Taiwanese Journal of Obstetrics & Gynecology最新文献

{"title":"47,XYY/45,X at amniocentesis in a pregnancy associated with a favorable fetal outcome and perinatal progressive decrease of the 45,X cell line","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.05.003","DOIUrl":"10.1016/j.tjog.2025.05.003","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 718-720"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-level mosaicism for 45,X in 45,X/46,XY at amniocentesis associated with complete cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the 45,X cell line and a favorable fetal outcome","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.05.008","DOIUrl":"10.1016/j.tjog.2025.05.008","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 733-734"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental mesenchymal dysplasia: A cause of intrauterine growth restriction and intrauterine death","authors":"Esra Çobankent Aytekin ,&nbsp;Ahmet Boduroğlu ,&nbsp;Cem Yaşar Sanhal ,&nbsp;Havva Serap Toru","doi":"10.1016/j.tjog.2025.04.009","DOIUrl":"10.1016/j.tjog.2025.04.009","url":null,"abstract":"<div><h3>Objective</h3><div>This study emphasizes the importance of recognizing and accurately diagnosing PMD and describes the clinical, gross, and histopathological findings of PMD in 18 cases. Placental mesenchymal dysplasia (PMD) was first recognized by Takayama et al. as a distinct pathologic entity of the placenta. The actual incidence and clinical outcomes of PMD haven’t been clarified yet.</div></div><div><h3>Materials and methods</h3><div>Eighteen patients diagnosed with PMD among 3760 placentas were reevaluated according to morphological diagnostic criteria and the immunohistochemical expression profile of p57.</div></div><div><h3>Results</h3><div>In all cases of PMD, abnormally enlarged stem villi, some of which had cisterns, hypercellular stroma, and thick-walled vessels, were present. Additionally, central thick-walled blood vessels with constricted lumens and scattered peripheral tiny capillaries were observed. In 14 cases of PMD, loss of p57 expression in stromal cells of dysplastic stem villi and chorangiomatoid changes was observed.</div></div><div><h3>Conclusion</h3><div>PMD is a rare and clinically significant lesion with high rates of IUFD and neonatal death. To diagnose PMD cases accurately and manage potential complications correctly, pregnancies with suspected PMD should be followed up in tertiary centers with resources for perinatal care and perinatal pathology testing.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 643-649"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum readmission associated with severe maternal morbidity: A systematic review","authors":"Wen-Chu Huang ,&nbsp;Ching-Ching Claire Lin","doi":"10.1016/j.tjog.2025.04.008","DOIUrl":"10.1016/j.tjog.2025.04.008","url":null,"abstract":"<div><div>Severe maternal morbidity (SMM) is now conceptualized to identify life-threatening events prior to maternal mortality worldwide. SMM could occur either during delivery hospitalization or arising from postpartum readmission (PPR). Apart from increase in medical cost and extended length of hospital stay during delivery, women with SMM also carry higher risk for postpartum readmission for management of delivery related complications or comorbidities. This review aims to collate published literature related to postpartum readmission associated with SMM including readmission rate, timeframe, diagnoses, personal and hospital factors. Literature search from PubMed was performed to identify relevant studies performed at population level published from 2015 to 2025. After exclusion, 11 articles were finally included. The PPR rate of SMM during delivery hospitalization varied from 2.45 % to 23.7 %. SMM at delivery was proven a 40–50 % increased risk for early and late readmission till one year postpartum. SMM arising from postpartum readmissions ranged from 12.1 % to 19.5 %. Over half of readmissions associated with SMM occurred within 7 days postpartum. Obstetric hemorrhage was the most popular diagnosis and blood transfusion was the most common SMM indicator in PPR associated with SMM. Hypertensive disorders of pregnancy such as eclampsia, preeclampsia were the other important etiology contributing to PPR. Cesarean delivery and other personal factors such as advanced maternal age, pre-exiting medical conditions were also important factors for PPR associated with SMM. This review confirmed women with SMM carried higher risk for readmission. However, the current evidence base is significantly limited by its overwhelming focus on the US context. The conditions in other regions, especially those with elevated maternal mortality or SMM rates, are a critical blind spot. Therefore, extensive research focusing on diverse global populations would be urgently needed.