World Journal of Biological Psychiatry最新文献_第2页

Evidence-based pharmacological interventions for insomnia: a systematic review on the effects of eszopiclone on insomnia comorbid with mental disturbances. 失眠的循证药物干预：艾司佐匹克隆治疗伴有精神障碍的失眠的系统综述。

IF 3.8 4区医学

World Journal of Biological Psychiatry Pub Date : 2026-04-01 Epub Date: 2026-03-16 DOI: 10.1080/15622975.2026.2641481

Laura Palagini, Bernardo M Dell'Osso, Luigi Ferini Strambi, Claudio Liguori, Giovanni Martinotti, Lino Nobili, Gabriele Sani, Andrea Fiorillo

{"title":"Evidence-based pharmacological interventions for insomnia: a systematic review on the effects of eszopiclone on insomnia comorbid with mental disturbances.","authors":"Laura Palagini, Bernardo M Dell'Osso, Luigi Ferini Strambi, Claudio Liguori, Giovanni Martinotti, Lino Nobili, Gabriele Sani, Andrea Fiorillo","doi":"10.1080/15622975.2026.2641481","DOIUrl":"10.1080/15622975.2026.2641481","url":null,"abstract":"Objectives: Insomnia is a common sleep disorder frequently co-occuring with psychiatric disturbances. Current research regarding the efficacy of sedative-hypnotic medications within psychiatric contexts underscores the need for further investigation in this domain. This review summarises pertinent findings that focus on eszopiclone, the latest Z-drug, in the treatment of insomnia linked to mental disorders.Methods: Initially, literature on mechanism and effects of eszopiclone on GABAergic transmission, sleep regulation and neurogenesis were analysed. Subsequently, we conducted a systematic review regarding its application in insomnia comorbid with psychiatric disorders, in accordance with PRISMA guidelines.Results: Data showed that eszopiclone has a distinctive chemical composition and, although it demonstrates certain pharmacological effects akin to benzodiazepines and other z-drugs, its distinctive structure differentiates it from other sedative-hypnotics. According to the systematic search, 12 articles were identified investigating the use of eszopiclone in psychiatric disorders, including major depression, anxiety and related disorders, as well as schizophrenia.Conclusions: Overall data indicated that the use of eszopiclone as an adjunctive treatment for insomnia may alleviates insomnia symptoms and also positively influences depressive, anxiety, and cognitive aspects related to psychiatric disorders.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"349-360"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of appetite hormone dysregulation on symptom trajectory in adolescents with attention deficit hyperactivity disorder: an exploratory prospective study. 食欲激素失调对青少年注意缺陷多动障碍症状轨迹的影响：一项探索性前瞻性研究。

IF 3.8 4区医学

World Journal of Biological Psychiatry Pub Date : 2026-03-29 DOI: 10.1080/15622975.2026.2646508

Ju-Wei Hsu, Wei-Chen Lin, Li-Chi Chen, Ya-Mei Bai, Shih-Jen Tsai, Mu-Hong Chen

{"title":"Effect of appetite hormone dysregulation on symptom trajectory in adolescents with attention deficit hyperactivity disorder: an exploratory prospective study.","authors":"Ju-Wei Hsu, Wei-Chen Lin, Li-Chi Chen, Ya-Mei Bai, Shih-Jen Tsai, Mu-Hong Chen","doi":"10.1080/15622975.2026.2646508","DOIUrl":"https://doi.org/10.1080/15622975.2026.2646508","url":null,"abstract":"Background: Cross-sectional studies have reported an association between attention deficit hyperactivity disorder (ADHD) and appetite hormone dysregulation. However, the association of appetite hormones with symptom trajectory in adolescents with ADHD remains uncertain.Methods: The present study included 32 adolescents with ADHD and 26 neurotypical adolescents. Appetite hormones (insulin, leptin, adiponectin, and ghrelin) were measured at baseline and at the third-year follow-up.Results: Generalised linear models adjusted for demographic characteristics and ADHD medication use revealed that adiponectin levels significantly decreased over time in adolescents with ADHD compared with the levels in neurotypical adolescents (p = .003). However, changes in insulin, leptin, and ghrelin levels did not differ significantly between the two groups. In the ADHD group, changes in adiponectin level were negatively associated with changes in Swanson, Nolan, and Pelham, Version IV inattention scores (B = -1.72, p = .018) and Child Behaviour Checklist Dysregulation Profile scores (B = -3.00, p = .015) after adjustment for age, sex, body mass index, and ADHD medication use.Conclusion: This study suggests that a greater reduction in adiponectin level over time is associated with worse attentional and emotional dysregulation symptoms. Our findings may inform innovative adiponectin-focused strategies for patients with ADHD.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"1-8"},"PeriodicalIF":3.8,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring purinergic and inflammatory pathways in bipolar disorder: evidence for diagnostic utility of UA, IL-6, NACHT, P2X7, ADA, XDH, ADO. 探索双相情感障碍的嘌呤能和炎症途径：UA、IL-6、NACHT、P2X7、ADA、XDH、ADO的诊断价值

