Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery最新文献

{"title":"MicroRNA-299-3p as a potential marker of tumor size in non-small cell lung cancer.","authors":"İbrahim Emre Tunca, Maruf Şanlı, Demet Taşdemir, Ahmet Ulusan, A Feridun Işık, Seval Kul","doi":"10.4274/tjtcs.2026.28665","DOIUrl":"10.4274/tjtcs.2026.28665","url":null,"abstract":"<p><strong>Background: </strong>Lung cancer is one of the world's leading causes of cancer-related death. A tumor biopsy is the gold standard for diagnosis but may not be representative of the whole tumor. We therefore need non-invasive biomarkers to guide us in structure, mass, prognosis and treatment. Therefore, alternative non-invasive and dynamic biomarkers are needed to assist physicians in evaluating tumor structure, histology, burden, prognosis, and treatment response. Telomerase dysregulation is key to cancer development. MicroRNAs can be both tumor suppressors and oncogenes. Bioinformatic analyses suggest that microRNA-299-3p interacts with telomerase. This study evaluated serum levels of microRNA-299-3p before and after surgery in patients with non-small cell lung cancer (NSCLC) and explored their potential association with tumor size.</p><p><strong>Methods: </strong>This observational pilot study included 15 NSCLC patients who underwent anatomical lung resection at a specialist hospital, following a power analysis. Blood samples were collected before and three weeks after surgery. MicroRNA was isolated using kits according to the manufacturer's protocols. Patients who had received chemotherapy or radiotherapy, had multiple primary cancers, or did not give informed consent were excluded.</p><p><strong>Results: </strong>There was no significant difference in miRNA-299-3p levels between preoperative and three-week postoperative serum samples. However, a significant negative correlation was identified between preoperative miRNA-299-3p levels and tumor size (r=-0.59; p=0.02).</p><p><strong>Conclusion: </strong>Preliminary findings suggest that levels of the molecule RNA-299-3p are linked to tumour size. It is thought that lower levels of RNA-299-3p may counteract the effect of telomerase, which can cause uncontrolled cell growth. More research is needed to confirm these results.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":" ","pages":"299-304"},"PeriodicalIF":0.9,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13360591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"D-Valine as a mirror-image antifibrotic agent: Inhibiting fibroblast proliferation and attenuating airway fibrosis.","authors":"Mehmet Akif Ekici, Ahmet Uluşan, Maruf Şanlı, Demet Kahraman, Cansu Bağcı Özyaşar, Ahmet Feridun Işık","doi":"10.4274/tjtcs.2026.28842","DOIUrl":"10.4274/tjtcs.2026.28842","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Postintubation tracheal stenosis is a fibroproliferative airway disorder with limited pharmacological treatment options. Excessive fibroblast proliferation and extracellular matrix deposition play a central role in its pathogenesis. D-amino acids such as D-Valine are thought to modulate L-Valine-dependent protein synthesis, thereby suppressing fibroblast activity. This study aimed to evaluate the antifibrotic effects of D-Valine in experimental models.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study evaluated the antifibrotic effects of D-Valine using both &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; models. Primary human bronchial epithelial cells and fibroblasts were cultured and treated with increasing concentrations of D-Valine (120 mM), and cell viability was assessed with the MTT assay (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide). For the &lt;i&gt;in vivo&lt;/i&gt; model, tracheal stenosis was surgically induced in 20 New Zealand rabbits, randomized into four groups: Control, physiological saline (PS), dexamethasone, and D-Valine. Submucosal thickness, fibrosis, and inflammatory infiltration were analyzed histopathologically.