Darragh Herlihy, Sneha Singh, Patrick Nicholson, Emma Griffin, Alan O'Hare, Paul Brennan, John Thornton, Sarah Power
{"title":"REtrieving thrombi and Separated Coils/catheters Unexpectedly detached during Endovascular therapy: RESCUE - the use of thrombectomy devices for rescue therapy in interventional neuroradiology.","authors":"Darragh Herlihy, Sneha Singh, Patrick Nicholson, Emma Griffin, Alan O'Hare, Paul Brennan, John Thornton, Sarah Power","doi":"10.1177/15910199241299139","DOIUrl":"10.1177/15910199241299139","url":null,"abstract":"<p><p>PurposeIntraprocedural complications during intracranial embolisation include thromboembolic vessel occlusion, catheter tip detachment and coil migration. Stentrievers and aspiration catheters are valuable devices for the management of these complications. We present our experience with the use of these devices. We describe the devices and techniques used, case details and clinical outcomes. Currently there is no standardised approach for the management of the above intraprocedural complications.MethodsWe performed a retrospective review of our interventional neuroradiology database of patients who underwent endovascular treatment in our institution from January 2012 to January 2019 and identified embolisation procedures during which either stentrievers or aspiration catheters were utilised.ResultsWe present a case series of 24 cases in which these devices were utilised as rescue devices over a period of 7 years. We provide three illustrative cases.ConclusionStentrievers and aspiration catheters can be used safely and effectively as adjunctive or rescue devices during embolisation procedures.</p>","PeriodicalId":49174,"journal":{"name":"Interventional Neuroradiology","volume":" ","pages":"2595-2603"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leandro Castaneyra-Ruiz, Brian W Hanak, Sora Sato, Michael Le, Michael Muhonen
{"title":"Reconsidering dimethyl sulfoxide in endovascular embolization: A potential toxic-dependent contributor to hydrocephalus?","authors":"Leandro Castaneyra-Ruiz, Brian W Hanak, Sora Sato, Michael Le, Michael Muhonen","doi":"10.1177/15910199251380379","DOIUrl":"10.1177/15910199251380379","url":null,"abstract":"<p><p>Dimethyl sulfoxide (DMSO) is widely used as a solvent in endovascular embolization procedures, yet its potential neurotoxic effects remain underexplored. In this correspondence, we highlight emerging evidence suggesting that DMSO exposure may contribute to the development of hydrocephalus through mechanisms involving ependymal damage and astrocyte apoptosis. Drawing on recent experimental findings, we propose that DMSO-induced neuroinflammation may play a role in post-embolization complications. We urge the research community to consider hydrocephalus as a possible, though unproven, outcome of DMSO exposure and to include it in long-term safety assessments of embolic agents.</p>","PeriodicalId":49174,"journal":{"name":"Interventional Neuroradiology","volume":" ","pages":"2895-2896"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ajay A Madhavan, Jeremy K Cutsforth-Gregory, Neeraj Kumar, Ivan Garza, Mark A Whealy, Narayan R Kissoon, Waleed Brinjikji
{"title":"CSF-venous fistulas associated with traumatic spinal pseudomeningoceles.","authors":"Ajay A Madhavan, Jeremy K Cutsforth-Gregory, Neeraj Kumar, Ivan Garza, Mark A Whealy, Narayan R Kissoon, Waleed Brinjikji","doi":"10.1177/15910199241276575","DOIUrl":"10.1177/15910199241276575","url":null,"abstract":"<p><p>CSF-venous fistulas (CVFs) are a common cause of spontaneous intracranial hypotension. These fistulas usually occur without any preceding major trauma, surgery, or other iatrogenic cause. Occasionally, patients have a history of minor trauma, though such cases are usually still considered spontaneous. Little is known about predisposing factors that cause patients to develop spontaneous CVFs. Most patients with CVFs have multiple meningeal diverticula on spine imaging, and fistulas usually arise in association with a diverticulum. In the vast majority of cases, the culprit diverticulum from which the CVF arises is atraumatic in origin, presumably on the spectrum of normal variation in spinal anatomy. Here, we present two cases of CVFs that arose in association with posttraumatic pseudomeningoceles. To our knowledge, this phenomenon has not yet been reported, and it potentially represents a novel etiology for CVFs that furthers understanding of their pathogenesis.</p>","PeriodicalId":49174,"journal":{"name":"Interventional Neuroradiology","volume":" ","pages":"2848-2852"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aizaz Ali, Rahul Rao, Brandon Sharkey, Alisa Gega, Marion Oliver, Tahao Chen, Richard Burgess, Mouhammad Jumaa, Syed Zaidi
