European Geriatric Medicine最新文献

{"title":"Sex-specific handgrip strength thresholds for short-term mortality risk stratification in Mexican older adults: derivation in MHAS and validation in Mex-Cog.","authors":"Enrique Díaz de León González, Hector Eduardo García Cavazos, Ana Celia Ibarra Hernandez, Abraham David Culebro Perez, Marcela Naycot Guevara Alcalá, Alfonso Martinez De León, Hugo Gutiérrez Hermosillo","doi":"10.1007/s41999-026-01611-x","DOIUrl":"https://doi.org/10.1007/s41999-026-01611-x","url":null,"abstract":"<p><strong>Purpose: </strong>Handgrip strength (HGS) is widely used in geriatric assessment, but mortality-oriented thresholds may not be directly transportable across populations. We aimed to derive sex-specific HGS thresholds for short-term mortality in Mexican adults aged ≥50 years and evaluate their performance in a primary non-overlapping validation sample.</p><p><strong>Methods: </strong>We conducted a secondary analysis of the Mexican Health and Aging Study and its ancillary Mex-Cog study. Sex-specific thresholds were derived in MHAS 2012 participants with HGS data and mortality follow-up through 2015 using receiver operating characteristic analysis and Youden's index. The derived thresholds were then applied without modification to a non-overlapping Mex-Cog 2016 validation sample, with mortality assessed through 2018 as a fixed-horizon binary outcome. Logistic regression models estimated associations with mortality.</p><p><strong>Results: </strong>The derivation cohort included 1922 participants, of whom 95 (4.9%) died. HGS showed acceptable discrimination overall (AUC 0.7219, 95% CI 0.6688-0.7751), in men (AUC 0.7806, 95% CI 0.7101-0.8510), and in women (AUC 0.7347, 95% CI 0.6668-0.8026). The derived thresholds were ≤ 28 kg in men and ≤ 18 kg in women. In the primary non-overlapping validation sample (n = 966; 55 deaths), HGS at or below the threshold was associated with higher mortality after age- and sex-adjustment (OR 2.33, 95% CI 1.15-4.73) and in the expanded complete-case model (OR 2.13, 95% CI 1.02-4.43).</p><p><strong>Conclusion: </strong>Sex-specific HGS thresholds identified Mexican adults at higher short-term mortality risk and retained prognostic utility in a non-overlapping validation sample within the same study platform. These thresholds should be interpreted as practical markers of vulnerability rather than stand-alone predictors of individual mortality.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scoping review on navigation interventions for older adults with cancer in Europe and beyond.","authors":"Agata Stodolska, Grzegorz Wójcik, Carla Reigada, Kelly Ashford, Rose Miranda, Lieve Van den Block, Emilia Malmur, Natalia Drapała, Katarzyna Szczerbińska","doi":"10.1007/s41999-026-01609-5","DOIUrl":"10.1007/s41999-026-01609-5","url":null,"abstract":"<p><strong>Purpose: </strong>Older adults with cancer often experience fragmented care, multimorbidity, and psychosocial barriers that limit access to timely, coordinated services. Patient navigation (PN) provides individualized support across medical and social domains; however, evidence on models tailored to older populations in Europe is limited. This study synthesizes current evidence on PN programs for older adults with cancer in Europe and compares it with findings from other regions.</p><p><strong>Methods: </strong>A scoping review was conducted following PRISMA-ScR guidelines. PubMed, CINAHL, and Web of Science were searched (1993-2025). Data extraction included study characteristics, target populations, intervention components, navigator roles, competencies, training, evaluation, recruitment, and funding.</p><p><strong>Results: </strong>Of 4249 records identified, 215 studies met the inclusion criteria, including 28 European PN interventions. Only two targeted adults aged ≥ 60 years, and six included participants aged 50-75 years. Compared with the United States, PN research for older adults remains less developed in Europe, while studies specifically involving adults aged ≥ 75 years are scarce worldwide. Most interventions for adults aged 50 years and older focused on patient education and barrier assessment during the screening phase and included navigator training. In this group, navigation services were mainly provided by social workers and lay navigators.