IF 3.8 4区医学

World Journal of Biological Psychiatry Pub Date : 2026-03-01 Epub Date: 2026-01-27 DOI: 10.1080/15622975.2025.2607086

Magda Malewska-Kasprzak, Magdalena Sikorski, Filip Rybakowski, Monika Dmitrzak-Weglarz

{"title":"Exploring purinergic and inflammatory pathways in bipolar disorder: evidence for diagnostic utility of UA, IL-6, NACHT, P2X7, ADA, XDH, ADO.","authors":"Magda Malewska-Kasprzak, Magdalena Sikorski, Filip Rybakowski, Monika Dmitrzak-Weglarz","doi":"10.1080/15622975.2025.2607086","DOIUrl":"10.1080/15622975.2025.2607086","url":null,"abstract":"Introduction: Bipolar affective disorder (BD) is a chronic psychiatric illness characterized by alternating manic and depressive episodes. Despite extensive research, its underlying mechanisms remain unclear. Recent studies suggest that purinergic signaling and inflammation may play key roles in BD pathophysiology. This study aimed to explore biomarkers related to these systems to improve understanding of BD and identify potential diagnostic and prognostic indicators.Methods: The study included 76 BD patients and 20 healthy controls from the Department of Adult Psychiatry, Poznan University of Medical Sciences. Blood samples were collected during acute episodes and after symptom remission. Biomarkers analyzed included uric acid (UA), interleukin-6 (IL-6), NACHT, P2X7 receptor, adenosine deaminase (ADA), xanthine dehydrogenase (XDH), and adenosine (ADO), measured by ELISA.Results: NACHT (p = 0.004) and P2X7 (p = 0.001) were significantly higher post-treatment. Age positively correlated with NACHT, and BMI with UA. P2X7 levels negatively correlated with depressive symptom improvement. Gender differences revealed higher pre-treatment ADA levels in women and greater post-treatment increases in NACHT, ADA, and XDH in men. IL-6 was elevated during depressive episodes, while NACHT and XDH were higher in manic states. ROC analysis indicated strong diagnostic potential for XDH (AUC=0.917) and ADA (AUC=0.903). Logistic regression identified post-treatment NACHT and P2X7 as significant BD predictors.Conclusions: The study highlights the involvement of purinergic and inflammatory pathways in BD pathophysiology. Biomarkers such as NACHT, P2X7, ADA, and XDH may aid in diagnosing BD and monitoring treatment responses, offering potential for biologically informed therapies.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"186-199"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146068251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased risk of suicide in substance use disorder: a neurobiological perspective. 物质使用障碍中自杀风险增加：神经生物学视角。

IF 3.8 4区医学

World Journal of Biological Psychiatry Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1080/15622975.2026.2618990

Srinagesh Mannekote Thippaiah, Michael Wang, Madison Ransdell, Yi-Yuan Tang, Ayman Fanous

{"title":"Increased risk of suicide in substance use disorder: a neurobiological perspective.","authors":"Srinagesh Mannekote Thippaiah, Michael Wang, Madison Ransdell, Yi-Yuan Tang, Ayman Fanous","doi":"10.1080/15622975.2026.2618990","DOIUrl":"10.1080/15622975.2026.2618990","url":null,"abstract":"Objectives: Human actions are inherently driven to reduce unpleasant, aversive experiences through physiological and behavioral adaptations. Addictive substances can temporarily fulfil this need for avoidance when conditions are perceived as excessively aversive. However, long-term use can impair cognitive processes involved in self-preservation. Substance use directly and indirectly influences acute and chronic mental states characterized by dysphoria, negative emotions, altered cognition, an altered sense of reality, and diminished awareness of negative consequences, all of which have deleterious effects on the individual.Methods: A narrative synthesis of the literature was conducted, focusing on neurochemical, neuroendocrine, neural pathway, immune, and genetic mechanisms implicated insuicide risk among individuals with SUD.Results: The complex mental state seen in individuals with problematic substance use is the result of altered neurobiology, which conveys a strong predisposition to suicidal behaviors. The etiology of suicide among individuals with substance use disorder (SUD) is multifactorial and mediated through several neurochemical modifications that eventually create a transient or long-lasting unique neurobiological state dependent on the pattern of use.Conclusions: Multiple neuroendocrine and immune response pathways, along with underlying genetic sequences of interest, are a leading focus in identifying individuals at risk for suicide and in understanding disease heterogeneity and universality.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"169-185"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutathione antioxidant pathways in patients with schizophrenia: relationship with metabolic syndrome. 精神分裂症患者谷胱甘肽抗氧化途径：与代谢综合征的关系。

