World Journal of Biological Psychiatry最新文献_第3页

Lymphoblast transcriptome analysis in 22q11.2 deletion syndrome individuals with schizophrenia-spectrum disorder. 22q11.2缺失综合征精神分裂症谱系障碍患者淋巴母细胞转录组分析。

IF 3.1 4区医学

World Journal of Biological Psychiatry Pub Date : 2024-04-01 Epub Date: 2024-05-01 DOI: 10.1080/15622975.2024.2327030

Elena Michaelovsky, Miri Carmel, Doron Gothelf, Abraham Weizman

{"title":"Lymphoblast transcriptome analysis in 22q11.2 deletion syndrome individuals with schizophrenia-spectrum disorder.","authors":"Elena Michaelovsky, Miri Carmel, Doron Gothelf, Abraham Weizman","doi":"10.1080/15622975.2024.2327030","DOIUrl":"10.1080/15622975.2024.2327030","url":null,"abstract":"Objectives: 22q11.2 deletion is the most prominent risk factor for schizophrenia (SZ). The aim of the present study was to identify unique transcriptome profile for 22q11.2 deletion syndrome (DS)-related SZ-spectrum disorder (SZ-SD).Methods: We performed RNA-Seq screening in lymphoblasts collected from 20 individuals with 22q11.2DS (10 men and 10 women, four of each sex with SZ-SD and six with no psychotic disorders (Np)).Results: Sex effect in RNA-Seq descriptive analysis led to separating the analyses between men and women. In women, only one differentially expressed gene (DEG), HLA-DQA2, was associated with SZ-SD. In men, 48 DEGs (adjp < 0.05) were found to be associated with SZ-SD. Ingenuity pathway analysis of top 85 DEGs (p < 4.66E - 04) indicated significant enrichment for immune-inflammatory response (IIR) and neuro-inflammatory signalling pathways. Additionally, NFATC2, IFNG, IFN-alpha, STAT1 and IL-4 were identified as upstream regulators. Co-expression network analysis revealed the contribution of endoplasmic reticulum protein processing and N-Glycan biosynthesis. These findings indicate dysregulation of IIR and post-translational protein modification processes in individuals with 22q11.2DS-related SZ-SD.Conclusions: Candidate pathways and upstream regulators may serve as novel biomarkers and treatment targets for SZ. Future transcriptome studies, including larger samples and proteomic analysis, are needed to substantiate our findings.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"242-254"},"PeriodicalIF":3.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequencies of CYP2C19 and CYP2D6 gene variants in a German inpatient sample with mood and anxiety disorders. 德国情绪和焦虑症住院病人样本中 CYP2C19 和 CYP2D6 基因变异的频率。

IF 3.1 4区医学

World Journal of Biological Psychiatry Pub Date : 2024-04-01 Epub Date: 2024-05-01 DOI: 10.1080/15622975.2024.2321553

Maike Scherf-Clavel, Heike Weber, Stefan Unterecker, Daniel J Müller, Jürgen Deckert

{"title":"Frequencies of CYP2C19 and CYP2D6 gene variants in a German inpatient sample with mood and anxiety disorders.","authors":"Maike Scherf-Clavel, Heike Weber, Stefan Unterecker, Daniel J Müller, Jürgen Deckert","doi":"10.1080/15622975.2024.2321553","DOIUrl":"10.1080/15622975.2024.2321553","url":null,"abstract":"Objectives: Previous results demonstrated that CYP2D6 and CYP2C19 gene variants affect serum concentrations of antidepressants. We implemented a PGx service determining gene variants in CYP2D6 and CYP2C19 in our clinical routine care and report on our first patient cohort.Methods: We analysed CYP2D6 and CYP2C19 allele, genotype, and phenotype frequencies, and actionable pharmacogenetic variants in this German psychiatric inpatient cohort. Two-tailed z-test was used to investigate for differences in CYP2D6 and CYP2C19 phenotypes and actionable/non-actionable genetic variant frequencies between our cohort and reference cohorts.Results: Out of the 154 patients included, 44.8% of patients were classified as CYP2D6 normal metabolizer, 38.3% as intermediate metabolizers, 8.4% as poor metabolizers, and 2.6% as ultrarapid metabolizers. As for CYP2C19, 40.9% of patients were classified as normal metabolizers, 19.5% as intermediate metabolizers, 2.6% as poor metabolizers, 31.2% as rapid metabolizers, and 5.8% as ultrarapid metabolizers. Approximately, 80% of patients had at least one actionable PGx variant.Conclusion: There is a high prevalence of actionable PGx variants in psychiatric inpatients which may affect treatment response. Physicians should refer to PGx-informed dosing guidelines in carriers of these variants. Pre-emptive PGx testing in general may facilitate precision medicine also for other drugs metabolised by CYP2D6 and/or CYP2C19.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"214-221"},"PeriodicalIF":3.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140141022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the impact of sex on high-frequency repetitive transcranial magnetic stimulation´s clinical response in schizophrenia - results from a secondary analysis. 评估性别对精神分裂症患者高频重复经颅磁刺激临床反应的影响--二次分析结果。