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 629-636"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plateletpheresis for treating essential thrombocythemia that developed during pregnancy: A case report","authors":"Naohisa Masuko ,&nbsp;Kenji Tanimura ,&nbsp;Koki Moriuchi ,&nbsp;Tomomi Kita ,&nbsp;Kenta Obata ,&nbsp;Sonoko Suda ,&nbsp;Hitomi Imafuku ,&nbsp;Masashi Deguchi ,&nbsp;Keiji Kurata ,&nbsp;Kimikazu Yakushijin ,&nbsp;Keiji Kono ,&nbsp;Takuya Kawakatsu ,&nbsp;Yoshito Terai","doi":"10.1016/j.tjog.2025.01.008","DOIUrl":"10.1016/j.tjog.2025.01.008","url":null,"abstract":"<div><h3>Objective</h3><div>Essential thrombocythemia (ET), a life-threatening disease, is associated with increased risks of hemorrhagic and thromboembolic complications. In particular, ET during pregnancy is rare and associated with an increased risk of obstetric complications. Drug therapies are frequently administered for managing pregnant women with ET, and plateletpheresis is considered to reduce platelet (PLT) counts rapidly.</div></div><div><h3>Case report</h3><div>A 28-year-old pregnant woman was referred to our hospital at 37 + 0/7 gestational weeks (GWs) due to severe thrombocythemia. She underwent plateletpheresis at 37 + 4/7 GWs because thrombocythemia was exacerbated. She delivered vaginally at 38 + 0/7 GWs without hemorrhagic or thromboembolic complications. She was diagnosed with ET based on a bone marrow biopsy, and ET gradually improved with medication. Thus, she and her baby were discharged without complications.</div></div><div><h3>Conclusion</h3><div>Plateletpheresis is useful for preventing hemorrhagic and thromboembolic complications at delivery in pregnant women with ET and severe thrombocythemia during the antepartum period.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 703-706"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prenatally diagnosed Klinefelter syndrome case of 46,XX/47,XXY mosaicism with partial deletion of Y chromosome","authors":"Haruna Okubo ,&nbsp;Yuki Ito ,&nbsp;Tomoko Kawai ,&nbsp;Hiromi Kamura ,&nbsp;Michihiro Yamamura ,&nbsp;Mikiko Kaneko ,&nbsp;Akihiro Hasegawa ,&nbsp;Ken Takahashi ,&nbsp;Masahisa Kobayashi ,&nbsp;Hiroshi Kawame ,&nbsp;Kenichiro Hata ,&nbsp;Osamu Samura ,&nbsp;Aikou Okamoto","doi":"10.1016/j.tjog.2024.12.030","DOIUrl":"10.1016/j.tjog.2024.12.030","url":null,"abstract":"<div><h3>Objective</h3><div>Herein, we report the first case of 46,XX/47,XXY mosaicism with a partially deleted Y chromosome.</div></div><div><h3>Case report</h3><div>Chorionic villus sampling (CVS; G-banding) was performed due to increased nuchal translucency; the results showed a 46,XX karyotype. However, ultrasonography revealed male-type external genitalia. The stored CVS nuclear plate was reanalyzed to investigate the cause of the fetal sex discordance. The result showed a mosaic of a small supernumerary marker chromosome (sSMC) derived from Y chromosome. The infant was delivered vaginally at 39 weeks. Peripheral blood G-banding and fluorescence <em>in situ</em> hybridization for the infant indicated 47,XX, +mar [27]/46,XX [3] ish der(Y) (SRY+,DYZ1-). Single nucleotide polymorphism analysis of cord blood and chorionic villi revealed a deletion in chrY: 13,133,449–28,817,579. The infant was phenotypically male, with good growth and development at 24 months.</div></div><div><h3>Conclusion</h3><div>The fetal sex discordance led to a diagnosis of 46,XX/47,XXY mosaicism, which could guide postnatal management.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 707-710"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstetric and neonatal outcomes in pregnant women with left-sided valvular stenosis in a tertiary medical center in Taiwan","authors":"Hui-Ling Lee ,&nbsp;Hao-Tien Liu ,&nbsp;Chi-Yuan Chiang ,&nbsp;Shih-Chun Chou ,&nbsp;Chung-Chuan Chou","doi":"10.1016/j.tjog.2024.10.023","DOIUrl":"10.1016/j.tjog.2024.10.023","url":null,"abstract":"<div><h3>Objective</h3><div>Left-sided valvular stenosis increases pregnancy-associated risks. We aim to compare maternal and neonatal outcomes between women with left-sided valvular stenosis and controls and to determine the predictors of adverse pregnancy outcomes.