World Journal of Biological Psychiatry最新文献

{"title":"The relationship between cortisol awakening response and trait resilience in two patient cohorts and one population-based cohort.","authors":"Patrick Linnemann,&nbsp;Nele Friedrich,&nbsp;Matthias Nauck,&nbsp;Henning Teismann,&nbsp;Klaus Berger","doi":"10.1080/15622975.2022.2129445","DOIUrl":"https://doi.org/10.1080/15622975.2022.2129445","url":null,"abstract":"<p><strong>Objectives: </strong>We examined (1) the proportion of cortisol awakening non-responders, (2) the association between cortisol awakening response (CAR) and trait resilience, and (3) the association between CAR increase and trait resilience in two patient cohorts (depression and myocardial infarction [CVD]) and one population-based cohort.</p><p><strong>Methods: </strong>Eight hundred and eighty study participants delivered CAR scores (response and increase) based on three self-collected saliva samples and a trait resilience score. Descriptive data of CAR non-responders were reported and calculated. Associations between CAR response/increase and trait resilience, sociodemographic and compliance variables were evaluated using multiple logistic and multiple linear regression analyses stratified by cohort.</p><p><strong>Results: </strong>The proportion of CAR non-responders was high in all cohorts (57% depression cohort, 53.4% CVD cohort, 51.6% control cohort). In the depression cohort age was associated with CAR response and increase. In the CVD cohort salivary collection on a weekday was associated with CAR response and awakening time with CAR increase. In the control cohort age was associated with CAR response and sex with CAR increase.</p><p><strong>Conclusions: </strong>We observed many CAR non-responders and significant associations between CAR response and CAR increase with single sociodemographic and compliance variables. We did not find significant relationships between CAR response or increase and trait resilience.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 5","pages":"429-438"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9682943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of medication side effects in patients with mostly resistant depression in a real-world setting.","authors":"Fabio Panariello,&nbsp;Siegfried Kasper,&nbsp;Joseph Zohar,&nbsp;Daniel Souery,&nbsp;Stuart Montgomery,&nbsp;Panagiotis Ferentinos,&nbsp;Dan Rujescu,&nbsp;Julien Mendlewicz,&nbsp;Diana De Ronchi,&nbsp;Alessandro Serretti,&nbsp;Chiara Fabbri","doi":"10.1080/15622975.2022.2134588","DOIUrl":"https://doi.org/10.1080/15622975.2022.2134588","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to identify factors associated with side effects of psychotropic drugs in a real-world setting enriched with treatment-resistant depression (TRD) patients.</p><p><strong>Methods: </strong>A total of 1410 depressed patients were treated in a naturalistic setting. Side effects were measured with the Udvalg for Kliniske Undersogelser Side Effect Rating Scale (UKU); the total score and UKU subscales were considered. Clinical-demographic variables were tested for association with side effects in univariate and then multivariate analyses.</p><p><strong>Results: </strong>Total, psychic and neurological side effects were associated with depressive symptom severity, while autonomic side effects were higher in those with somatic comorbidities and other side effects were lower in patients receiving trazodone. In multivariate analyses, depressive symptom severity was associated with psychic and total side effects, while generalised anxiety disorder (GAD) with neurological side effects and somatic comorbidities remained associated with autonomic side effects. Trazodone was associated with lower side effects and with augmentation treatments. Augmentation therapies showed opposite effects depending on response status, i.e. increased or decreased the risk of side effects in responders and non-responders/resistant patients, respectively.</p><p><strong>Conclusions: </strong>Psychic side effects may be difficult to distinguish from depressive symptoms and factors associated with different types of side effects are heterogeneous and likely interacting.