Journal of Medical Devices-Transactions of the Asme最新文献_第10页

Using Smartphones for Clinical Assessment in Cervical Spondylotic Myelopathy a Feasibility Study. 使用智能手机进行脊髓型颈椎病临床评估的可行性研究。

IF 0.9 4区医学

Journal of Medical Devices-Transactions of the Asme Pub Date : 2021-12-01 Epub Date: 2021-10-22 DOI: 10.1115/1.4052609

Julien Francisco Zaldivar-Jolissaint, François Lechanoine, Bernard Krummenacher, Rivus Ferreira Arruda, Lukas Bobinski, Emmanuel de Schlichting, John Michael Duff

{"title":"Using Smartphones for Clinical Assessment in Cervical Spondylotic Myelopathy a Feasibility Study.","authors":"Julien Francisco Zaldivar-Jolissaint, François Lechanoine, Bernard Krummenacher, Rivus Ferreira Arruda, Lukas Bobinski, Emmanuel de Schlichting, John Michael Duff","doi":"10.1115/1.4052609","DOIUrl":"https://doi.org/10.1115/1.4052609","url":null,"abstract":"Degenerative cervical myelopathy (DCM) is characterized by a progressive deterioration in spinal cord function. Its evaluation requires subjective clinical examination with wide interobserver variability. Objective quantification of spinal cord function remains imprecise, even though validated myelopathy-grading scales have emerged and are now widely used. We created a Smartphone Application, the N-Outcome App, with the aim of quantifying accurately and reliably spinal cord dysfunction using a 5-minute Test. A patient suffering from DCM was clinically evaluated before surgery, at 3 and 6 months follow-up after surgical decompression of the cervical spinal cord. Standard scores (Nurick grade, modified Japanese Orthopedic Association (mJOA) score) were documented at these time points. A 5-minute motor and proprioceptive performance test aided by a smartphone with the N-outcome App was also performed. Motor performance in rapid alternating movements and finger tapping improved in correlation with improvements in standard grading scale scores. Clinical improvements were seen in maximum reflex acceleration and in Romberg testing which showed less closed/open eyes variation, suggesting pyramidal and proprioceptive function recovery. We demonstrate that using the N-Outcome App as an adjunct to clinical evaluation of compressive myelopathy is feasible and potentially useful. The results correlate with the results of clinical assessment obtained by standard validated myelopathy scores.","PeriodicalId":49305,"journal":{"name":"Journal of Medical Devices-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822463/pdf/med-20-1212_044503.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39621411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Apparatus for In Vivo Knee Laxity Assessment Using High-Speed Stereo Radiography. 高速立体放射摄影在体膝关节松弛度评估装置。

IF 0.9 4区医学

Journal of Medical Devices-Transactions of the Asme Pub Date : 2021-12-01 Epub Date: 2021-09-10 DOI: 10.1115/1.4051834

Thor E Andreassen, Landon D Hamilton, Donald Hume, Sean E Higinbotham, Yashar Behnam, Chadd Clary, Kevin B Shelburne

{"title":"Apparatus for In Vivo Knee Laxity Assessment Using High-Speed Stereo Radiography.","authors":"Thor E Andreassen, Landon D Hamilton, Donald Hume, Sean E Higinbotham, Yashar Behnam, Chadd Clary, Kevin B Shelburne","doi":"10.1115/1.4051834","DOIUrl":"https://doi.org/10.1115/1.4051834","url":null,"abstract":"Computational modeling is of growing importance in orthopedics and biomechanics as a tool to understand differences in pathology and predict outcomes from surgical interventions. However, the computational models of the knee have historically relied on in vitro data to create and calibrate model material properties due to the unavailability of accurate in vivo data. This work demonstrates the design and use of a custom device to quantify anterior-posterior (AP) and internal-external (IE) in vivo knee laxity, with an accuracy similar to existing in vitro methods. The device uses high-speed stereo radiography (HSSR) tracking techniques to accurately measure the resulting displacements of the femur, tibia, and patella bones during knee laxity assessment at multiple loads and knee flexion angles. The accuracy of the knee laxity apparatus was determined by comparing laxity data from two cadaveric specimens between the knee laxity apparatus and an existing in vitro robotic knee joint simulator. The accuracy of the knee laxity apparatus was within 1 mm (0.04 in.) for AP and 2.5 deg for IE. Additionally, two living subjects completed knee laxity testing to confirm the laboratory use of the novel apparatus. This work demonstrates the ability to use custom devices in HSSR to collect accurate data, in vivo, for calibration of computational models.","PeriodicalId":49305,"journal":{"name":"Journal of Medical Devices-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546959/pdf/med-20-1204_041004.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39579787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Preliminary Evaluation of Hydraulic Needle Delivery System for Magnetic Resonance Imaging-Guided Prostate Biopsy Procedures 磁共振成像引导前列腺活检液压针头输送系统的初步评价