IF 3.1 4区医学

World Journal of Biological Psychiatry Pub Date : 2024-04-01 Epub Date: 2024-05-01 DOI: 10.1080/15622975.2024.2327028

Mattia Campana, Thomas Schneider-Axmann, Thomas Wobrock, Berend Malchow, Berthold Langguth, Michael Landgrebe, Peter Eichhammer, Elmar Frank, Joachim Cordes, Wolfgang Wölwer, Wolfgang Gaebel, Georg Winterer, Göran Hajak, Christian Ohmann, Pablo E Verde, Marcella Rietschel, Raees Ahmed, Matin Mortazavi, Wolfgang Strube, Peter Falkai, Alkomiet Hasan, Elias Wagner

{"title":"Assessing the impact of sex on high-frequency repetitive transcranial magnetic stimulation´s clinical response in schizophrenia - results from a secondary analysis.","authors":"Mattia Campana, Thomas Schneider-Axmann, Thomas Wobrock, Berend Malchow, Berthold Langguth, Michael Landgrebe, Peter Eichhammer, Elmar Frank, Joachim Cordes, Wolfgang Wölwer, Wolfgang Gaebel, Georg Winterer, Göran Hajak, Christian Ohmann, Pablo E Verde, Marcella Rietschel, Raees Ahmed, Matin Mortazavi, Wolfgang Strube, Peter Falkai, Alkomiet Hasan, Elias Wagner","doi":"10.1080/15622975.2024.2327028","DOIUrl":"10.1080/15622975.2024.2327028","url":null,"abstract":"Background: The evidence for repetitive transcranial magnetic stimulation (rTMS) to treat negative symptoms in schizophrenia (SCZ) is increasing, although variable response rates remain a challenge. Subject´s sex critically influences rTMS´ treatment outcomes. Females with major depressive disorder are more likely to respond to rTMS, while SCZ data is scarce.Methods: Using data from the 'rTMS for the Treatment of Negative Symptoms in Schizophrenia' (RESIS) trial we assessed the impact of sex on rTMS´ clinical response rate from screening up to 105 days after intervention among SCZ patients. The impact of resting motor threshold (RMT) on response rates was also assessed.Results: 157 patients received either active or sham rTMS treatment. No significant group differences were observed. Linear mixed model showed no effects on response rates (all p > 0.519). Apart from a significant sex*time interaction for the positive subscale of the positive and negative syndrome scale (PANSS) scores (p = 0.032), no other significant effects of sex on continuous PANSS scores were observed. RMT had no effect on response rate.Conclusion: In the largest rTMS trial on the treatment of SCZ negative symptoms we did not observe any significant effect of sex on treatment outcomes. Better assessments of sex-related differences could improve treatment individualisation.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"233-241"},"PeriodicalIF":3.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140141020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copy number variant risk loci for schizophrenia converge on the BDNF pathway. 精神分裂症的拷贝数变异风险位点汇聚在 BDNF 通路上。

IF 3.1 4区医学

World Journal of Biological Psychiatry Pub Date : 2024-04-01 Epub Date: 2024-05-01 DOI: 10.1080/15622975.2024.2327027

Friederike Ehrhart, Ana Silva, Therese van Amelsvoort, Emma von Scheibler, Chris Evelo, David E J Linden

