Clinical Neuroradiology最新文献

{"title":"Microstructural Characteristics of Cervical Spinal Cord Using High Angular Resolution Diffusion Imaging (HARDI) and Tractography in Healthy Subjects.","authors":"Corentin Dauleac, Amine Boukhari, Timothée Jacquesson, Carole Frindel, François Cotton","doi":"10.1007/s00062-024-01481-5","DOIUrl":"10.1007/s00062-024-01481-5","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to characterize spinal cord microstructure in healthy subjects using high angular resolution diffusion imaging (HARDI) and tractography.</p><p><strong>Methods: </strong>Forty-nine healthy subjects (18-50 years, divided into 2 age groups) were included in a prospective study. HARDI of the cervical spinal cord were acquired using a 3T MRI scanner with: 64 directions, b‑value: 1000s/mm², reduced field-of-view (zonally magnified oblique multi-slice), and opposed phase-encoding directions. Distortions were corrected using the FSL software package. Fiber tracking was performed using a deterministic approach with DSI-Studio software. Tensor metrics-fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD)-and tractography statistics were then extracted, at each spine level, and after grey-white matter segmentation.</p><p><strong>Results: </strong>The microstructural organization of the spinal cord differed between upper and lower cervical spine levels: FA, and AD significantly decreased (p < 0.001); and RD significantly increased (p < 0.05) in lower levels, demonstrating changes in axonal density and myelinated fibers according to a cranio-caudal axis. FA, MD, AD, and RD values were significantly higher in spinal cord white matter (p < 0.0001), compared to grey matter. Age was not associated with a significant change in FA, while there is for MD, AD and RD (p < 0.05). Spinal cord tractography may provide information on the architectural organization of fibers and spinal tracts.</p><p><strong>Conclusion: </strong>This study proposes a database in cervical spinal cord HARDI, allowing to study the microstructural organization of the spinal cord in healthy subjects, and providing a foundation for comparison with patients presenting spinal cord pathologies.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"315-324"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epstein-Barr Virus Encephalitis Mimicking Herpes Encephalitis On Neuroimaging: A Case Report.","authors":"Negin Eissazade, Mahsa Peykani, Mostafa Almasi-Dooghaee","doi":"10.1007/s00062-024-01485-1","DOIUrl":"10.1007/s00062-024-01485-1","url":null,"abstract":"","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"413-415"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Intracranial Aneurysms with the FRED X Flow Diverter Stent: Mid-term Angiographic and Safety Results.","authors":"David W Wen, James Ayre, Mani Puthuran, Paul Maliakal, Souhyb Masri, Richard Pullicino, Aubrey Smith, Feyi Babatola, Gilbert Gravino, Nasr Abdelsalam, Hamed Nejadhamzeeigilani, Arun Chandran","doi":"10.1007/s00062-024-01487-z","DOIUrl":"10.1007/s00062-024-01487-z","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of our study was to assess the mid-term efficacy and safety of the FRED X flow diverting stent (FDS) in the treatment of intracranial aneurysms. The FRED X FDS is relatively new with limited data on its longer-term effectiveness and safety profile.</p><p><strong>Methods: </strong>Patients with intracranial aneurysms treated with the FRED X FDS at two UK centres, between March 2021 and July 2022 with at least 18 months follow-up, were retrospectively reviewed. Clinical, procedural and imaging data was analyzed.</p><p><strong>Results: </strong>Twenty-two patients with 24 aneurysms treated with the FRED X device, and had completed at least 18 months of follow-up, were included in this study. The rate of complete aneurysm occlusion (Raymond-Roy Class I) was 83.3% at a mean follow-up duration of 21.5 months. One case of major adverse event (4.3%) related to a post-procedural stroke which is also the only case of permanent neurological deficit (4.3%) in our cohort. Three cases of minor adverse events (13.0%) and 2 cases of asymptomatic adverse events (8.7%) were also recorded.</p><p><strong>Conclusion: </strong>Use of the FRED X FDS to treat intracranial aneurysms has acceptable safety profile and efficacy in the mid-term.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"379-384"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperdense Middle Cerebral Artery Sign as a Predictor of First-Pass Recanalization and Favorable Outcomes in Direct Thrombectomy Patients.","authors":"Yiyang Sun, Dapeng Sun, Baixue Jia, Xiaochuan Huo, Xu Tong, Anxin Wang, Ning Ma, Feng Gao, Dapeng Mo, Zhongrong Miao","doi":"10.1007/s00062-024-01484-2","DOIUrl":"10.1007/s00062-024-01484-2","url":null,"abstract":"<p><strong>Background: </strong>The Hyperdense Middle Cerebral Artery Sign (HMCAS) is an early marker of acute MCA occlusion on non-contrast CT (NCCT), which has been linked with stroke type and thrombus composition.