World Journal of Biological Psychiatry最新文献

{"title":"Psychiatric onset of prodromal dementia with Lewy bodies: Current insights into neuroimaging tools.","authors":"Niels Hansen,&nbsp;Sebastian Johannes Müller,&nbsp;Eya Khadhraoui,&nbsp;Marielle Ernst,&nbsp;Christian Heiner Riedel,&nbsp;Jens Wiltfang,&nbsp;Claudia Lange,&nbsp;Carolin Bouter","doi":"10.1080/15622975.2023.2191008","DOIUrl":"10.1080/15622975.2023.2191008","url":null,"abstract":"<p><strong>Purpose: </strong>Our article is dedicated to describing the state-of-the-art in imaging techniques for assessing prodromal dementia with Lewy bodies (pro-DLB) with a psychiatric-onset.</p><p><strong>Materials and methods: </strong>Imaging biomarker techniques are discussed.</p><p><strong>Results: </strong>(123)-I-2-ß-carbomethoxy-3ß-(4-iodophenyl)-<i>N</i>-(3-fluoropropyl) nortropane single photon emission computed tomography (123I-FP-CIT SPECT) seems to be a promising method as it reveals abnormalities in pro-DLB with a psychiatric-onset. New potential biomarkers can be revealed <i>via</i> novel techniques, such as manual segmentation in magnetic resonance imaging (MRI), which helps detect atrophy of the substantia innominata in pro-DLB with a psychiatric-onset as opposed to an onset with mild cognitive impairment (MCI). FDG-PET can also help us distinguish patients with mixed pro-DLB from those pro-DLB patients with a psychiatric-onset or MCI-onset. Changes in large-scale networks in the posterior standard mode and in attentional networks could be early signs in resting-state functional MRI to characterise pro-DLB.</p><p><strong>Conclusions: </strong>In conclusion, there is a wide range of techniques that need to be explored in large-scale studies and are of promising value in understanding pro-DLB with a psychiatric-onset.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 7","pages":"558-563"},"PeriodicalIF":3.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9880403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral ketamine for depression: An updated systematic review.","authors":"Shakila Meshkat,&nbsp;Sipan Haikazian,&nbsp;Joshua D Di Vincenzo,&nbsp;Farhan Fancy,&nbsp;Danica Johnson,&nbsp;David Chen-Li,&nbsp;Roger S McIntyre,&nbsp;Rodrigo Mansur,&nbsp;Joshua D Rosenblat","doi":"10.1080/15622975.2023.2169349","DOIUrl":"10.1080/15622975.2023.2169349","url":null,"abstract":"<p><p><b>Objectives:</b> Ketamine is a glutamate N-methyl-D-aspartate receptor antagonist that can be used to treat major depressive disorder by single or repeated infusions. However, the accessibility and scalability of oral ketamine make it preferred over intravenous ketamine. In this systematic review, we aim to evaluate the efficacy, tolerability, and safety of oral ketamine, esketamine and r-ketamine for unipolar and bipolar depression. <b>Materials and methods:</b> Electronic databases were searched from inception to September 2022 to identify relevant articles. <b>Results:</b> Twenty-two studies, including four randomized clinical trials (RCTs), one case series, six case reports, five open-label trials and six retrospective chart review studies involving 2336 patients with depression were included. All included studies reported significant improvement following ketamine administration. Ketamine was well tolerated without serious adverse events. However, RCTs had a high risk of bias due to analysis methods and adverse events monitoring. Ketamine dosage varied from 0.5 to 1.25 mg/kg. The frequency of administration was daily to monthly. Several important limitations were identified, most notably the small number of RCTs. <b>Conclusions:</b> Taken together, preliminary evidence suggests the potential for antidepressant effect of oral ketamine. However, further research with large sample size and long follow-up period is needed to better determine the antisuicidal effect and efficacy in treatment-resistant depression.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 7","pages":"545-557"},"PeriodicalIF":3.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9876933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory and oxidative endophenotypes in borderline personality disorder: A biomarker cluster analysis.","authors":"J M López-Villatoro,&nbsp;M Díaz-Marsá,&nbsp;A De la Torre-Luque,&nbsp;K S MacDowell,&nbsp;C Prittwitz,&nbsp;J C Leza,&nbsp;J L Carrasco","doi":"10.1080/15622975.2023.2183254","DOIUrl":"10.1080/15622975.2023.2183254","url":null,"abstract":"<p><strong>Objectives: </strong>This study is designed to search for aggrupation of inflammatory/oxidative biomarker alterations in borderline personality disorder (BPD) and their association with phenotypic features.