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 5","pages":"439-448"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9682940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decline of stress resilience in aging rats: Focus on choroid plexus-cerebrospinal fluid-hippocampus.","authors":"Kaige Liu,&nbsp;Huizhen Li,&nbsp;Ningxi Zeng,&nbsp;Wenjun Lu,&nbsp;Xiaofeng Wu,&nbsp;Hanfang Xu,&nbsp;Can Yan,&nbsp;Lili Wu","doi":"10.1080/15622975.2022.2151044","DOIUrl":"https://doi.org/10.1080/15622975.2022.2151044","url":null,"abstract":"<p><strong>Objectives: </strong>This study was designed to examine the mechanisms underlying decline of stress resilience in aged rats from the perspective of CP-CSF-hippocampus.</p><p><strong>Methods: </strong>Male Wistar rats (7-8 weeks old or 20 months old) were subjected to chronic unpredictable mild stress (CUMS) for 6 weeks. The behavioral tests were conducted to assess anxiety, depression and cognitive function. Hippocampal neurogenesis, apoptosis and synaptic plasticity were detected by western blot (WB) and/or immunofluorescence (IF) assay. Differential expression of growth factors (GFs) and axon guidance proteins (AGPs) in CSF was analyzed using the quantitative proteomics approach. IF and WB were performed to detect expression of occludin-1, Ki-67/Transthyretin, and folate transporters in choroid plexus (CP).</p><p><strong>Results: </strong>Decreased proliferation, impaired structure and transport function of CP were correlated with CSF composition alterations in stressed aging rats, including reduced 5-Methyltetrahydrofolate, growth factors and axon growth factors. Nutritional support of CSF upon hippocampus was attenuated, therefore affecting hippocampal plasticity. It has led to depression-like behaviors and cognitive deficits in stressful aged rats.</p><p><strong>Conclusions: </strong>Keeping normal structure and function of CP-CSF system may be a practical strategy for neuropsychological disorders in the elderly. This work provides evidential basis for CP transplant and CSF replacement therapy in future studies.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 6","pages":"508-522"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9748296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The decoupling of structural and functional connectivity of auditory networks in individuals at clinical high-risk for psychosis.","authors":"Mina Langhein, Amanda E Lyall, Saskia Steinmann, Johanna Seitz-Holland, Felix L Nägele, Suheyla Cetin-Karayumak, Fan Zhang, Jonas Rauh, Marius Mußmann, Tashrif Billah, Nikos Makris, Ofer Pasternak, Lauren J O'Donnell, Yogesh Rathi, Gregor Leicht, Marek Kubicki, Martha E Shenton, Christoph Mulert","doi":"10.1080/15622975.2022.2112974","DOIUrl":"10.1080/15622975.2022.2112974","url":null,"abstract":"<p><strong>Objectives: </strong>Disrupted auditory networks play an important role in the pathophysiology of psychosis, with abnormalities already observed in individuals at clinical high-risk for psychosis (CHR). Here, we examine structural and functional connectivity of an auditory network in CHR utilising state-of-the-art electroencephalography and diffusion imaging techniques.</p><p><strong>Methods: </strong>Twenty-six CHR subjects and 13 healthy controls (HC) underwent diffusion MRI and electroencephalography while performing an auditory task. We investigated structural connectivity, measured as fractional anisotropy in the Arcuate Fasciculus (AF), Cingulum Bundle, and Superior Longitudinal Fasciculus-II. Gamma-band lagged-phase synchronisation, a functional connectivity measure, was calculated between cortical regions connected by these tracts.</p><p><strong>Results: </strong>CHR subjects showed significantly higher structural connectivity in the right AF than HC (<i>p</i> < .001). Although non-significant, functional connectivity between cortical areas connected by the AF was lower in CHR than HC (<i>p</i> = .078). Structural and functional connectivity were correlated in HC (<i>p</i> = .056) but not in CHR (<i>p</i> = .29).</p><p><strong>Conclusions: </strong>We observe significant differences in structural connectivity of the AF, without a concomitant significant change in functional connectivity in CHR subjects. This may suggest that the CHR state is characterised by a decoupling of structural and functional connectivity, possibly due to abnormal white matter maturation.