{"title":"Medium vessel occlusion thrombectomy: Single center experience using the 3 MAX catheter.","authors":"Aizaz Ali, Rahul Rao, Brandon Sharkey, Alisa Gega, Marion Oliver, Tahao Chen, Richard Burgess, Mouhammad Jumaa, Syed Zaidi","doi":"10.1177/15910199241264328","DOIUrl":"10.1177/15910199241264328","url":null,"abstract":"<p><p>IntroductionThrombectomy for medium vessel occlusion is a topic of great interest. We describe a single-center experience with the Penumbra 3-MAX aspiration catheter in stroke thrombectomy of medium vessel occlusion(MeVO). We investigated the use of 3-MAX as a de-novo first pass catheter and as a rescue aspiration device following attempted thrombectomy with other devices. This is the first description of the first pass effect and successful recanalization rate of the 3-MAX catheter in de-novo vs. rescue use of this catheter.MethodsFrom January 2017 to January 2023, 84 patients underwent mechanical thrombectomy with use of a Penumbra 3MAX aspiration catheter at our comprehensive stroke center. Patient charts were retrospectively reviewed. Primary efficacy outcome was successful recanalization following mechanical thrombectomy. Primary safety outcome was intracerebral hemorrhage.ResultsA total of 84 patients underwent MT with the 3MAX device. It was used as a de novo catheter in 27(32.1%) and as a rescue catheter in 57(67.9%) patients. 35(41.6%) patients achieved angiographic TICI grade ≥ 2c. De novo 3MAX use led to 68.18% successful recanalization and rescue use led to 72.22% recanalization (p = 0.67) as measured by TICI score of 2c or better. Parenchymal intracerebral hemorrhages (PH) were present in 8 patients (9.5%).ConclusionThe Penumbra 3MAX catheter is safe and effective when used as a first pass or a rescue device in mechanical thrombectomy. We found similar rates of successful recanalization and minimal hemorrhagic risk when comparing the 3MAX as a rescue or de novo aspiration catheter.</p>","PeriodicalId":49174,"journal":{"name":"Interventional Neuroradiology","volume":" ","pages":"2143-2149"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
James Bonner, Christopher J Love, Vipul Bhat, James E Siegler
{"title":"Should they stay or should they go? Stroke transfers across a hospital network pre- and post-implementation of an automated image interpretation and communication platform.","authors":"James Bonner, Christopher J Love, Vipul Bhat, James E Siegler","doi":"10.1177/15910199241272652","DOIUrl":"10.1177/15910199241272652","url":null,"abstract":"<p><p>BackgroundA key decision facing nonthrombectomy capable (spoke) hospitals is whether to transfer a suspected large vessel occlusion (LVO) patient to a comprehensive stroke center (CSC). In a retrospective cohort study, we investigated the rate of transfers resulting in endovascular thrombectomy (EVT) and associated costs before and after implementation of an artificial intelligence (AI)-based software.MethodsAll patients with a final diagnosis of acute ischemic stroke presenting across a five-spoke community hospital network in affiliation with a CSC were included. The Viz LVO (Viz.ai, Inc.) software was implemented across the spokes with image sharing and messaging between providers across sites. In a cohort of patients before (pre-AI, December 2018-October 2020) and after (post-AI, October 2020-August 2022) implementation, we compared the EVT rate among ischemic stroke patients transferred out of our health system to the CSC. Secondary outcomes included the EVT rate based on spoke computed tomography angiography (CTA) and estimated transfer costs.ResultsA total of 3113 consecutive eligible patients (mean age 71 years, 50% female) presented to the spoke hospitals with 162 transfers pre-AI and 127 post-AI. The rate of transfers treated with EVT significantly increased (32.1% pre-AI vs. 45.7% post-AI, p = 0.02). There was a sharp increase in CTA use post-AI at the spoke hospitals for all patients and transfers that likely contributed to the increased EVT transfer rate, but prior spoke CTA use alone was not sufficient to account for all improvement in EVT transfer rate (37.2% pre-AI vs. 49.2% post-AI, p = 0.12). In a binary logistic regression model, the odds of an EVT transfer in the intervention period were 1.85 greater as compared to preintervention (adjusted odds ratio 1.85, 95% confidence interval 1.12-3.06). The decrease in non-EVT transfers resulted in an estimated annual benefit of $206,121 in spoke revenue and $119,921 in payor savings (all US dollars).ConclusionsThe implementation of an automated image interpretation and communication platform was associated with increased CTA use, more transfers treated with EVT, and potential economic benefits.</p>","PeriodicalId":49174,"journal":{"name":"Interventional Neuroradiology","volume":" ","pages":"2219-2226"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iman Moeini-Naghani, Shoaib A Syed, Ankita Jain, Eris Spirollari, Ariel Sacknovitz, Ilya Frid, Ahmed Elmashad, Gurmeen Kaur, Chirag D Gandhi, Fawaz Al-Mufti