</div></div><div><h3>Materials and methods</h3><div>We retrospectively retrieved data in the Chang Gung Research Database from women who had at least one prenatal examination record or pregnancy-related diagnosis code and gave birth, terminated the pregnancy, or took abortion pills in the hospital and had confirmed aortic stenosis or mitral stenosis based on echocardiographic reports, surgical reports, and discharge summaries. Propensity score matching (PSM) was used to balance covariates between the left-sided valvular stenosis and control groups.</div></div><div><h3>Results</h3><div>Patients in the left-sided valvular stenosis group were of shorter height, lower weight and body mass index, and had a higher rate of atrial fibrillation compared to controls. After PSM, the left-sided valvular stenosis group (n = 52) had more heart failure, chronic kidney disease, and use of digoxin and anticoagulants than did the control group (n = 260). Pregnancy outcomes in the left-sided valvular stenosis group included a higher cesarean section rate, lower gestational age, and a higher rate of newborn intensive care unit transfer than controls. The composite adverse maternal event rate did not differ significantly between the two groups, but the composite adverse neonatal event rate (premature birth, low birth weight) was higher in the left-sided valvular stenosis group. Regional anesthesia was most commonly used during cesarean section in both groups. Left-sided valvular stenosis, heart failure, general anesthesia, and cesarean section were significant factors associated with increased risks of composite adverse neonatal events.</div></div><div><h3>Conclusions</h3><div>Among pregnant women, those with left-sided valvular stenosis had more comorbidities and medication use during pregnancy and were more likely to give birth to premature babies with low birth weight and poor vitality.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 655-661"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first report of a successful birth by preimplantation genetic testing for leukodystrophy induced by IBA57 gene","authors":"Juan Wang ,&nbsp;Zuying Xu ,&nbsp;Dawei Chen ,&nbsp;Huifen Xiang","doi":"10.1016/j.tjog.2025.01.007","DOIUrl":"10.1016/j.tjog.2025.01.007","url":null,"abstract":"<div><h3>Objective</h3><div>Leukodystrophies are a group of heterogeneous disorders affecting the white matter, resulting from various genetic defects. Multiple recessive mutations in the IBA57 gene, which codes for a protein involved in the final stages of the mitochondrial Fe/S biogenesis pathway, have been linked to the development of leukodystrophy.</div></div><div><h3>Case report</h3><div>In this study, we first report the identification of a compound heterozygous mutation in the IBA57 gene, with one mutation (c.286T &gt; C) inherited from the father and another mutation (c.697C &gt; T) inherited from the mother, who has previously given birth to two children with leukodystrophy. Through preimplantation genetic testing (PGT-M), one successful intrauterine pregnancy was achieved, resulting in the delivery of a healthy male infant at 38 + 3 weeks of gestation.</div></div><div><h3>Conclusion</h3><div>This study confirms the significant role of IBA57 in leukoencephalopathy and provides valuable insights for molecular diagnosis and genetic counseling related to IBA57-related disorders.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 700-702"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Locally advanced cervical cancer treatment: Immunotherapy or induction dose-dense chemotherapy?","authors":"Peng-Hui Wang,&nbsp;Wei-Ting Chao,&nbsp;Tsung-Cheng Kuo","doi":"10.1016/j.tjog.2025.05.014","DOIUrl":"10.1016/j.tjog.2025.05.014","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 605-607"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The decision for adjuvant therapy for early-stage high-risk endometrial cancer is in dilemma","authors":"Peng-Hui Wang,&nbsp;Yoichi Kobayashi,&nbsp;Byoung-Gie Kim","doi":"10.1016/j.tjog.2025.05.012","DOIUrl":"10.1016/j.tjog.2025.05.012","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 599-601"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}