Taiwanese Journal of Obstetrics & Gynecology最新文献

{"title":"Use of dinoprostone vaginal insert followed by mechanical dilation for poor cervical maturation shorten the time length for uterotonics administration","authors":"Tamae Nabeshima ,&nbsp;Mari Ichinose ,&nbsp;Takahiro Yamashita ,&nbsp;Yukiko Kawana ,&nbsp;Yoshiharu Takeda ,&nbsp;Tomoko Adachi ,&nbsp;Takeshi Nagamatsu ,&nbsp;Mikio Momoeda","doi":"10.1016/j.tjog.2024.10.019","DOIUrl":"10.1016/j.tjog.2024.10.019","url":null,"abstract":"<div><h3>Objective</h3><div>The clinical efficacy of the combined usage of a dinoprostone vaginal insert (DVI) with mechanical cervical dilatation for the labor induction with poor cervical maturation has not been established. A retrospective observational study was conducted aiming to evaluate the efficacy of this approach on labor induction.</div></div><div><h3>Materials and methods</h3><div>The clinical features of 71 pregnant women with Bishop score of 0–2 treated with DVI were analyzed to identify the clinical factors associated with the necessity for additional mechanical dilation after DVI use and whether DVI was removed due to labor progression. Further analysis was focused on the subgroup of 43 women who went through labor induction with DVI due to post-date pregnancy. The delivery outcome of DVI group was compared with the historical control group of 71 women who underwent mechanical dilatation without DVI due to post-date pregnancy.</div></div><div><h3>Results</h3><div>Among the 71 women treated with DVI, 38 did not require additional mechanical dilation and 24 had DVI removed after labor progressed. Lower pre-pregnancy body mass index was significantly associated with DVI efficacy. Whereas the success rate for vaginal delivery was comparable between Control group and DVI group, the time duration of uterotonics administration was shorter in DVI group than that in the Control group (13.9 h vs 29.2 h, p = 0.01).</div></div><div><h3>Conclusion</h3><div>Low BMI was a factor that facilitates the effectiveness of DVI. A cervical maturation approach using DVI in combination with a mechanical dilator reduced the time of uterotonics administration among populations with extremely poor cervical maturation.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 3","pages":"Pages 450-457"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of fractional CO2 laser treatment on postpartum vulvovaginal atrophy: A prospective observational study","authors":"Wen-Chu Huang ,&nbsp;Chun-Yuan Su ,&nbsp;Yeou-Lih Wang","doi":"10.1016/j.tjog.2025.02.002","DOIUrl":"10.1016/j.tjog.2025.02.002","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the changes of vaginal health and vulvovaginal atrophy (VVA) symptoms following CO₂ laser treatment in postpartum breastfeeding women. The number of treatment sessions required to alleviate related symptoms was also determined.</div></div><div><h3>Materials and methods</h3><div>Postpartum healthy women who continued breastfeeding and suffered from VVA related symptoms were included in this prospective study. All the participants underwent three consecutive fractional CO₂ laser treatments using Lumenis AcuPulse system with FemTouch™ handpiece at four-weeks interval. Following each laser treatment, the severity of VVA symptoms and Vaginal Health Index (VHI) score were assessed as subjective and objective outcomes. The changes in VHI score and VVA symptom severity were compared with baseline data to detect the onset of significant improvement.</div></div><div><h3>Results</h3><div>Thirty postpartum breastfeeding women with VVA symptoms completed the treatment courses and associated measurements. Their age ranged from 25 to 41 with an average of 34.6 years. The mean duration of breastfeeding prior to the initial laser treatment was 3.3 months. Vaginal dryness and dyspareunia were the most bothersome VVA symptoms prior to laser treatment and alleviated after two to three treatment sessions. The significant change of VHI score reaching non-atrophic level was found after the first treatment (media of score post:18 vs. pre:14, p &lt; 0.05) and sustained stable through the following two treatments.</div></div><div><h3>Conclusion</h3><div>Application of fractional CO₂ vaginal laser on the management of postpartum vulvovaginal atrophy was proven effectively in our study. Objective and subjective improvements were detected after the first and second laser treatment, respectively. Two consecutive laser treatment sessions were clinically sufficient to alleviate VVA related symptoms in these young female population under postpartum breastfeeding.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 3","pages":"Pages 463-468"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of a disomy X cell line in uncultured amniocytes by fluorescence in situ hybridization in a pregnancy with 45,X/47,XXX at amniocentesis, cytogenetic discrepancy cultured amniocytes and uncultured amniocytes and a favorable fetal outcome","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.04.003","DOIUrl":"10.1016/j.tjog.2025.04.003","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 3","pages":"Pages 576-579"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is buprenorphine use in pregnancy linked to decreased fetal breathing movement","authors":"Caroline M. Bulger ,&nbsp;Nicole H. Lewis ,&nbsp;Aleksandr M. Fuks ,&nbsp;Chaur-Dong Hsu ,&nbsp;Martin E. Olsen","doi":"10.1016/j.tjog.2025.02.001","DOIUrl":"10.1016/j.tjog.2025.02.001","url":null,"abstract":"<div><h3>Objective</h3><div>Biophysical profile (BPP) testing of opioid-exposed fetuses in the third trimester is a commonly used assessment. Opioid use in pregnancy is associated with modest increased odds of stillbirth (OR 1.3). Our hypothesis was that BPP score results in buprenorphine patients might be different from a control group of high-risk patients.