</p><p><strong>Conclusion: </strong>Evidence on PN for older adults with cancer in Europe remains limited but suggests potential benefits across the cancer care continuum. Given the high prevalence of multimorbidity and frailty among older adults, further research is needed to adapt patient navigation programs to the complex and individual needs of older patients with cancer.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary incontinence in older adults: call for action in geriatric care and research.","authors":"Maria S Nuotio, Maria P Panourgia","doi":"10.1007/s41999-026-01607-7","DOIUrl":"https://doi.org/10.1007/s41999-026-01607-7","url":null,"abstract":"","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How should evidence be judged for medication optimisation tools? Reflections on Boland et al. and O'Mahony et al.","authors":"Lorenz Van der Linden, Qi Shao, Jos Tournoy","doi":"10.1007/s41999-026-01545-4","DOIUrl":"https://doi.org/10.1007/s41999-026-01545-4","url":null,"abstract":"","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Position paper: a coordinated approach to fracture and fall prevention from seven international organizations.","authors":"Nathalie van der Velde, Lotta J Seppala, Gulistan Bahat, Hubert Blain, Alvaro Casas Herrero, Nicholas C Harvey, Tahir Masud, René Rizzoli, Jean-Yves Reginster, Carmelinda Ruggiero, Mario Barbagallo, Alex Barreto de Lima, Maria Bonnici, Jean Bousquet, Bernard Cortet, Lorenzo Chiari, Yannis Dionyssiotis, Karsten Dreinhöfer, Gustavo Duque, Chris Easthope Awai, Frede Frihagen, James Frith, Ellen Freiberger, Deniz Cengiz, Eleftheria Giannouli, Tomasz Grodzicki, Nataliia Grygorieva, Evrim Gökçe, Jorunn L Helbostad, Christof J Kadane, Meltem Koca, Marko Kolšek, Tomasz Kostka, Jūratė Macijauskienė, Finbarr C Martin, Lisa McGarrigle, Emeline Michel, Marta Neira Álvarez, Maria Panourgia, Stany Perkisas, Christoph Pertinatsch, Carmen Queirós, Regina Roller-Wirnsberger, Erik Rosendahl, Jesper Ryg, Cheryl A Sadowski, Opinder Sahota, Schroder Sattar, Dawn A Skelton, François-Xavier Sibille, Balamrit Singh Sokhal, Joke Spildooren, Emma Stanmore, Timo E Strandberg, Tim Stuckenschneider, Chris Todd, Hana Vankova, Ellen Vlaeyen, Ozlem Yilmaz, Yelda Öztürk","doi":"10.1007/s41999-026-01596-7","DOIUrl":"https://doi.org/10.1007/s41999-026-01596-7","url":null,"abstract":"<p><p>Fragility fractures constitute a major global health burden and often result from falls. However, clinical care for fragility fractures is currently organized separately from fall prevention services leading to gaps in integrated care delivery. This joint position paper from the European Geriatric Medicine Society, the Fragility Fracture Network, the World Falls Prevention Society, the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, the International Osteoporosis Foundation, the European Union of Medical Specialists-Geriatric Medicine Section, and the International Association of Gerontology and Geriatrics-European Region highlights the critical need for integrated falls and fracture prevention, with a focus on evidence-based clinical practice, knowledge dissemination, education, policy strategies, and research. We outline existing guidelines on fall and fracture prevention, with particular emphasis on how fracture risk assessment can be incorporated into fall prevention services and on integrating fall assessment into fracture prevention services. We advocate that future implementation guidelines place greater emphasis on fully integrated models of care. Moreover, training and education programs should be designed to encourage interdisciplinary collaboration among healthcare professionals. Integrated fall and fracture prevention services should be recognized as a public health priority and incorporated into national strategies for healthy aging, supported by adequate, dedicated, and sustainable resources including evidence-based exercise provision. Finally, future research should focus on evaluating the (cost) effectiveness of integrated care models and examining their practical implementation in real-world settings.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations between ATN biomarkers and episodic memory diminish as age increases.","authors":"Urban Ekman, Måns Gyllenhammar, Ove Almkvist, Anton Ocklind, Leo Hallerstam, Daniel Ferreira, Maria Eriksdotter, Lars-Olof Wahlund, Anna Rennie, Eric Westman","doi":"10.1007/s41999-026-01606-8","DOIUrl":"https://doi.org/10.1007/s41999-026-01606-8","url":null,"abstract":"<p><strong>Purpose: </strong>The relationship between age, biomarkers, and cognitive function at advanced ages remains underexplored. By utilizing a naturalistic memory clinic cohort, we aimed to clarify how the A/T/N biomarkers are associated with verbal episodic memory performance and the moderating effect of age.