Clinical Neuroradiology最新文献

{"title":"Impact of Stenting with Angioplasty and MTICI 2c-3 Recanalization On Outcome in Acute MCA Occlusion with Underlying Stenosis.","authors":"Andrea Maria Alexandre, Arturo Consoli, Luca Scarcia, Enrico Di Stasio, Valerio Brunetti, Wen Sun, Yingjie Xu, Xianjun Huang, Charlotte Chung, Alessandro Sgreccia, Mohamad Abdalkader, Nicola Limbucci, Alessandro Pedicelli, Francesco Capasso, Francesco Arba, Ludovica Migliaccio, Mariangela Piano, Maria Porzia Ganimede, Emilio Lozupone, Chiara Gaudino, Francesca Ricchetti, Riccardo Russo, Julien Burel, Francesco D'Argento, Serena Abruzzese, Julien Allard, Nicolas Chausson, Roberta Partesano, Nicola Cavasin, Nicolò Mandruzzato, Joseph Domenico Gabrieli, Pietro Trombatore, Antonio Armando Caragliano, Federico Mazzacane, Giancarlo Salsano, Antioco Sanna, Pietro Panni, Andrea Zini, Frédéric Clarençon, Eytan Raz, Thanh Nguyen, Aldobrando Broccolini","doi":"10.1007/s00062-025-01577-6","DOIUrl":"10.1007/s00062-025-01577-6","url":null,"abstract":"<p><strong>Purpose: </strong>Mechanical thrombectomy (MT) is standard care for acute large vessel occlusion (LVO), but it fails in 10-20% of cases, often due to underlying intracranial artery stenosis (ICAS). In such cases, rescue stenting (RS), with or without angioplasty, may improve recanalization, but its clinical benefit remains debated. The purpose of this study was to define predictors of clinical outcome in this patient population.</p><p><strong>Methods: </strong>We conducted a retrospective multicenter study including 115 patients with ICAS-related occlusion of the middle cerebral artery (MCA) treated with MT and RS across 27 international stroke centers. Baseline, procedural, and post-procedural variables were analyzed. The outcome measure was the ordinal shift of the 90-day modified Rankin Scale (mRS) score. Stepwise multivariate regression and structural equation modeling (SEM) were used to identify outcome predictors and explore mediation pathways.</p><p><strong>Results: </strong>Successful recanalization (modified Treatment in Cerebral Infarction (mTICI) score ≥ 2b) was achieved in 94.8% of patients, with 73.0% reaching mTICI 2c‑3. SEM showed that baseline Alberta Stroke Program Early CT Score (ASPECTS), stenting with angioplasty and achieving mTICI 2c‑3 were associated with improved functional outcome, mediated by higher post-procedural ASPECTS. Post-procedural ASPECTS influenced functional outcome both directly (estimate = -0.45, p < 0.001) and indirectly by reducing the occurrence of symptomatic intracranial hemorrhage (sICH) (estimate = -0.09, p = 0.004). This model explained 36.5% of the variance in 90-day mRS scores.</p><p><strong>Conclusion: </strong>In patients with acute ICAS-related MCA occlusion, stenting with angioplasty and achieving mTICI 2c-3 recanalization are associated with improved clinical outcome. These benefits are mediated by better post-procedural ASPECTS and reduced sICH. Prospective studies are warranted to confirm these findings.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"329-337"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General Versus Non-General Anesthesia in Endovascular Thrombectomy for Distal/Medium Vessel Occlusions: A Systematic Review and Meta-Analysis.","authors":"Luiz Guilherme Silva Almeida, Ocílio Ribeiro Gonçalves, Mariana Lee Han, Yasmin Picanço Silva, Lucca Tamara Alves Carretta, Marcelo Costa, Paweł Łajczak, Luiz Felipe Simões Antunes Nery Dos Santos, Rafael Torres Fonseca Dos Santos, Ahmet Günkan, Pascal Jabbour","doi":"10.1007/s00062-025-01592-7","DOIUrl":"10.1007/s00062-025-01592-7","url":null,"abstract":"<p><strong>Purpose: </strong>With the expanding use of endovascular thrombectomy (EVT) for distal and medium vessel occlusions (DMVOs), evaluating how anesthesia type affects clinical outcomes is essential. This meta-analysis compared outcomes between general anesthesia (GA) and non-GA in patients undergoing EVT for DMVOs.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase, Cochrane Library, and Web of Science for eligible studies. Primary outcomes included successful reperfusion, 90-day mortality, excellent functional outcome (Modified Rankin Scale [mRS] 0-1), and symptomatic intracranial hemorrhage (sICH). Risk ratios (RR) with 95% confidence intervals (CI) were calculated using the Mantel-Haenszel method and a random-effects model. Heterogeneity was assessed with I² and Cochran's Q test.