IF 0.9 4区医学

Journal of Medical Devices-Transactions of the Asme Pub Date : 2021-12-01 DOI: 10.1115/1.4051610

D. I. Mahcicek, Korel D. Yildirim, Gokce Kasaci, O. Kocaturk

引用次数: 0

Functional Evaluation of a Personalized Orthosis for Knee Osteoarthritis: A Motion Capture Analysis 膝骨关节炎个性化矫形器的功能评估：运动捕捉分析

IF 0.9 4区医学

Journal of Medical Devices-Transactions of the Asme Pub Date : 2021-12-01 DOI: 10.1115/1.4051626

M. Huber, M. Eschbach, K. Kazerounian, H. Ilies

{"title":"Functional Evaluation of a Personalized Orthosis for Knee Osteoarthritis: A Motion Capture Analysis","authors":"M. Huber, M. Eschbach, K. Kazerounian, H. Ilies","doi":"10.1115/1.4051626","DOIUrl":"https://doi.org/10.1115/1.4051626","url":null,"abstract":"\u0000 Orthotic treatments for knee osteoarthritis (OA) typically rely on simple mechanisms such as three-point bending straps and single-pin hinges. These commonly prescribed braces cannot treat bicompartmental knee OA, do not consider the muscle weakness that typically accompanies the condition, and employ hinges that restrict the knee's natural biomechanics. Utilizing a novel, personalized joint mechanism in conjunction with magnetorheological dampers, we have developed and evaluated a brace which attempts to address these shortcomings. This process has respected three principal design goals: reducing the load experienced across the entire knee joint, generating a supportive moment to aid the thigh muscles in shock absorption, and interfering minimally with gait kinematics. Two healthy volunteers were chosen to test the system's basic functionality through gait analysis in a motion capture laboratory. Combining the collected kinematic and force-plate data with data taken from sensors onboard the brace, we integrated the brace and leg system into a single inverse dynamics analysis, from which we were able to evaluate the effect of the brace design on the subjects' knee loads and moments. Of the three design goals: a reduction in knee contact forces was demonstrated; increased shock absorption was observed, but not to statistical significance; and natural gait was largely preserved. Taken in total, the outcome of this study supports additional investigation into the system's clinical effectiveness, and suggests that further refinement of the techniques presented in this paper could open the doors to more effective OA treatment through patient specific braces.","PeriodicalId":49305,"journal":{"name":"Journal of Medical Devices-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41475684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

In Vitro Evaluation of a Nasal Interface Used to Improve Delivery from a Portable Oxygen Concentrator 用于改善便携式氧气浓缩器输送的鼻界面的体外评价

IF 0.9 4区医学

Journal of Medical Devices-Transactions of the Asme Pub Date : 2021-11-24 DOI: 10.1115/1.4053115