{"title":"Recalibrating the COMPASS: Insights from the first global deployment of CEREGLIDE™ 71 Intermediate Catheter in endovascular treatment of stroke.","authors":"Iman Moeini-Naghani, Shoaib A Syed, Ankita Jain, Eris Spirollari, Ariel Sacknovitz, Ilya Frid, Ahmed Elmashad, Gurmeen Kaur, Chirag D Gandhi, Fawaz Al-Mufti","doi":"10.1177/15910199251350216","DOIUrl":"10.1177/15910199251350216","url":null,"abstract":"<p><p>PurposeEndovascular treatment has become the standard of care for the treatment of patients with acute ischemic stroke with large vessel occlusion, however, the optimal first-line strategy for mechanical thrombectomy continues to be debated. Recent advancements in large-bore aspiration catheters have enhanced the efficacy of A Direct Aspiration First Pass Technique (ADAPT), offering promising improvements in procedural success. This study aims to evaluate the characteristics and technical outcomes associated with endovascular treatment for acute ischemic stroke following the inaugural global use of the CEREGLIDE™ 71 Intermediate Catheter at our institution.Materials and methodsIn this retrospective, single-center study, a total of 25 consecutive patients with verified large vessel occlusion in the anterior circulation were included from October 2023 to May 2024. All patients were treated with endovascular therapy using a CEREGLIDE™ 71 intermediate catheter. The angiographic outcome was assessed using the thrombolysis in cerebral infarction (TICI) scale.ResultsA total of 25 patients were included in the study. The mean age at baseline was 72.3 years old, and 52% of patients were female. Mean National Institutes of Health Stroke Scale score at admission was 16.4. Occlusion locations included the M1 segment of the middle cerebral artery (MCA) (60%), internal carotid artery terminus (20%), and M2 segment of MCA (16%). The average number of passes per intervention was 2.2. Successful reperfusion (TICI 2b, TICI 2c, and TICI 3) was achieved in 88% of patients.ConclusionsThis report of the first center to implement the CEREGLIDE™ 71 Intermediate Catheter for acute ischemic stroke demonstrated successful recanalization rates. This is largely attributed to the large inner diameter of the catheter, which results in higher aspiration force as well as improved trackability allowing for enhanced navigation through cerebrovascular anatomy.</p>","PeriodicalId":49174,"journal":{"name":"Interventional Neuroradiology","volume":" ","pages":"2827-2832"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmad Sweid, Ahmad Chahine, Stephanie Hage, Rami Z Morsi, Sonam Thind, Lina Karar, Archit Baskaran, Julián Carrión-Penagos, Harsh Desai, Sachin A Kothari, Rohini Rana, Okker Verhagen Metman, Jehad Zakaria, James E Siegler, Issam Awad, Michael C Hurley, Shyam Prabhakaran, Sean Polster, Tareq Kass-Hout
{"title":"Fourth-generation Pipeline<sup>™</sup> Vantage flow diversion: First reported US experience of safety and feasibility.","authors":"Ahmad Sweid, Ahmad Chahine, Stephanie Hage, Rami Z Morsi, Sonam Thind, Lina Karar, Archit Baskaran, Julián Carrión-Penagos, Harsh Desai, Sachin A Kothari, Rohini Rana, Okker Verhagen Metman, Jehad Zakaria, James E Siegler, Issam Awad, Michael C Hurley, Shyam Prabhakaran, Sean Polster, Tareq Kass-Hout","doi":"10.1177/15910199241301119","DOIUrl":"10.1177/15910199241301119","url":null,"abstract":"<p><p>BackgroundThe Pipeline<sup>™</sup> Vantage embolization device (Medtronic, Irvine, CA) is the fourth generation of Pipeline flow diverter devices, offering numerous technical improvements. This study aimed to assess the feasibility and safety of The Pipeline<sup>™</sup> Vantage embolization device (Medtronic, Irvine, CA).MethodsThis was a single-center retrospective study describing the use of The Pipeline<sup>™</sup> Vantage embolization device for the treatment of intracranial aneurysms. Technical feasibility and safety were assessed in terms of intra and postprocedural complications, as well as neurological morbidity upon follow-up. Both ruptured and unruptured aneurysms were included.ResultsWe included 12 patients in our study (mean age 