Taiwanese Journal of Obstetrics & Gynecology最新文献

{"title":"The real-world efficacy and toxicity of first-line paclitaxel and cisplatin with bevacizumab in platinum-naïve primary stage IVB cervical cancer","authors":"Junhwan Kim ,&nbsp;Eun-Byul Park ,&nbsp;Shin-Wha Lee ,&nbsp;Jeong-Yeol Park ,&nbsp;Dae-Yeon Kim ,&nbsp;Dae-Shik Suh ,&nbsp;Jong-Hyeok Kim ,&nbsp;Yong-Man Kim ,&nbsp;Ju-Hyun Kim","doi":"10.1016/j.tjog.2020.07.035","DOIUrl":"10.1016/j.tjog.2020.07.035","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the real-world efficacy and toxicity of paclitaxel-cisplatin-bevacizumab and identify prognostic factors for paclitaxel-cisplatin-bevacizumab in platinum-naïve primary stage IVB cervical cancer.</div></div><div><h3>Materials and methods</h3><div>We retrospectively reviewed patients with stage IVB cervical cancer who received paclitaxel-cisplatin-bevacizumab as first-line treatment between July 2015 and December 2021 at Asan Medical Center, Korea. Patient data including clinicopathologic characteristics, imaging, paclitaxel-cisplatin-bevacizumab administration, recurrence, and survival were collected.</div></div><div><h3>Results</h3><div>Overall, 61 patients were included in this study. The median age of the patients was 56 (range, 28−79) years. Patients received a median of 9 (range, 2−30) cycles of paclitaxel-cisplatin-bevacizumab. The most common adverse event (all grades) during treatment was azotemia (80.3 %). Dose reduction and drug interruption were conducted in 41.0 % and 26.2 % of patients, respectively. The median progression-free survival (PFS) and the median overall survival (OS) were 11.8 (95 % confidence interval [CI], 9.3−14.2) and 24.3 (95 % CI, 16.9−31.7) months, respectively. Multivariate analysis indicated that cervical mass size reduction rate ≥40 % at the longest diameter was an independent prognostic factor for PFS (adjusted hazard ratio, 0.24; 95 % CI, 0.11−0.53; <em>p</em> &lt; 0.001). The median PFS of the patients with cervical mass size reduction rate ≥40 % and &lt;40 % were 13.7 (95 % CI, 10.9−16.5) and 5.9 (95 % CI, 0−12.6) months, respectively (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Paclitaxel-cisplatin-bevacizumab is effective and tolerable as a first-line treatment for platinum-naïve primary stage IVB cervical cancer. Cervical mass size reduction rate ≥40 % during paclitaxel-cisplatin-bevacizumab treatment might be a potential prognostic factor for PFS in patients with platinum-naïve primary stage IVB cervical cancer.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 1","pages":"Pages 61-67"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of fetuses with severe diaphragmatic hernia after fetal endoluminal tracheal occlusion treatment: A series of case reports","authors":"ChunYan Zhong ,&nbsp;XiaoHang Zhang ,&nbsp;SuZhen Ran","doi":"10.1016/j.tjog.2024.09.024","DOIUrl":"10.1016/j.tjog.2024.09.024","url":null,"abstract":"<div><h3>Objective</h3><div>To explore outcomes of fetuses with severe congenital diaphragmatic hernia (CDH) after fetal endoluminal tracheal occlusion (FETO) treatment.</div></div><div><h3>Case report</h3><div>Fetuses diagnosed with severe CDH and taken FETO for intrauterine treatment from January 2020 to December 2023 were recruited. There was no significant difference in general conditions, as well as O/E LHR and measurements related to CDH (p &gt; 0.05). All babies were born prematurely. One got poor Apgar score and died soon after birth and 3 died after treatment in NICU for some time. Only one associated with congenital cystic adenomatoid malformation (CCAM) was survived and got good outcome after long time follow-up. It seemed CCAM associated occupying a part volume of left thorax which may help to protect abdominal organs from herniating.</div></div><div><h3>Conclusion</h3><div>FETO treatment may not improve the survival rate of severe CDH significantly, but associated with CCAM may helpful to protect abdominal organs from herniating.