</p><p><strong>Aims: </strong>To assess the prognostic value of HMCAS in M1 occlusion patients treated with endovascular thrombectomy and explore its predictive value across different patients.</p><p><strong>Methods: </strong>Patients with M1 occlusion were selected from the ANGEL-ACT registry, which comprised 1793 individuals. Cohorts were divided based on the presence of HMCAS. The primary outcome was functional independence (mRS 0-2) at 90 days. Secondary outcomes included excellent outcome (mRS 0-1), good functional outcome (mRS 0-3), modified first pass effect (mFPE), successful recanalization, intracranial hemorrhage, and 90-day mortality. Propensity score matching (PSM) was employed to adjust for confounders, with 96 patients in each matched group. Subgroup analysis was performed to determine whether the effect of HMCAS on clinical outcomes differed between groups.</p><p><strong>Results: </strong>Among 714 acute M1 occlusion patients, 96 (13.4%) had HMCAS. PSM analysis showed that HMCAS was independently associated with mFPE (OR: 1.97, 95% CI: 1.04-3.75, p = 0.038) but had no significant effects on other clinical outcomes. There was a significant association between HMCAS and functional independence for patients who underwent direct thrombectomy but not for patients who underwent bridging therapy (P for interaction = 0.033).</p><p><strong>Conclusion: </strong>This study indicates that in patients with acute M1 occlusion undergoing EVT, HMCAS on pretreatment NCCT is not significantly associated with functional independence but is linked to a higher first-pass recanalization rate. Its clinical impact on outcomes depends on whether intravenous thrombolysis is administered before thrombectomy.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"325-336"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Favourable Clinical Outcomes in Idiopathic Intracranial Hypertension with Venous Sinus Stenosis Stenting.","authors":"Jie He, Hongchao Yang, Raynald, Xu Tong, Yilong Wang, Zhongrong Miao, Dapeng Mo","doi":"10.1007/s00062-024-01477-1","DOIUrl":"10.1007/s00062-024-01477-1","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the factors influencing favourable clinical outcomes in idiopathic intracranial hypertension (IIH) patients with venous sinus stenosis (VSS) who received stenting treatment.</p><p><strong>Methods: </strong>In this prospective cohort study, we analyzed a total of 172 IIH patients with VSS treated with venous sinus stenting. Clinical outcomes were categorized as either \"complete resolved\" or \"improved\". We employed multivariable logistic regression modeling to identify independent factors associated with the clinical outcomes. The predictive accuracy of the model was assessed using receiver operating characteristic (ROC) analysis.</p><p><strong>Results: </strong>Out of the total cohort, 126 patients exhibited asymptomatic clinical outcomes, while 46 patients showed improved clinical outcomes. Patients with asymptomatic clinical outcomes demonstrated notably lower preoperative BMI (26.8 kg/m² versus 28.7 kg/m², P = 0.013). In multivariate analysis, preoperative BMI (odds ratio [OR] = 1.108, 95% confidence interval [CI] = 1.009-1.216) was an independent factor of complete resolution of the symptoms. In the receiver operating characteristic (ROC) analysis, the identified cut-off BMI for the highest sensitivity (0.5) and specificity (0.754) was determined to be 29.3 kg/m².</p><p><strong>Conclusion: </strong>Lower BMI may be associated with the complete resolution of symptoms in IIH patients with VSS who received venous sinus stenting treatment.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"287-293"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long and Large Stentrievers Improve Reperfusion Outcomes in Acute Intracranial Terminal Internal Carotid Artery Occlusion: Interim Results of the Rossetti Registry.","authors":"Antonio Lopez-Rueda, Josep Puig, Pepus Daunis-I-Estadella, Mariano Werner, Eva González, Ion Labayen, Pedro Vega, Eduardo Murias, Elvira Jimenez-Gomez, Isabel Bravo Rey, Manuel Moreu, Carlos Pérez-García, Oscar Chirife Chaparro, Sonia Aixut, Mikel Terceño, Guillem Dolz, José Manuel Pumar, Yeray Aguilar Tejedor, Jose Carlos Mendez, Fernando Aparici-Robles, Lluis Morales-Caba, José Carlos Rayón, Luis San Roman, Jordi Blasco","doi":"10.1007/s00062-024-01486-0","DOIUrl":"10.1007/s00062-024-01486-0","url":null,"abstract":"<p><strong>Introduction: </strong>Although stentrievers (SRs) are widely used for mechanical thrombectomy (MT), the impact of device dimensions on optimizing reperfusion outcomes in high clot burden cases is unclear. Our study aimed to investigate the effect of SR size on angiographic and clinical outcomes in patients with acute terminal internal cerebral artery (TICA) occlusion.