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;&lt;i&gt;In vitro&lt;/i&gt; assays showed a concentration-related decrease in fibroblast viability, as assessed by the MTT assay; however, this trend did not reach statistical significance (mean absorbance values ranged from 0.84±0.31 to 0.97±0.44 compared with 0.95±0.31 in the PS group; p=0.326). Epithelial cell viability also declined slightly at higher doses (mean 0.85±0.36 vs. 0.90±0.72, p=0.214). A moderate positive correlation was observed between epithelial and connective tissue viability at 20 mM D-Valine (r=0.494, p=0.002, n=6). In vivo, submucosal thickness was highest in the saline group (1.08±0.44 mm) and lowest in the control group (0.28±0.08 mm; p=0.011). The dexamethasone and D-Valine groups showed reduced submucosal thickening (0.98±0.13 mm and 0.86±0.24 mm, respectively), though differences versus saline were not statistically significant (p=0.989 and p=0.534). The fibrosis rate was greatest in the saline group (74±15.17%) and lowest in controls (37±12.55%, p=0.001). D-Valine (56±11.4%) and dexamethasone (56.25±4.79%) groups exhibited markedly lower fibrosis than saline (p=0.057 and p=0.056, respectively).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This study provides experimental evidence that D-Valine suppresses fibroblast proliferation and attenuates fibrosis in a New Zealand White rabbit model of tracheal stenosis. The antifibrotic effects observed may be related to interference with valine-dependent protein synthesis. However, considering the concurrent effects on epithelial cells and the inherent limitations of experimental models, further mechanistic and translational studies are required before potential clinical implications can be considered. These findings suggest that D-Valine represents a promising experimental antifibrotic candidate for airway fibrosis r","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":" ","pages":"310-318"},"PeriodicalIF":0.9,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13360701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac herniation after surgically induced pericardial defects: A systematic review.","authors":"Kristian Kurniawan, Stephanie Aurelia, Audrey Vanessa, Vony Yurike, Heunice Precious, Vania Carolyn, Kezia Calista, Tatiana Tantrakumara","doi":"10.4274/tjtcs.2025.28664","DOIUrl":"10.4274/tjtcs.2025.28664","url":null,"abstract":"<p><p>Cardiac herniation is a rare but potentially fatal complication following thoracic or cardiovascular procedures involving pericardial defects. We systematically reviewed 29 reported cases to evaluate causes, presentations, and outcomes. Most occurred after right intrapericardial pneumonectomy, though mediastinal tumour resections, transplantation, and trauma were also implicated. Clinical features included hypotension, superior vena cava syndrome, and cardiac arrest. Diagnosis was achieved by radiography, computed tomography, or echocardiography. Emergent re-thoracotomy with cardiac repositioning and pericardial repair was essential for survival, while delayed recognition was often fatal. Vigilant monitoring and preventive pericardial reinforcement are recommended.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":" ","pages":"292-298"},"PeriodicalIF":0.9,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13360695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of ultra-fast-track cardiac anesthesia on vasoactive-inotropic support after coronary artery bypass grafting.","authors":"Nezir Yılmaz, Abdurrahman Dağhan, Mehmet Ziya Ertaş, Cengiz Güven, Abuzer Deniz Sürücü","doi":"10.4274/tjtcs.2026.2026-2-38","DOIUrl":"10.4274/tjtcs.2026.2026-2-38","url":null,"abstract":"<p><strong>Background: </strong>Ultra-fast-track cardiac anesthesia (UFTCA) aims to promote rapid tracheal extubation and has increasingly been incorporated into enhanced recovery protocols after coronary artery bypass grafting (CABG). Nevertheless, its influence on early postoperative hemodynamic stability, particularly in terms of vasoactive-inotropic requirements, remains insufficiently defined.</p><p><strong>Methods: </strong>In this study with a prospective, randomized design, adult patients scheduled for elective isolated CABG were assigned in a 1:1 ratio to either immediate extubation in the operating theater (UFTCA group) or conventional extubation in the intensive care unit (ICU). All participants received standardized general anesthesia combined with ultrasound-guided thoracic paravertebral and femoral nerve blocks. The primary endpoint was the cumulative vasoactive-inotropic score (VIS) within the first 24 hours postoperatively. Secondary endpoints included ICU and hospital length of stay, time to mobilization, chest tube removal, postoperative pain, nausea and vomiting, delirium, and quality of recovery evaluated using the quality of recovery-15 (QoR-15).</p><p><strong>Results: </strong>Outcome analyses were performed on 98 randomized patients (60.2% male; mean age 63.1±8.4 years) with comparable baseline variables between groups. The UFTCA group demonstrated significantly lower 24-hour cumulative VIS values compared with the conventional extubation group (1.74±1.75 <i>vs</i>. 