Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences最新文献_第8页

In vitro acetylcholinesterase, tyrosinase inhibitory potentials of secondary metabolites from Euphorbia schimperiana and Euphorbia balsamifera. 大戟和香薷次生代谢产物乙酰胆碱酯酶、酪氨酸酶体外抑制电位的研究。

IF 2 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2023-05-25 DOI: 10.1515/znc-2021-0178

Salha M Aljubiri, Eman Abd Elsalam, Faten K Abd El Hady, Mohamed O Radwan, Abdulrahman I Almansour, Kamel H Shaker

{"title":"In vitro acetylcholinesterase, tyrosinase inhibitory potentials of secondary metabolites from Euphorbia schimperiana and Euphorbia balsamifera.","authors":"Salha M Aljubiri, Eman Abd Elsalam, Faten K Abd El Hady, Mohamed O Radwan, Abdulrahman I Almansour, Kamel H Shaker","doi":"10.1515/znc-2021-0178","DOIUrl":"https://doi.org/10.1515/znc-2021-0178","url":null,"abstract":"Acetylcholinesterase, tyrosinase, and α-glucosidase inhibition activities of Euphorbia schimperiana and Euphorbia balsamifera extracts, fractions, and available pure compounds were evaluated for the first time. Acetylcholinesterase assay revealed a significant inhibitory activity of E. balsamifera total extract and n-hexane fraction with 47.7% and 43.3%, respectively, compared to the reference drug, which was 75%. The n-butanol fraction demonstrated tyrosinase inhibitory activity for E. balsamifera and E. schimperiana with 36.7% and 29.7%, respectively, compared to 60% for the reference drug. Quercetin-3-O-α-glucuronide, quercetin-3-O-β-D-glucuronide-methyl ester, quercetin-3-O-α-L-rhamnoside, 3,3'-di-O-methyl ellagic acid, 3,3'-di-O-methyl-ellagic acid-4-β-D-xylopyranoside, and 4-O-ethyl gallic acid were identified from E. schimperiana while quercetin-3-O-glucopyranoside and isoorientin were determined from E. balsamifera. The AChE inhibitory effect of pure compounds exhibited promising activity, where 4-O-ethylgallic acid demonstrated 51.1%, while the highest tyrosinase inhibition was demonstrated by isoorientin with 50.6% compared to the reference drug (60%). Finally, a molecular docking study was performed for the most promising AChE and tyrosinase inhibitors. The extracts, fractions, and isolated compounds showed no α-glucosidase inhibitory activity.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"78 5-6","pages":"209-216"},"PeriodicalIF":2.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9366141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Two new natural products from Portulaca oleracea L. and their bioactivities. 马齿苋两种新天然产物及其生物活性研究。

IF 2 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2023-05-25 DOI: 10.1515/znc-2022-0197

Mingyang Song, Zheming Ying, Xixiang Ying, Lianqun Jia, Guanlin Yang

引用次数: 0

Chemical constituents from Ficus sur Forssk (Moraceae). 桑科无花果的化学成分。

IF 2 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2023-05-25 DOI: 10.1515/znc-2022-0165

Eitel Ngoh Misse Mouelle, Mohamed Foundikou Nsangou, Vanini Samiyatou Michiren Mandou, Jean Duplex Wansi, Sergi Herve Akone, Emmanuel Ngeufa Happi

引用次数: 1

Tissue specific changes of phytochemicals, antioxidant, antidiabetic and anti-inflammatory activities of tea [Camellia sinensis (L.)] extracted with different solvents. 不同溶剂提取茶(Camellia sinensis (L.))植物化学物质、抗氧化、抗糖尿病和抗炎活性的组织特异性变化

IF 2 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2023-05-25 DOI: 10.1515/znc-2022-0174

Tania Baishya, Priya Das, Gouhar Jahan Ashraf, Tarun Kumar Dua, Paramita Paul, Gouranga Nandi, Malay Bhattacharya, Ranabir Sahu

