World Journal of Biological Psychiatry最新文献_第2页

The cholinergic anti-inflammatory reflex as a function of depression severity in adolescent non-suicidal self-injury. 青少年非自杀性自伤中胆碱能抗炎反射与抑郁严重程度的关系。

IF 3 4区医学

World Journal of Biological Psychiatry Pub Date : 2025-06-24 DOI: 10.1080/15622975.2025.2521023

Thomas P Nguyen, Luise Baumeister-Lingens, Anna Markser, Anna-Sophia Rösch, Michael Kaess, Julian Koenig

{"title":"The cholinergic anti-inflammatory reflex as a function of depression severity in adolescent non-suicidal self-injury.","authors":"Thomas P Nguyen, Luise Baumeister-Lingens, Anna Markser, Anna-Sophia Rösch, Michael Kaess, Julian Koenig","doi":"10.1080/15622975.2025.2521023","DOIUrl":"https://doi.org/10.1080/15622975.2025.2521023","url":null,"abstract":"Objectives: Non-suicidal self-injury (NSSI) is associated with pro-inflammatory states. The cholinergic anti-inflammatory reflex is a neural pathway, modulating the body's inflammatory response. This study aimed to investigate the cholinergic anti-inflammatory reflex in adolescents with and without NSSI in a first, cross-sectional observational study.Methods: Heart rate variability (HRV; a proxy for vagus nerve activity), inflammatory markers (leukocytes, c-reactive protein (CRP), interleukin-6 (IL-6)) and several clinical measures were assessed in female adolescents with NSSI (n = 154) and healthy controls (n = 46). Statistical analyses tested for group differences and correlations between HRV, inflammatory markers and depression in patients and controls. Mediation analyses were conducted to test direct and indirect effects.Results: The NSSI group showed greater depressive symptoms and leukocyte levels, but lower HRV compared to the control group. In the full sample, depression severity was positively correlated with leukocyte and CRP levels and negatively correlated with HRV. HRV was also negatively correlated with leukocyte and CRP levels. Depression severity mediated the association between leukocytes and HRV.Conclusions: Overall, this study lends initial support that lower vagal activity is associated with increased inflammatory markers in a sample of adolescents with NSSI which suggests altered functioning of the cholinergic anti-inflammatory reflex.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"1-10"},"PeriodicalIF":3.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Escape genes from X-chromosome inactivation: new insights into candidate genes for intellectual disability in females. 逃避x染色体失活的基因：对女性智力残疾候选基因的新认识。

IF 3 4区医学

World Journal of Biological Psychiatry Pub Date : 2025-06-24 DOI: 10.1080/15622975.2025.2517040

Lizandra Abreu de Oliveira, Rafael Mina Piergiorge, Cíntia Barros Santos-Rebouças

{"title":"Escape genes from X-chromosome inactivation: new insights into candidate genes for intellectual disability in females.","authors":"Lizandra Abreu de Oliveira, Rafael Mina Piergiorge, Cíntia Barros Santos-Rebouças","doi":"10.1080/15622975.2025.2517040","DOIUrl":"https://doi.org/10.1080/15622975.2025.2517040","url":null,"abstract":"Objectives: X-chromosome inactivation (XCI) is a dosage compensation mechanism in female mammals. Given that the Xchromosome harbours numerous genes implicated in cognitive function, variants in these genes can affect neurodevelopment and contribute to Intellectual Disability (ID). While research on ID has predominantly focused on males due to their hemizygous Xchromosome state, females, though often presenting with milder symptoms, may be affected by escape genes that evade XCI and influence the phenotype. This study investigated the role of escape genes in female ID.Methods: We employed data mining to analyse X-chromosome genes based on their XCI status, followed by functional enrichment analyses. Additionally, we conducted co-expression module evaluations in the main brain regions associated with ID and a protein-protein interaction (PPI) network analysis.Results: We identified 31 significant modules linking XCI escape genes with ID-associated genes. The PPI network analysis further revealed direct interactions between the products of 25 genes and ID-related proteins. Five new candidate genes (RBMX2, PNPLA4, UBA1, RPS4X, and EIF1AX) were identified, four linked to known ID pathways.Conclusions: This study underscores the importance of escape genes in the context of female ID and paves the way for future experimental validation and molecular investigations into the functions of these genes.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"1-12"},"PeriodicalIF":3.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression profile of the ADHD risk gene ADGRL3 during human neurodevelopment and the effects of genetic variation. ADHD风险基因ADGRL3在人类神经发育过程中的表达谱及其遗传变异的影响