</p><p><strong>Methods: </strong>We analyzed ROSSETTI registry data to compare technical and clinical outcomes of TICA occlusion patients treated with MT without rescue therapy, according to SR diameter and length: 6 × 41-50 mm, 6 × 20-40 mm, and <6 × 20-50 mm. The first-pass effect (FPE) was defined as achieving a TICI2c‑3 after a single pass.</p><p><strong>Results: </strong>We included 491 patients, 240 (41.5%) in 6 × 41-50 group, 117 (20.2%) in 6 × 20-40 group, and 134 (23.2%) in < 6 × 20-50 group. The MT procedure time for the 6 × 41-50 group was shorter, but the FPE rate was similar across all groups. The highest final mTICI 2c‑3 rate was in 6 × 41-50 group (81.2%), compared to 6 × 20-40 group (68.4%) and 4-6 × 20-50 group (72.4%) (p = 0.016). Distal catheter use was associated with final mTICI 0-2b (62% of patients). Clinical outcomes were similar between the groups. Larger diameter and longer length of the SR, as well as not using an intermediate catheter, were independent predictors of final mTICI 2c‑3. The use of 6 × 41-50 SRs (OR 1.64, 95% CI 1.06-2.52; p = 0.024) and distal catheter use (OR 0.62, 95%CI 0.40-0.96; p = 0.034) were independent predictors of final mTICI 2c‑3.</p><p><strong>Conclusions: </strong>Use of longer and larger SRs in acute intracranial TICA occlusion improves final reperfusion rate.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"295-301"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Stenotic Carotid Plaques and Rate of DWI-positive MRI in Patients with Lower-Risk Transient or Persistent Minor Neurologic Events: DOUBT Sub Study.","authors":"Nishita Singh, Fouzi Bala, Francois Moreau, Thalia S Field, Mayank Goyal, Michael D Hill, Shelagh B Coutts, Mohammed Almekhlafi","doi":"10.1007/s00062-024-01483-3","DOIUrl":"10.1007/s00062-024-01483-3","url":null,"abstract":"<p><strong>Background & purpose: </strong>Non-stenotic (< 50%) carotid plaques are increasingly recognized as a potential mechanism for ischemic stroke. We assessed the prevalence of such plaques in patients with low-risk neurologic events and evidence of DWI (Diffusion Weighted Imaging)-positive ischemia.</p><p><strong>Methods: </strong>This is a post-hoc exploratory analysis from the DOUBT study, a prospective, observational, multicenter study of patients with low-risk transient or persistent minor focal neurological symptoms. Patients who had baseline CT angiography (CTA) and an MRI within 8 days of their event were included in the study. We aimed to assess the prevalence of non-stenotic carotid disease in patients with versus without DWI-positive events, and in patients with ipsilateral DWI-positive events. A carotid-level analysis with univariable logistic regression analysis was performed to assess whether any of the assessed plaque features were associated with ipsilateral stroke.</p><p><strong>Results: </strong>Of the 334 patients (mean age 62.7 years, 50.4% females) with available vascular neuroimaging, 153 (45.9%) had non-stenotic carotid plaques (≤50% stenosis), 174 (52.1%) had no stenosis and 7 (2.1%) patients had >50% stenosis. Of those with non-stenotic carotid plaques, 31/153 (20.3%) had evidence of DWI-positive ischemia, approximately half (15/31; 48.4%) of which was in the territory of the carotid plaque. Amongst patients with DWI-positive ischemia, non-stenotic plaques were significantly more common on the side of DWI-positive lesions [31/49 (63.3%) versus 18/49(36.7%)]. Presence of non-stenotic plaque was a risk marker for DWI-positive events (RR 1.4, 95% CI 1.1-1.8, p 0.012). On matched analysis, non-stenotic plaques were more likely on the side of DWI+ ischemia (odds ratio 1.14, 95% CI 0.36-3.70, McNemar's p value 0.80). Plaque features, including hypodensity, irregularity and greater plaque thickness were significantly associated with a higher likelihood of ipsilateral DWI+ ischemia.</p><p><strong>Conclusion: </strong>In patients with low-risk transient or persistent neurologic events, non-stenotic carotid plaques are more common in patients with DWI-positive ischemia. Plaque features like hypodense and irregular plaque were more common with DWI-positive changes in the territory of the affected carotid.