{"title":"Copy number variant risk loci for schizophrenia converge on the BDNF pathway.","authors":"Friederike Ehrhart, Ana Silva, Therese van Amelsvoort, Emma von Scheibler, Chris Evelo, David E J Linden","doi":"10.1080/15622975.2024.2327027","DOIUrl":"10.1080/15622975.2024.2327027","url":null,"abstract":"Objectives: Schizophrenia genetics is intricate, with common and rare variants' contributions not fully understood. Certain copy number variations (CNVs) elevate risk, pivotal for understanding mental disorder models. Despite CNVs' genome-wide distribution and variable gene and protein effects, we must explore beyond affected genes to interaction partners and molecular pathways.Methods: In this study, we developed machine-readable interactive pathways to enable analysis of functional effects of genes within CNV loci and identify ten common pathways across CNVs with high schizophrenia risk using the WikiPathways database, schizophrenia risk gene collections from GWAS studies, and a gene-disease association database.Results: For CNVs that are pathogenic for schizophrenia, we found overlapping pathways, including BDNF signalling, cytoskeleton, and inflammation. Common schizophrenia risk genes identified by different studies are found in all CNV pathways, but not enriched.Conclusions: Our findings suggest that specific pathways - BDNF signalling - are critical contributors to schizophrenia risk conferred by rare CNVs. Our approach highlights the importance of not only investigating deleted or duplicated genes within pathogenic CNV loci, but also study their direct interaction partners, which may explain pleiotropic effects of CNVs on schizophrenia risk and offer a broader field for interventions.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"222-232"},"PeriodicalIF":3.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140141021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota: A potential player in psychiatric symptoms during COVID-19. 肠道微生物群：COVID-19 期间精神症状的潜在参与者。

IF 3 4区医学

World Journal of Biological Psychiatry Pub Date : 2024-04-01 Epub Date: 2024-04-27 DOI: 10.1080/15622975.2024.2342846

Zijie Zeng, Weilong Tang

{"title":"Gut microbiota: A potential player in psychiatric symptoms during COVID-19.","authors":"Zijie Zeng, Weilong Tang","doi":"10.1080/15622975.2024.2342846","DOIUrl":"10.1080/15622975.2024.2342846","url":null,"abstract":"Objectives: This study aims to explore the potential interconnections among gut microbiota, COVID-19 infection, depression and anxiety disorder. Additionally, it tries to assess potential therapeutic interventions that may improve the dysbiosis of gut microbiota.Methods: To achieve these objectives, we reviewed existing literature, encompassing studies and critical reviews that intersect the domains of gut microbiota, COVID-19, depression and anxiety disorders.Results: The findings highlight a notable correlation between the dysbiosis of gut microbiota and psychiatric symptoms in the context of COVID-19. Specifically, there is a marked reduction in the populations of bacteria that generate anti-inflammatory short-chain fatty acids (SCFAs), alongside a rise in the prevalence of gut bacterial clusters linked to inflammatory processes. Furthermore, several potential treatment strategies were summarised for improving the dysbiosis.Conclusions: Gut microbiota plays a significant role in psychiatric symptoms during COVID-19, which has significant implications for the study and prevention of psychiatric symptoms in major epidemic diseases.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"267-280"},"PeriodicalIF":3.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal imaging measures in the prediction of clinical response to deep brain stimulation for refractory depression: A machine learning approach. 预测难治性抑郁症患者对深部脑刺激临床反应的多模态成像措施：机器学习方法。

IF 3.1 4区医学

World Journal of Biological Psychiatry Pub Date : 2024-03-01 Epub Date: 2024-01-17 DOI: 10.1080/15622975.2023.2300795

Rajamannar Ramasubbu, Elliot C Brown, Pauline Mouches, Jasmine A Moore, Darren L Clark, Christine P Molnar, Zelma H T Kiss, Nils D Forkert

{"title":"Multimodal imaging measures in the prediction of clinical response to deep brain stimulation for refractory depression: A machine learning approach.","authors":"Rajamannar Ramasubbu, Elliot C Brown, Pauline Mouches, Jasmine A Moore, Darren L Clark, Christine P Molnar, Zelma H T Kiss, Nils D Forkert","doi":"10.1080/15622975.2023.2300795","DOIUrl":"10.1080/15622975.2023.2300795","url":null,"abstract":"Objectives: This study compared machine learning models using unimodal imaging measures and combined multi-modal imaging measures for deep brain stimulation (DBS) outcome prediction in treatment resistant depression (TRD).Methods: Regional brain glucose metabolism (CMRGlu), cerebral blood flow (CBF), and grey matter volume (GMV) were measured at baseline using 18F-fluorodeoxy glucose (18F-FDG) positron emission tomography (PET), arterial spin labelling (ASL) magnetic resonance imaging (MRI), and T1-weighted MRI, respectively, in 19 patients with TRD receiving subcallosal cingulate (SCC)-DBS. Responders (n = 9) were defined by a 50% reduction in HAMD-17 at 6 months from the baseline. Using an atlas-based approach, values of each measure were determined for pre-selected brain regions. OneR feature selection algorithm and the naïve Bayes model was used for classification. Leave-out-one cross validation was used for classifier evaluation.Results: The performance accuracy of the CMRGlu classification model (84%) was greater than CBF (74%) or GMV (74%) models. The classification model using the three image modalities together led to a similar accuracy (84%0 compared to the CMRGlu classification model.Conclusions: CMRGlu imaging measures may be useful for the development of multivariate prediction models for SCC-DBS studies for TRD. The future of multivariate methods for multimodal imaging may rest on the selection of complementing features and the developing better models.Clinical Trial Registration: ClinicalTrials.gov (#NCT01983904).","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"175-187"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Common changes in rat cortical gene expression after antidepressant drug treatment: Impacts on metabolism of polyamines, mRNA splicing, regulation of RAS by GAPs, neddylation and GPCR ligand binding. 抗抑郁药物治疗后大鼠大脑皮层基因表达的常见变化：对多胺代谢、mRNA 剪接、GAPs 对 RAS 的调控、needdylation 和 GPCR 配体结合的影响。