IF 3 4区医学

World Journal of Biological Psychiatry Pub Date : 2025-06-24 DOI: 10.1080/15622975.2025.2520518

Rhiannon Victoria McNeill, Matthias Nieberler, Zora Schickardt, Franziska Radtke, Andreas Chiocchetti, Sarah Kittel-Schneider

{"title":"Expression profile of the ADHD risk gene ADGRL3 during human neurodevelopment and the effects of genetic variation.","authors":"Rhiannon Victoria McNeill, Matthias Nieberler, Zora Schickardt, Franziska Radtke, Andreas Chiocchetti, Sarah Kittel-Schneider","doi":"10.1080/15622975.2025.2520518","DOIUrl":"https://doi.org/10.1080/15622975.2025.2520518","url":null,"abstract":"Objectives: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, with symptoms including hyperactivity, inattention and impulsivity. Moreover, ADHD persists into adulthood in ∼50% cases, significantly affecting quality of life. Currently, the complex aetiology of ADHD remains unclear. Single nucleotide polymorphisms (SNPs) in the adhesion G protein-coupled receptor isoform L3 gene (ADGRL3) have been associated with ADHD development, with the rs1397547 SNP found associated with altered ADGRL3 transcription in fibroblast cells. However, ADGRL3 function has not been investigated in human neurodevelopment.Methods: We used human induced pluripotent stem cell (hiPSC)-derived cortical neurons to characterise ADGRL3 expression during human neurogenesis and investigated the effects of the rs1397547 SNP on gene expression.Results: We found that ADGRL3 expression peaks early in neurodevelopment. ADGRL3 protein was found primarily expressed in glutamatergic neurons, and localised to growth cone-like structures, supporting a role in neurite outgrowth and glutamatergic synapse development. We found rs1397547 was associated with significantly increased ADGRL3 transcription in early neurodevelopmental stages. Moreover, single-cell RNA sequencing of maturing cortical neurons revealed a unique transcriptional profile in SNP carriers.Conclusions: Our results further implicate ADGRL3 in ADHD development and suggest that genetic variation may result in dysregulated glutamatergic neuron development.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"1-14"},"PeriodicalIF":3.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimism moderates the relationship between inflammatory polygenic risk and major depressive disorder in U.S. Military veterans. 乐观调节炎症性多基因风险与美国退伍军人重度抑郁症之间的关系。

IF 3 4区医学

World Journal of Biological Psychiatry Pub Date : 2025-06-01 Epub Date: 2025-05-09 DOI: 10.1080/15622975.2025.2498352

Ian C Fischer, Cassie Overstreet, Brenda Cabrera-Mendoza, Dan Qiu, John H Krystal, Renato Polimanti, Joel Gelernter, Robert H Pietrzak

{"title":"Optimism moderates the relationship between inflammatory polygenic risk and major depressive disorder in U.S. Military veterans.","authors":"Ian C Fischer, Cassie Overstreet, Brenda Cabrera-Mendoza, Dan Qiu, John H Krystal, Renato Polimanti, Joel Gelernter, Robert H Pietrzak","doi":"10.1080/15622975.2025.2498352","DOIUrl":"10.1080/15622975.2025.2498352","url":null,"abstract":"Objectives: Major depressive disorder (MDD) is a leading cause of disability, and chronic inflammation is a contributing factor to its onset and progression. This study examined the relationship between genetic predisposition to inflammation and MDD risk in a nationally representative sample of U.S. military veterans, as well as psychosocial moderators of this association.Methods: A composite polygenic risk score (PRS) for inflammatory biomarkers was derived from the UK Biobank and examined in relation to a positive MDD screen in 1,660 European-American veterans. The analysis adjusted for known correlates of inflammation and MDD, including medical conditions and cumulative trauma burden.Results: Each standard deviation increase in the inflammatory PRS was associated with more than two-fold increased odds of screening positive for MDD (OR = 2.51, 95% CI = 1.39-4.54). Interaction analyses revealed that optimism moderated this association; among those in the highest PRS tertile, individuals with high optimism were more than 30 times less likely to screen positive for MDD compared to those with low optimism (0.7% vs. 22.6%). Pathway-based analyses identified enrichment of immune- and brain-related gene sets, highlighting potential biological mechanisms linking inflammation and MDD.Conclusions: Findings suggest genetic risk for inflammation contributes to MDD vulnerability and that optimism may buffer this risk.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"189-198"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered cerebral functional activity and its associated genetic profiles underlying chronic insomnia disorder before and after treatment. 治疗前后慢性失眠症的脑功能活动改变及其相关基因谱