C. Christianson, K. Pillay, John Z Chen, W. Finlay, Andrew R. Martin

{"title":"In Vitro Evaluation of a Nasal Interface Used to Improve Delivery from a Portable Oxygen Concentrator","authors":"C. Christianson, K. Pillay, John Z Chen, W. Finlay, Andrew R. Martin","doi":"10.1115/1.4053115","DOIUrl":"https://doi.org/10.1115/1.4053115","url":null,"abstract":"\u0000 Portable oxygen concentrators (POCs) are widely used to administer long-term oxygen therapy (LTOT) and employ pulsed delivery modes to conserve oxygen. Efficient pulsed delivery requires that POCs are triggered by patient inhalation. Triggering is known to fail for some patients during periods of quite breathing, as occurs during sleep. The present article describes a new nasal interface designed to improve triggering of pulsed oxygen delivery from portable oxygen concentrators (POCs). In vitro experiments incorporating realistic nasal airway replicas and simulated breathing were conducted. The pressure monitored via oxygen supply tubing (the signal pressure) was measured over a range of constant inhalation flow rates with the nasal interface inserted into the nares of the nasal airway replicas, and compared with signal pressures measured for standard and flared nasal cannulas. Triggering efficiency and the fraction of inhaled oxygen (FiO2) were then evaluated for the nasal interface and cannulas used with a commercial POC during simulated tidal breathing through the replicas. Higher signal pressures were achieved for the nasal interface than for nasal cannulas at all flow rates studied. The nasal interface triggered pulsed delivery from the POC in cases where nasal cannulas failed to trigger. FiO2 was significantly higher for successful triggering cases than for failed triggering cases. The nasal interface improved triggering of pulsed oxygen delivery from a POC and presents a simple solution that could be used with commercially-available POCs to reliably supply oxygen during periods of quiet breathing.","PeriodicalId":49305,"journal":{"name":"Journal of Medical Devices-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47366711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Designing and Testing a Closed-loop Magnetically Actuated Laser Scanning System for Tissue Ablation 用于组织消融的闭环磁驱动激光扫描系统的设计与测试

IF 0.9 4区医学

Journal of Medical Devices-Transactions of the Asme Pub Date : 2021-11-20 DOI: 10.1115/1.4053073

Hamed Mohammadbagherpoor, Alperen Acemoglu, L. Mattos, D. Caldwell, James J. Johnson, J. Muth, E. Grant

{"title":"Designing and Testing a Closed-loop Magnetically Actuated Laser Scanning System for Tissue Ablation","authors":"Hamed Mohammadbagherpoor, Alperen Acemoglu, L. Mattos, D. Caldwell, James J. Johnson, J. Muth, E. Grant","doi":"10.1115/1.4053073","DOIUrl":"https://doi.org/10.1115/1.4053073","url":null,"abstract":"\u0000 Biomedical robotic systems continue to hold unlimited potential for surgical procedures. Robotized laser endoscopic tools provide surgeons with increased accuracy in the laser ablation of tissue and tumors. The research here catalogs the design and implementation of a new laser endoscopic tool for tissue ablation. A novel feature of this new device is the inclusion of a feedback loop that measures the position of the laser beam via a photo-detector sensor. The scale of this new device was governed by the dimensions of the photo-detector sensor. The tip of the laser's fiber optic cable is controlled by the torque interaction between permanent magnet rings surrounding the fiber optic and the custom designed solenoid coils. Prior to building the physical test-bed the system was modeled and simulated using COMSOL software. In pre-clinical trials, the physical experimental results showed that the designed prototype laser scanner system accurately track different ablation patterns and gives a consistent output position for the laser beam however, the heat diffusion into the tissue around the desired line of the geometric shape would give wider ablation margins than was desirable.","PeriodicalId":49305,"journal":{"name":"Journal of Medical Devices-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42565241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Leaflet Type and Leaflet-Stent Attachment Height on Transcatheter Aortic Valve Leaflet Thrombosis Potential 小叶类型和支架附着高度对经导管主动脉瓣小叶血栓形成电位的影响

IF 0.9 4区医学

Journal of Medical Devices-Transactions of the Asme Pub Date : 2021-11-03 DOI: 10.1115/1.4052902

