育龄妇女卵巢储备与有机磷阻燃剂的关系

IF 2 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-05-01 DOI:10.1016/j.tjog.2024.11.012

Hao-Ting Lien , Yu-Che Ou , Yin-Hua Cheng , Chia-Te Kung , Yung-Chiao Chang , Pei-Ling Weng , Kuo-Chung Lan

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引用次数: 0

摘要

目的探讨有机磷阻燃剂（OPFRs）与育龄妇女卵巢储备功能的关系。材料与方法本横断面研究于2020年8月至2022年10月在台湾高雄医疗中心长庚纪念医院妇产科门诊招募参与者。纳入标准如下：育龄成年妇女符合参加条件。老年人（50岁）、使用抗抑郁药和抗精神病药超过数月的患者被排除在外。我们测量了10种OPFR化合物的尿浓度来评估暴露模式，并比较了亚组中临床和尿OPFR的概况，以确定这些OPFR化合物是否与AMH、FSH和LH水平独立相关。使用问卷评估环境和生活方式因素，以确定OPFR暴露的危险因素。结果本研究共纳入99名受试者。校正协变量后，尿中二（1,3-二氯-2-丙基）磷酸（BDCPP）和磷酸二苯酯（DPHP）浓度较高是较低AMH亚组较高AMH亚组的预测因子(低AMH vs高AMH（临界值：1.5 ng/mL），比值比（OR）（95%置信区间（CI））， 5.714 (1.435-22.727), p = 0.007；4.149 (1.004-17.241), p = 0.037)。在我们的研究中，FSH和LH水平与10个opfr无显著相关性。结论OPFR暴露在育龄妇女中普遍存在，尿标本检出率为100%。此外，较高的尿BDCPP和DPHP浓度是低AMH亚组与高AMH亚组相比的预测因子。需要进一步研究以更深入地了解育龄妇女接触OPFRs的模式和潜在的生殖毒性。

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Association between ovarian reserve and organophosphate flame retardants in women of childbearing age

Objective

This study aimed to investigate the association between organophosphate flame retardants (OPFRs) and ovarian reserve in women of childbearing age.

Materials and methods

In this Cross-sectional study, the participants were recruited from August 2020 to October 2022 at the outpatient department of Obstetrics and Gynecology in Chang Gung Memorial Hospital, Kaohsiung Medical Center in Taiwan. The inclusion criteria were as follows: adult women of childbearing age were eligible to participate. Old age (>50 years old), patients using antidepressants and antipsychotics for over months were excluded. We measured the urinary concentrations of 10 OPFR compounds to assess exposure patterns and compared the clinical and urinary OPFR profiles among subgroups to determine whether these OPFR compounds were independently correlated with AMH, FSH, and LH levels. Environmental and lifestyle factors were assessed using questionnaires to determine the risk factors for OPFR exposure.

Results

Total 99 participants were enrolled in our study. after adjusting for covariates, higher urinary concentrations of bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosphate (DPHP) were predictors of the lower AMH subgroup compared to the high AMH subgroup (low vs. high AMH (cut-off value: 1.5 ng/mL), odds ratio (OR) (95 % confidence interval (CI)), 5.714 (1.435–22.727), p = 0.007; 4.149 (1.004–17.241), p = 0.037, respectively). FSH and LH levels were not significantly associated with the 10 OPFRs in our study.

Conclusion

Our study revealed that OPFR exposure was widespread among women of childbearing age, with a 100 % detection rate in urinary samples. Additionally, higher urinary concentrations of BDCPP and DPHP were predictors of the lower AMH subgroup compared to the high AMH subgroup. Further research is required to gain a deeper understanding of the exposure patterns and potential reproductive toxicity of OPFRs in women of childbearing age.

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来源期刊

Taiwanese Journal of Obstetrics & Gynecology OBSTETRICS & GYNECOLOGY-

CiteScore

3.60

自引率

23.80%

发文量

207

审稿时长

4-8 weeks

期刊介绍： Taiwanese Journal of Obstetrics and Gynecology is a peer-reviewed journal and open access publishing editorials, reviews, original articles, short communications, case reports, research letters, correspondence and letters to the editor in the field of obstetrics and gynecology. The aims of the journal are to: 1.Publish cutting-edge, innovative and topical research that addresses screening, diagnosis, management and care in women''s health 2.Deliver evidence-based information 3.Promote the sharing of clinical experience 4.Address women-related health promotion The journal provides comprehensive coverage of topics in obstetrics & gynecology and women''s health including maternal-fetal medicine, reproductive endocrinology/infertility, and gynecologic oncology. Taiwan Association of Obstetrics and Gynecology.