IF 3 4区医学

World Journal of Biological Psychiatry Pub Date : 2025-06-01 Epub Date: 2025-05-18 DOI: 10.1080/15622975.2025.2503938

Leyi Zhang, Zhiguo Guo, Yiding Han, Haohao Yan, Dongsheng Lv, Ping Yao, Jingping Zhao, Lixia Chen, Wenbin Guo

{"title":"Altered cerebral functional activity and its associated genetic profiles underlying chronic insomnia disorder before and after treatment.","authors":"Leyi Zhang, Zhiguo Guo, Yiding Han, Haohao Yan, Dongsheng Lv, Ping Yao, Jingping Zhao, Lixia Chen, Wenbin Guo","doi":"10.1080/15622975.2025.2503938","DOIUrl":"10.1080/15622975.2025.2503938","url":null,"abstract":"Objectives: The resting-state cerebral functional activity underlying chronic insomnia disorder (CID) remains inconsistent, and the effects of pharmacotherapy on such activity are unclear.Methods: Imaging data and clinical variables were acquired from 82 patients with CID and 54 healthy controls (HCs). Patients were assigned to receive either modified Suanzaoren decoction (MSZRD) or estazolam treatment for six weeks. Spontaneous brain activity was evaluated by amplitude of low-frequency fluctuations (ALFF), Wavelet-ALFF, and fractional ALFF (fALFF). Machine-learning and cross-sample transcriptomic analysis were performed.Results: Compared to HCs, patients with CID exhibited increased functional activity in the left precuneus/posterior cingulate cortex, left superior parietal gyrus, and bilateral angular gyrus; they also presented decreased activity in the right inferior parietal gyrus and bilateral middle frontal gyrus. After pharmacotherapy, patients in the MSZRD group showed increased activity in the left middle occipital gyrus compared to baseline. Receiver operating characteristic (ROC) curves based on these metrics were 0.98, 088, and 0.98; correlation coefficients between predicted and actual treatment responses ranged from 0.806 to 0.965.Conclusion: Altered neural activity in regions of the default mode network, frontoparietal network and visual network might contribute to the neuropathological and therapeutic mechanisms of CID. (Clinical trial registration number: NCT06452953).","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"211-223"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular immune phenotype of major depressive disorder - findings from the EMBARC study. 重度抑郁症的细胞免疫表型——来自EMBARC研究的发现。

IF 3 4区医学

World Journal of Biological Psychiatry Pub Date : 2025-06-01 Epub Date: 2025-05-03 DOI: 10.1080/15622975.2025.2486137

Cherise R Chin Fatt, Srividya Vasu, Nabila Haque, Emine Rabia Ayvaci, Manish K Jha, Jane A Foster, Madhukar H Trivedi