IF 3.8 4区医学

World Journal of Biological Psychiatry Pub Date : 2026-03-01 Epub Date: 2026-01-26 DOI: 10.1080/15622975.2026.2613246

Irina A Mednova, Yuliya V Shternis, Elena G Kornetova, Nikolay A Bokhan, Svetlana A Ivanova

{"title":"Glutathione antioxidant pathways in patients with schizophrenia: relationship with metabolic syndrome.","authors":"Irina A Mednova, Yuliya V Shternis, Elena G Kornetova, Nikolay A Bokhan, Svetlana A Ivanova","doi":"10.1080/15622975.2026.2613246","DOIUrl":"10.1080/15622975.2026.2613246","url":null,"abstract":"Objectives: In light of the frequent co-occurrence of metabolic syndrome (MetS) in schizophrenia and their common links to oxidative stress, the aim of our study was to evaluate glutathione (GSH) metabolism parameters in patients with schizophrenia and MetS.Methods: The study cohort comprised two groups: (1) 60 patients with schizophrenia and MetS and (2) 70 patients with schizophrenia without MetS,. GSH and its fractions concentration, and GSH-enzymes activity in serum were determined spectrophotometrically.Results: Total GSH and oxidised GSH (GSSG) concentration was significantly higher in schizophrenia patients with MetS (p = 0.003 and p = 0.028 respectively) than in those without MetS. The rGSH/GSSG ratio was significantly reduced in schizophrenia patients with MetS relative to those without MetS (p = 0.022). Glutathione S-transferase (GST) activity was significantly higher in patients with MetS than in those without MetS (p = 0.019).Conclusions: The findings of this study suggest that MetS in schizophrenia patients is associated with GSH metabolism dysregulation.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"248-256"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146054481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variants in TPH2 and ADARB1 genes in completed suicide from the Slovenian population - a follow-up to findings on attempted suicide in the Serbian population. 斯洛文尼亚人自杀未遂中的TPH2和ADARB1基因变异——对塞尔维亚人自杀未遂的后续研究

IF 3.8 4区医学

World Journal of Biological Psychiatry Pub Date : 2026-03-01 Epub Date: 2026-01-23 DOI: 10.1080/15622975.2026.2617200

Jelena Karanović, Špela Supej, Iris Šalamon Arčan, Maja Pantović-Stefanović, Maja Ivković, Tomaž Zupanc, Dušanka Savić-Pavićević, Alja Videtič Paska

{"title":"Variants in TPH2 and ADARB1 genes in completed suicide from the Slovenian population - a follow-up to findings on attempted suicide in the Serbian population.","authors":"Jelena Karanović, Špela Supej, Iris Šalamon Arčan, Maja Pantović-Stefanović, Maja Ivković, Tomaž Zupanc, Dušanka Savić-Pavićević, Alja Videtič Paska","doi":"10.1080/15622975.2026.2617200","DOIUrl":"10.1080/15622975.2026.2617200","url":null,"abstract":"Introduction: Suicidal behaviour, including completed suicide and attempted suicide, is affected by genetic factors, involving serotonergic system genes. TPH2 gene encodes tryptophan hydroxylase 2, rate-limiting brain serotonin synthetising enzyme whose pre-mRNAs are edited by ADAR enzymes, including ADARB1. TPH2 rs4290270 and ADARB1 rs9983925/rs4819035 variants have been previously implicated in suicide attempt in Serbian psychiatric patients. Our aim was to investigate whether these variants could also contribute to genetic predisposition for a more extreme phenotype-completed suicide differentiated by violent and non-violent method-in a Slovenian cohort.Methods: Genotyping of TPH2 rs4290270 and ADARB1 rs9983925/rs4819035 was performed on sample including 333 suicide completers (305 violent and 28 non-violent), and 357 non-suicidal autopsy controls from Slovenia. Statistical analyses were performed in PLINK ver. 1.9.Results: TPH2 rs4290270 AA genotype increased the risk of completed suicide compared to controls (p = 0.032/0.031corrected), mainly driven by violent suicide (p = 0.045/0.044corrected). Preliminary, ADARB1 rs4819035 GT and GG genotypes increased the risk of non-violent completed suicide compared to controls (p = 0.015/0.011corrected), and to violent completed suicide (p = 0.026/0.022corrected).Conclusion: TPH2 and ADARB1 genetic variants shape different genetic backgrounds in different types of suicidal behaviour, completed and attempted suicide. Preliminary, these variants might also differentiate between various methods of completed suicide, violent and non-violent.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"212-220"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral brain-derived neurotrophic factor in stable love relationships: a study in healthy humans. 稳定恋爱关系中的外周脑源性神经营养因子：一项健康人的研究。