</p><p><strong>Results: </strong>Five studies comprising 1643 patients were included. There was no significant difference in successful reperfusion between GA and non-GA groups (RR 1.01; 95% CI 0.94-1.08; I² = 32.3%). However, GA was associated with significantly higher 90-day mortality (RR 1.55; 95% CI 1.23-1.96; I² = 0%). Excellent functional outcomes (mRS 0-1 at 90 days) were similar between groups (RR 0.92; 95% CI 0.78-1.10; I² = 24.2%). No statistically significant difference in sICH was observed between the GA and non-GA groups (RR 2.61; 95% CI 0.99-6.86; I² = 40.8%). However, the leave-one-out analysis revealed a significant association indicating a higher risk of sICH with GA (RR 3.88; 95% CI 1.79-8.41; I² = 0%).</p><p><strong>Conclusion: </strong>GA was linked to increased 90-day mortality in EVT for DMVOs, with no differences in reperfusion or functional recovery. A possible higher risk of sICH was noted. Further prospective studies are needed to guide anesthetic strategy.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"273-284"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145606798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arteriopathic Effects of Hypertension by Signal Intensity Gradient from Time-of-Flight Magnetic Resonance Angiography.","authors":"Chan-Hyuk Lee, Seul-Ki Jeong, Hyun Jin Kim, Robert S Rosenson, Wookjin Yang, Keun-Hwa Jung","doi":"10.1007/s00062-025-01594-5","DOIUrl":"10.1007/s00062-025-01594-5","url":null,"abstract":"<p><strong>Purpose: </strong>Hypertension is the most prevalent RF for cerebrovascular disease (CVD). Although previous studies have employed ultrasonography and phase-contrast magnetic resonance image (MRI) to assess cerebral hemodynamics, the quantitative impact of hypertension on cerebral arterial flow characteristics remains incompletely understood. This study focused on the relationship between hypertension, other risk factors (RF), and arterial velocity gradient using the signal intensity gradient (SIG) from time-of-flight magnetic resonance angiography (TOF-MRA).</p><p><strong>Methods: </strong>This cross-sectional study included individuals who underwent health screening at our institution between January 2015 and June 2021. Participants with no history of CVD who underwent intracranial TOF-MRA were included. Arterial wall SIGs was measured in the cerebral arteries. Participants were categorized into four groups according to vascular RFs: none (no RF), other RFs (RFs except hypertension), hypertension-only, and hypertension-plus (hypertension with other RFs).</p><p><strong>Results: </strong>A total of 1154 healthy subjects (mean age 63.2 ± 9.5 years, 43.2% women) were enrolled. The hypertension-plus group had the highest systolic (125.3 ± 19.1 mm Hg) and diastolic (74.7 ± 10.5 mm Hg) blood pressures, HbA1c (6.1 ± 0.7%), intima-media thickness (0.86 ± 0.24 mm), and the highest rates of intracranial artery stenosis (14.4%) and chronic kidney disease (6.1%). The hypertension-plus group showed the lowest SIG values among all cerebral arteries. After adjusting for confounding factors, the hypertension-plus group showed significantly lower SIG values in the intracranial arteries but not in the extracranial arteries.</p><p><strong>Conclusion: </strong>The arterial wall SIG was significantly associated with hypertension and other vascular RFs. SIG may offer quantitative information on the arteriopathic effects of hypertension, especially intracranial cerebral arteries.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"423-430"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Through-&-Through Technique: A Safe Bailout Access Route for Difficult Aortic Arch Anatomy During Thrombectomy.","authors":"Johan Wasselius, Emma Hall, Lovisa Sandell, Alex Szolics, Björn Hansen","doi":"10.1007/s00062-025-01612-6","DOIUrl":"10.1007/s00062-025-01612-6","url":null,"abstract":"","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"785-789"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Patient Dose and Exposure Time Across Various Techniques Used to Treat Intracranial Aneurysms : Analysis of the German Neurointerventional Database (DeGIR/DGNR) from 2018 to 2023.","authors":"Constantin Schareck, Caroline Florack, Roland Schwab, Erelle Fuchs, Peter Schramm","doi":"10.1007/s00062-025-01584-7","DOIUrl":"10.1007/s00062-025-01584-7","url":null,"abstract":"<p><strong>Purpose: </strong>The national diagnostic reference level (DRL) for intracranial aneurysm therapy is set at 20,000 cGy cm² for the patient. An adjustment between the expected dosage and exposure time requirement among a variety of applicable techniques is not commonly provided. Therefore patient dose and exposure times were analyzed when using the following techinques; dosimetric data of coils (CE), flow diverter (FD), stent-assisted coiling (SAC), intra-aneurysmatic flow diverter (IaFD), balloon-assisted coiling (BAC), flow diverter assisted coiling (FDAC), IaFD-assisted coiling (IaFDAC), x, y or t‑remodeling stent-assisted coiling (xyt-SAC), and stent-assisted IaFD (SAIaFD).