3.97±2.82; p<0.05). Additionally, ICU and hospital stay durations, time to mobilization, and chest tube removal occurred earlier in the UFTCA cohort. QoR-15 scores were significantly improved in the UFTCA group. Postoperative pain scores, rescue analgesic use, nausea, vomiting, and delirium rates did not differ significantly. No reintubation or respiratory complications were observed following ultra-fast-track management.</p><p><strong>Conclusion: </strong>Immediate extubation using an UFTCA strategy was associated with reduced vasoactive-inotropic support requirements and improved early recovery metrics after CABG, without compromising safety.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":" ","pages":"239-245"},"PeriodicalIF":0.9,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13360684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of type II endoleak after EVAR: Risk assessment and surveillance.","authors":"Garip Altıntaş, Alp Yıldırım, Sinan Özçelik, Emre Külahçıoğlu, Ayça Haksever, Fatma Akça Özsar, Bahadır Aytekin, Hakkı Zafer İşcan","doi":"10.4274/tjtcs.2026.2026-1-37","DOIUrl":"10.4274/tjtcs.2026.2026-1-37","url":null,"abstract":"<p><strong>Background: </strong>Type II endoleak (T2EL) is the most frequently reported complication following endovascular aneurysm repair (EVAR). Although generally considered benign and often self-limiting, spontaneous resolution does not always occur, and secondary intervention may be required. In this study, morphological and morphovolumetric parameters were compared between patients who developed T2EL and those without endoleak, in order to identify predictors of T2EL development in the pre-EVAR period. Additionally, our experience in the management of T2EL was reviewed in the context of the existing literature.</p><p><strong>Methods: </strong>A total of 472 patients who underwent EVAR were initially evaluated. After exclusion of other endoleak types, 408 patients were included in the final analysis, of whom 53 (13%) developed T2EL. The no-endoleak group comprised 355 patients (87%). Overall, T2EL accounted for 45.2% of all detected endoleaks. Primary endpoints were the identification of factors influencing T2EL development and the assessment of morphological and morphovolumetric parameters associated with endoleak formation. Secondary endpoints included secondary intervention rates, as well as post-EVAR mortality and morbidity.</p><p><strong>Results: </strong>No early mortality was observed. The mean follow-up duration was 33.2±21.2 months (median: 25 months; range: 12-99 months). All patients had at least one year of follow-up. Both univariate and multivariate analyses identified age, antiplatelet therapy regimen, inferior mesenteric artery (IMA) diameter, number of patent lumbar arteries, thrombus localisation, and the intraluminal thrombus-to-aneurysm volume ratio as significant predictors of T2EL development. Late mortality for the entire cohort was 23.0%, with cardiac-related causes being the most common (11.0%). Mean intensive care unit stay was 5.2±5.1 hours, and mean hospital stay was 2.6±1.0 days.</p><p><strong>Conclusion: </strong>Although EVAR effectively reduces aneurysm diameter and volume during follow-up, the presence of T2EL may limit this benefit. Lumbar arteries were the most common source of T2EL. An IMA diameter >3 mm, female sex, double antiplatelet therapy, presence of four or more lumbar arteries, absence of coronary artery disease, and thrombus characteristics were associated with increased T2EL risk. D-dimer appears to be a useful biomarker for T2EL detection. Morphovolumetric analysis is more sensitive than maximum diameter measurement in the surveillance of low-flow endoleaks.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":" ","pages":"284-291"},"PeriodicalIF":0.9,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13360253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148297149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of intermittent antegrade cardioplegia and antegrade/retrograde cardioplegia in cardiac surgery: A propensity-matched analysis.","authors":"Osman Fehmi Beyazal, Süleyman Yazıcı, Zeki Temiztürk, Cemalettin Aydın, Emre Doğan, Daniiar Malikov, Nihan Kayalar, Mehmed Yanartaş","doi":"10.4274/tjtcs.2026.28228","DOIUrl":"10.4274/tjtcs.2026.28228","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study is to compare the clinical results of intermittent antegrade and intermittent antegrade/continuous retrograde cardioplegia techniques in patients undergoing cardiac surgery.