</p><p><strong>Methodology: </strong>Inflammatory/nitrosative proteins were measures in plasma and peripheral blood mononuclear cells obtained from BPD patients. Patients were assessed on different clinical dimensions of BPD. Oxidative damage was tested by measuring TBARS, nitrites, catalase, GPx and SOD. Protein expression of IκBα, NFκB, iNOS, COX-2, PPARγ, Keap1, NQO1, Nrf2 and α7nAChR was also determined. Western blot and ELISA were used for measurements and a cluster analysis of inflammatory/oxidative biomarkers alterations was performed to investigate subgroups of patients with similar alterations and its relationship with clinical features of BPD.</p><p><strong>Results: </strong>69 patients were included in the study. Two inflammatory/nitrosative clusters of patients were found: Cluster 1 patients showed significantly higher levels of GPx, IκBα, keap1, NQO1, PPARγ, α7nAChR and Nrf2 than cluster 2 patients. These patients had significantly longer duration of illness, milder anxiety symptoms and lower prescription of antipsychotic drugs than cluster 2.</p><p><strong>Conclusions: </strong>Two clusters of BPD patients according to the inflammatory/nitrosative profiles were identified. Cluster 1 had increased antioxidant and anti-inflammatory biomarkers and was characterised by greater chronicity of illness but less acute symptomatic severity.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 7","pages":"587-594"},"PeriodicalIF":3.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9880399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laterality in functional and metabolic state of the bulbectomised rat brain detected by ASL and ¹H MRS: A pilot study.","authors":"Iveta Pavlova,&nbsp;Eva Drazanova,&nbsp;Lucie Kratka,&nbsp;Petra Amchova,&nbsp;Ondrej Macicek,&nbsp;Jana Starcukova,&nbsp;Zenon Starcuk,&nbsp;Jana Ruda-Kucerova","doi":"10.1080/15622975.2022.2124450","DOIUrl":"https://doi.org/10.1080/15622975.2022.2124450","url":null,"abstract":"<p><strong>Objectives: </strong>Pilot study validating the animal model of depression - the bilateral olfactory bulbectomy in rats - by two nuclear magnetic resonance methods, indirectly detecting the metabolic state of the brain. Furthermore, the study focussed on potential differences in brain laterality.</p><p><strong>Methods: </strong>Arterial spin labelling assessed cerebral brain flow in prefrontal, sensorimotor, and piriform cortices, nucleus accumbens, hippocampus, thalamus, circle of Willis, and whole brain. Proton magnetic resonance spectroscopy provided information about relative metabolite concentrations in the cortex and hippocampus.</p><p><strong>Results: </strong>Arterial spin labelling found no differences in cerebral perfusion in the group comparison but revealed lateralisation in the thalamus of the control group and the sensorimotor cortex of the bulbectomized rats. Lower Cho/tCr and Cho/NAA levels were found in the right hippocampus in bulbectomized rats. The differences in lateralisation were shown in the hippocampus: mI/tCr in the control group, Cho/NAA, NAA/tCr, Tau/tCr in the model group, and in the cortex: NAA/tCr, mI/tCr in the control group.</p><p><strong>Conclusion: </strong>Olfactory bulbectomy affects the neuronal and biochemical profile of the rat brain laterally and, as a model of depression, was validated by two nuclear magnetic resonance methods.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 5","pages":"414-428"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10053472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin B12, homocysteine, and folic acid in patients suffering from bipolar disorders: Relationship with suicide.","authors":"Paola Mangiapane,&nbsp;Manuel Glauco Carbone,&nbsp;Alessandro Arone,&nbsp;Lucia Massa,&nbsp;Stefania Palermo,&nbsp;Walter Flamini,&nbsp;Elisabetta Parra,&nbsp;Benedetto Morana,&nbsp;Florinda Morana,&nbsp;Giovanni Bertini,&nbsp;Donatella Marazziti","doi":"10.1080/15622975.2022.2134589","DOIUrl":"https://doi.org/10.1080/15622975.2022.2134589","url":null,"abstract":"<p><strong>Objectives: </strong>Vitamin B12, folic acid, and homocysteine play a key role in 'one-carbon metabolism', involved in different brain processes. Altered levels have been reported in mood disorders (MDs), particularly in major depression (MDD), while the information in bipolar disorders (BDs) is limited. The present study aimed at assessing vitamin B12, homocysteine, and folic acid in 69 bipolar inpatients.