Viruses-Basel最新文献

Trafficking and Activation of Henipavirus, Parahenipavirus, and Henipa-like Virus Fusion Proteins. 亨尼帕病毒、副亨尼帕病毒和亨尼帕样病毒融合蛋白的转运和激活。

IF 3.8 3区医学

Viruses-Basel Pub Date : 2025-06-19 DOI: 10.3390/v17060866

Chanakha K Navaratnarajah, Roberto Cattaneo

{"title":"Trafficking and Activation of Henipavirus, Parahenipavirus, and Henipa-like Virus Fusion Proteins.","authors":"Chanakha K Navaratnarajah, Roberto Cattaneo","doi":"10.3390/v17060866","DOIUrl":"10.3390/v17060866","url":null,"abstract":"Henipaviruses are emerging zoonotic viruses that have caused deadly outbreaks in humans and livestock across several regions of the world. The fusion (F) protein of henipaviruses plays a critical role in viral entry into host cells and represents a key determinant of viral pathogenicity. This review provides a comprehensive analysis of current knowledge regarding trafficking, activation, as well as the role in particle assembly, of henipavirus F proteins. We discuss the unique characteristics of henipavirus F proteins compared to other paramyxovirus fusion proteins, with particular emphasis on their distinctive trafficking and activation mechanisms. Attention is also given to novel henipaviruses that have been detected in hosts other than bats, namely rodents and shrews. These viruses are sufficiently different that the International Committee on Taxonomy of Viruses has proposed a new genus for them, the Parahenipaviruses. We discuss how variations in F protein characteristics between Henipaviruses, Parahenipaviruses, and yet-unclassified henipa-like viruses might influence their trafficking and activation. Understanding these molecular mechanisms is crucial for developing effective therapeutic strategies against henipavirus infections and for predicting the emergence of novel henipavirus strains with pandemic potential.","PeriodicalId":49328,"journal":{"name":"Viruses-Basel","volume":"17 6","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12197483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery of a Novel Parahenipavirus, Parahenipavirus_GH, in Shrews in South Korea, 2022. 2022年，在韩国鼩鼱中发现了一种新的Parahenipavirus_GH。

IF 3.8 3区医学

Viruses-Basel Pub Date : 2025-06-19 DOI: 10.3390/v17060867

Gyuri Sim, Chi-Hwan Choi, Minji Lee, Hak Seon Lee, Seong Yoon Kim, Seung Hun Lee, Hee Il Lee, Yoon-Seok Chung

{"title":"Discovery of a Novel Parahenipavirus, Parahenipavirus_GH, in Shrews in South Korea, 2022.","authors":"Gyuri Sim, Chi-Hwan Choi, Minji Lee, Hak Seon Lee, Seong Yoon Kim, Seung Hun Lee, Hee Il Lee, Yoon-Seok Chung","doi":"10.3390/v17060867","DOIUrl":"10.3390/v17060867","url":null,"abstract":"Highly pathogenic henipaviruses (Nipah and Hendra viruses) and parahenipaviruses (Langya virus) have demonstrated significant zoonotic potential. We aimed to identify Henipavirus or Parahenipavirus species in rodents and shrews in South Korea to underline the potential zoonotic transmission risk. Kidney and lung tissues from 285 rodents and shrews were screened for Henipavirus and Parahenipavirus using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) targeting the Gamak virus and Daeryong virus (DARV) sequences. Based on the qRT-PCR results, 75 out of the 285 individuals tested positive, with the highest viral loads in the kidneys of Apodemus agrarius, Crocidura lasiura, and Crocidura shantungensis. A kidney sample from C. shantungensis that exhibited the lowest Ct value was further analyzed using PCR, Sanger sequencing, and metagenomic analysis, yielding a near-complete genome of a novel Parahenipavirus, designated Parahenipavirus_GH (PHNV-GH), which is phylogenetically related to DARV and Jingmen virus but exhibits distinct genomic features. Ixodes granulatus ticks were also identified on the host shrew. The identification of PHNV-GH in southern South Korea expands the known geographical distribution range of parahenipaviruses and highlights the ongoing risk of zoonotic transmission. Given the uncertain transmission dynamics and pathogenic potential of parahenipaviruses, comprehensive environmental surveillance and characterization of emerging parahenipaviruses are essential for preventing future outbreaks.","PeriodicalId":49328,"journal":{"name":"Viruses-Basel","volume":"17 6","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12197346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Viroporin Function and Structure: A Comparative Analysis of Alphavirus 6K with Well-Characterized Viroporins. 病毒孔蛋白功能和结构的研究进展：甲型病毒6K与特性明确的病毒孔蛋白的比较分析。