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"337-345"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air Embolism-induced Stroke Linked to Esophago-atrial Fistula: a Diagnostic and Therapeutic Challenge.","authors":"Elisa Antolinos-Macho, Beatriz Alba-Pérez, Teresa Presa-Abos, José Montilla","doi":"10.1007/s00062-025-01527-2","DOIUrl":"https://doi.org/10.1007/s00062-025-01527-2","url":null,"abstract":"","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Performance of Quantitative Susceptibility Mapping in Cerebral Microbleed Detection Relative to 2D GRE.","authors":"Sabina Iqbal, Nikita Seth, Tamkin Shahraki, Aristotelis Filippidis, Magdy Selim, Ajith J Thomas, Yan Wen, Pascal Spincemaille, Yi Wang, Salil Soman","doi":"10.1007/s00062-025-01529-0","DOIUrl":"https://doi.org/10.1007/s00062-025-01529-0","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the potential overestimation of cerebral microbleed (CMB) burden by Quantitative Susceptibility Mapping (QSM) compared to 2D gradient recalled echo (2D GRE), as well as the impact of increased motion degradation due to longer scan times, reduced CMB detection from skull-stripping failures, and the relative visibility of CMBs between techniques.</p><p><strong>Methods: </strong>Seventy-nine adult subjects with intracranial hemorrhage underwent same-session brain MRI including 2D GRE and multi-echo GRE for QSM processing, as part of routine clinical care. Images were reviewed by a neuroradiologist and trained research assistant for CMB detection, visibility rating, and anatomical distribution. Motion artifacts and areas of non-visualized brain due to skull-stripping were assessed. Statistical analysis included Wilcoxon signed-rank tests for CMB counts, Mann-Whitney U test for motion assessment, and Fisher's exact testing for anatomical distribution patterns.</p><p><strong>Results: </strong>QSM showed no significant difference in median CMB counts compared to 2D GRE (1 vs 2, p = 0.175) with strong correlation (r = 0.879, p < 1.65e-26). No significant difference in motion degradation was found between techniques (p = 0.7465). Skull-stripping failures affected only 2% of candidate CMBs, in 5 of 79 (6%) subjects. QSM-detected CMBs showed superior conspicuity (73 vs 33 better visualized lesions, p = 0.00975) with 261 rated equally visible. QSM identified 26 calcifications in 20 subjects, 25 of which were misclassified as CMBs on 2D GRE.</p><p><strong>Conclusion: </strong>QSM demonstrates comparable or slightly lower CMB counts than 2D GRE while offering superior lesion conspicuity and ability to distinguish calcifications, supporting its potential clinical implementation for CMB detection.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial Contamination of Angiographic Materials in Diagnostic and Interventional Neuroangiography.","authors":"Christiane Franz, Claudia Fleu, Sophia Honecker, Manuela Schmiech, Dimah Hasan, Hani Ridwan, Omid Nikoubashman, Sebastian Lemmen, Martin Wiesmann","doi":"10.1007/s00062-025-01526-3","DOIUrl":"https://doi.org/10.1007/s00062-025-01526-3","url":null,"abstract":"<p><strong>Purpose: </strong>Bacterial contamination has been reported to occur during angiographies, although data on its frequency and relevance are limited. The purpose of our study was to determine whether angiographic materials such as catheters and guide wires remain sterile during angiographies. We sought to differentiate between different materials, and to detect the frequency, the extent and the spectrum of bacterial contamination.</p><p><strong>Methods: </strong>We prospectively collected 698 fluid or material samples from 100 neuroangiographies. Per angiography we analyzed proximal ends and distal tips of catheters and guide wires, and fluid samples from the water container (working bowl) in which materials were stored during the angiography. We analyzed the frequency and extent of contamination and determined the bacterial spectrum.</p><p><strong>Results: </strong>The majority of samples (51.4%) were contaminated. There was no angiography that showed no contamination (0%). The highest proportion of contaminated samples was found in the fluid from the working bowl after completion of the examination (92.9%). Catheters and wires were contaminated in 34.1-49.2% of samples. Contamination of the samples increased with longer duration of the angiographic procedures. Most of the bacterial species were environmental or skin contaminants (86.2%).</p><p><strong>Conclusion: </strong>Bacterial contamination during diagnostic neuroangiographies or interventions is a frequent finding although its clinical significance is believed to be small. Bacterial contamination increases with longer duration of angiographic procedures.</p>","PeriodicalId":49298,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}