</p><p><strong>Methods: </strong>Twenty-seven patients were diagnosed with BDI, 15 BDII, 16 schizoaffective disorders, and 11 MDD, according to DSM-5 criteria. The clinical picture was assessed by the MINI, HRSD, YMRS, and CGI. The blood parameters were measured according to common clinical-chemical methods.</p><p><strong>Results: </strong>Thirty-four patients had significantly lower vitamin B12, and 14 higher homocysteine levels than normative values. Folic acid levels were normal in the majority of the sample. Patients with a family history of suicide showed significantly lower levels of vitamin B12.</p><p><strong>Conclusions: </strong>Our results underline the utility of assessing vitamin B12, homocysteine, and folic acid in patients with BD. Although other studies are necessary, the present findings that lower levels of vitamin B12 seem typical of patients with a family history of suicide independently from the phase of illness suggest that they might constitute a possible predictor of suicide.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 6","pages":"476-484"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9745410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical guidelines for the use of lifestyle-based mental health care in major depressive disorder: World Federation of Societies for Biological Psychiatry (WFSBP) and Australasian Society of Lifestyle Medicine (ASLM) taskforce.","authors":"Wolfgang Marx, Sam H Manger, Mark Blencowe, Greg Murray, Fiona Yan-Yee Ho, Sharon Lawn, James A Blumenthal, Felipe Schuch, Brendon Stubbs, Anu Ruusunen, Hanna Demelash Desyibelew, Timothy G Dinan, Felice Jacka, Arun Ravindran, Michael Berk, Adrienne O'Neil","doi":"10.1080/15622975.2022.2112074","DOIUrl":"10.1080/15622975.2022.2112074","url":null,"abstract":"<p><strong>Objectives: </strong>The primary objectives of these international guidelines were to provide a global audience of clinicians with (a) a series of evidence-based recommendations for the provision of lifestyle-based mental health care in clinical practice for adults with Major Depressive Disorder (MDD) and (b) a series of implementation considerations that may be applicable across a range of settings.</p><p><strong>Methods: </strong>Recommendations and associated evidence-based gradings were based on a series of systematic literature searches of published research as well as the clinical expertise of taskforce members. The focus of the guidelines was eight lifestyle domains: physical activity and exercise, smoking cessation, work-directed interventions, mindfulness-based and stress management therapies, diet, sleep, loneliness and social support, and green space interaction. The following electronic bibliographic databases were searched for articles published prior to June 2020: PubMed, EMBASE, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Methodology Register), CINAHL, PsycINFO. Evidence grading was based on the level of evidence specific to MDD and risk of bias, in accordance with the World Federation of Societies for Biological Psychiatry criteria.</p><p><strong>Results: </strong>Nine recommendations were formed. The recommendations with the highest ratings to improve MDD were the use of physical activity and exercise, relaxation techniques, work-directed interventions, sleep, and mindfulness-based therapies (Grade 2). Interventions related to diet and green space were recommended, but with a lower strength of evidence (Grade 3). Recommendations regarding smoking cessation and loneliness and social support were based on expert opinion. Key implementation considerations included the need for input from allied health professionals and support networks to implement this type of approach, the importance of partnering such recommendations with behaviour change support, and the need to deliver interventions using a biopsychosocial-cultural framework.</p><p><strong>Conclusions: </strong>Lifestyle-based interventions are recommended as a foundational component of mental health care in clinical practice for adults with Major Depressive Disorder, where other evidence-based therapies can be added or used in combination. The findings and recommendations of these guidelines support the need for further research to address existing gaps in efficacy and implementation research, especially for emerging lifestyle-based approaches (e.g. green space, loneliness and social support interventions) where data are limited. Further work is also needed to develop innovative approaches for delivery and models of care, and to support the training of health professionals regarding lifestyle-based mental health care.