</p><p><strong>Methods: </strong>This cross-sectional study included 676 patients from memory clinics in the Stockholm metropolitan region, comprised of 141 with Alzheimer's disease dementia, 403 with mild cognitive impairment, and 132 with subjective cognitive impairment. We used weighted least-squares regressions to evaluate the association between episodic memory and the biomarkers and the moderating effect of age.</p><p><strong>Results: </strong>There was a significant interaction between age and A (Aβ42), where the negative impact of Aβ42 abnormality on Rey Auditory Verbal Learning (RAVLT) delayed recall was reduced with higher age (β = 0.22, p < 0.001). In addition, a corresponding interaction effect was observed between age and N (MTA) on RAVLT delayed recall (β = 0.13, p < 0.01). Additional exploration analyses showed that at age 80 or older, the ATN biomarkers showed weaker associations with episodic memory performance.</p><p><strong>Conclusions: </strong>Although interpretations should be conducted with caution, these findings raise questions about the justification for assessing CSF in patients older than 80 years, given its weak associations with core clinical measures, such as learning and free recall of episodic memory. Further clinical studies are needed to validate these results and also evaluate other core cognitive measures. The naturalistic nature of the memory clinic population, with its clinically driven diagnoses, may help clarify these findings.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma neuroimmune pathway signatures are associated with clinical impairment and lower MRI-derived hippocampal volume across the Alzheimer's disease continuum.","authors":"Mubarak Alruwaili, Muhannad Faleh Alanazi, Hailah M Almohaimeed, Saud S Alharbi, Nourah Alruwais, Eman Ali Elkordy, Mohammed S Alshuhri","doi":"10.1007/s41999-026-01604-w","DOIUrl":"https://doi.org/10.1007/s41999-026-01604-w","url":null,"abstract":"<p><strong>Methods: </strong>This retrospective observational study included 506 Alzheimer's Disease Neuroimaging Initiative participants: 53 cognitively normal individuals, 352 with mild cognitive impairment, and 101 with dementia. Plasma proteins from the quality-controlled Rules-Based Medicine multiplex dataset were standardized and grouped into five circulating protein scores: complement-acute-phase, endothelial-associated, extracellular matrix remodeling, myeloid, and interleukin. Outcomes included Mini-Mental State Examination, Clinical Dementia Rating Sum of Boxes, Functional Activities Questionnaire, normalized hippocampal volume, and normalized brain volume. Multivariable models were adjusted for age, sex, education, and APOE ε4 carrier status.</p><p><strong>Results: </strong>In the primary cross-sectional pathway-level analyses, complement-acute-phase scores were higher in participants with dementia than in cognitively normal participants after FDR correction (β = 0.314, 95% CI 0.118 to 0.511; FDR q = 0.018). Higher complement-acute-phase scores were associated with lower MMSE (β = -0.859; FDR q < 0.001), higher CDR-SB (β = 0.622; FDR q < 0.001), and higher FAQ scores (β = 2.473; FDR q < 0.001). Higher endothelial-associated plasma protein scores were associated with lower normalized hippocampal volume (β = -1.47 × 10⁻⁴; FDR q = 0.028).</p><p><strong>Conclusions: </strong>Plasma neuroimmune signatures showed pathway-specific associations with Alzheimer's disease-related phenotypes, with complement-acute-phase score linked most consistently to clinical impairment and endothelial-associated circulating protein profile linked to hippocampal volume.