血管模拟用凝胶材料的力学性能和光弹性性能研究

IF 0.8 4区医学 Q4 ENGINEERING, BIOMEDICAL

Journal of Medical Devices-Transactions of the Asme Pub Date : 2021-09-01 DOI:10.1115/1.4051516

Daichi Yamada, Simon Hori, Shuhei Abe, Yuki Kumeno, T. Yamazaki, C. Oka, J. Sakurai, S. Hata

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引用次数: 1

摘要

导管手术是一种微创治疗，其中视觉信息仅限于x射线相机生成的二维图像。这导致导管施加在血管壁上的压力可能会损坏血管。因此，医生必须精通导管手术。我们提出了一种导管手术模拟器，可以利用光弹性来可视化施加在血管壁上的应力。制造这个模拟器需要创造血管模拟物，利用光弹性再现血管组织的物理特性。本研究考察了凝胶材料的力学和光弹性性能，并选择了一种适合制作血管模拟物的凝胶组合物。通过改变组成比，聚乙烯醇(PVA)水凝胶的力学性能在70 ~ 335 kPa范围内发生变化;通过改变组成比，双网(DN)凝胶的力学性能在0.13 ~ 1.06 MPa范围内变化。这些凝胶可以通过改变材料成分来调节，以提供类似于血管的杨氏模量。通过改变组成比，PVA水凝胶的光弹性变化范围为1.38 ~ 2.76 × 10−9/Pa;通过改变组成比，DN凝胶的光弹性变化范围为0.012 ~ 0.029 × 10−9/Pa。

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Examination of Mechanical Properties and Photoelastic Properties of Gel Material for Blood Vesssel Mimics

Catheter surgery is a minimally invasive treatment in which visual information is limited to a two-dimensional image generated by an X-ray camera. This results in the possibility that stress applied by the catheter onto a blood vessel wall damages the vessel. Doctors must therefore be skillful at catheter surgery. We proposed a catheter surgery simulator that visualizes the stress applied to the blood vessel wall using photoelasticity. The manufacture of this simulator requires creating blood vessel mimics that reproduce the physical properties of blood vessel tissue using photoelasticity. This study investigated the mechanical and photoelastic properties of gel materials and selected a gel composition suitable for making blood vessel mimics. The mechanical properties of polyvinyl alcohol (PVA) hydrogel changed in the range 70–335 kPa by changing the composition ratio, and double network (DN) gel changed in the range 0.13–1.06 MPa by changing the composition ratio. These gels could be adjusted by changing the material composition to provide Young's moduli similar to that of blood vessels. The photoelastic properties of PVA hydrogel changed in the range 1.38–2.76 × 10−9/Pa by changing the composition ratio, and DN gel changed in the range 0.012–0.029 × 10−9/Pa by changing the composition ratio.

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来源期刊

Journal of Medical Devices-Transactions of the Asme ENGINEERING, BIOMEDICAL-

CiteScore

1.80

自引率

11.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Medical Devices presents papers on medical devices that improve diagnostic, interventional and therapeutic treatments focusing on applied research and the development of new medical devices or instrumentation. It provides special coverage of novel devices that allow new surgical strategies, new methods of drug delivery, or possible reductions in the complexity, cost, or adverse results of health care. The Design Innovation category features papers focusing on novel devices, including papers with limited clinical or engineering results. The Medical Device News section provides coverage of advances, trends, and events.