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 5","pages":"387-399"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9929093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telomere length and mitochondrial DNA copy number in bipolar disorder: A sibling study.","authors":"Luana Spano,&nbsp;Bruno Etain,&nbsp;Jean-Louis Laplanche,&nbsp;Marion Leboyer,&nbsp;Sébastien Gard,&nbsp;Frank Bellivier,&nbsp;Cynthia Marie-Claire","doi":"10.1080/15622975.2022.2131907","DOIUrl":"https://doi.org/10.1080/15622975.2022.2131907","url":null,"abstract":"<p><strong>Objectives: </strong>An accelerated cellular ageing has been observed in bipolar disorder (BD) using biomarkers such as telomere length (TL) and mitochondrial DNA copy number (mtDNAcn). Several risk factors might drive premature ageing in individuals with BD, including a familial predisposition. This study compared TL and mtDNAcn between individuals with BD and their (un)-affected siblings, and explored factors that may explain proband-sibling differences.</p><p><strong>Methods: </strong>Sixty individuals with BD and seventy-four siblings (34 affected with BD or mood disorders and 40 unaffected) were included. Quantitative polymerase chain reaction (qPCR) was used to measure TL and mtDNAcn from peripheral blood genomic DNA.</p><p><strong>Results: </strong>TL and mtDNAcn did not significantly differ between probands and their siblings, whatever these latter were affected or not with mood disorders. However, the correlation plots of TL or mtDNAcn in proband-sibling pairs suggested that some pairs were discordant. The within proband-sibling pairs differences for TL and mtDNAcn were not explained by differences in all tested factors.</p><p><strong>Conclusions: </strong>This study shows that probands with BD and their siblings are concordant for TL and mtDNAcn suggesting that they may share some environmental or genetic determinants of these two biomarkers of cellular ageing.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 5","pages":"449-456"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9679882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of neurofeedback for alcohol use disorders - a systematic review.","authors":"Forum Dave,&nbsp;Ravikesh Tripathi","doi":"10.1080/15622975.2022.2151043","DOIUrl":"https://doi.org/10.1080/15622975.2022.2151043","url":null,"abstract":"<p><strong>Background: </strong>Alcoholism is a serious social, economic and public health problem. Alcoholism can affect the gastrointestinal, neurological, cardiovascular and respiratory systems, and it can be fatal, costing the healthcare system huge amounts of money. Despite the availability of cognitive-behavioural and psychosocial therapies, alcoholism has a high recurrence rate and a dismal prognosis, with a wide inter-individual variation. As a result, better or adjuvant therapies that improve or facilitate alcoholism therapy are required. We conducted a systematic review to look into the published studies that reported the effectiveness of non-pharmacological neurofeedback (NF) interventions in patients with alcohol use disorders (AUDs).</p><p><strong>Methods: </strong>PubMed, Google Scholar, The Cochrane Library, Science Direct and Clinicaltrial.gov were searched until 4 April 2022. Original articles of any design reporting on the use of NF approaches in the treatment of AUDs were included. Information related to study design, participants, control group, neuromodulation therapy, number of sessions and key findings of the study were extracted. The Joanna Briggs Institute's (JBI) Critical Appraisal Checklist for Studies was used to assess the quality of studies.</p><p><strong>Results: </strong>A total of 20 research articles (including 618 participants) were retrieved and included for qualitative analysis. The sample size ranged from 1 (case report) to 80, with years of publication ranging from 1977 to 2022. Nine of the 20 articles included in the study were conducted in the United States, followed by Germany, the United Kingdom, India, the Netherlands and South Korea. Out of the 20 studies included, 8 (40%) had a moderate risk of bias, while the other, i.e. 60% had a low risk of bias. The effectiveness of various neurological treatments in the treatment of AUDs was established in these 20 studies. There have been 11 studies on EEG NF training, three studies on real-time FMRI NF, two studies each on transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS), and one study each on deep brain stimulation (DBS) and theta burst stimulation (TBS). These alternative neurological therapies have been demonstrated to lower alcohol cravings and consumption temporarily, reduce anxiety and depression scores, reduce relapse rates and increase control of brain activity.</p><p><strong>Conclusions: </strong>The use of various neuromodulation approaches to the treatment of AUD shows promise. However, more research with larger sample size is required.