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quand tu danses, healing through the art of ballet.","authors":"Hege Ihle-Hansen","doi":"10.1007/s41999-026-01598-5","DOIUrl":"https://doi.org/10.1007/s41999-026-01598-5","url":null,"abstract":"","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stigma of concerns about falling among older adults.","authors":"Samuel R Nyman, Lynn McKeague, Liam P Satchell","doi":"10.1007/s41999-026-01589-6","DOIUrl":"https://doi.org/10.1007/s41999-026-01589-6","url":null,"abstract":"<p><strong>Purpose: </strong>The 2022 world guidelines for falls prevention and management for older adults recommended the inclusion of concerns about falls in fall risk assessments, and to use the term 'concerns about falling'. This qualitative study is the first to explore if older adults perceive a stigma around concerns about falls, how older adults discuss their concerns about falling, and older adults' views on associated terminology.</p><p><strong>Methods: </strong>We conducted six focus groups with 22 community-dwelling older adults (16 women, 6 men, mean 75.10 years). Audio recordings were transcribed verbatim and thematically analysed inductively, and then deductively to directly address our research focus.</p><p><strong>Results: </strong>Our sample did not express preference for particular terminology when discussing concerns about falling. We identified two themes: 1) Fear and anxiety of falling: While participants used terms interchangeably, fear and anxiety represented two distinct lived experiences: Fear was a protective instinct in response to a specific threat of falling in the moment, whereas anxiety was worry about an indirect threat of falling outside of its context. 2) Stigma of falls: Participants were at ease in discussing concerns about falls with their peer group but not with others due to stigma. They expressed a reluctance to speak with their doctor about their concerns about falls.</p><p><strong>Conclusion: </strong>Our findings suggest that there is a stigma of concerns about falling that may inhibit older adults seeking support to reduce their risk of falls. Practitioners will need to be proactive and sensitive in discussing concerns about falls with older adults.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant fractures in older patients with proximal femoral fractures: rib fractures are associated with increased complications and mortality for consideration in european geriatric medicine.","authors":"Clemens Roitzsch, Franziska Beyer, Klaus-Dieter Schaser, Marcel Mäder, Lorenz C Hofbauer, Babette Engler, Roman Riedel, Ivonne Panchyrz, Anne Postler","doi":"10.1007/s41999-026-01603-x","DOIUrl":"https://doi.org/10.1007/s41999-026-01603-x","url":null,"abstract":"<p><strong>Purpose: </strong>Proximal femoral fractures (PFF) are a global health burden in aging populations. Evidence on the prevalence and clinical relevance of concomitant fractures in this population remains limited. This study investigated the impact of concomitant fractures on mortality, complications, transfusion requirements, and postoperative mobility in patients with geriatric PFF.</p><p><strong>Methods: </strong>This single-center cohort study included patients ≥ 65 years with a positive geriatric screening, who underwent surgery for a PFF after low-energy trauma between January 2019 and December 2023. Patients with concomitant fractures were compared with those with isolated PFF. Outcomes included mortality, perioperative parameters, complications, and mobility at discharge. Uni- and multivariable regression models were applied adjusting for age, sex, comorbidities, body mass index (BMI), and fracture type.</p><p><strong>Results: </strong>A total of 1553 patients were analyzed; 164 (10.5%) sustained concomitant fractures (n = 180), most commonly of the upper limb (57%), pelvis (16%), and ribs (13%). Concomitant fractures were ipsilateral in 89% and surgically treated in 29%. Compared with isolated PFF, these patients had higher rates of in-house venous thromboembolism (VTE) (5.5% vs. 0.9%, p < 0.001), required 0.4 more units of blood transfusion (95% confidence interval (CI) 0.114-0.744), and showed impaired mobilization at discharge (odds ratio (OR) 0.5, 95%CI 0.328-0.654). No difference in overall in-house or 90-day mortality was observed. However, concomitant rib fractures markedly increased the risk of non-surgical complications (OR 2.8, 95%CI 1.175-6.804), VTE (OR 14.8, 95%CI 4.078-53.492), blood transfusion by 1.1 units (95%CI 0.323-1.925), and 90-day mortality (OR 6.4, 95%CI 2.675-15.469).</p><p><strong>Conclusion: </strong>Concomitant fractures occur in over 10% of geriatric PFF patients and worsen clinical outcomes, particularly VTE risk, transfusion needs, and mobility. Rib fractures are a high-risk subgroup requiring specific clinical attention.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}