Beatrice Ncho, Andrew W. Siefert, V. Sadri, Jillian Ortner, A. Yoganathan

{"title":"Effect of Leaflet Type and Leaflet-Stent Attachment Height on Transcatheter Aortic Valve Leaflet Thrombosis Potential","authors":"Beatrice Ncho, Andrew W. Siefert, V. Sadri, Jillian Ortner, A. Yoganathan","doi":"10.1115/1.4052902","DOIUrl":"https://doi.org/10.1115/1.4052902","url":null,"abstract":"\u0000 Transcatheter aortic valve replacement devices vary in leaflet material and in the height for which leaflets attach to the stented valve frame. Combinations of these features can influence leaflet dynamics, neo-sinus geometries, and fluid dynamics, thereby reducing or exacerbating the potential for blood flow stasis and leaflet thrombosis. To investigate these interconnected relationships, this study evaluated the effects of transcatheter valve leaflet type (porcine vs. bovine pericardium) and the leaflet-stent attachment height (low, mid, and high) on flow stasis and potential for leaflet thrombosis. Transcatheter valve models were manufactured and tested within an aortic simulator under pulsatile left heart hemodynamic conditions. Transvalvular hemodynamics, leaflet kinematics, and flow structures were evaluated by direct measurement, high-speed imaging, and two differing techniques of particle image velocimetry. Transcatheter valves with porcine pericardial leaflets were observed to be less stiff, exhibit a lesser resistance to flow, were associated with reduced regions of neo-sinus flow stasis, and superior sinus washout times. More elevated attachments of the leaflets were associated with less neo-sinus flow stasis. These initial results and observations suggest combinations of leaflet type and stent attachment height may reduce transcatheter aortic valve flow stasis and the potential for leaflet thrombosis.","PeriodicalId":49305,"journal":{"name":"Journal of Medical Devices-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45495826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Design and Preliminary Validation of Grasp Assistive Device for an Industrial Environment 工业环境抓取辅助装置的设计与初步验证

IF 0.9 4区医学

Journal of Medical Devices-Transactions of the Asme Pub Date : 2021-11-03 DOI: 10.1115/1.4052899

Daniel Loewen, N. Chandrashekar

{"title":"Design and Preliminary Validation of Grasp Assistive Device for an Industrial Environment","authors":"Daniel Loewen, N. Chandrashekar","doi":"10.1115/1.4052899","DOIUrl":"https://doi.org/10.1115/1.4052899","url":null,"abstract":"\u0000 Carpal tunnel syndrome and tendonitis are two common upper extremity cumulative trauma disorders (CTD) related to repetitive and forceful activities in industrial environments. Reducing the muscular force during activities such as the operation of a pistol grip hand tool could result in lower incidence of CTDs. The objective of this research was to reduce the muscular contribution to the grip force using an active orthosis system. A novel soft, pneumatic grasp assist device, that used a unique design of sinusoidal bellows oriented at 45 degrees, was designed to augment the users' strength during operation of pistol grip hand tool. The optimized design was fabricated using rapid prototyping. Device effectiveness was quantified by measuring muscle activity and grip force during an in vivo study of a common industrial activity. Nine subjects experienced with power tools employed by an automobile manufacturer installed 18 fasteners using a pistol grip DC tool with and without the grasp assist device. Surface electromyography (sEMG) was used to measure the activity of four muscles commonly associated with grasping. Results showed that the grasp assist significantly reduced the mean, combined, normalized muscle activity by 18% (p<0.05). Muscle activation results were contextualized using the revised strain index (RSI). The grasp assist device trial yielded a significantly lower mean RSI value than the typical trial by 13% (p<0.05). The study showed that using an active grasp assist orthosis could reduce the incidence of CTDs in able bodied industrial workers using DC hand tools.","PeriodicalId":49305,"journal":{"name":"Journal of Medical Devices-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48043745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PEGASOS - A New Linking Mechanism for Modular Osteosynthesis Plates in Minimally Invasive Acetabular Surgery PEGASOS-微创髋臼手术中模块化接骨板的新型连接机制