IF 3.1 4区医学

World Journal of Biological Psychiatry Pub Date : 2024-03-01 DOI: 10.1080/15622975.2024.2312475

Brian Dean, Elizabeth Scarr

{"title":"Common changes in rat cortical gene expression after antidepressant drug treatment: Impacts on metabolism of polyamines, mRNA splicing, regulation of RAS by GAPs, neddylation and GPCR ligand binding.","authors":"Brian Dean, Elizabeth Scarr","doi":"10.1080/15622975.2024.2312475","DOIUrl":"10.1080/15622975.2024.2312475","url":null,"abstract":"Objectives: This study sought to identify pathways affected by rat cortical RNA that were changed after treatment with fluoxetine or imipramine.Methods: We measured levels of cortical RNA in male rats using GeneChip® Rat Exon 1.0 ST Array after treatment with vehicle (0.9% NaCl), fluoxetine (10 mg/kg/day) or imipramine (20 mg/kg/day) for 28 days. Levels of coding and non-coding RNA in vehicle treated rats were compared to those in treated rats using ANOVA in JMP Genomics 13 and the Panther Gene Ontology Classification System was used to identify pathways involving the changed RNAs.Results: 18,876 transcripts were detected; there were highly correlated changes in 1010 levels of RNA after both drug treatments that would principally affect the metabolism of polyamines, mRNA splicing, regulation of RAS by GAPs, neddylation and GPCR ligand binding. Using our previously published data, we compared changes in transcripts after treatment with antipsychotic and mood stabilising drugs.Conclusions: Our study shows there are common, correlated, changes in coding and non-coding RNA in the rat cortex after treatment with fluoxetine or imipramine; we propose the pathways affected by these changes are involved in the therapeutic mechanisms of action of antidepressant drugs.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"200-213"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139724689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum proteomics analysis of drug-naïve patients with generalised anxiety disorder: Tandem mass tags and multiple reaction monitoring. 对未经药物治疗的广泛性焦虑症患者进行血清蛋白质组学分析：串联质量标记和多反应监测。

IF 3.1 4区医学

World Journal of Biological Psychiatry Pub Date : 2024-03-01 Epub Date: 2024-01-21 DOI: 10.1080/15622975.2023.2301064

Xue Li, Sisi Zheng, Zhengtian Feng, Xinzi Liu, Ying Ding, Lina Zhang, Guofu Zhang, Min Liu, Hong Zhu, Hongxiao Jia

{"title":"Serum proteomics analysis of drug-naïve patients with generalised anxiety disorder: Tandem mass tags and multiple reaction monitoring.","authors":"Xue Li, Sisi Zheng, Zhengtian Feng, Xinzi Liu, Ying Ding, Lina Zhang, Guofu Zhang, Min Liu, Hong Zhu, Hongxiao Jia","doi":"10.1080/15622975.2023.2301064","DOIUrl":"10.1080/15622975.2023.2301064","url":null,"abstract":"Objectives: The prevalence of generalised anxiety disorder (GAD) is high. However, the underlying mechanisms remain elusive. Proteomics techniques can be employed to assess the pathological mechanisms involved in GAD.Methods: Twenty-two drug-naive GAD patients were recruited, their serum samples were used for protein quantification and identified using Tandem Mass Tag and Multiple Reaction Monitoring (MRM). Machine learning models were employed to construct predictive models for disease occurrence by using clinical scores and target proteins as input variables.Results: A total of 991 proteins were differentially expressed between GAD and healthy participants. Gene Ontology analysis revealed that these proteins were significantly associated with stress response and biological regulation, suggesting a significant implication in anxiety disorders. MRM validation revealed evident disparities in 12 specific proteins. The machine learning model found a set of five proteins accurately predicting the occurrence of the disease at a rate of 87.5%, such as alpha 1B-glycoprotein, complement component 4 A, transferrin, V3-3, and defensin alpha 1. These proteins had a functional association with immune inflammation.Conclusions: The development of generalised anxiety disorder might be closely linked to the immune inflammatory stress response.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"188-199"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139514217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corticosteroids and mania: A systematic review. 皮质类固醇与躁狂症：系统综述。

