541 of 4244 women (36.3 %) who delivered at our hospital underwent IOL. Among them, 326 women had a failed IOL, an estimated incidence of 21.2 % (95 % confidence interval [CI]: 19.1 %–23.3 %). The multivariable analysis revealed that older age (adjusted odds ratio [aOR] = 1.07 for each 1-year increase, 95 % CI: 1.04–1.11, P < 0.001), primiparity (aOR = 0.24 95 % CI: 0.16–0.35, P < 0.001), conception by using assisted reproductive technology (aOR = 1.45 95 % CI: 1.06–2.00, P = 0.021) larger birth weight (aOR = 1.05 for each 100 g increase, 95 % CI: 1.01–1.65, P = 0.023), hypertensive disorders of pregnancy (HDPs) (aOR = 2.53, 95 % CI: 1.80–3.56, P < 0.001), the lower simplified Bishop score before induction (aOR = 0.70 for each 1-point increase, 95 % CI: 0.61–0.80 P < 0.001), and the use of no epidural anesthesia (aOR = 0.42, 95 % CI: 0.31–0.57, P < 0.001) were independently associated with failed IOL.</div></div><div><h3>Conclusions</h3><div>Age, primiparity, method of conception, birth weight, HDPs, and simplified Bishop score should be considered as the predictor of failed IOL.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 687-692"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Instruction for Authors 作者须知

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/S1028-4559(25)00169-X

引用次数: 0

47,XYY/45,X at amniocentesis in a pregnancy associated with a favorable fetal outcome and perinatal progressive decrease of the 45,X cell line 47、XYY/45，X在羊膜穿刺术中与胎儿结局良好和围产期45，X细胞系进行性减少相关

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2025.05.003

Chih-Ping Chen

引用次数: 0

Low-level mosaicism for 45,X in 45,X/46,XY at amniocentesis associated with complete cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the 45,X cell line and a favorable fetal outcome 羊膜穿刺术中45、X、X/46、XY的低嵌合与培养羊膜细胞和非培养羊膜细胞之间的完全细胞遗传学差异、围产期45、X细胞系的进行性减少和良好的胎儿结局有关

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2025.05.008

Chih-Ping Chen

引用次数: 0

Placental mesenchymal dysplasia: A cause of intrauterine growth restriction and intrauterine death 胎盘间充质发育不良：宫内生长受限和宫内死亡的原因

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2025.04.009

Esra Çobankent Aytekin , Ahmet Boduroğlu , Cem Yaşar Sanhal , Havva Serap Toru

{"title":"Placental mesenchymal dysplasia: A cause of intrauterine growth restriction and intrauterine death","authors":"Esra Çobankent Aytekin , Ahmet Boduroğlu , Cem Yaşar Sanhal , Havva Serap Toru","doi":"10.1016/j.tjog.2025.04.009","DOIUrl":"10.1016/j.tjog.2025.04.009","url":null,"abstract":"<div><h3>Objective</h3><div>This study emphasizes the importance of recognizing and accurately diagnosing PMD and describes the clinical, gross, and histopathological findings of PMD in 18 cases. Placental mesenchymal dysplasia (PMD) was first recognized by Takayama et al. as a distinct pathologic entity of the placenta. The actual incidence and clinical outcomes of PMD haven’t been clarified yet.</div></div><div><h3>Materials and methods</h3><div>Eighteen patients diagnosed with PMD among 3760 placentas were reevaluated according to morphological diagnostic criteria and the immunohistochemical expression profile of p57.</div></div><div><h3>Results</h3><div>In all cases of PMD, abnormally enlarged stem villi, some of which had cisterns, hypercellular stroma, and thick-walled vessels, were present. Additionally, central thick-walled blood vessels with constricted lumens and scattered peripheral tiny capillaries were observed. In 14 cases of PMD, loss of p57 expression in stromal cells of dysplastic stem villi and chorangiomatoid changes was observed.</div></div><div><h3>Conclusion</h3><div>PMD is a rare and clinically significant lesion with high rates of IUFD and neonatal death. To diagnose PMD cases accurately and manage potential complications correctly, pregnancies with suspected PMD should be followed up in tertiary centers with resources for perinatal care and perinatal pathology testing.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 643-649"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postpartum readmission associated with severe maternal morbidity: A systematic review 与严重产妇发病率相关的产后再入院：一项系统综述

