Respiratory syncytial virus infection in adult and paediatric patients admitted to intensive care in Australia: A nation-wide comparison with COVID-19

IF 1.4 4区医学 Q3 CRITICAL CARE MEDICINE

Critical Care and Resuscitation Pub Date : 2025-06-01 DOI:10.1016/j.ccrj.2025.100113

Yaodong Tang PhD , Peinan Zhao PhD , Allen C. Cheng MBBS, PhD , Aaliya Ibrahim MClinEpid , Jenna Hassall MPhil , Edward Litton MBChB, PhD , Christopher R. Andersen MBBS, FCICM , Cindy Liang RN, GradCertN , Elissa M. Milford MBBS, PhD , Morgan Rose MBBS, PhD , Mark Plummer FCICM, PhD , Jing Kong RN, GradCertN , Kerry Johnson RN, GradCertN , Shailesh Bihari FCICM, PhD , Anis Chaba MBBS, MMSBR , Husna Begum PhD , Sherene Magana Cruz DipLH , Sze Ng MBBS , Tony Trapani B.Ed , Lewis Campbell MBChB, MSc Epi, FCICM , Aidan Burrell MBBS, PhD, FCICM

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引用次数: 0

Abstract

Objective

To assess the characteristics, treatments and outcomes of paediatric and adult intensive care unit (ICU) patients with respiratory syncytial virus (RSV) infection, and compare these with coronavirus disease (COVID-19) during the same period.

Design, setting, and participants

We conducted a multicenter, prospective, observational study using data from the short period incidence study of severe acute respiratory infection (SPRINT SARI) Australia, in 38 Australian ICUs from 1 June 2022 to 1 September 2024. Demographic, treatment, and outcome data were analysed for patients with confirmed RSV or COVID-19. The primary outcome was in-hospital mortality.

Results

Of 4693 patients were recorded in the SPRINT-SARI database, 2540 met inclusion criteria. RSV was more common in paediatric patients (410/620, 62%) than in adults (249/1920, 13%). Adult with RSV had more chronic pulmonary conditions than those with COVID-19. Paediatric patients with RSV had fewer comorbidities and less invasive mechanical ventilation (IMV) compared to those with COVID-19 (P < 0.05), but required longer duration of IMV once intubated. In-hospital mortality was similar for both adult RSV and COVID-19 (36/249, 14.5%) vs (260/1671, 15.6%), and paediatric RSV(3/410 [0.7%] vs 7/210 [3.3%] P = 0.07). Mortality in adults was associated with male sex, older age, comorbidities, and IMV. Mortality in children was associated with IMV only.

Conclusions

RSV infection can result in an attributable number of ICU admission in Australia, especially in specific populations including young children and older adults with respiratory comorbidities. Mortality in patients admitted to ICU is similar to COVID-19.

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澳大利亚重症监护成人和儿科患者呼吸道合胞病毒感染：与COVID-19的全国比较

目的探讨呼吸道合胞病毒（RSV）感染的儿科和成人重症监护病房（ICU）患者的特点、治疗方法和预后，并与同期的冠状病毒病（COVID-19）进行比较。设计、环境和参与者我们进行了一项多中心、前瞻性、观察性研究，使用来自澳大利亚严重急性呼吸道感染短期发病率研究（SPRINT SARI）的数据，从2022年6月1日至2024年9月1日在38个澳大利亚icu中进行。分析确诊RSV或COVID-19患者的人口统计学、治疗和结局数据。主要终点是住院死亡率。结果在SPRINT-SARI数据库中记录的4693例患者中，2540例符合纳入标准。RSV在儿科患者（410/620,62%）中比在成人（249/1920,13%）中更常见。患有RSV的成人比患有COVID-19的成人有更多的慢性肺部疾病。与COVID-19患者相比，RSV患儿的合并症和侵入性机械通气（IMV）较少(P <；0.05)，但需要较长的IMV插管时间。成人RSV和COVID-19的住院死亡率相似（36/249,14.5%）vs(260/1671, 15.6%)，儿科RSV（3/410 [0.7%] vs 7/210 [3.3%] P = 0.07）。成人死亡率与男性、年龄、合并症和IMV有关。儿童死亡率仅与IMV有关。结论srsv感染可导致澳大利亚ICU住院人数的归因，特别是在特定人群中，包括患有呼吸道合并症的幼儿和老年人。ICU住院患者的死亡率与COVID-19相似。

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来源期刊

Critical Care and Resuscitation CRITICAL CARE MEDICINE-

CiteScore

7.70

自引率

3.40%

发文量

审稿时长

>12 weeks

期刊介绍： ritical Care and Resuscitation (CC&R) is the official scientific journal of the College of Intensive Care Medicine (CICM). The Journal is a quarterly publication (ISSN 1441-2772) with original articles of scientific and clinical interest in the specialities of Critical Care, Intensive Care, Anaesthesia, Emergency Medicine and related disciplines. The Journal is received by all Fellows and trainees, along with an increasing number of subscribers from around the world. The CC&R Journal currently has an impact factor of 3.3, placing it in 8th position in world critical care journals and in first position in the world outside the USA and Europe.