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 5","pages":"333-386"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10972571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9679888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between cortisol awakening response and trait resilience in two patient cohorts and one population-based cohort.","authors":"Patrick Linnemann,&nbsp;Nele Friedrich,&nbsp;Matthias Nauck,&nbsp;Henning Teismann,&nbsp;Klaus Berger","doi":"10.1080/15622975.2022.2129445","DOIUrl":"https://doi.org/10.1080/15622975.2022.2129445","url":null,"abstract":"<p><strong>Objectives: </strong>We examined (1) the proportion of cortisol awakening non-responders, (2) the association between cortisol awakening response (CAR) and trait resilience, and (3) the association between CAR increase and trait resilience in two patient cohorts (depression and myocardial infarction [CVD]) and one population-based cohort.</p><p><strong>Methods: </strong>Eight hundred and eighty study participants delivered CAR scores (response and increase) based on three self-collected saliva samples and a trait resilience score. Descriptive data of CAR non-responders were reported and calculated. Associations between CAR response/increase and trait resilience, sociodemographic and compliance variables were evaluated using multiple logistic and multiple linear regression analyses stratified by cohort.</p><p><strong>Results: </strong>The proportion of CAR non-responders was high in all cohorts (57% depression cohort, 53.4% CVD cohort, 51.6% control cohort). In the depression cohort age was associated with CAR response and increase. In the CVD cohort salivary collection on a weekday was associated with CAR response and awakening time with CAR increase. In the control cohort age was associated with CAR response and sex with CAR increase.</p><p><strong>Conclusions: </strong>We observed many CAR non-responders and significant associations between CAR response and CAR increase with single sociodemographic and compliance variables. We did not find significant relationships between CAR response or increase and trait resilience.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 5","pages":"429-438"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9682943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of medication side effects in patients with mostly resistant depression in a real-world setting.","authors":"Fabio Panariello,&nbsp;Siegfried Kasper,&nbsp;Joseph Zohar,&nbsp;Daniel Souery,&nbsp;Stuart Montgomery,&nbsp;Panagiotis Ferentinos,&nbsp;Dan Rujescu,&nbsp;Julien Mendlewicz,&nbsp;Diana De Ronchi,&nbsp;Alessandro Serretti,&nbsp;Chiara Fabbri","doi":"10.1080/15622975.2022.2134588","DOIUrl":"https://doi.org/10.1080/15622975.2022.2134588","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to identify factors associated with side effects of psychotropic drugs in a real-world setting enriched with treatment-resistant depression (TRD) patients.</p><p><strong>Methods: </strong>A total of 1410 depressed patients were treated in a naturalistic setting. Side effects were measured with the Udvalg for Kliniske Undersogelser Side Effect Rating Scale (UKU); the total score and UKU subscales were considered. Clinical-demographic variables were tested for association with side effects in univariate and then multivariate analyses.</p><p><strong>Results: </strong>Total, psychic and neurological side effects were associated with depressive symptom severity, while autonomic side effects were higher in those with somatic comorbidities and other side effects were lower in patients receiving trazodone. In multivariate analyses, depressive symptom severity was associated with psychic and total side effects, while generalised anxiety disorder (GAD) with neurological side effects and somatic comorbidities remained associated with autonomic side effects. Trazodone was associated with lower side effects and with augmentation treatments. Augmentation therapies showed opposite effects depending on response status, i.e. increased or decreased the risk of side effects in responders and non-responders/resistant patients, respectively.</p><p><strong>Conclusions: </strong>Psychic side effects may be difficult to distinguish from depressive symptoms and factors associated with different types of side effects are heterogeneous and likely interacting.