</p><p><strong>Methods: </strong>A retrospective analysis of the German DeGIR-QS registry was conducted between 2018 and 2023. This study aimed to investigate the median dose-area product and exposure time for each technique, aneurysm location, type and size. The goal was to ascertain which technique is the most time- and dose-efficient.</p><p><strong>Results: </strong>FD (84.13%/79.41%) and IaFD (89.64%/73.53%) exhibited superior performance in terms of both effectiveness and efficiency when compared to CE (100% dose-area product/100% exposure time). However, certain aneurysm types and location combinations resulted in lower dose-area product and exposure time when CE was used rather than IaFD or FD. A comparison of the median dose-area product technique with the DRL reveals that all of the aforementioned procedures fall below this value. Aneurysm size has little impact on the finding that FD and IaFD are more efficient in terms of dose and time consumption than CE.</p><p><strong>Conclusion: </strong>Patients' exposure can be reduced by selecting a technique associated with lower exposure levels, depending on the aneurysm's location and type. However, conformity is provided for all techniques mentioned.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"439-449"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT-guided Lumbar Puncture for Intrathecal Nusinersen Injection in Patients with Spinal Muscular Atrophy: Technical Effectiveness, Safety, and Radiation Dose.","authors":"Yannick Laurent Thal, Marcel Opitz, Raya Ocker-Serger, Laura Valentina Klüner, Daniel Rosok, Marcel Alexander Drews, Denise Bos, Johannes Haubold, Christoph Kleinschnitz, Tim Hagenacker, Michael Forsting, Cornelius Deuschl, Sebastian Zensen","doi":"10.1007/s00062-025-01590-9","DOIUrl":"10.1007/s00062-025-01590-9","url":null,"abstract":"<p><strong>Purpose: </strong>Spinal muscular atrophy (SMA) is a rare neuromuscular disease treated with intrathecal nusinersen. In patients with complex spinal anatomy or spinal instrumentation, repeated lumbar punctures can be challenging. This study evaluated the feasibility, safety, and radiation exposure of CT-guided nusinersen administration in SMA.</p><p><strong>Methods: </strong>In this retrospective single-center study, 458 CT-guided nusinersen injections in 44 SMA patients (October 2017-August 2024) were analyzed. Technical success, complications, procedure and puncture times, and radiation exposure were compared between subgroups. Procedures were performed in prone, lateral, or combined (oblique) positions depending on anatomy.</p><p><strong>Results: </strong>Technical success was 98.3% (449/458). Rates were slightly lower in patients with dorsal spondylodesis (97.1% vs. 98.8%). Complications occurred in 1.1% (5/458), including transient pain and two hematomas. Spondylodesis was associated with longer puncture (11.9 vs. 10.3 min) and procedure durations (16.3 vs. 14.0 min) and higher radiation doses (effective dose 2.22 vs. 1.74 mSv; all p < 0.01). Failed or complicated procedures showed prolonged durations and higher exposure. Needle repositioning correlated with duration and dose.</p><p><strong>Conclusion: </strong>CT-guided lumbar puncture for intrathecal nusinersen injection is a safe and effective technique, even in complex spinal anatomy. Dorsal spondylodesis increases procedural complexity. Tailored puncture level selection, optimized positioning, and dose-reduction strategies are essential for high success rates and minimal radiation. While CT guidance ensures excellent anatomical visualization, fluoroscopy may reduce radiation and procedure time; future comparative studies should define optimal modality selection.