World Journal of Biological Psychiatry最新文献

{"title":"A systematic review and meta-analysis of optical coherence tomography studies in schizophrenia, bipolar disorder and major depressive disorder.","authors":"Akash Prasannakumar,&nbsp;Vijay Kumar,&nbsp;Pooja Mailankody,&nbsp;Abhishek Appaji,&nbsp;Rajani Battu,&nbsp;Tos T J M Berendschot,&nbsp;Naren P Rao","doi":"10.1080/15622975.2023.2203231","DOIUrl":"10.1080/15622975.2023.2203231","url":null,"abstract":"<p><strong>Objectives: </strong>Due to the common neurodevelopmental origin and easy accessibility, the retina serves as a surrogate marker for changes in the brain. Hence, Optical Coherence Tomography (OCT), a tool to examine the neuronal layers of retina has gained importance in investigating psychiatric disorders. Several studies in the last decade have reported retinal structural alterations in schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). However, the findings are inconsistent. Hence, we conducted a meta-analysis to investigate alterations in OCT parameters in patients with SCZ, BD and MDD.</p><p><strong>Methods: </strong>We searched electronic databases for studies that examined OCT parameters in patients with SCZ, BD and MDD published up to January 2023. The primary outcome measures were thickness and volumes of the retinal Nerve Fibre Layer (RNFL). We conducted meta-analysis using a random effects model.</p><p><strong>Results: </strong>The searches yielded 2638 publications of which 43 studies were included in the final analysis across all disorders. Compared to controls, the RNFL was thinner in SCZ patients (SMD = -0.37, <i>p</i> = <0.001) and BD patients (SMD = -0.67, <i>p</i> = < 0.001), but not in MDD patients (SMD = -0.08, <i>p</i> = 0.54). On quadrant wise analysis, temporal quadrant RNFL was thinner in SCZ but not in BD, while all other quadrants were thinner in both SCZ and BD.</p><p><strong>Conclusion: </strong>We found significant reductions in RNFL thickness in SCZ and BD, but not in MDD. The differential involvement in various quadrants and parameters across the disorders has potential implications for using retinal parameters as a diagnostic biomarker.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"707-720"},"PeriodicalIF":3.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9513687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basal glutamate in the hippocampus and the dorsolateral prefrontal cortex in schizophrenia: Relationships to cognitive proficiency investigated with structural equation modelling.","authors":"Jeffrey A Stanley,&nbsp;Ana M Daugherty,&nbsp;Claire Richter Gorey,&nbsp;Patricia Thomas,&nbsp;Dalal Khatib,&nbsp;Asadur Chowdury,&nbsp;Usha Rajan,&nbsp;Luay Haddad,&nbsp;Alireza Amirsadri,&nbsp;Vaibhav A Diwadkar","doi":"10.1080/15622975.2023.2197653","DOIUrl":"10.1080/15622975.2023.2197653","url":null,"abstract":"<p><strong>Objectives: </strong>Schizophrenia is characterised by deficits across multiple cognitive domains and altered glutamate related neuroplasticity. The purpose was to investigate whether glutamate deficits are related to cognition in schizophrenia, and whether glutamate-cognition relationships are different between schizophrenia and controls.</p><p><strong>Methods: </strong>Magnetic resonance spectroscopy (MRS) at 3 Tesla was acquired from the dorsolateral prefrontal cortex (dlPFC) and hippocampus in 44 schizophrenia participants and 39 controls during passive viewing visual task. Cognitive performance (working memory, episodic memory, and processing speed) was assessed on a separate session. Group differences in neurochemistry and mediation/moderation effects using structural equation modelling (SEM) were investigated.</p><p><strong>Results: </strong>Schizophrenia participants showed lower hippocampal glutamate (<i>p</i> = .0044) and myo-Inositol (<i>p</i> = .023) levels, and non-significant dlPFC levels. Schizophrenia participants also demonstrated poorer cognitive performance (<i>p</i> < .0032). SEM-analyses demonstrated no mediation or moderation effects, however, an opposing dlPFC glutamate-processing speed association between groups was observed.