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 6","pages":"496-507"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9748297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential association between psychiatric symptoms and the use of levonorgestrel intrauterine devices (LNG-IUDs): A systematic review.","authors":"Mohamed Elsayed,&nbsp;Khaled T Dardeer,&nbsp;Nimrat Khehra,&nbsp;Inderbir Padda,&nbsp;Heiko Graf,&nbsp;Amr Soliman,&nbsp;Abdelrahman M Makram,&nbsp;René Zeiss,&nbsp;Carlos Schönfeldt-Lecuona","doi":"10.1080/15622975.2022.2145354","DOIUrl":"https://doi.org/10.1080/15622975.2022.2145354","url":null,"abstract":"<p><strong>Background: </strong>Levonorgestrel (LNG)-intrauterine devices (IUDs) are an effective method of contraception; however, there is growing evidence regarding potential psychiatric side effects such as depressive symptoms, anxiety, and suicidal thoughts. Therefore, we conducted this systematic review to summarise the psychiatric effects of using LNG-IUDs.</p><p><strong>Methods: </strong>We searched six databases (MEDLINE, Web of Science, Scopus, Science Direct, Cochrane Library, and PsycInfo), and we included all study designs. The included studies were extracted, quality assessed, and qualitatively summarised.</p><p><strong>Results: </strong>Out of the screened studies, only 22 were finally included. While ten studies showed increased depressive symptoms, two studies showed reduced symptoms. Moreover, one study showed increased anxiety, another one reported an increased risk of suicide, four studies concluded no association with depressive symptoms, and four other studies showed uncertainty about a potential association but mentioned other psychiatric symptoms.</p><p><strong>Conclusion: </strong>Despite unreliable data, many studies report psychiatric symptoms associated with LNG-IUDs, predominantly depression. Gynaecologists, general practitioners, and psychiatrists should therefore be aware of these potential risks, especially depressive symptoms and suicidality. Counselling patients about these risks should be mandatory. Further studies should investigate the absolute risk of mental disorders associated with LNG-IUDs and other hormonal contraceptives.KEY MESSAGESMany researchers are reporting adverse psychiatric events associated with levonorgestrel intrauterine devices (LNG-IUDs).Despite their effectiveness, a proper psychiatric assessment should be done before inserting LNG-IUDs.Proper counselling regarding the depressive symptoms and suicidality should be done by the treating obstetrician.Further studies should investigate the absolute risk of mental disorders associated with LNG-IUDs and other hormonal contraceptives.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 6","pages":"457-475"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10075739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obsessive-compulsive symptoms in two patients with chromosomal disorders involving the X chromosome.","authors":"Isabelle Matteit,&nbsp;Andrea Schlump,&nbsp;Marco Reisert,&nbsp;Katharina von Zedtwitz,&nbsp;Kimon Runge,&nbsp;Kathrin Nickel,&nbsp;Miriam A Schiele,&nbsp;Volker A Coenen,&nbsp;Katharina Domschke,&nbsp;Andreas Tzschach,&nbsp;Dominique Endres","doi":"10.1080/15622975.2022.2147997","DOIUrl":"https://doi.org/10.1080/15622975.2022.2147997","url":null,"abstract":"<p><strong>Introduction: </strong>The etio-pathophysiology of obsessive-compulsive disorder (OCD) can be explained using a biopsychosocial model. Little is known about obsessive-compulsive symptoms (OCS) in the context of chromosomal disorders involving the X chromosome.</p><p><strong>Methods: </strong>Case studies of two patients with chromosomal disorders involving the X chromosome (Patient 1 with a variant of Turner syndrome and Patient 2 with triple X syndrome).</p><p><strong>Results: </strong>Both patients were treated due to severe OCS. In the research MRI analysis, the most pronounced MRI change in both patients was a gray matter volume loss in the orbitofrontal cortex. Patient 1 additionally showed left mesiotemporal changes. Patient 2 presented with global gray matter volume reduction, slowing in EEG, and a reduced intelligence quotient.</p><p><strong>Discussion: </strong>OCS could occur in the context of Turner syndrome or triple X syndrome. The detected MRI changes would be compatible with dysfunction of the cortico-striato-thalamo-cortical loops involved in OCD pathophysiology. Further studies with larger patient groups should investigate whether this association can be validated.