IF 3.8 3区医学

Viruses-Basel Pub Date : 2025-06-19 DOI: 10.3390/v17060868

Vashi Negi, Andrew S Miller, Richard J Kuhn

引用次数: 0

The Multigene Family Genes-Encoded Proteins of African Swine Fever Virus: Roles in Evolution, Cell Tropism, Immune Evasion, and Pathogenesis. 非洲猪瘟病毒的多基因家族基因编码蛋白：在进化、细胞趋向性、免疫逃避和发病机制中的作用。

IF 3.8 3区医学

Viruses-Basel Pub Date : 2025-06-19 DOI: 10.3390/v17060865

Ruojia Huang, Rui Luo, Jing Lan, Zhanhao Lu, Hua-Ji Qiu, Tao Wang, Yuan Sun

{"title":"The Multigene Family Genes-Encoded Proteins of African Swine Fever Virus: Roles in Evolution, Cell Tropism, Immune Evasion, and Pathogenesis.","authors":"Ruojia Huang, Rui Luo, Jing Lan, Zhanhao Lu, Hua-Ji Qiu, Tao Wang, Yuan Sun","doi":"10.3390/v17060865","DOIUrl":"10.3390/v17060865","url":null,"abstract":"African swine fever virus (ASFV), the causative agent of African swine fever (ASF), poses a catastrophic threat to global swine industries through its capacity for immune subversion and rapid evolution. Multigene family genes (MGFs)-encoded proteins serve as molecular hubs governing viral evolution, immune evasion, cell tropism, and disease pathogenesis. This review synthesizes structural and functional evidence demonstrating that MGFs-encoded proteins suppress both interferon signaling and inflammasome activation, while their genomic plasticity in variable terminal regions drives strain diversification and adaptation. Translationally, targeted deletion of immunomodulatory MGFs enables the rational design of live attenuated vaccines that improve protective efficacy while minimizing residual virulence. Moreover, hypervariable MGFs provide strain-specific signatures for PCR-based diagnostics and phylogeographic tracking, directly addressing outbreak surveillance challenges. By unifying virology with translational innovation, this review establishes MGFs as priority targets for next-generation ASF countermeasures.","PeriodicalId":49328,"journal":{"name":"Viruses-Basel","volume":"17 6","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12197721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First Molecular Evidence of Equine Herpesvirus Type 1 (EHV-1) in Ocular Swabs of Clinically Affected Horses. 临床感染马眼拭子中马疱疹病毒1型（EHV-1）的首个分子证据

IF 3.8 3区医学

Viruses-Basel Pub Date : 2025-06-18 DOI: 10.3390/v17060862

Beatriz Musoles-Cuenca, Miguel Padilla-Blanco, Valentina Vitale, Teresa Lorenzo-Bermejo, María de la Cuesta-Torrado, Beatriz Ballester, Elisa Maiques, Consuelo Rubio-Guerri, Ana Velloso Alvarez