</p><p><strong>Methods: </strong>Between 2023 and 2025, 915 patients (648 males; 59±11.3 years) who underwent cardiac surgery were evaluated. The patients were divided into two groups. Group A (n=415): Those given intermittent antegrade cardioplegia, and Group B (n=500): Those given intermittent antegrade and continuous retrograde cardioplegia. Subgroups were obtained by propensity matching. Group 1 (n=284): Those given intermittent antegrade cardioplegia, and Group 2 (n=284): Those given intermittent antegrade and continuous retrograde cardioplegia.</p><p><strong>Results: </strong>Baseline demographics, comorbidities, the European system for cardiac operative risk evaluation II, preoperative echocardiographic findings, operative data, cross-clamp times, cardiopulmonary bypass times, and the number of bypassed grafts were similar between Groups 1 and 2. Postoperative ejection fraction was similar between the groups. Postoperative tricuspid annular plane systolic excursion was higher in Group 1 than in Group 2 (median 17-15 mm, respectively, p=0.005). Vasoactive inotrope score was lower in Group 1 than in Group 2. There were no differences between the groups in terms of postoperative day 1 arterial blood gas findings, postoperative blood product use, and postoperative bleeding volume. The laboratory parameters were also similar between the groups on postoperative day 1. There was no statistically significant difference between the two groups in terms of postoperative outcomes. Postoperative exploration, continuous renal replacement therapy, tracheostomy, and mortality were higher in Group 1 compared to Group 2. Conversely, intubation time was longer in Group 2 compared to Group 1. However, no statistically significant difference was observed.</p><p><strong>Conclusion: </strong>This propensity-matched study supports that intermittent anterograde cardioplegia alone can yield similar postoperative outcomes compared to the combined strategy.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":" ","pages":"220-230"},"PeriodicalIF":0.9,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13360788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147534122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of carotid endarterectomy performed under local anesthesia with near-infrared spectroscopy in the detection of early neurological events.","authors":"Faruk Toktaş, Kadir Kaan Özsin, Umut Serhat Sanrı, Şenol Yavuz","doi":"10.4274/tjtcs.2026.28320","DOIUrl":"10.4274/tjtcs.2026.28320","url":null,"abstract":"<p><strong>Background: </strong>We aimed to determine the relationship between near-infrared spectroscopy (NIRS) changes and shunt use, and the role of wakefulness in detecting early neurological events during carotid endarterectomy (CEA) surgeries performed under local anesthesia (LA) while the patient was awake.</p><p><strong>Methods: </strong>Patients who underwent CEA under LA were included in the study. All data were obtained retrospectively from patient files in our institution's archives. Shunt use, decreases in NIRS values, internal carotid artery (ICA) closure technique, and clamping time were recorded during the procedure. Patients were divided into two groups: Those with and those without contralateral total occlusion (CTO). These groups were compared in terms of decrease rates in NIRS values and shunt use.</p><p><strong>Results: </strong>Present study included 635 patients (68% male, mean age: 66.7±5.6 years). One hundred thirty-four (21.1%) of the patients had bilateral ICA stenosis of 70% or greater. The patients were divided into two groups: With and without CTO. CTO was detected in 97 (15.3%) patients. In all groups, shunts were applied to patients with a 30% or more decrease in NIRS values. In the CTO group, percentage decreases in NIRS values were greater and statistically significant (p<0.001), except for decreases below 10% (p<0.001). Shunt usage in the CTO group was found to be statistically significant (p=0.042). However, shunt use was associated with a decrease in NIRS rather than the presence of CTO (r=0.747, p<0.001). The most common complications in the postoperative period were voice disorder and hoarseness at a rate of 20.8%.