IF 3.8 4区医学

World Journal of Biological Psychiatry Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1080/15622975.2026.2624464

Donatella Marazziti, Federico Mucci, Riccardo Gurrieri, Lionella Palego, Laura Betti, Gino Giannaccini, Sue Carter

{"title":"Peripheral brain-derived neurotrophic factor in stable love relationships: a study in healthy humans.","authors":"Donatella Marazziti, Federico Mucci, Riccardo Gurrieri, Lionella Palego, Laura Betti, Gino Giannaccini, Sue Carter","doi":"10.1080/15622975.2026.2624464","DOIUrl":"10.1080/15622975.2026.2624464","url":null,"abstract":"Objectives: The study aimed to investigate whether involvement in a stable romantic partnership is associated with differences in peripheral brain-derived neurotrophic factor (BDNF) levels.Methods: In a cross-sectional study, 60 healthy adults (32 women; mean age 27.4 ± 4.1 years) were classified as in a stable relationship (n = 31) or not (n = 29) after a clinical interview. Morning fasting blood was collected to quantify serum and platelet BDNF using a mature-BDNF sandwich ELISA. Data were analysed with t-tests and two-way ANOVA (group, sex), reporting effect sizes.Results: Participants in a relationship showed higher PLT-BDNF (4.36 ± 1.22 vs 2.85 ± 0.67 ng/mg; t(58) = 5.90, p < 0.001, d = 1.52) and higher serum BDNF (36.83 ± 6.95 vs 25.47 ± 5.23 ng/ml; t(58) = 7.12, p < 0.001, d = 1.84) than participants without a current stable romantic relationship. Two-way ANOVA confirmed a main effect of group for PLT-BDNF (F = 35.35, p < 0.001, η2 = 0.39) and serum BDNF (F ≈ 50, p < 0.001, η2≈0.47), while the sex and group × sex interactions were not statistically significant for both PLT-BDNF and serum BDNF.Conclusions: Our results would indicate that a stable romantic partnership is associated with higher intraplatelet and serum BDNF levels. These findings support an association between current committed romantic relationship status and peripheral BDNF measures in healthy adults.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"233-247"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond first-line antidepressants: lithium, quetiapine, or esketamine? Integrating meta-analyses and preliminary head-to-head evidence. 除了一线抗抑郁药：锂、喹硫平还是艾氯胺酮？整合元分析和初步面对面证据。

IF 3.8 4区医学

World Journal of Biological Psychiatry Pub Date : 2026-03-01 Epub Date: 2026-01-22 DOI: 10.1080/15622975.2026.2617195

David Eckert, Siegfried Kasper

{"title":"Beyond first-line antidepressants: lithium, quetiapine, or esketamine? Integrating meta-analyses and preliminary head-to-head evidence.","authors":"David Eckert, Siegfried Kasper","doi":"10.1080/15622975.2026.2617195","DOIUrl":"10.1080/15622975.2026.2617195","url":null,"abstract":"Objectives: Treatment-resistant depression (TRD) poses a major challenge in research and clinical practice. Various guidelines recommend different pharmacological approaches. While lithium and second-generation antipsychotics have traditionally been the drugs of choice in cases of medication resistance, recent years have seen increasing evidence for the efficacy of esketamine as a fast-acting agent against depression. Although there is a large body of meta-analytical evidence, direct comparisons between the agents are scarce.Methods: A systematic review of databases was conducted for randomised and naturalistic head-to-head studies comparing augmentation with lithium, quetiapine, or (es)ketamine in adults with TRD was included. Findings from relevant meta-analyses were integrated qualitatively.Results: We found four studies, comprising three trials comparing lithium and quetiapine and one comparing esketamine and quetiapine. In summary, (1) all three agents are effective, (2) there may be a descriptive superiority of esketamine over quetiapine and of quetiapine over lithium.Conclusions: The results generally argue for a re-evaluation of existing treatment algorithms in guidelines. However, since all three are fundamentally different molecules with different pharmacokinetic and pharmacodynamic properties and differ in (1) side effects and contraindications as well as (2) profile focus, embedding them in a comprehensive clinical context is important.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"200-211"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146031436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kidney function and five types of psychiatric traits/disorders: a bidirectional mendelian randomisation study. 肾功能和五种精神特征/障碍：双向孟德尔随机研究。