{"title":"First Molecular Evidence of Equine Herpesvirus Type 1 (EHV-1) in Ocular Swabs of Clinically Affected Horses.","authors":"Beatriz Musoles-Cuenca, Miguel Padilla-Blanco, Valentina Vitale, Teresa Lorenzo-Bermejo, María de la Cuesta-Torrado, Beatriz Ballester, Elisa Maiques, Consuelo Rubio-Guerri, Ana Velloso Alvarez","doi":"10.3390/v17060862","DOIUrl":"10.3390/v17060862","url":null,"abstract":"Equine Herpesvirus Type 1 (EHV-1) is a significant pathogen within the Alphaherpesvirinae subfamily, causing respiratory disease, abortions, and, in severe cases, equine herpesvirus myeloencephalopathy (EHM). While nasal swabs and blood samples are commonly used for real-time polymerase chain reaction (RT-PCR) diagnosis, variability in viral shedding necessitates exploring additional sample types. This study reports the first molecular detection of EHV-1 in ocular swabs from naturally infected horses during an outbreak in the Valencian Community in 2023. Nasal and ocular swabs were collected from ten symptomatic horses and analyzed via RT-PCR. EHV-1 was detected in all cases, with higher viral loads in nasal samples. Although nasal swabs remain the most reliable sample for EHV-1 detection, the presence of viral DNA in tear fluid suggests a previously unrecognized route of viral shedding. These findings support further investigation into the role of ocular secretions in the pathogenesis and epidemiology of EHV-1. Additional studies are needed to determine the clinical relevance and potential utility of ocular swabs in specific outbreak scenarios.","PeriodicalId":49328,"journal":{"name":"Viruses-Basel","volume":"17 6","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12197432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complete Genome and Recombination Analysis of a Novel Porcine Reproductive and Respiratory Syndrome Virus 2 (Variant 1H.18) Identified in the Midwestern USA. 美国中西部发现的新型猪繁殖与呼吸综合征病毒2（变异h .18）的全基因组和重组分析

IF 3.8 3区医学

Viruses-Basel Pub Date : 2025-06-18 DOI: 10.3390/v17060863

Joao P Herrera da Silva, Stephanie Rossow, Igor A D Paploski, Mariana Kikuti, Cesar A Corzo, Kimberly VanderWaal

引用次数: 0

Brainstem Encephalitis: An Atypical Manifestation of Zika Virus Infection in Brazil. 脑干脑炎：巴西寨卡病毒感染的非典型表现。

IF 3.8 3区医学

Viruses-Basel Pub Date : 2025-06-18 DOI: 10.3390/v17060864

Mateus Santana do Rosário, Pedro Antonio Pereira de Jesus, Italo Andrade Barbosa Lima, Marcos Vinicius Oliveira Francisco, Cleiton Silva Santos, Lorena Cunha Martins, Luiza Vieira Luedy Trindade, Ricardo Khouri, Isadora Cristina de Siqueira

{"title":"Brainstem Encephalitis: An Atypical Manifestation of Zika Virus Infection in Brazil.","authors":"Mateus Santana do Rosário, Pedro Antonio Pereira de Jesus, Italo Andrade Barbosa Lima, Marcos Vinicius Oliveira Francisco, Cleiton Silva Santos, Lorena Cunha Martins, Luiza Vieira Luedy Trindade, Ricardo Khouri, Isadora Cristina de Siqueira","doi":"10.3390/v17060864","DOIUrl":"10.3390/v17060864","url":null,"abstract":"Zika virus (ZIKV), once considered a relatively benign pathogen, has emerged as a cause of severe neurological complications, including Guillain-Barrè Syndrome and encephalitis. This report presents the case of a 21-year-old Brazilian woman who initially presented with fever, rash, and arthralgia. Seven days later, she developed confusion, speech impairment, and gait disturbance. Following a tonic-clonic seizure, neurological examination revealed dysphonia, dysarthria and facial palsy, suggestive of brainstem involvement. ZIKV infection was detected by positive IgM serology and a plaque reduction neutralization test. The patient was treated with corticosteroids and antiepileptic drugs, leading to substantial clinical improvement, and discharge after 25 days of hospitalization. This case underscores the neuroinvasive potential of ZIKV and highlights the importance of early recognition and management of atypical neurological manifestations. It also reinforces the need to consider ZIKV in the differential diagnosis of encephalitis, particularly in endemic regions, and contributes to the growing understanding of ZIKV neurotropism and possible therapeutic approaches for severe presentations.","PeriodicalId":49328,"journal":{"name":"Viruses-Basel","volume":"17 6","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12197392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention Studies. 有症状的指数病例家庭接触者中的登革热感染：对社区干预研究的意义