</div></div><div><h3>Materials and methods</h3><div>This retrospective chart review analyzed the BPP assessments of patients receiving buprenorphine compared to patients followed for chronic hypertension. Patients seen between July 1, 2016, to June 30, 2020, were evaluated. Two hundred twenty-seven patients were in the buprenorphine group and 46 patients were in the chronic hypertension control group. The diagnosis of chronic hypertension did not include pre-eclampsia, gestational hypertension, or superimposed pre-eclampsia. Some patients were treated with antihypertensive medications.</div></div><div><h3>Results</h3><div>Fetuses exposed to maternal buprenorphine administration are more likely to receive a zero score for breathing movements than fetuses receiving BPP assessments due to maternal chronic hypertension. (p-value = 0.002)</div></div><div><h3>Conclusion</h3><div>This is the first study to show that fetal breathing movement assessment is affected by buprenorphine administration. Current guidelines minimize the effects of maternal buprenorphine administration on fetal development. Further study on the dose-related long-term and short-term effects of buprenorphine on fetal breathing movement is warranted.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 3","pages":"Pages 458-462"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mosaic trisomy 18 at amniocentesis in a pregnancy associated with omphalocele, intrauterine growth restriction, trisomy 18 placenta, an elevated sFlt-1/PlGF ratio and an adverse perinatal outcome in the fetus","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.03.008","DOIUrl":"10.1016/j.tjog.2025.03.008","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 3","pages":"Pages 555-559"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-level mosaic trisomy 18 at amniocentesis in a pregnancy associated with congenital heart defect, intrauterine growth restriction, trisomy 18 placenta, oligohydramnios and an adverse perinatal outcome in the fetus","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.03.009","DOIUrl":"10.1016/j.tjog.2025.03.009","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 3","pages":"Pages 560-563"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin reverses bisphenol A-induced toxicity in granulosa cells: Restoration of FSHR and connexin 43 expression","authors":"Ta-Chin Lin ,&nbsp;Kai-Hung Wang ,&nbsp;Kuo-Hsiang Chuang ,&nbsp;An-Pei Kao ,&nbsp;Tsung-Cheng Kuo","doi":"10.1016/j.tjog.2025.02.003","DOIUrl":"10.1016/j.tjog.2025.02.003","url":null,"abstract":"<div><h3>Objective</h3><div>Bisphenol A (BPA) is an estrogen-like endocrine-disrupting chemical commonly found in various daily consumer products. It causes female reproductive disorders by interfering with endocrine signaling. Normal folliculogenesis, oocyte maturation, ovulation, and luteal growth/involution rely on the gap junctional intercellular communication between granulosa cells (GCs) and oocytes. Connexin 43 (Cx43) is a key gap junction protein in GCs. The expression of Cx43 in GCs is regulated by follicle-stimulating hormone (FSH) at every stage of folliculogenesis. Melatonin, which exerts anti-inflammatory and antioxidative effects, is primarily released by the pineal gland and reproductive cells, including GCs. In this study. We investigated the protective role of melatonin against BPA-induced toxicity in GCs.</div></div><div><h3>Materials and methods</h3><div>After controlled ovarian stimulation, GCs were collected from patients undergoing in vitro fertilization. To investigate the effect of melatonin on BPA-induced toxicity in GCs, we evaluated biological activity, gene expression, and protein expression in GCs treated with melatonin and BPA.</div></div><div><h3>Results</h3><div>BPA downregulated the expression of FSH receptor (FSHR) and inhibited the FSH-induced expression of Cx43 in GCs. It also reduced the proportion of FSHR⁺Cx43⁺ cells population in GCs (10.2 %–6.3 %). Melatonin treatment in BPA-treated GCs reversed the BPA-induced downregulation of FSHR expression, restored the FSH-induced expression of Cx43, and the proportion of FSH-increased FSHR⁺Cx43⁺ cells population in GCs (8.6 %–21.3 %).</div></div><div><h3>Conclusion</h3><div>Clinical trials in recent years have shown that melatonin could effectively prevent cell damage, and could also affect reproductive diseases and pregnancy outcomes. Our results elucidated the mechanisms underlying BPA-induced toxicity in GCs. Melatonin may mitigate the adverse effects of BPA on female reproductive function, which are interesting for exploring new targets in the prevention and treatment of reproductive diseases.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 3","pages":"Pages 469-476"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal diagnosis of SRY(+) 46, XX male and the confirmation of a de novo unbalanced Xp;Yp translocation with the karyotype of 46,X,der(X)t(X;Y) (p22.33;p11.2) in a fetus with a favorable fetal outcome","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.03.007","DOIUrl":"10.1016/j.tjog.2025.03.007","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 3","pages":"Pages 551-554"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Instruction for Authors","authors":"","doi":"10.1016/S1028-4559(25)00115-9","DOIUrl":"10.1016/S1028-4559(25)00115-9","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 3","pages":"Pages E1-E7"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of a whole-arm balanced X;autosome translocation of 46,X,t(X;4) (p10;p10) in a 39-year-old, gravida 4, para 1, woman with recurrent miscarriages","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.03.011","DOIUrl":"10.1016/j.tjog.2025.03.011","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 3","pages":"Pages 567-568"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}