{"title":"Tissue specific changes of phytochemicals, antioxidant, antidiabetic and anti-inflammatory activities of tea [Camellia sinensis (L.)] extracted with different solvents.","authors":"Tania Baishya, Priya Das, Gouhar Jahan Ashraf, Tarun Kumar Dua, Paramita Paul, Gouranga Nandi, Malay Bhattacharya, Ranabir Sahu","doi":"10.1515/znc-2022-0174","DOIUrl":"https://doi.org/10.1515/znc-2022-0174","url":null,"abstract":"Different parts of Camellia sinensis (L.) were extracted with solvents according to polarity, and the extracts' phytochemical profiling and biological activities were examined. The total phenolic (TPC) and total flavonoid (TFC) contents increased with the increasing polarity of the solvent which met its maximum in polar solvents. The increasing antioxidant, anti-inflammatory and antidiabetic activities were recorded with increasing polarity of solvents which showed hydroalcoholic as best solvent. The strong and significant correlation was among the TPC, TFC, DPPH, anti-inflammatory and antidiabetic activities for different parts of tea. HPTLC study of individual phenolic acids, epigallocatechin gallate, gallocatechin and theaflavin met their maximum level of content with polar solvents like hydroalcohol, methanol and water mostly in mainly tea leaves. Our finding suggested that the polar solvents and young leaves of tea were beneficial for obtaining extracts. On the other hand, phenolics were found to be potent antioxidant, anti-inflammatory and antidiabetic agent.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"78 5-6","pages":"235-246"},"PeriodicalIF":2.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9359712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Exploring phytochemical constituents of Achillea arabica Kotschy. ethanolic flower extract by LC-MS/MS and its possible antioxidant and antidiabetic effects in diabetic rats. 阿拉比卡阿喀琉叶植物化学成分的研究。用LC-MS/MS分析乙醇花提取物对糖尿病大鼠的抗氧化和降糖作用。

IF 2 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2023-05-25 DOI: 10.1515/znc-2022-0082

Hanife Ceren Hanalp, Abdulahad Dogan, Tuba Kusman Saygi, Fatih Donmez, Abdulhamit Battal

{"title":"Exploring phytochemical constituents of Achillea arabica Kotschy. ethanolic flower extract by LC-MS/MS and its possible antioxidant and antidiabetic effects in diabetic rats.","authors":"Hanife Ceren Hanalp, Abdulahad Dogan, Tuba Kusman Saygi, Fatih Donmez, Abdulhamit Battal","doi":"10.1515/znc-2022-0082","DOIUrl":"https://doi.org/10.1515/znc-2022-0082","url":null,"abstract":"The aim of this study was to reveal the antidiabetic and antioxidant effects of ethanolic lyophilized extract of Achillea arabica flower extract against streptozotosine (STZ)-induced in diabetic rats and to determine its phytochemical content by liquid chromatography with tandem mass spectrometry (LC-MS/MS). After toxicity test, 35 female rats were divided into five groups. Control, diabetes mellitus (DM), A.arabica (400 mg/kg) extract, DM + A. arabica (400 mg/kg) extract and DM + Glibenclamide (2 mg/kg). It was determined that while diabetic rats treated A.arabica plant extract significantly decreased blood glucose level, serum glucose, HbA1c, liver and kidney damage biomarker levels, and malondialdehyde (MDA) content compared to the DM group, it caused fluctuations in antioxidant enzyme levels. According to LC-MS/MS results of A. arabica flower extract, quinic acid (2439.9 μg/g), cyranoside (858.4 μg/g), chlorogenic acid (698.7 μg/g), and cosmosiin (347.8 μg/g) were determined as major compounds, respectively. In addition, two new compounds were determined in this extract according to nuclear magnetic resonance (NMR) and Mass analyses and these compounds were named edremitine and achillosine, respectively. Thus, A.arabica flower extract has possible therapeutic effects to prevent high blood glucose level and oxidative stress caused by DM in liver and kidney via its high phenolic content.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"78 5-6","pages":"189-199"},"PeriodicalIF":2.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9371160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Limonoids and insecticidal activity on Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) of Trichilia catigua A. Juss. (Meliaceae). 柠檬素及其对卡提瓜毛毛虫(鳞翅目:夜蛾科)的杀虫活性。(楝科)。

IF 2 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2023-05-25 DOI: 10.1515/znc-2022-0202

Cristiane M Cazal, Andreia P Matos, Vanessa de Cássia Domingues, Gracielle Oliveira Sabbag Cunha, Paulo Cezar Vieira, Maria Fátima das Graças Fernandes da Silva, João Batista Fernandes