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 6","pages":"539-544"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9749166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term treatment of adult ADHD in a naturalistic setting: Clinical predictors of attrition, medication choice, improvement, and response.","authors":"Giulio Emilio Brancati,&nbsp;Francesco De Dominicis,&nbsp;Alessandra Petrucci,&nbsp;Alessandro Pallucchini,&nbsp;Marco Carli,&nbsp;Pierpaolo Medda,&nbsp;Elisa Schiavi,&nbsp;Pietro De Rossi,&nbsp;Stefano Vicari,&nbsp;Giulio Perugi","doi":"10.1080/15622975.2023.2168750","DOIUrl":"https://doi.org/10.1080/15622975.2023.2168750","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to identify clinical predictors of treatment attrition, medication choice, improvement and response to pharmacotherapy in adult attention-deficit/hyperactivity disorder (ADHD).</p><p><strong>Methods: </strong>150 ADHD patients were enrolled and naturalistically followed-up for at least 4 months. Conners' Adult ADHD Rating Scales-Observer: Screening Version (CAARS-O:SV) were used to measure ADHD severity.</p><p><strong>Results: </strong>58 subjects (38.7%) were lost at follow-up, while 75 (50%) completed follow-up assessment, on average after 26.05 ± 11.99 weeks; 35 were treated with atomoxetine (ATX) and 40 with methylphenidate (MPH). Treatments were moderately effective (<i>d</i> = 0.72) and 37 patients (49.3%) were responders (≥30% CAARS-O:SV decrease). Patients lost at follow-up had lower inattentive symptoms, less generalised anxiety and family history of bipolar disorder, more amphetamine use disorder than follow-up completers. Compared to ATX-treated subjects, MPH-treated patients had greater severity of hyperactivity/impulsivity and were more frequently diagnosed with alcohol use disorder. While MPH and ATX showed similar efficacy, more pronounced improvements were observed in patients with combined ADHD, anxiety and substance use disorders. ADHD severity and comorbid substance use positively predicted response.</p><p><strong>Conclusions: </strong>Consensus-based hierarchical treatment of ADHD comorbidity is not consistently supported. Comorbid anxiety, mood and substance use disorders should not discourage the treatment of adult ADHD.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 6","pages":"523-538"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9749180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of machine learning to diagnose somatic symptom disorder: Are the biomarkers beneficial for the diagnosis?","authors":"Chi-Shin Wu,&nbsp;Shih-Cheng Liao,&nbsp;Wei-Lieh Huang","doi":"10.1080/15622975.2022.2149853","DOIUrl":"https://doi.org/10.1080/15622975.2022.2149853","url":null,"abstract":"<p><strong>Objectives: </strong>We used machine learning to incorporate three types of biomarkers (respiratory sinus arrhythmia, RSA; skin conductance, SC; finger temperature, FT) for examining the performance of diagnosing somatic symptom disorder (SSD).</p><p><strong>Methods: </strong>We recruited 97 SSD subjects and 96 controls without psychiatric history or somatic distress. The values of RSA, SC and FT were recorded in three situations (resting state, under a cognitive task and under paced breathing) and compared for the two populations. We used machine learning to combine the biological signals and then applied receiver operating characteristic curve analysis to examine the performance of diagnosing SSD regarding the distinct indicators and situations. Subgroup analysis for subjects without depression/anxiety was also conducted.</p><p><strong>Results: </strong>FT was significantly different between SSD patients and controls, especially in the resting state and under paced breathing. However, the biomarkers (0.75-0.76) did not reveal an area under the curve (AUC) comparable with the psychological questionnaires (0.86). Combining the biological and psychological indicators gave a high AUC (0.86-0.92). When excluding individuals with depression/anxiety, combining three biomarkers (0.79-0.83) and adopting psychological questionnaires (0.78) revealed a similar AUC.</p><p><strong>Conclusions: </strong>The performance of RSA/SC/FT was unsatisfactory for diagnosing SSD but became comparable when excluding comorbid depression/anxiety.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 6","pages":"485-495"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9748293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}