IF 3.8 3区医学

Viruses-Basel Pub Date : 2025-06-17 DOI: 10.3390/v17060859

Erik Koehne, Liesbeth Van Wesenbeeck, Martin L Hibberd, Annemie Buelens, Michiko Toizumi, Kim De Clerck, Leen Vijgen, Ole Lagatie, Lucy Masdin, Hien Anh Thi Nguyen, Hoang Huy Le, Duc Anh Dang, Mai Kim Huynh, Lien Thuy Le, Trieu Bao Nguyên, Stephane Hue, Hung Thai Do, Guillermo Herrera-Taracena, Freya Rasschaert, Lay-Myint Yoshida

{"title":"Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention Studies.","authors":"Erik Koehne, Liesbeth Van Wesenbeeck, Martin L Hibberd, Annemie Buelens, Michiko Toizumi, Kim De Clerck, Leen Vijgen, Ole Lagatie, Lucy Masdin, Hien Anh Thi Nguyen, Hoang Huy Le, Duc Anh Dang, Mai Kim Huynh, Lien Thuy Le, Trieu Bao Nguyên, Stephane Hue, Hung Thai Do, Guillermo Herrera-Taracena, Freya Rasschaert, Lay-Myint Yoshida","doi":"10.3390/v17060859","DOIUrl":"10.3390/v17060859","url":null,"abstract":"Background: Dengue is a global health concern, with half of the world's population at risk and no antiviral treatment available. This Phase 0 study investigated dengue infections among household contacts (HHCs) of dengue index cases (ICs) and assessed the feasibility of conducting a Phase 2 trial for a novel antiviral.Methods: Participants were enrolled in Nha Trang, Vietnam, from April 2022 to February 2023. Dengue ICs were identified within 72 h of fever onset, and their healthy adult HHCs enrolled within 48 h. Blood samples and questionnaires were collected bi-weekly for four weeks, with a follow-up visit on day 40. DENV RT-qPCR, NS1, and anti-DENV IgM/IgG ELISAs were performed.Results: Overall, 130 dengue ICs and 301 HHCs were enrolled, with 91.7% (276/301) completing all follow-up visits. Baseline anti-DENV IgG showed prior dengue infections in 262/301 HHCs (87.0%). Fifty HHCs were excluded from the HHC infection analysis based on evidence of a DENV infection (viral load [VL], NS1, IgM, and IgG results) at enrollment. During follow-up, 2.0% of HHCs (5/251) had DENV infections based on virological parameters (DENV RNA and/or NS1 positivity), and anti-DENV IgG/IgM seroconversion was detected in 7.2% (18/251).Conclusions: This study demonstrated the operational feasibility of a dengue IC-HHC design for a Phase 2 trial.","PeriodicalId":49328,"journal":{"name":"Viruses-Basel","volume":"17 6","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12197545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparison of Vaccination Policies and Immunity Assessment for Measles Control: Insights from the United States and Japan. 麻疹控制疫苗接种政策和免疫评估的比较：来自美国和日本的见解

IF 3.8 3区医学

Viruses-Basel Pub Date : 2025-06-17 DOI: 10.3390/v17060861

Naruhito Otani, Toshiomi Okuno, Toshie Tsuchida, Kaori Ishikawa, Kaoru Ichiki, Takashi Ueda, Satoshi Higasa, Kazuhiko Nakajima