</p><p><strong>Conclusions: </strong>Hippocampal glutamate deficits in schizophrenia participants are consistent with evidence of reduced neuropil density. Moreover, SEM analyses indicated that hippocampal glutamate deficits in schizophrenia participants as measured during a passive state were not driven by poorer cognitive ability. We suggest that functional MRS may provide a better framework for investigating glutamate-cognition relationships in schizophrenia.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"730-740"},"PeriodicalIF":3.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591941/pdf/nihms-1930869.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9707006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide DNA methylation analysis in families with multiple individuals diagnosed with schizophrenia and intellectual disability.","authors":"Shengmin Zhang,&nbsp;Kaiyu Shi,&nbsp;Nan Lyu,&nbsp;Yunshu Zhang,&nbsp;Guangming Liang,&nbsp;Wufang Zhang,&nbsp;Xijin Wang,&nbsp;Hong Wen,&nbsp;Liping Wen,&nbsp;Hong Ma,&nbsp;Jijun Wang,&nbsp;Xin Yu,&nbsp;Lili Guan","doi":"10.1080/15622975.2023.2198595","DOIUrl":"10.1080/15622975.2023.2198595","url":null,"abstract":"<p><strong>Objectives: </strong>Schizophrenia (SZ) and intellectual disability (ID) are both included in the continuum of neurodevelopmental disorders (NDDs). DNA methylation is known to be important in the occurrence of NDDs. The family study is conducive to eliminate the effects of relative epigenetic backgrounds, and to screen for differentially methylated positions (DMPs) and regions (DMRs) that are truly associated with NDDs.</p><p><strong>Methods: </strong>Four monozygotic twin families were recruited, and both twin individuals suffered from NDDs (either SZ, ID, or SZ plus ID). Genome-wide methylation analysis was performed in all samples and each family. DMPs and DMRs between NDD patients and unaffected individuals were identified. Functional and pathway enrichment analyses were performed on the annotated genes.</p><p><strong>Results: </strong>Two significant DMPs annotated to <i>CYP2E1</i> were found in all samples. In Family One, 1476 DMPs mapped to 880 genes, and 162 DMRs overlapping with 153 unique genes were recognised. Our results suggested that the altered methylation levels of <i>FYN</i>, <i>STAT3</i>, <i>RAC1</i>, and <i>NR4A2</i> were associated with the development of SZ and ID. Neurodevelopment and the immune system may participate in the occurrence of SZ and ID.</p><p><strong>Conclusions: </strong>Our findings suggested that DNA methylation participated in the development of NDDs by affecting neurodevelopment and the immune system.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"741-753"},"PeriodicalIF":3.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9314553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red cell distribution width and depressive symptoms: A failed replication in female adolescents.","authors":"Valentin Kriegmair,&nbsp;Christine Sigrist,&nbsp;Jasper Vöckel,&nbsp;Michael Kaess,&nbsp;Julian Koenig","doi":"10.1080/15622975.2023.2203222","DOIUrl":"10.1080/15622975.2023.2203222","url":null,"abstract":"<p><strong>Objectives: </strong>Despite the increasingly high prevalence and serious consequences of depression in adolescents, there is a lack of economical and reliable biomarkers to aid the diagnostic process. Recent findings suggest that red blood cell distribution width (RDW) is an easily obtainable biomarker of depression in adults. Here, we aimed to replicate the finding of increased RDW in clinically depressed adolescents.</p><p><strong>Methods: </strong>Data from depressed adolescent female patients (<i>n</i> = 93) and healthy controls (HC) (<i>n</i> = 43) aged 12-17 years from the AtR!Sk-bio cohort study were retrospectively analysed. We compared RDW between groups and tested whether there was an association between RDW and depression severity and global (psychiatric) symptom severity. We also examined the influence of age on RDW.</p><p><strong>Results: </strong>There was no significant difference between depressed patients and healthy controls and no association between RDW and depression severity. However, higher RDW values were associated with greater global symptom severity. Regardless of group, there was a positive association between RDW and age.