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"401-410"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145606325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anesthesia Modality in Intracranial Stenting for Acute Stroke-A Sub-Analysis of the RESISTANT International Registry.","authors":"João André Sousa, Marta Olivé-Gadea, Francesco Diana, Johannes Kaesmacher, Adnan Mujanovic, Serdar Geyik, Songul Senadim, Amedeo Cervo, Andrea Salcuni, Mariangela Piano, Manuel Moreu, Alfonso López-Frías, Ameer Hassan, Samantha Miller, Elena Zapata-Arriaza, Asier de Albóniga-Chindurza, Mauro Bergui, Stefano Molinaro, Fabio Gomes, Joao Sargento-Freitas, Andrea Alexandre, Alessandro Pedicelli, Jeremy Hofmeister, Paolo Machi, Luca Scarcia, Erwah Kalsoum, Jose Amorim, Torcato Meira, Santiago Ortega Gutierrez, Aaron Rodriguez-Calienes, Leonardo Renieri, Francesco Capasso, Daniele Romano, Eduardo Bárcena-Ruiz, David Seoane, Mohamad Abdalkader, Piers Klein, Thanh N Nguyen, Catarina Perry, Isabel Fragata, Dileep Yavagal, Jude Charles, Jose Rodriguez Castro, Pedro Vega, Atilla Özcan Özdemir, Zehra Uysal Kocabaş, Stanislas Smajda, Sadiq Al Salman, Jane Khalife, Tudor Jovin, Francesco Biraschi, Francesca Ricchetti, Pedro Castro, Luis Albuquerque, Adnan Siddiqui, Vinay Jaikumar, Pedro Navia, Nikos Ntoulias, Marios Psychogios, Mariano Velo, Joaquin Zamarro, Gonzalo De Paco, Yazan Ashouri, Mohammad AlMajali, Juan F Arenillas, Alicia Sierra, Michele Romoli, João Pedro Marto, Shadi Yaghi, Marc Ribo, Alejandro Tomasello, Manuel Requena","doi":"10.1007/s00062-026-01619-7","DOIUrl":"10.1007/s00062-026-01619-7","url":null,"abstract":"<p><strong>Purpose: </strong>The optimal anesthetic approach for intracranial stenting in acute stroke remains unclear. We compared outcomes of patients under general anesthesia (GA) versus local anesthesia or conscious sedation.</p><p><strong>Methods: </strong>The RESISTANT registry is a multicenter observational study on acute intracranial stenting during thrombectomy. Patients treated between January 2016 and June 2023 were included and stratified into GA and local anestesia/conscious sedation groups. The primary outcome was an adjusted shift analysis of the modified Rankin Scale (mRS) at 90 days. Secondary outcomes included mRS 0-2 at 90 days and final modified Thrombolysis in Cerebral Infarction (mTICI) 2c/3 scores. Safety outcomes were symptomatic intracranial hemorrhage (sICH) and mortality. Adjusted ordinal and logistic regression with mixed-effects models were performed.</p><p><strong>Results: </strong>Of 876 patients, 445 (50.8%) received GA. Median age was 67 years [59-77]; 567 (64.8%) were men. No differences were found in 90-day mRS (adjusted common OR = 1.256 [0.887-1.780], p = 0.199). Rates of functional independence (39.0% vs 44.5%; aOR = 0.956 [0.606-1.507], p = 0.846), mTICI 2c/3 (68.9% vs 68.7%; aOR = 0.941 [0.602-1.471], p = 0.790), and sICH (8.0% vs 8.6%; aOR = 0.769 [0.374-1.584], p = 0.477) were comparable. In-hospital (23.0% vs 12.0%; aOR = 2.39 [1.35-4.22], p = 0.003) and 90-day mortality (33.3% vs 21.1%; aOR = 2.017 [1.227-3.315], p = 0.006) were higher in the GA group.</p><p><strong>Conclusion: </strong>In patients undergoing intracranial stenting during thrombectomy, anesthesia modality was not associated with better outcomes. GA was linked to higher mortality, likely due to indication bias.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"635-645"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular Treatment of Hydrocephalus: A Systematic Literature Review.","authors":"Olga Ciobanu-Caraus, Philip Heesen, Nicolin Hainc, Markus A Möhlenbruch, Martin Bendszus","doi":"10.1007/s00062-026-01614-y","DOIUrl":"10.1007/s00062-026-01614-y","url":null,"abstract":"<p><strong>Introduction: </strong>Hydrocephalus is traditionally managed with ventriculoperitoneal shunting (VPS), which is associated with high rates of infection, mechanical failure, and surgical revisions. Recent innovations in endovascular techniques have led to the development of minimally invasive cerebrospinal fluid (CSF) diversion techniques. This literature review systematically examines the development, procedural techniques, efficacy, and safety profile of endovascular treatments for communicating hydrocephalus.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed/MEDLINE, Embase, Scopus and clinicaltrials.gov from inception until March 15, 2025, following the PRISMA guidelines (PROSPERO registration number: CRD420251012455). Two reviewers independently screened and extracted data. Results are summarized descriptively.