{"title":"Limonoids and insecticidal activity on Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) of Trichilia catigua A. Juss. (Meliaceae).","authors":"Cristiane M Cazal, Andreia P Matos, Vanessa de Cássia Domingues, Gracielle Oliveira Sabbag Cunha, Paulo Cezar Vieira, Maria Fátima das Graças Fernandes da Silva, João Batista Fernandes","doi":"10.1515/znc-2022-0202","DOIUrl":"https://doi.org/10.1515/znc-2022-0202","url":null,"abstract":"The aim of the study was to evaluate the effects of the seeds, exocarp and aril extracts from Trichilia catigua A. Juss. (Meliaceae) against Spodoptera frugiperda and present the phytochemical study carried out with the aril extract of T. catigua. Limonoids were isolated from the aril of T. catigua through chromatographic techniques and their structures were proposed by spectroscopic analysis and comparison with literature data. The effects of the seeds, exocarp and aril extracts from T. catigua against S. frugiperda were evaluated considering as parameters the duration and mortality of the larval phase, in addition to the pupal weight. Phytochemical investigation of the aril extracts of T. catigua has led to the identification of the limonoids 6α-O-acetyl-7-deacetyl-14,15-dihydro-15-oxo-nimocinol (1), cedrelone (2) and 6α-O-acetyl-7-deacetylnimocinol (3). The hexane and CH2Cl2 extracts of the aril showed a high rate of larval mortality (100 and 90%, respectively). In addition, a prolongation of larval phase and a reduction in the pupal weight were observed for insects treated with hexane, CH2Cl2 and methanol extracts of seeds and with CH2Cl2 extract of exocarp of T. catigua.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"78 5-6","pages":"229-233"},"PeriodicalIF":2.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9735829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical constituents of Desmodium triflorum and their antifungal activity against various phytopathogenic fungi. 三花莲的化学成分及其对多种植物病原真菌的抗真菌活性。

IF 2 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2023-05-25 DOI: 10.1515/znc-2022-0048

Hieu Nguyen-Ngoc, Trang Nguyen-Thi-Thu, Kieu-Anh Vo-Thi, Tung Nguyen-Huu, Lam Tran-Dai, Hoang Dinh Vu, Duc Trong Nghiem, Quang Le Dang

{"title":"Chemical constituents of Desmodium triflorum and their antifungal activity against various phytopathogenic fungi.","authors":"Hieu Nguyen-Ngoc, Trang Nguyen-Thi-Thu, Kieu-Anh Vo-Thi, Tung Nguyen-Huu, Lam Tran-Dai, Hoang Dinh Vu, Duc Trong Nghiem, Quang Le Dang","doi":"10.1515/znc-2022-0048","DOIUrl":"https://doi.org/10.1515/znc-2022-0048","url":null,"abstract":"In the course of finding new antifungal natural compounds against plant pathogens, the methanol extract of Desmodium triflorum was investigated phytochemically. From n-butanol-soluble fraction, seven compounds (1-7) were isolated and structurally elucidated. Of which, six compounds belong to flavone 6- or 8-C-glycoside class (1-6). Three major compounds (1-3) exhibited moderate in vitro antifungal activity against Sclerotium rolfsii, Fusarium oxysporum f. sp. cubense, and Phytophthora palmivora. Compound 1 (IC50 = 162.1 μg/mL) was most active against S. rolfsii in a dose-dependent manner. At 300 μg/mL, compounds 1 and 2 significantly inhibited P. palmivora, whereas compound 3 lacked effectiveness. In addition, the nanoemulsion of the methanol extract with a droplet size of 12.2 nm displayed an excellent inhibition against S. rolfsii and P. palmivora compared with the normal extract. The presence of 1 (0.846%) and 2 (0.759%) in the methanol extract may attribute to the antifungal activity of D. triflorum. These results proved the potential of D. triflorum and its C-glycoside flavonoids against phytopathogenic fungi for the first time. Besides, an enhancement in the effectiveness of nanoemulsion containing D. triflorum extract against the fungi was confirmed. The structural characteristics of 1 and 2 could be considered to develop new fungicidal substances in the future.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"78 5-6","pages":"179-187"},"PeriodicalIF":2.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9365633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A novel eudesmol derivative from the leaf essential oil of Guatteria friesiana (Annonaceae) and evaluation of the antinociceptive activity. 从番石榴叶精油中提取一种新型苦参酚衍生物及抗伤活性评价。

IF 2 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2023-05-25 DOI: 10.1515/znc-2022-0059

Emmanoel V Costa, Leociley R Alencar Menezes, Lívia M Dutra, Maria Lúcia B Pinheiro, Érica M Lavor, Mariana G Silva, Cristiane Dos S C Alves, Jackson R G S Almeida, Felipe Moura A da Silva, Hector H F Koolen, Andersson Barison

