经颅磁刺激（TMS）的抗抑郁效果无性别差异：来自大量真实世界样本的回顾性分析结果。

IF 3 4区医学 Q2 PSYCHIATRY

World Journal of Biological Psychiatry Pub Date : 2025-04-01 Epub Date: 2025-04-24 DOI:10.1080/15622975.2025.2488357

Antonia Feyrer, Katharina Kerkel, Eva Mlcochova, Berthold Langguth, Martin Schecklmann

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引用次数: 0

摘要

目的：关于性别对重复经颅磁刺激（rTMS）治疗抑郁症有效性的影响，目前所知有限。在这里，我们分析了大量真实世界的抑郁症患者样本，关于rTMS治疗的潜在性别特异性效应。方法：对984例患者资料进行分析，其中女性539例，男性445例。患者接受了各种抗抑郁的经颅磁刺激方案，大多数是10Hz， 20hz， Theta爆发或加速方案在左背外侧前额皮质。比较男女患者汉密尔顿抑郁量表（HAMD）和重度抑郁量表（MDI）评分的变化以及缓解率和缓解率。结果：女性和男性患者的预后无显著差异。根据HAMD-21评分，女性的应答率为34.3%，男性为30.1%，MDI的应答率分别为33.1%和33.5%。在另一项探索性分析中，20赫兹方案对女性有更好的结果趋势。结论：rTMS的抗抑郁效果在男性和女性之间没有差异。

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No sex difference in the antidepressive effect of transcranial magnetic stimulation (TMS): results from a retrospective analysis of a large real-world sample.

Objectives: There is only limited knowledge about the impact of sex on the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in depressive disorders. Here, we analysed a large real-world sample of depressive patients with respect to potential sex-specific effects of rTMS treatment.

Methods: Data of 984 patients (539 females/445 males) were analysed. Patients received various antidepressant TMS protocols, most of them 10Hz, 20 Hz, Theta burst or accelerated protocols over the left dorsolateral prefrontal cortex. Changes in Hamilton Depression Scale (HAMD) and Major Depression Inventory (MDI) scores as well as response and remission rates were compared between female and male patients.

Results: There were no significant differences in any outcome between female and male patients. Response rates according to the HAMD-21 scores were 34.3% for females and 30.1% for males, according to the MDI 33.1% and 33.5% respectively. In an additional explorative analysis there was a tendency towards better outcome for females for the 20 Hz protocol.

Conclusions: The antidepressive effectiveness of rTMS does not differ between men and women.

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来源期刊

World Journal of Biological Psychiatry 医学-精神病学

CiteScore

7.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of The World Journal of Biological Psychiatry is to increase the worldwide communication of knowledge in clinical and basic research on biological psychiatry. Its target audience is thus clinical psychiatrists, educators, scientists and students interested in biological psychiatry. The composition of The World Journal of Biological Psychiatry , with its diverse categories that allow communication of a great variety of information, ensures that it is of interest to a wide range of readers. The World Journal of Biological Psychiatry is a major clinically oriented journal on biological psychiatry. The opportunity to educate (through critical review papers, treatment guidelines and consensus reports), publish original work and observations (original papers and brief reports) and to express personal opinions (Letters to the Editor) makes The World Journal of Biological Psychiatry an extremely important medium in the field of biological psychiatry all over the world.