</p><p><strong>Conclusions: </strong>RDW appears to be unfit as an aid for clinical diagnosis of depression in adolescents, but may be useful in assessing global psychiatric symptom burden.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"754-759"},"PeriodicalIF":3.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9457004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of biomarkers for diagnosing insomnia: Consensus statement of the WFSBP Task Force on Sleep Disorders.","authors":"Dimitris Dikeos,&nbsp;Adam Wichniak,&nbsp;Periklis Y Ktonas,&nbsp;Thorsten Mikoteit,&nbsp;Tatjana Crönlein,&nbsp;Anne Eckert,&nbsp;Jana Kopřivová,&nbsp;Maria Ntafouli,&nbsp;Kai Spiegelhalder,&nbsp;Martin Hatzinger,&nbsp;Dieter Riemann,&nbsp;Constantin Soldatos","doi":"10.1080/15622975.2023.2171479","DOIUrl":"10.1080/15622975.2023.2171479","url":null,"abstract":"<p><strong>Objectives: </strong>Thus far, the diagnosis of insomnia is based on purely clinical criteria. Although a broad range of altered physiological parameters has been identified in insomniacs, the evidence to establish their diagnostic usefulness is very limited. Purpose of this WFSBP Task Force consensus paper is to systematically evaluate a series of biomarkers as potential diagnostic tools for insomnia.</p><p><strong>Methods: </strong>A newly created grading system was used for assessing the validity of various measurements in establishing the diagnosis of insomnia; these measurements originated from relevant studies selected and reviewed by experts.</p><p><strong>Results: </strong>The measurements with the highest diagnostic performance were those derived from psychometric instruments. Biological measurements which emerged as potentially useful diagnostic instruments were polysomnography-derived cyclic alternating pattern, actigraphy, and BDNF levels, followed by heart rate around sleep onset, deficient melatonin rhythm, and certain neuroimaging patterns (mainly for the activity of frontal and pre-frontal cortex, hippocampus and basal ganglia); yet, these findings need replication, as well as establishment of commonly accepted methodology and diagnostic cut-off points. Routine polysomnography, EEG spectral analysis, heart rate variability, skin conductance, thermoregulation, oxygen consumption, HPA axis, and inflammation indices were not shown to be of satisfactory diagnostic value.</p><p><strong>Conclusions: </strong>Apart from psychometric instruments which are confirmed to be the gold standard in diagnosing insomnia, six biomarkers emerge as being potentially useful for this purpose.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"614-642"},"PeriodicalIF":3.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10850217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture alleviates depression-like behaviours via a neural mechanism involving activation of Nucleus Accumbens Shell.","authors":"Hua-Min Zhang,&nbsp;Zhe-Yu Chen","doi":"10.1080/15622975.2022.2155993","DOIUrl":"10.1080/15622975.2022.2155993","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigated the effects of electroacupuncture (EA) on the depression-like behaviours in a mouse model of chronic restraint stress (CRS) and explored the underlying neural mechanisms.</p><p><strong>Methods: </strong>Depression-like behaviours including sucrose preference test (SPT), open field test (OFT) and tail suspension test (TST) were carried out to evaluate the effects of CRS and EA treatment. Using immunohistochemistry to measure the expression of c-Fos. The Nucleus Accumbens Shell (NAc Shell) in C57BL/6J mice were activated or inhibited using Chemogenetics.</p><p><strong>Results: </strong>All the CRS stimulated groups showed lower sucrose preference in the SPT and decreased centre times in the OFT, and increased immobility time in the TST when compared to the normal control. Interestingly, EA at LR3 or HT7 exerted anti-depressant effects, and LR3 EA exhibited a more significant restoration than HT7. Furthermore, EA at LR3 increased expression of c-Fos in the NAc Shell. Chemogenetic inhibition of NAc Shell blocked the effects of EA, whereas enhancement of NAc Shell activity profoundly reversed depressive phenotypes.</p><p><strong>Conclusions: </strong>LR3 EA was effective in alleviating the depressive-like behaviours, and this therapeutic effect was associated with the activation of NAc Shell. Collectively, these findings revealed that EA may represent a promising therapeutic strategy for depression.