{"title":"A novel eudesmol derivative from the leaf essential oil of Guatteria friesiana (Annonaceae) and evaluation of the antinociceptive activity.","authors":"Emmanoel V Costa, Leociley R Alencar Menezes, Lívia M Dutra, Maria Lúcia B Pinheiro, Érica M Lavor, Mariana G Silva, Cristiane Dos S C Alves, Jackson R G S Almeida, Felipe Moura A da Silva, Hector H F Koolen, Andersson Barison","doi":"10.1515/znc-2022-0059","DOIUrl":"https://doi.org/10.1515/znc-2022-0059","url":null,"abstract":"In the present study, it was evaluated the chemical composition and the antinociceptive activity of the essential oil obtained from the leaves of Guatteria friesiana. Seven compounds corresponding to 96.2% of the crude essential oil were identified. The main components identified were the mixture of β-eudesmol and α-eudesmol (58.1%), and γ-eudesmol (16.8%). A new α-eudesmol derivative, named 5-hydroxy-α-eudesmol, was isolated together with the known compounds β-eudesmol and a mixture of α-eudesmol, β-eudesmol and γ-eudesmol of the essential oil. The chemical structures were determined by 1D and 2D NMR, and MS experiments. Essential oil has significant antinociceptive properties, which are related probably with the involvement of the opioid receptors and K+-ATP channels.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"78 5-6","pages":"169-177"},"PeriodicalIF":2.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9720074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anonazepine, a new alkaloid from the leaves of Annona muricata (Annonaceae). 从番荔枝科番荔枝叶中提取的一种新生物碱——Anonazepine。

IF 2 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2023-05-25 DOI: 10.1515/znc-2022-0136

Ngoc Vinh Huynh, Duc Minh Nguyen Huu, Ngoc Trinh Huynh, Duc Hoa Chau, Cong Dinh Nguyen, Quoc Dung Nguyen Truong, Dinh Tri Mai, Phu Hoang Dang

引用次数: 0

Essential oils of the ginger plants Meistera caudata and Conamomum vietnamense: chemical compositions, antimicrobial, and mosquito larvicidal activities. 姜属植物尾叶和越南柯南的精油：化学成分、抗菌剂和杀蚊活性。

IF 2 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2023-05-11 Print Date: 2023-09-26 DOI: 10.1515/znc-2022-0244

Le Thi Huong, Ninh The Son, Ly Ngoc Sam, Phan Nhat Minh, Nguyen Dinh Luyen, Nguyen Huy Hung, Do Ngoc Dai

{"title":"Essential oils of the ginger plants Meistera caudata and Conamomum vietnamense: chemical compositions, antimicrobial, and mosquito larvicidal activities.","authors":"Le Thi Huong, Ninh The Son, Ly Ngoc Sam, Phan Nhat Minh, Nguyen Dinh Luyen, Nguyen Huy Hung, Do Ngoc Dai","doi":"10.1515/znc-2022-0244","DOIUrl":"10.1515/znc-2022-0244","url":null,"abstract":"The current study describes the chemical identification, antimicrobial, and mosquito larvicidal activities of essential oils from Meistera caudata and Conamomum vietnamense, growing in Vietnam. Essential oils were extracted from the leaves and rhizomes, and characterized by the GC-FID/MS (gas chromatography-flame ionization detection/mass spectrometry) analysis. Monoterpenes (33.1-89.2 %) were the main chemical class found in these oils. β-Pinene (30.8 %) and α-pinene (23.8 %) were two major compounds in M. caudata leaf oil. C. vietnamense leaf and rhizome essential oils were dominated by 1,8-cineole (47.9-62.0 %) and limonene (10.3-16.2 %). With the same MIC (minimum inhibitory concentration) value of 25 μg/mL, C. vietnamense leaf and rhizome essential oils strongly inhibited the growth of Gram-positive bacteria Staphylococcus aureus ATCC 29213 and Bacillus subtilis ATCC 6501, respectively. For 24 and 48-h treatments, C. vietnamense leaf essential oil strongly controlled the growth of mosquito Aedes aegypti with the respective LC50 values of 7.67 and 6.73 μg/mL, and the respective LC90 values of 13.37 and 10.83 μg/mL. In the same manner, C. vietnamense rhizome essential oil also showed strong mosquito larvicidal activity against Aedes albopictus with the LC50 values of 12.37 and 12.00 μg/mL, and the LC90 values of 20.56 and 18.58 μg/mL, respectively. C. vietnamense essential essential oils containing a high amount of 1,8-cineole are generally better than M. caudata essential essential oils in both two biological assays.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"78 9-10","pages":"337-344"},"PeriodicalIF":2.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10190911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1