IF 3 4区医学

World Journal of Biological Psychiatry Pub Date : 2024-03-01 Epub Date: 2024-03-13 DOI: 10.1080/15622975.2024.2312572

Mathias De Bock, Pascal Sienaert

{"title":"Corticosteroids and mania: A systematic review.","authors":"Mathias De Bock, Pascal Sienaert","doi":"10.1080/15622975.2024.2312572","DOIUrl":"10.1080/15622975.2024.2312572","url":null,"abstract":"Objectives: Corticosteroids are widely prescribed for a variety of medical conditions. Accumulating evidence suggests that their use may be associated with adverse psychiatric effects, including mania. In this systematic review, we aim to critically evaluate the existing literature on the association between corticosteroid use and the emergence of mania.Methods: We conducted a comprehensive search of major electronic databases (PubMed, Embase, Cochrane Library) for relevant studies published up to the date of the search (12th January 2023). Inclusion criteria involve studies that investigate the association between corticosteroid use and the emergence of mania in adult patients. The primary outcome is the prevalence of (hypo)mania following corticosteroid administration. Secondary outcomes include potential risk factors, dose-response relationships, and differences among various corticosteroid formulations.Results: The identified studies were subjected to a systematic selection process and data extraction by an independent reviewer. A total of 47 articles met the inclusion criteria for our systematic review.Conclusion: Our findings suggest that mania is a common side-effect of corticosteroid use, particularly in prednisone equivalent doses above 40 mg. These findings hold practical significance for clinicians and provide insights into potential interventions, including careful monitoring, dose adjustments, and consideration of psychotropic medications when managing corticosteroid-induced mania.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"161-174"},"PeriodicalIF":3.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender differences in brain region activation during verbal fluency task as detected by fNIRS in patients with depression. fNIRS检测抑郁症患者言语流畅性任务时脑区激活的性别差异。

IF 3.1 4区医学

World Journal of Biological Psychiatry Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI: 10.1080/15622975.2023.2287735

Hailong Lyu, Miaomiao Zhao, Pengfeng Xu, Ying Li, Chaonan Jiang, Haoyang Zhao, Wenjing Shen, Xiaohan Hu, Kaiqi Wang, Yi Xu, Manli Huang

{"title":"Gender differences in brain region activation during verbal fluency task as detected by fNIRS in patients with depression.","authors":"Hailong Lyu, Miaomiao Zhao, Pengfeng Xu, Ying Li, Chaonan Jiang, Haoyang Zhao, Wenjing Shen, Xiaohan Hu, Kaiqi Wang, Yi Xu, Manli Huang","doi":"10.1080/15622975.2023.2287735","DOIUrl":"10.1080/15622975.2023.2287735","url":null,"abstract":"Background: Gender plays a role in the mechanisms of depression, but fewer studies have focused on gender differences in the abnormal activation of brain regions when patients perform specific cognitive tasks.Methods: A total of 110 major depressive disorder (MDD) patients and 106 healthy controls were recruited. The relative change in oxygen-haemoglobin (oxy-Hb) concentration during the verbal fluency task were measured by a 52-channel near-infra-red spectroscopy (NIRS) system. Differences in brain region activation between patients and healthy controls and between genders of depression patients were compared.Results: MDD patients demonstrated significantly decreased [oxy-Hb] changes in the right inferior frontal gyrus (p = 0.043) compared to healthy controls. A marked increase in leftward functional language lateralisation in the inferior frontal gyrus was observed in the MDD group in contrast to the HC group (p = 0.039). Furthermore, female patients in the MDD group exhibited significant reductions in [oxy-Hb] changes in the right frontal region (specifically, the superior and middle frontal gyrus; p = 0.037) compared with male patients.Conclusions: Gender impacts depression-related brain activation during cognitive tasks, potentially influencing depression's pathogenesis.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"141-150"},"PeriodicalIF":3.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138300503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0