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 1","pages":"Pages 138-141"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using machine learning to predict patients with polycystic ovary disease in Chinese women","authors":"Chen-Yu Wang ,&nbsp;Dee Pei ,&nbsp;Chun-Kai Wang ,&nbsp;Jyun-Cheng Ke ,&nbsp;Siou-Ting Lee ,&nbsp;Ta-Wei Chu ,&nbsp;Yao-Jen Liang","doi":"10.1016/j.tjog.2024.09.019","DOIUrl":"10.1016/j.tjog.2024.09.019","url":null,"abstract":"<div><h3>Objective</h3><div>With an estimated global frequency ranging from5 % to 21 %, polycystic ovary syndrome (PCOS) is one of the most prevalent hormonal disorders. There are many factors found to be related to PCOS. However, most of these researches used traditional methods such as multiple logistic regression (LR). Nowadays, machine learning (Mach-L) emerges as a new method and can be used in medical researches. In the present study, there were two goals: 1. Compare the accuracy of five alternative Mach-L techniques with that of conventional LR. 2. Use Mach-L to forecast PCOS and prioritize the risk factors.</div></div><div><h3>Materials and methods</h3><div>Totally, 170 PCOS patients and 950 control participants were included. We collected information on demographics, biochemistry, and lifestyle. PCOS was identified using Rotterdam criteria. Random Forest (RF), stochastic gradient boosting (SGB), multivariate adaptive regression splines (MARS), extreme gradient boosting (XGBoost), and gradient boosting with categorical features support (CatBoost) are five Mach-L algorithms that were used. Models with lower estimation errors were better.</div></div><div><h3>Results</h3><div>By using <em>t</em>-test, we found subjects with PCOS were younger, glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), γ-Glutamyl transferase (γ-GT), Triglyceride (TG), and educational levels were higher. All the five Mach-L methods had lower estimation errors compared to LR. The average of the AUC derived from Mach-L was mean AUC of 0.6669, higher than the that of LR (0.5908). Finally, age, TG, GPT, white blood cell count (WBC), uric acid (UA), and platelet (Plt) were the six most important risk factors selected by Mach-L.</div></div><div><h3>Conclusion</h3><div>Mach-L methods overtook conventional LR and age was the most significant factor, followed by TG, GPT, WBC, UA, and Plt in a cohort of Chinese women.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 1","pages":"Pages 68-75"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and outcomes associated with true knots of the umbilical cord: A retrospective study","authors":"Shouzhen Chen ,&nbsp;Zhaozhen Liu ,&nbsp;Qian Lin ,&nbsp;Liping Huang","doi":"10.1016/j.tjog.2024.07.019","DOIUrl":"10.1016/j.tjog.2024.07.019","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the pregnancy outcomes and independent risk factors associated with true knots of the umbilical cord (TKUC).</div></div><div><h3>Materials and methods</h3><div>This retrospective study included 8140 deliveries at Fujian Maternal and Child Health Hospital from 2017 to 2021. Mothers and newborns diagnosed with TKUC were included in the TKUC group, while the others were included in the control group. The data were obtained from the hospital's electronic medical record system. Multiple pregnancies were excluded.</div></div><div><h3>Results</h3><div>The incidence of TKUC was 0.61 %. The TKUC group had significantly higher proportions of advanced maternal age, multiparae and mothers with more than two pregnancies (<em>P</em> &lt; 0.05). The neonates in the TKUC group were more male, had longer lengths and umbilical cords, heavier placentas, and a higher incidence of umbilical cord entanglement (<em>P</em> &lt; 0.05). In terms of pregnancy outcomes, the TKUC group exhibited higher rates of cesarean section and preterm birth (<em>P</em> &lt; 0.001; <em>P</em> &lt; 0.05). However, there were no significant differences in birthweight, Apgar scores, stillbirth rate, and neonatal malformation rate between the two groups (<em>P</em> &gt; 0.05). The results of logistic regression indicated that multiparae (<em>OR</em> = 1.386, <em>P</em> = 0.001), male fetus (<em>OR</em> = 1.499, <em>P</em> &lt; 0.001), excessive long umbilical cord (<em>OR</em> = 11.022, <em>P</em> &lt; 0.001), and umbilical cord entanglement (<em>OR</em> = 1.284, <em>P</em> = 0.019) were risk factors for TKUC.