IF 0.9 4区医学

Journal of Medical Devices-Transactions of the Asme Pub Date : 2021-10-19 DOI: 10.1115/1.4052786

A. Trulson, M. Küper, Artur Leis, U. Stöckle, F. Stuby, M. Hossfeld

{"title":"PEGASOS - A New Linking Mechanism for Modular Osteosynthesis Plates in Minimally Invasive Acetabular Surgery","authors":"A. Trulson, M. Küper, Artur Leis, U. Stöckle, F. Stuby, M. Hossfeld","doi":"10.1115/1.4052786","DOIUrl":"https://doi.org/10.1115/1.4052786","url":null,"abstract":"\u0000 Background: Recently presented minimally invasive endoscopic surgical techniques demonstrated the feasibility of implanting standard osteosynthesis plates for pelvic fractures. The reconstruction and internal fixation of complex acetabular fractures is still challenging. The goal of this study is to introduce a divisible implant, with a positive-locking in situ linking mechanism for plate osteosynthesis, making it possible to stabilize large and complex acetabular fractures with involvement of the quadrilateral surface.\u0000 Method: Standard implants were used to recreate a base design. Using computer aided design (CAD), a three-dimensional standard implant was divided into two parts, so they could be re-allocated in situ. A critical objective was to reduce the cross-section of each part (clearance gauge). To connect the separated parts in situ, a new linking mechanism (cone in cone) was created. The new construct also features self-stabilization, self-centering, reinforced positional movement and preloading effects.\u0000 Results: A linking system for plate osteosynthesis was developed entitled PEGASOS (\"Percutaneous Endoscopic Guided Acetabulum-Stabilizing Osteosynthesis System\"). Endoscopic implantation and in-situ-linking could be performed in a human cadaver. Therefore, we could demonstrate, that buttressing the quadrilateral surface of the acetabulum could be performed minimally invasive using a divisible suprapectineal buttress plate.\u0000 Conclusion: We created a linking mechanism to couple two plates in situ. This mechanism enables an extremely strong, positive-locking connection, whereas its geometric shape allows for different relative movements during the locking procedure, with a single screw.","PeriodicalId":49305,"journal":{"name":"Journal of Medical Devices-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44109426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Performance Evaluation of a Hybrid Hand Exoskeleton for Hand Opening/Closing 一种用于手打开/关闭的混合手外骨骼的设计和性能评估

IF 0.9 4区医学

Journal of Medical Devices-Transactions of the Asme Pub Date : 2021-10-13 DOI: 10.1115/1.4052448

M. A. Gull, S. Bai, J. Blicher, Tobias Glaston Staermose

{"title":"Design and Performance Evaluation of a Hybrid Hand Exoskeleton for Hand Opening/Closing","authors":"M. A. Gull, S. Bai, J. Blicher, Tobias Glaston Staermose","doi":"10.1115/1.4052448","DOIUrl":"https://doi.org/10.1115/1.4052448","url":null,"abstract":"\u0000 Finger extensor muscle weakness and flexor hypertonia are the most commonly reported issues among patients suffering from amyotrophic lateral sclerosis (ALS). Moreover, the relative hyperflexion of the wrist and fingers has limited their ability to voluntarily open the hand and interact with the external environment. In this work, a hybrid hand exoskeleton is developed to prevent the relative hyperflexion of the fingers and wrist and facilitate the users in their functional hand opening by compensating the flexor hypertonia. This exoskeleton, combining a passive device with the soft extra muscle (SEM) glove, assists users in normal hand opening/closing required for some basic activities of daily living. The paper presents kinematic and static models of passive hand exoskeleton design. Moreover, the proposed design is tested and evaluated by comparing the volunteer hand opening with the exoskeleton assistance using the flex sensors attached on the dorsal side of the middle finger, ring finger, and thumb with both healthy subjects and patients. The results show the effectiveness of using the hybrid exoskeleton in improving anatomical hand opening/closing capabilities.","PeriodicalId":49305,"journal":{"name":"Journal of Medical Devices-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46779063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2