</p><p><strong>Conclusion: </strong>With carotid surgery performed under LA, significant neurological deficits were detected early and necessary revisions were performed. We also found that a decrease in NIRS values is significant for shunt use, and a decrease of more than 30% in NIRS could be note worthy for shunt use.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":" ","pages":"269-275"},"PeriodicalIF":0.9,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13360912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146208204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic-assisted release of the median arcuate ligament: A case report.","authors":"Mehmet Şengör, Ünal Aydın","doi":"10.4274/tjtcs.2026.2026-1-36","DOIUrl":"https://doi.org/10.4274/tjtcs.2026.2026-1-36","url":null,"abstract":"<p><p>Median arcuate ligament syndrome (MALS) is a rare clinical condition caused by extrinsic compression of the celiac artery by the median arcuate ligament of the diaphragm. Clinically, patients typically present with postprandial epigastric pain, nausea, vomiting, and progressive weight loss. Diagnosis requires findings of celiac artery compression using appropriate imaging modalities. The primary goal of treatment is surgical release of the median arcuate ligament to relieve compression of the celiac artery. In this case report, we present the robotic surgical management of a patient with MALS.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A giant coronary aneurysm posing as a cardiac mass: The stepwise diagnosis, medical and surgical management of Behçet disease in an adolescent.","authors":"Bahar Çaran, Erman Çilsal, Sezen Ugan Atik, Sertaç Haydin, Alper Doğan, Nuray Aktay Ayaz, Alper Güzeltaş","doi":"10.4274/tjtcs.2026.2026-1-12","DOIUrl":"10.4274/tjtcs.2026.2026-1-12","url":null,"abstract":"<p><p>Behçet's disease (BD) is a rare, systemic vasculitis characterized by recurrent oral and genital ulcers, ocular inflammation, and multiorgan involvement. Cardiovascular complications are uncommon in BD; however, when they occur, they are potentially life-threatening. Coronary artery aneurysms (CAAs) are one of the most severe vascular manifestations of BD, particularly in the pediatric population, where they remain poorly documented and their prognosis is largely unknown. Here, we report the case of a 13-year-old male patient with the diagnosis of BD who presented with a giant right coronary artery aneurysm initially identified as a cardiac mass on imaging. Due to the medically refractory and life-threatening nature of the aneurysm, the patient underwent coronary artery bypass grafting. This case highlights the rare but critical cardiovascular complications of BD in a pediatric patient and underscores the challenges in diagnosis and surgical management. Clinicians should maintain a high index of suspicion for vascular complications, including CAAs, in pediatric patients with BD.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148333521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Implementation of the \"Software-Based Enhanced Recovery After Cardiac Surgery\" (ERACS) Protocol in Ankara University School of Medicine Heart Center.","authors":"Atilla Aral, Ayşegül Güven, Melisa Kandemir, Onur Büyükçakır, Mustafa Bahadır İnan, Evren Özçınar, Mehmet Cahit Sarıcaoğlu, Ahmet Onat Bermede, Neslihan Alkış, Levent Yazıcıoğlu","doi":"10.4274/tjtcs.2026.2026-3-1","DOIUrl":"https://doi.org/10.4274/tjtcs.2026.2026-3-1","url":null,"abstract":"<p><p>Enhanced recovery after cardiac surgery (ERACS) is a multidisciplinary strategy designed to optimize perioperative care, reduce complications, and shorten hospital length of stay. However, consistent implementation remains challenging due to variability in practice and the dynamic nature of postoperative recovery. In this manuscript, we describe the development and implementation of a software-supported ERACS platform that integrates protocol standardization with patient-specific personalization. The system prospectively captures and analyzes perioperative data, enabling continuous risk stratification and real-time adaptation of care pathways according to each patient's evolving clinical status. To our knowledge, this is the first report from Türkiye describing the software-based implementation of an ERACS program in cardiac surgery. Clinical outcome analysis is ongoing. This digital framework provides a scalable model for translating enhanced recovery principles into precision perioperative care.</p>","PeriodicalId":49413,"journal":{"name":"Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148266748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}