</div></div><div><h3>Conclusion</h3><div>Male fetus, multiparae, umbilical cord entanglement, and especially excessively long umbilical cord were identified as independent risk factors for TKUC. TKUC had a minimal impact on the newborn's condition at birth, while it's associated with higher rates of cesarean section and preterm birth.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 1","pages":"Pages 40-45"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A proposal for reference list format in medical journals: Considering the last author's name","authors":"Shigeki Matsubara,&nbsp;Daisuke Matsubara","doi":"10.1016/j.tjog.2024.08.009","DOIUrl":"10.1016/j.tjog.2024.08.009","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 1","pages":"Pages 191-192"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The fertility outcome of assisted oocyte activation combined with spindle view-assisted intracytoplasmic sperm injection in patients with low fertilization rate” [Taiwanese J Obstetrics Gynecol 63 (2024) 513–517]","authors":"Wei-Che Lo ,&nbsp;Chieh-Yu Lin ,&nbsp;Chia-Jung Li ,&nbsp;Chiung-Hui Hou ,&nbsp;Lin-Hsuan Dai ,&nbsp;Hsien-Ming Wu","doi":"10.1016/j.tjog.2024.11.001","DOIUrl":"10.1016/j.tjog.2024.11.001","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 1","pages":"Page 205"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current genetic test for ovarian cancer","authors":"Szu-Ting Yang,&nbsp;Peng-Hui Wang","doi":"10.1016/j.tjog.2024.11.006","DOIUrl":"10.1016/j.tjog.2024.11.006","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 1","pages":"Pages 8-10"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic counselling and prenatal diagnosis of a de novo chromosomal 10q11.21q11.23 duplication associated with normal phenotype","authors":"Lijun Liu ,&nbsp;Guiying Yu ,&nbsp;Tou Tou ,&nbsp;Tianzi Wu ,&nbsp;Fen Li","doi":"10.1016/j.tjog.2024.08.008","DOIUrl":"10.1016/j.tjog.2024.08.008","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 1","pages":"Pages 184-186"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation for ChatGPT use in paper writing","authors":"Shigeki Matsubara","doi":"10.1016/j.tjog.2024.07.023","DOIUrl":"10.1016/j.tjog.2024.07.023","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 1","pages":"Pages 197-198"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retroperitoneal Müllerian cyst causing uterine protrusion in a teenage girl","authors":"Fu-Chieh Chu ,&nbsp;Hsu-Han Wang ,&nbsp;Yen-Tin Chen ,&nbsp;Ya-Chun Chuang ,&nbsp;Liang-Ming Lo ,&nbsp;Steven W. Shaw","doi":"10.1016/j.tjog.2023.11.014","DOIUrl":"10.1016/j.tjog.2023.11.014","url":null,"abstract":"<div><h3>Objective</h3><div>To describe a rare case of a retroperitoneal Müllerian cyst in a teenage girl with a protruding uterus and associated urogenital anomalies, and to discuss the challenges faced in differential diagnosis and management of such cases.</div></div><div><h3>Case report</h3><div>We present the case of a 14-year-old girl presented with a protruding uterus for several weeks, with a history of twin–twin transfusion syndrome at birth. Initial ultrasonography identified a large pelvic cystic tumor. Notably, during laparoscopy, a significant left retroperitoneal tubulocystic tumor was discovered, and the left ureter was absent. A computed tomography scan confirmed left renal agenesis, right kidney hyperplasia, a bicornuate uterus, and pectus excavatum. Surgical exploration and excision of the tumor were performed, with histological and immunohistochemical analyses confirming the presence of a Müllerian-type epithelium. Post-surgery, the protruding uterus improved, and the patient demonstrated notable recovery at a six-month follow-up.</div></div><div><h3>Conclusion</h3><div>Retroperitoneal Müllerian cysts, though rare, should be considered in differential diagnoses of retroperitoneal cystic tumors, especially in patients with associated urogenital anomalies. Immunohistochemical profiling plays a critical role in distinguishing Müllerian cysts from other urogenital cysts. Patients with renal anomalies should be evaluated for associated urogenital anomalies, and surgical intervention should be considered based on symptom presentation and potential for malignancy.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 1","pages":"Pages 125-127"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}