{"title":"A Comparison of Vaccination Policies and Immunity Assessment for Measles Control: Insights from the United States and Japan.","authors":"Naruhito Otani, Toshiomi Okuno, Toshie Tsuchida, Kaori Ishikawa, Kaoru Ichiki, Takashi Ueda, Satoshi Higasa, Kazuhiko Nakajima","doi":"10.3390/v17060861","DOIUrl":"10.3390/v17060861","url":null,"abstract":"Measles is a highly contagious viral disease and remains a global health challenge despite the availability of effective vaccines. Although many regions have successfully eliminated measles, outbreaks continue to occur owing to vaccine hesitancy, inadequate coverage, and imported cases. Differences in epidemiology, vaccination policies, and immunity assessment influence measles control across countries. This paper compares measles epidemiology, vaccination policies, and immunity assessment approaches in the United States and Japan. Data were obtained from surveillance reports, national immunization programs, and peer-reviewed literature. The introduction of the measles vaccine led to substantial reductions in incidence. The United States eliminated measles in 2000 but continues to experience outbreaks due to vaccine hesitancy and imported cases. Japan implemented a two-dose policy in 2006, reducing case numbers; however, sporadic outbreaks among adults persist. In the United States, immunity is primarily assessed using documented vaccination history, whereas in Japan, enzyme immunoassay is commonly used to evaluate immunity status. Despite progress in measles elimination, achieving high vaccination coverage and addressing vaccine hesitancy remain critical challenges. Variations in immunity assessment methods impact surveillance accuracy and outbreak control. Strengthening international collaboration, standardizing assessment protocols, and enhancing public health education are crucial for sustained measles elimination.","PeriodicalId":49328,"journal":{"name":"Viruses-Basel","volume":"17 6","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12197691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rotavirus alphagastroenteritidis: Circulating Strains After the Introduction of the Rotavirus Vaccine (Rotarix^®) in Luanda Province of Angola. 轮状病毒甲肠胃炎：安哥拉罗安达省引入轮状病毒疫苗（Rotarix®）后的流行毒株

IF 3.8 3区医学

Viruses-Basel Pub Date : 2025-06-17 DOI: 10.3390/v17060858

Dikudila G Vita, Cristina Santiso-Bellón, Manuel Lemos, Zoraima Neto, Elsa Fortes-Gabriel, Miguel Brito, Cruz S Sebastião, Jesus Rodriguez-Diaz, Celso Cunha, Claudia Istrate

{"title":"Rotavirus alphagastroenteritidis: Circulating Strains After the Introduction of the Rotavirus Vaccine (Rotarix®) in Luanda Province of Angola.","authors":"Dikudila G Vita, Cristina Santiso-Bellón, Manuel Lemos, Zoraima Neto, Elsa Fortes-Gabriel, Miguel Brito, Cruz S Sebastião, Jesus Rodriguez-Diaz, Celso Cunha, Claudia Istrate","doi":"10.3390/v17060858","DOIUrl":"10.3390/v17060858","url":null,"abstract":"Rotavirus alphagastroenteritidis (R. alphagastroenteritidis) remains the leading cause of pediatric diarrhea. Although Angola introduced Rotarix®, the human monovalent R. alphagastroenteritidis vaccine since 2014 as part of its routine childhood immunization program, no follow-up study has been conducted. The aim of this study was to evaluate the distribution of R. alphagastroenteritidis genotypes among children under five years of age, hospitalized with acute gastroenteritis (AGE), after the introduction of the rotavirus vaccine. To achieve this goal, stool samples collected between 2021 and 2022 from children under 5 years of age diagnosed with AGE at six hospitals in Luanda Province were analyzed. The R. alphagastroenteritidis-antigen immunochromatographic test (SD Bioline™, Abbott, Chicago, IL, USA) was performed, and 121 positive samples were genotyped. Ten samples were randomly selected for further Sanger sequencing. The results showed that the G9P[6] was the most prevalent genotype (17.3%), followed by G9P[8] (16.5%), G2P[4] (14.9%), G3P[6] (13.2%), G8P[6] (11.5%), and less frequently G12P[8] (9.1%), G1P[6] (4.1%), and G1P[8] (2.5%). The genotype combinations G3P[6], G8P[6], and G12P[8] were detected for the first time in Luanda Province. In conclusion, the emergence of new genotype combinations supports the need for continuous surveillance to identify the trend in R. alphagastroenteritidis infection and the emergence of new strains circulating in Luanda Province in the post-vaccination period.","PeriodicalId":49328,"journal":{"name":"Viruses-Basel","volume":"17 6","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12197630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0