</p><p><strong>Results: </strong>Of 5319 records identified, 16 studies were included. Of those, six were published as original articles and 10 as conference abstracts. Overall, two technical reports of endovascular treatment of hydrocephalus were found: eShunt® (n = 14 studies) and choroidal artery embolization (n = 1 studies). Outcome data are available for 70 patients treated with the eShunt®. In patients with idiopathic normal pressure hydrocephalus treated with eShunt® implantation, the Timed Up and Go test improved by 35.7%, Montreal Cognitive Assessment scores by +1.6 points, and neurogenic bladder symptom scores by -3.6s at one year. No device-related serious adverse events were reported.</p><p><strong>Discussion: </strong>Endovascular CSF diversion represents an emerging, minimally invasive alternative to traditional shunting techniques for communicating hydrocephalus. While early results demonstrate technical feasibility and encouraging safety profiles, long-term data from ongoing clinical trials are critical to establish its role in standard neurosurgical and neurointerventional practice.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"309-320"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unique Imaging Characteristics in Anti-GABA-A Receptor Encephalitis: A Case Report.","authors":"Ekdanai Uawithya, Jiraporn Jitprapaikulsan","doi":"10.1007/s00062-025-01581-w","DOIUrl":"10.1007/s00062-025-01581-w","url":null,"abstract":"","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"775-778"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Learning Reconstruction of Diffusion-weighted MRI Enables Shorter Examination Times While Maintaining Image Quality in Head and Neck Imaging.","authors":"Haidara Almansour, Jan Michael Brendel, Christoph Neatu, Sebastian Gassenmaier, Judith Herrmann, Sebastian Werner, Vitali Koch, Omar Darwich, Elisabeth Weiland, Thomas Benkert, Sebastian Altmann, Andrea Kronfeld, Ahmed E Othman, Konstantin Nikolaou, Saif Afat","doi":"10.1007/s00062-025-01604-6","DOIUrl":"10.1007/s00062-025-01604-6","url":null,"abstract":"<p><strong>Rationale and objectives: </strong>Diffusion-weighted imaging (DWI) of the head and neck is essential for various clinical applications but is often hampered by artifacts and reduced image quality. Deep learning (DL) reconstruction has the potential to enhance the quality of head and neck DWI. This study aims to evaluate the performance of an accelerated, DL-reconstructed DWI (DWI_DL) in terms of image quality and diagnostic confidence.</p><p><strong>Materials and methods: </strong>This retrospective study included patients who underwent clinically indicated head and neck DWI at 1.5 T and 3 T between August 2023 and January 2024 at a tertiary care center. Imaging was performed at low b‑values (0 or 50 sec/mm²) and high b‑values (800 sec/mm²), and apparent diffusion coefficient (ADC) maps were computed. After acquiring standard single-shot echoplanar imaging DWI sequences, the raw MR datasets underwent simulated acceleration by reducing the number of signal averages. These accelerated exams were then reconstructed using a novel DL-based algorithm that combined DL-based k‑space to image reconstruction with DL-based super-resolution processing (DWI_DL). Three readers analyzed the images using a visual Likert score to evaluate image sharpness, artifacts, noise, overall image quality, and diagnostic confidence. Comparisons were made using the Wilcoxon signed-rank test. A quantitative analysis of signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and apparent diffusion coefficient values (ADC) was also performed.</p><p><strong>Results: </strong>The study included 30 patients (mean age, 55 ± 19 years; range, 24-84; 18 men) with various pathologies. Scan times were reduced by 67% at 1.5 T and up to 55% at 3 T. The quantitative analysis revealed a minimal but statistically significant decrease in SNR and CNR in the deep learning-reconstructed images (p = 0.002 and p < 0.001, respectively). However, readers reported no significant differences between DWI and DWI_DL regarding image quality parameters or diagnostic confidence for both low and high b‑value images, as well as the ADC (all p > 0.05).</p><p><strong>Conclusion: </strong>DL reconstruction of head and neck DWI is feasible, significantly reducing examination time without compromising image quality or diagnostic confidence. This technique enables accelerated and effective diagnostic DWI of the head and neck.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"523-533"},"PeriodicalIF":3.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}