IF 3.8 4区医学

World Journal of Biological Psychiatry Pub Date : 2026-03-01 Epub Date: 2026-02-02 DOI: 10.1080/15622975.2026.2621062

Ying Yu, Min Wen, Yang Meng, Marady Hun, Chuzi Xie, Mingyi Zhao, Qingnan He

{"title":"Kidney function and five types of psychiatric traits/disorders: a bidirectional mendelian randomisation study.","authors":"Ying Yu, Min Wen, Yang Meng, Marady Hun, Chuzi Xie, Mingyi Zhao, Qingnan He","doi":"10.1080/15622975.2026.2621062","DOIUrl":"10.1080/15622975.2026.2621062","url":null,"abstract":"Background: Psychiatric traits/disorders and kidney dysfunction frequently co-occur, yet the causal relationships between them remain unclear.Methods: A bidirectional MR study investigated causal links between psychiatric traits/disorders and kidney function related traits/diseases. Genetic instruments came from large-scale GWAS. IVW analysis provided primary causal estimates, supplemented by sensitivity methods. We further tested whether modifiable lifestyle factors mediated these associations.Results: The effects of psychiatric traits/disorders on conventional kidney function related traits/diseases are considerably more complex, while the reverse causal effects from kidney on psychiatric traits/disorders tend to be more limited. Specifically, anxiety and MDD reduced CRE; anxiety raised uric acid; schizophrenia showed bidirectional causality with uric acid and BUN. Collectively, these disorders elevated eGFRcrea. Anxiety and neuroticism increased AKI risk, while bipolar disorder heightened CKD risk. Mediation analysis demonstrated that BMI, education, alcohol consumption and smoking serve as significant mediators in the pathways from psychiatric traits/disorders to renal function.Conclusion: Bidirectional genetic causality was observed between psychiatric traits/disorders and kidney function related traits/diseases, though causal effects from psychiatric traits/disorders on kidney impairment were more pronounced. Modifiable lifestyle factors may be potential targets for prevention and clinical intervention.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"221-232"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positive correlation between plasma and cerebrospinal fluid galectin-3 in suicide attempters. 自杀未遂者血浆和脑脊液半凝集素-3正相关

IF 3.8 4区医学

World Journal of Biological Psychiatry Pub Date : 2026-02-01 Epub Date: 2025-12-12 DOI: 10.1080/15622975.2025.2597331

Annamaria Bontidean, Daniel Lindqvist, Cécile Grudet, Lena Brundin, Tomas Deierborg, Filip Ventorp

{"title":"Positive correlation between plasma and cerebrospinal fluid galectin-3 in suicide attempters.","authors":"Annamaria Bontidean, Daniel Lindqvist, Cécile Grudet, Lena Brundin, Tomas Deierborg, Filip Ventorp","doi":"10.1080/15622975.2025.2597331","DOIUrl":"10.1080/15622975.2025.2597331","url":null,"abstract":"Objectives: Both depression and suicidal behaviour have been associated with neuroinflammation. Galectin-3 (Gal-3), a protein involved in microglial activation, has been linked to pro-inflammatory cytokines and the severity of depressive symptoms. The extent to which peripheral levels of Gal-3 reflect neuroinflammation is unknown, as is the relationship between Gal-3 and suicidality.Methods: Blood and CSF samples were collected from recent suicide attempters and healthy controls. CSF levels of cytokines interleukin (IL)-8, IL-1β, IL-6, and tumour necrosis factor-alpha (TNF-α) were available from a subset of the suicide attempters. The Montgomery-Åsberg Depression Rating Scale (MADRS) was used for the assessment of depression symptom severity.Results: We found a strong positive correlation between Gal-3 levels in plasma and CSF (r = 0.77, p < 0.001, n = 22). There were no significant differences in Gal-3 between suicide attempters and controls in plasma (n = 16 and 23, respectively) or CSF (n = 13 and 18, respectively). Among suicide attempters, we found a negative correlation between Gal-3 and IL-8 in CSF (r = -0.40, p = 0.01, n = 39). Gal-3 did not correlate significantly with any of the other cytokines.Conclusions: Peripheral Gal-3 levels seem to reflect Gal-3 in the central nervous system. Results from this small-scale study do not support the role of Gal-3 in the pathophysiology of suicidal behaviour.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"157-161"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0