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 5","pages":"439-448"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9682940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decline of stress resilience in aging rats: Focus on choroid plexus-cerebrospinal fluid-hippocampus.","authors":"Kaige Liu,&nbsp;Huizhen Li,&nbsp;Ningxi Zeng,&nbsp;Wenjun Lu,&nbsp;Xiaofeng Wu,&nbsp;Hanfang Xu,&nbsp;Can Yan,&nbsp;Lili Wu","doi":"10.1080/15622975.2022.2151044","DOIUrl":"https://doi.org/10.1080/15622975.2022.2151044","url":null,"abstract":"<p><strong>Objectives: </strong>This study was designed to examine the mechanisms underlying decline of stress resilience in aged rats from the perspective of CP-CSF-hippocampus.</p><p><strong>Methods: </strong>Male Wistar rats (7-8 weeks old or 20 months old) were subjected to chronic unpredictable mild stress (CUMS) for 6 weeks. The behavioral tests were conducted to assess anxiety, depression and cognitive function. Hippocampal neurogenesis, apoptosis and synaptic plasticity were detected by western blot (WB) and/or immunofluorescence (IF) assay. Differential expression of growth factors (GFs) and axon guidance proteins (AGPs) in CSF was analyzed using the quantitative proteomics approach. IF and WB were performed to detect expression of occludin-1, Ki-67/Transthyretin, and folate transporters in choroid plexus (CP).</p><p><strong>Results: </strong>Decreased proliferation, impaired structure and transport function of CP were correlated with CSF composition alterations in stressed aging rats, including reduced 5-Methyltetrahydrofolate, growth factors and axon growth factors. Nutritional support of CSF upon hippocampus was attenuated, therefore affecting hippocampal plasticity. It has led to depression-like behaviors and cognitive deficits in stressful aged rats.</p><p><strong>Conclusions: </strong>Keeping normal structure and function of CP-CSF system may be a practical strategy for neuropsychological disorders in the elderly. This work provides evidential basis for CP transplant and CSF replacement therapy in future studies.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 6","pages":"508-522"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9748296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The decoupling of structural and functional connectivity of auditory networks in individuals at clinical high-risk for psychosis.","authors":"Mina Langhein, Amanda E Lyall, Saskia Steinmann, Johanna Seitz-Holland, Felix L Nägele, Suheyla Cetin-Karayumak, Fan Zhang, Jonas Rauh, Marius Mußmann, Tashrif Billah, Nikos Makris, Ofer Pasternak, Lauren J O'Donnell, Yogesh Rathi, Gregor Leicht, Marek Kubicki, Martha E Shenton, Christoph Mulert","doi":"10.1080/15622975.2022.2112974","DOIUrl":"10.1080/15622975.2022.2112974","url":null,"abstract":"<p><strong>Objectives: </strong>Disrupted auditory networks play an important role in the pathophysiology of psychosis, with abnormalities already observed in individuals at clinical high-risk for psychosis (CHR). Here, we examine structural and functional connectivity of an auditory network in CHR utilising state-of-the-art electroencephalography and diffusion imaging techniques.</p><p><strong>Methods: </strong>Twenty-six CHR subjects and 13 healthy controls (HC) underwent diffusion MRI and electroencephalography while performing an auditory task. We investigated structural connectivity, measured as fractional anisotropy in the Arcuate Fasciculus (AF), Cingulum Bundle, and Superior Longitudinal Fasciculus-II. Gamma-band lagged-phase synchronisation, a functional connectivity measure, was calculated between cortical regions connected by these tracts.</p><p><strong>Results: </strong>CHR subjects showed significantly higher structural connectivity in the right AF than HC (<i>p</i> < .001). Although non-significant, functional connectivity between cortical areas connected by the AF was lower in CHR than HC (<i>p</i> = .078). Structural and functional connectivity were correlated in HC (<i>p</i> = .056) but not in CHR (<i>p</i> = .29).</p><p><strong>Conclusions: </strong>We observe significant differences in structural connectivity of the AF, without a concomitant significant change in functional connectivity in CHR subjects. This may suggest that the CHR state is characterised by a decoupling of structural and functional connectivity, possibly due to abnormal white matter maturation.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 5","pages":"387-399"},"PeriodicalIF":3.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9929093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}