Critical Care and Resuscitation最新文献

A study of Professor Bellomo's contribution to cardiac arrest research 贝洛莫教授对心脏骤停研究的贡献

IF 1.7 4区医学

Critical Care and Resuscitation Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100120

Glenn M. Eastwood BN BN(Hons) GDipNurs CritCare, PhD, Niklas Nielsen MD, PhD

引用次数: 0

Unravelling the paradox of vitamin C research in sepsis 揭示败血症中维生素C研究的悖论

IF 1.7 4区医学

Critical Care and Resuscitation Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100134

Tomoko Fujii MD, PhD , Clive N. May PhD , Yugeesh R. Lankadeva PhD

{"title":"Unravelling the paradox of vitamin C research in sepsis","authors":"Tomoko Fujii MD, PhD , Clive N. May PhD , Yugeesh R. Lankadeva PhD","doi":"10.1016/j.ccrj.2025.100134","DOIUrl":"10.1016/j.ccrj.2025.100134","url":null,"abstract":"<div><div>Professor Rinaldo Bellomo’s lasting impact on critical care research stems from his commitment to structured, biologically grounded research programs over isolated studies. His work on vitamin C in sepsis exemplifies this approach. While early enthusiasm grew around combination therapies involving vitamin C, Rinaldo championed a cautious, rigorous, and methodical investigation. He worked closely with collaborators to address key methodological issues, including dosing, stability, and the design of appropriate control groups, which ultimately led to the international VITAMINS trial. This landmark study compared vitamin C, hydrocortisone, and thiamine to hydrocortisone alone in septic shock and found no clinical benefit. Rinaldo embedded a pharmacokinetic substudy to confirm supraphysiological serum vitamin C levels, ensuring biological plausibility of the trial design. Beyond clinical research, he fostered translational research with the Florey Institute using a preclinical sheep model of sepsis. This collaboration uncovered critical mechanisms of septic acute kidney injury and led to the development of mega-dose sodium ascorbate therapy. The program progressed from proof-of-concept to a double-blind pilot randomised trial in septic shock and now underpins a national multicentre phase Ib and II clinical trials. Rinaldo’s legacy is defined by scientific rigour, mentorship, and humility. His visionary, disciplined approach remains a model for impactful research and continues to guide ongoing efforts to advance care for critically ill patients.</div></div>","PeriodicalId":49215,"journal":{"name":"Critical Care and Resuscitation","volume":"27 3","pages":"Article 100134"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Honouring Rinaldo Bellomo’s tour de force in sepsis research 表彰里纳尔多·贝洛莫在败血症研究方面的杰出成就

IF 1.7 4区医学

Critical Care and Resuscitation Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100139

S. Peake MD, PhD , A. Delaney MD, PhD , B. Venkatesh MD, PhD

引用次数: 0

A gardener lost in spring 一个迷失在春天的园丁

IF 1.7 4区医学

Critical Care and Resuscitation Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100125

Neil R. Orford MBBS, FCICM, FANZCA, PGDipEcho, PhD

引用次数: 0

Critical care nutrition and the legacy of Rinaldo Bellomo 重症监护营养和里纳尔多·贝洛莫的遗产

IF 1.7 4区医学

Critical Care and Resuscitation Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100147

Adam M. Deane MBBS, PhD , Sandra L. Peake BMBS, PhD , Andrew R. Davies MBBS , Yasmine Ali Abdelhamid MBBS, PhD , Moritoki Egi MD, PhD , Marianne J. Chapman BMBS, PhD , Emma J. Ridley APD, PhD

引用次数: 0

The Australian and New Zealand Intensive Care Research Centre and Rinaldo Bellomo 澳大利亚和新西兰重症监护研究中心和里纳尔多·贝洛莫

IF 1.7 4区医学

Critical Care and Resuscitation Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100129

D. Jamie Cooper AO, MD

引用次数: 0

A tribute to Rinaldo Bellomo: Why randomised behaviour is better than random behaviour 向Rinaldo Bellomo致敬：为什么随机行为比随机行为更好

IF 1.7 4区医学

Critical Care and Resuscitation Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100123

John A. Myburgh MBBCh PhD DSc, FCICM, Balasubramanian Venkatesh MD, FCICM

引用次数: 0

Sedation Practice in Intensive Care Evaluation, SPICE and beyond, Rinaldo’s legacy in sedation and delirium research 重症监护评估中的镇静实践，SPICE及其他，Rinaldo在镇静和谵妄研究中的遗产

IF 1.7 4区医学

Critical Care and Resuscitation Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100142

Yahya Shehabi MBBS, PhD, EMBA, FCICM, FANZCA, Michael C. Reade MBBS, MPH, DPhil, DMedSc, GAICD, AFRACMA, FHEA, FCCM, FANZCA, FCICM

引用次数: 0

Rinaldo Bellomo and the ‘Dark Arts’ of clinical trials 里纳尔多·贝洛莫和临床试验的“黑魔法”

IF 1.7 4区医学

Critical Care and Resuscitation Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100146

Steve A. Webb MBBS, PhD, Alisa M. Higgins BPhysio(Hons), PhD

引用次数: 0

Rinaldo Bellomo: A clinician with a passion for preclinical research 里纳尔多·贝洛莫：一位对临床前研究充满热情的临床医生

IF 1.7 4区医学

Critical Care and Resuscitation Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100128

Clive N. May PhD , Yugeesh R. Lankadeva PhD , Shailesh Bihari PhD

{"title":"Rinaldo Bellomo: A clinician with a passion for preclinical research","authors":"Clive N. May PhD , Yugeesh R. Lankadeva PhD , Shailesh Bihari PhD","doi":"10.1016/j.ccrj.2025.100128","DOIUrl":"10.1016/j.ccrj.2025.100128","url":null,"abstract":"<div><div>Professor Rinaldo Bellomo was a pioneer in intensive care medicine whose influence extended beyond clinical trials to preclinical and translational research. His long-standing collaboration with the Florey Institute established ovine sepsis models that overturned dogma, demonstrating that septic acute kidney injury can occur despite increased renal blood flow, and clarifying the effects of fluids, noradrenaline, vasopressin, and angiotensin II. These studies advanced understanding of renal medullary hypoperfusion and hypoxia, guided antioxidant strategies, and inspired clinical investigation of megadose sodium ascorbate. Rinaldo also championed integration of preclinical science into the ANZICS Clinical Trials Group, legitimising dedicated sessions, fostering collaboration, and ensuring basic discoveries informed hypothesis-driven clinical trials. A gifted mentor and communicator, he inspired generations of researchers with his curiosity, humility, and passion for physiology. His legacy as both clinician and scientist underscores the enduring value of discovery research in advancing critical care.</div></div>","PeriodicalId":49215,"journal":{"name":"Critical Care and Resuscitation","volume":"27 3","pages":"Article 100128"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0