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":" ","pages":"721-729"},"PeriodicalIF":3.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9918315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral signature of altered synaptic integrity in young onset cannabis use disorder: A proteomic study of circulating extracellular vesicles.","authors":"Suhas Ganesh, TuKiet T Lam, Rolando Garcia-Milian, Deepak Cyril D'Souza, Angus C Nairn, Katya Elgert, Erez Eitan, Mohini Ranganathan","doi":"10.1080/15622975.2023.2197039","DOIUrl":"10.1080/15622975.2023.2197039","url":null,"abstract":"<p><strong>Background: </strong>Rates of Cannabis Use Disorder (CUD) are highest amongst young adults. Paucity of brain tissue samples limits the ability to examine the molecular basis of cannabis related neuropathology. Proteomic studies of neuron-derived extracellular vesicles (NDEs) isolated from the biofluids may reveal markers of neuropathology in CUD.</p><p><strong>Methods: </strong>NDEs were extracted using ExoSORT, an immunoaffinity method to enrich NDEs from plasma samples from patients with young onset CUD and matched controls. Differential proteomic profiles were explored with Label Free Quantification (LFQ) mass spectrometry. Selected proteins were validated using orthogonal methods.</p><p><strong>Results: </strong>A total of 231 (±10) proteins were identified in NDE preparations from CUD and controls of which 28 were differentially abundant between groups. The difference in abundance of properdin (<i>CFP</i> gene) was statistically significant. SHANK1 (<i>SHANK1</i> gene), an adapter protein at the post-synaptic density, was nominally depleted in the CUD NDE preparations.</p><p><strong>Conclusion: </strong>In this pilot study, we noted a decrease in SHANK1 protein, involved in the structural and functional integrity of glutamatergic post-synapse, a potential peripheral signature of CUD neuropathology. The study shows that LFQ mass spectrometry proteomic analysis of NDEs derived from plasma may yield important insights into the synaptic pathology associated with CUD.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 7","pages":"603-613"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10144640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase-and disorder-specific differences in peripheral metabolites of the kynurenine pathway in major depression, bipolar affective disorder and schizophrenia.","authors":"Murielle Brum,&nbsp;Matthias Nieberler,&nbsp;Christopher Kehrwald,&nbsp;Katrin Knopf,&nbsp;Nathalie Brunkhorst-Kanaan,&nbsp;Semra Etyemez,&nbsp;Kelly A Allers,&nbsp;Robert A Bittner,&nbsp;David A Slattery,&nbsp;Rhiannon V McNeill,&nbsp;Andreas Reif,&nbsp;Sarah Kittel-Schneider","doi":"10.1080/15622975.2023.2169348","DOIUrl":"10.1080/15622975.2023.2169348","url":null,"abstract":"<p><strong>Objectives: </strong>Kynurenine, kynurenic and quinolinic acid are important metabolites in tryptophan metabolism. Due to an involvement in glutamatergic neurotransmission and immune response, previous studies have investigated this pathway in mental disorders such as major depressive disorder (MDD), bipolar disorder (BD) or schizophrenia (SCZ). Tryptophan and kynurenine have been shown to be decreased across disorders, hinting at the missing link how inflammation causes neurotoxicity and psychiatric symptoms. The main aim of our study was to investigate if individual catabolites could serve as diagnostic biomarkers for MDD, BD and SCZ.</p><p><strong>Methods: </strong>We measured plasma levels of tryptophan, kynurenine, kynurenic acid, quinolinic acid and ratio of quinolinic acid/kynurenic acid using mass spectrometry in <i>n</i> = 175 participants with acute episodes and after remission, compared with controls.</p><p><strong>Results: </strong>Decreased levels of all tryptophan catabolites were found in the whole patient group, driven by the difference between BD and HC. Manic and mixed phase BD individuals displayed significantly lower kynurenine and kynurenic acid levels. We could not find significant differences between disorders. Upon reaching remission, changes in catabolite levels partially normalised.