{"title":"Cellular immune phenotype of major depressive disorder - findings from the EMBARC study.","authors":"Cherise R Chin Fatt, Srividya Vasu, Nabila Haque, Emine Rabia Ayvaci, Manish K Jha, Jane A Foster, Madhukar H Trivedi","doi":"10.1080/15622975.2025.2486137","DOIUrl":"10.1080/15622975.2025.2486137","url":null,"abstract":"Objectives: Major depressive disorder (MDD) is associated with immune dysfunction. This study aimed to characterize the cellular immunophenotypes that may underpin immune dysregulation in MDD.Methods: Peripheral blood mononuclear cell (PBMC) samples at baseline from participants with MDD from the Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) study were included. A panel of 33 antibodies was analyzed using mass cytometry to compare the immune cell abundance and marker expression profiles between participants with mild and moderate/severe depression. Mass cytometry data were investigated using (1) Uniform Manifold Approximation and Projection for Dimension Reduction (UMAP), (2) FlowSOM (self-organizing maps) for clustering, and (3) Significance Analysis of Microarrays (SAM) for statistical analyzes.Results: FlowSOM identified 8 clusters of distinct cell types. The abundance of cytotoxic T, NK, NK T, and Naïve B cells was significantly lower in participants with moderate/severe depression compared to mild depression. NKT cells had significantly lower CD56 and CD16 expression in patients with moderate/severe depression compared to patients with mild depression.Conclusion: Our observations provide evidence for alterations in B, NKT, and NK cell abundance and their cell surface markers in moderate/severe depression. Further investigations into immune cell dysfunction in moderate/severe depression are necessary.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"179-188"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do serum endocannabinoid and N-acylethanolamine concentrations reflect their brain levels in two different rat stress models? 在两种不同的大鼠应激模型中，血清内源性大麻素和n -酰基乙醇胺浓度是否反映了它们的大脑水平？

IF 3 4区医学

World Journal of Biological Psychiatry Pub Date : 2025-06-01 Epub Date: 2025-05-14 DOI: 10.1080/15622975.2025.2502394

Ruhan Deniz Topuz, Buse Cevık, Kursat Guler, Ozgur Gunduz, Cetin Hakan Karadag, Ahmet Ulugol

{"title":"Do serum endocannabinoid and N-acylethanolamine concentrations reflect their brain levels in two different rat stress models?","authors":"Ruhan Deniz Topuz, Buse Cevık, Kursat Guler, Ozgur Gunduz, Cetin Hakan Karadag, Ahmet Ulugol","doi":"10.1080/15622975.2025.2502394","DOIUrl":"10.1080/15622975.2025.2502394","url":null,"abstract":"Background: Although the brain is not the only source of circulating endocannabinoids and their levels can be affected by many factors, it is underlined that serum endocannabinoid levels can be used as a biomarker in psychiatric disorders. In this study, we aimed to examine whether serum endocannabinoid and N-acylethanolamine concentrations reflect their brain levels.Methods: In the present study acute immobilisation (AIS) and post-traumatic stress (PTSD) models were applied to Wistar albino male rats. Rota rod performance, forced swim, open field and elevated plus maze tests were performed. Endocannabinoid and N-acylethanolamine levels in serum and hippocampus, amygdala and cortex were assessed using LC-MS/MS.Results: We observed significant increases in anandamide (AEA), palmitoylethanolamide (PEA) and oleoethylethanolamide (OEA) levels in the amygdala and hippocampus in both models except PEA in amygdala in the AIS group, while 2-AG levels decreased. There was no change in serum AEA and 2-AG levels in all groups; in the PTSD group serum PEA levels were higher whereas OEA levels were lower in both the AIS and the PTSD groups.Conclusion: Our results show that there is no correlation in endocannabinoid and N-acylethanolamine levels between serum and specific brain regions in two stress models of rat.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"199-210"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypothermia and fluctuations in body temperature should be considered for the positive diagnosis of Neuroleptic Malignant Syndrome. 低体温和体温波动应视为神经性恶性综合征的阳性诊断。

IF 3 4区医学

World Journal of Biological Psychiatry Pub Date : 2025-04-01 Epub Date: 2025-04-04 DOI: 10.1080/15622975.2025.2481621

Antoine Wicker, Hugo Bottemanne, Walid Choucha, Romain Colle, Emmanuelle Corruble

引用次数: 0

No sex difference in the antidepressive effect of transcranial magnetic stimulation (TMS): results from a retrospective analysis of a large real-world sample. 经颅磁刺激（TMS）的抗抑郁效果无性别差异：来自大量真实世界样本的回顾性分析结果。