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2025.04.008

Wen-Chu Huang , Ching-Ching Claire Lin

{"title":"Postpartum readmission associated with severe maternal morbidity: A systematic review","authors":"Wen-Chu Huang , Ching-Ching Claire Lin","doi":"10.1016/j.tjog.2025.04.008","DOIUrl":"10.1016/j.tjog.2025.04.008","url":null,"abstract":"<div><div>Severe maternal morbidity (SMM) is now conceptualized to identify life-threatening events prior to maternal mortality worldwide. SMM could occur either during delivery hospitalization or arising from postpartum readmission (PPR). Apart from increase in medical cost and extended length of hospital stay during delivery, women with SMM also carry higher risk for postpartum readmission for management of delivery related complications or comorbidities. This review aims to collate published literature related to postpartum readmission associated with SMM including readmission rate, timeframe, diagnoses, personal and hospital factors. Literature search from PubMed was performed to identify relevant studies performed at population level published from 2015 to 2025. After exclusion, 11 articles were finally included. The PPR rate of SMM during delivery hospitalization varied from 2.45 % to 23.7 %. SMM at delivery was proven a 40–50 % increased risk for early and late readmission till one year postpartum. SMM arising from postpartum readmissions ranged from 12.1 % to 19.5 %. Over half of readmissions associated with SMM occurred within 7 days postpartum. Obstetric hemorrhage was the most popular diagnosis and blood transfusion was the most common SMM indicator in PPR associated with SMM. Hypertensive disorders of pregnancy such as eclampsia, preeclampsia were the other important etiology contributing to PPR. Cesarean delivery and other personal factors such as advanced maternal age, pre-exiting medical conditions were also important factors for PPR associated with SMM. This review confirmed women with SMM carried higher risk for readmission. However, the current evidence base is significantly limited by its overwhelming focus on the US context. The conditions in other regions, especially those with elevated maternal mortality or SMM rates, are a critical blind spot. Therefore, extensive research focusing on diverse global populations would be urgently needed.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 629-636"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plateletpheresis for treating essential thrombocythemia that developed during pregnancy: A case report 采血小板治疗妊娠期间发生的原发性血小板增多症：1例报告

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2025.01.008

Naohisa Masuko , Kenji Tanimura , Koki Moriuchi , Tomomi Kita , Kenta Obata , Sonoko Suda , Hitomi Imafuku , Masashi Deguchi , Keiji Kurata , Kimikazu Yakushijin , Keiji Kono , Takuya Kawakatsu , Yoshito Terai

{"title":"Plateletpheresis for treating essential thrombocythemia that developed during pregnancy: A case report","authors":"Naohisa Masuko , Kenji Tanimura , Koki Moriuchi , Tomomi Kita , Kenta Obata , Sonoko Suda , Hitomi Imafuku , Masashi Deguchi , Keiji Kurata , Kimikazu Yakushijin , Keiji Kono , Takuya Kawakatsu , Yoshito Terai","doi":"10.1016/j.tjog.2025.01.008","DOIUrl":"10.1016/j.tjog.2025.01.008","url":null,"abstract":"<div><h3>Objective</h3><div>Essential thrombocythemia (ET), a life-threatening disease, is associated with increased risks of hemorrhagic and thromboembolic complications. In particular, ET during pregnancy is rare and associated with an increased risk of obstetric complications. Drug therapies are frequently administered for managing pregnant women with ET, and plateletpheresis is considered to reduce platelet (PLT) counts rapidly.</div></div><div><h3>Case report</h3><div>A 28-year-old pregnant woman was referred to our hospital at 37 + 0/7 gestational weeks (GWs) due to severe thrombocythemia. She underwent plateletpheresis at 37 + 4/7 GWs because thrombocythemia was exacerbated. She delivered vaginally at 38 + 0/7 GWs without hemorrhagic or thromboembolic complications. She was diagnosed with ET based on a bone marrow biopsy, and ET gradually improved with medication. Thus, she and her baby were discharged without complications.</div></div><div><h3>Conclusion</h3><div>Plateletpheresis is useful for preventing hemorrhagic and thromboembolic complications at delivery in pregnant women with ET and severe thrombocythemia during the antepartum period.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 703-706"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0