</p><p><strong>Conclusions: </strong>Our data suggests an involvement of the kynurenine pathway in mental disorders, especially BD but disqualifying those metabolites as biomarkers for differential diagnosis.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 7","pages":"564-577"},"PeriodicalIF":3.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9876937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoter methylation of the glucocorticoid receptor following trauma may be associated with subsequent development of PTSD.","authors":"Lior Carmi, Joseph Zohar, Alzbeta Juven-Wetzler, Frank Desarnaud, Louri Makotkine, Linda M Bierer, Hagit Cohen, Rachel Yehuda","doi":"10.1080/15622975.2023.2177342","DOIUrl":"10.1080/15622975.2023.2177342","url":null,"abstract":"<p><strong>Objectives: </strong>The ability to identify persons at elevated risk for post-traumatic stress disorder (PTSD) soon after exposure to trauma, could aid clinical decision-making and treatment. In this study, we explored whether cytosine methylation of the 1 F promoter of the <i>NR3C1</i> (glucocorticoid receptor [GR]) gene obtained immediately following a trauma could predict PTSD.</p><p><strong>Methods: </strong>Our sample comprised 52 trauma survivors (28 women, 24 men), presenting to the Emergency Department (ED) within six hours of a traumatic event and followed for 13 months. Blood samples were taken at intake (<i>n</i> = 42) and again at the end of the study (13 months later, <i>n</i> = 27) to determine <i>NR3C1-1F</i> promoter methylation as well as plasma levels of cortisol, adrenocorticotropic-hormone (ACTH), and neuropeptide-Y (NPY).</p><p><strong>Results: </strong>At the 13-month follow-up, participants who met the PTSD criteria (<i>n</i> = 4) showed significantly lower <i>NR3C1-1F</i> promoter sum percent methylation compared to the non-PTSD group (<i>n</i> = 38). Further, <i>NR3C1-1F</i> methylation at ED intake was inversely correlated with PTSD severity 13 months later, indicating that lower <i>NR3C1-1F</i> promoter methylation in the immediate aftermath of trauma was associated with the development of PTSD.</p><p><strong>Conclusion: </strong>To the extent that reduced promoter methylation is associated with greater GR expression and responsivity, this finding is consistent with the hypothalamic-pituitary-adrenal dysregulation previously described for PTSD.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 7","pages":"578-586"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10042432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of depression and borderline personality disorder with 1 Hz repetitive transcranial magnetic stimulation of the orbitofrontal cortex - A pilot study.","authors":"C Reinsberg,&nbsp;M Schecklmann,&nbsp;M A Abdelnaim,&nbsp;F C Weber,&nbsp;B Langguth,&nbsp;T Hebel","doi":"10.1080/15622975.2023.2186484","DOIUrl":"10.1080/15622975.2023.2186484","url":null,"abstract":"<p><p>Borderline personality disorder (BPD) is characterised by impairments in emotional regulation, impulse control and interpersonal interaction. Comorbid depression is common. The orbitofrontal cortex (OFC) plays a crucial role in the biological substrate of BPD. We investigated the effects of 1 Hz repetitive transcranial magnetic stimulation (rTMS) targeting the OFC on depressive symptoms and symptoms of BPD in 15 patients suffering from both conditions to assess feasibility and effectiveness. Target treatment intensity was 120% of resting motor threshold (RMT) and intended duration four weeks. Treatment improved both symptoms of depression as measured by the Hamilton Depression Rating Scale and of BPD as measured by Borderline Symptom List-23 and Barratt Impulsivity Scale. Drop-out rates were high with 7/15 patients not completing the full course of rTMS, but only two drop-outs were related to treatment. Only a minority of patients tolerated target treatment intensity. Despite the limitations, the results suggest efficacy of treatment and welcome further research.</p>","PeriodicalId":49358,"journal":{"name":"World Journal of Biological Psychiatry","volume":"24 7","pages":"595-602"},"PeriodicalIF":3.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9880397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}