IF 3 4区医学

World Journal of Biological Psychiatry Pub Date : 2025-04-01 Epub Date: 2025-04-24 DOI: 10.1080/15622975.2025.2488357

Antonia Feyrer, Katharina Kerkel, Eva Mlcochova, Berthold Langguth, Martin Schecklmann

{"title":"No sex difference in the antidepressive effect of transcranial magnetic stimulation (TMS): results from a retrospective analysis of a large real-world sample.","authors":"Antonia Feyrer, Katharina Kerkel, Eva Mlcochova, Berthold Langguth, Martin Schecklmann","doi":"10.1080/15622975.2025.2488357","DOIUrl":"10.1080/15622975.2025.2488357","url":null,"abstract":"Objectives: There is only limited knowledge about the impact of sex on the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in depressive disorders. Here, we analysed a large real-world sample of depressive patients with respect to potential sex-specific effects of rTMS treatment.Methods: Data of 984 patients (539 females/445 males) were analysed. Patients received various antidepressant TMS protocols, most of them 10Hz, 20 Hz, Theta burst or accelerated protocols over the left dorsolateral prefrontal cortex. Changes in Hamilton Depression Scale (HAMD) and Major Depression Inventory (MDI) scores as well as response and remission rates were compared between female and male patients.Results: There were no significant differences in any outcome between female and male patients. Response rates according to the HAMD-21 scores were 34.3% for females and 30.1% for males, according to the MDI 33.1% and 33.5% respectively. In an additional explorative analysis there was a tendency towards better outcome for females for the 20 Hz protocol.Conclusions: The antidepressive effectiveness of rTMS does not differ between men and women.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"26 4","pages":"170-178"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Summer and SERT: Effect of daily sunshine hours on SLC6A4 promoter methylation in seasonal affective disorder. 夏季和SERT：日照时数对季节性情感障碍SLC6A4启动子甲基化的影响

IF 3 4区医学

World Journal of Biological Psychiatry Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.1080/15622975.2025.2477463

Patricia A Handschuh, Matej Murgaš, Dietmar Winkler, Edda Winkler-Pjrek, Annette M Hartmann, Katharina Domschke, Pia Baldinger-Melich, Dan Rujescu, Rupert Lanzenberger, Marie Spies

{"title":"Summer and SERT: Effect of daily sunshine hours on SLC6A4 promoter methylation in seasonal affective disorder.","authors":"Patricia A Handschuh, Matej Murgaš, Dietmar Winkler, Edda Winkler-Pjrek, Annette M Hartmann, Katharina Domschke, Pia Baldinger-Melich, Dan Rujescu, Rupert Lanzenberger, Marie Spies","doi":"10.1080/15622975.2025.2477463","DOIUrl":"10.1080/15622975.2025.2477463","url":null,"abstract":"Objectives: Knowledge on how sunlight impacts SERT activity via SLC6A4 promoter methylation in Seasonal Affective Disorder (SAD) remains limited. This study aimed to investigate the effect of daily sunshine duration on SLC6A4 promoter methylation in 28 patients with SAD and 40 healthy controls (HC).Methods: Daily sunlight data for Vienna, Austria (mean of 28 days before blood sampling), were obtained from ©GeoSphere Austria. A general linear model analysed SLC6A4 promoter methylation as the dependent variable, with sunlight hours as the independent variable, and group (SAD, HC), age, sex, and 5-HTTLPR/rs25531 as covariates. Exploratory analyses examined the effects of sunlight hours and methylation on Beck Depression Inventory (BDI) scores.Results: Sunlight had a significant effect on SLC6A4 promoter methylation (p = 0.03), with more sunlight hours resulting in lower methylation (r = -0.25). However, the interaction between sunlight and group was non-significant, suggesting a rather general effect across both groups. Sunlight also influenced BDI scores (p < 0.01), with fewer sunlight hours leading to higher scores (r = -0.25), which aligns with previous research. SLC6A4 promoter methylation had no significant effect on BDI scores.Conclusions: Our findings suggest that sunlight influences SLC6A4 methylation without SAD specificity.","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"159-169"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0