62; females: <i>n</i> = 9/12, 75%). Aneurysm morphology varied between saccular (41.6%), fusiform (41.6%), blister (8.3%), and pseudoaneurysm (8.3%). Three cases (25%) involved ruptured aneurysms treated in the acute setting. A transradial access was used in 10 cases (83.3%). There was a 100% success in deployment. Seven cases (58.3%) were treated with adjunct embolization device other than a flow diversion. Eight cases (66.6%) were treated with a single flow diversion, three cases (25%) were treated with two flow diversion, and one case (8.3%) was treated with three flow diversion stents. There were no intraoperative complications. There was one postprocedural complication in a dissecting ruptured PICA aneurysm that was ultimately treated with two flow diversion stents and an intrasaccular device.DiscussionTo our knowledge, this is the first US series assessing the periprocedural safety and feasibility of consecutive patients with intracranial aneurysms treated with the Pipeline<sup>™</sup> Vantage device (Medtronic, Irvine, CA).</p>","PeriodicalId":49174,"journal":{"name":"Interventional Neuroradiology","volume":" ","pages":"2550-2557"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olav Søvik, Halvor Øygarden, Arnstein Tveiten, Martin Wilhelm Kurz, Kathinka Dæhli Kurz, Pål Johan Stokkeland, Hanne Brit Hetland, Hege Langli Ersdal, Per Kristian Hyldmo
{"title":"Barriers to stroke treatment: The price of long-distance from thrombectomy centers.","authors":"Olav Søvik, Halvor Øygarden, Arnstein Tveiten, Martin Wilhelm Kurz, Kathinka Dæhli Kurz, Pål Johan Stokkeland, Hanne Brit Hetland, Hege Langli Ersdal, Per Kristian Hyldmo","doi":"10.1177/15910199241278036","DOIUrl":"10.1177/15910199241278036","url":null,"abstract":"<p><p>BackgroundEndovascular thrombectomy, the preferred treatment for acute large-vessel occlusion stroke, is highly time-dependent. Many patients live far from thrombectomy centers due to large geographical variations in stroke services. This study aimed to explore the consequences of long transport distance on the proportion of thrombectomy-eligible patients who underwent thrombectomy, the clinical outcomes with or without thrombectomy, the timelines for patients transported, and the diagnostic accuracy of large-vessel occlusion in primary stroke centers.MethodsWe conducted a retrospective observational study in a county with only primary stroke centers, ∼ 300 km from the nearest thrombectomy center. All stroke patients admitted over a year were retrieved from the Norwegian Stroke Registry. A neuroradiologist identified all computed tomography images with large-vessel occlusions. A panel determined whether these patients had a corresponding clinical indication for thrombectomy.ResultsA total of 50% of the eligible patients did not receive thrombectomy. These patients had a significantly higher risk of severe disability or death compared to the patients who underwent thrombectomy. The median time from computed tomography imaging at the primary stroke center to arrival at the thrombectomy center was over 3 hours. Additionally, 30% of the large-vessel occlusions were initially undiagnosed, and half of these patients had a corresponding clinical indication for thrombectomy.ConclusionsIn a county with a long transport distance to a thrombectomy center, a high proportion of eligible patients did not undergo thrombectomy, negatively impacting clinical outcomes. The transport time was considerable. A high rate of large-vessel occlusions was initially not diagnosed.</p>","PeriodicalId":49174,"journal":{"name":"Interventional Neuroradiology","volume":" ","pages":"2328-2335"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Santhosh Arul, Erik Jassen, Jennifer Ayers-Ringler, Oana Madalina Mereuta, Yigit Can Senol, Atakan Orscelik, Sherief Ghozy, Waleed Brinjikji, David F Kallmes, Ramanathan Kadirvel
{"title":"Circulating miRNA profiles as predictive biomarkers for aneurysm healing following endovascular treatment: a prospective study.","authors":"Santhosh Arul, Erik Jassen, Jennifer Ayers-Ringler, Oana Madalina Mereuta, Yigit Can Senol, Atakan Orscelik, Sherief Ghozy, Waleed Brinjikji, David F Kallmes, Ramanathan Kadirvel","doi":"10.1177/15910199241298321","DOIUrl":"10.1177/15910199241298321","url":null,"abstract":"<p><p>BackgroundAneurysm treatments are crucial to minimize the rupture risk. The underlying molecular processes mediating cellular remodeling, endothelialization, and aneurysm healing following endovascular treatment are poorly understood. The current study aims to explore circulating miRNA as a treatment and outcome-associated biomarkers in patients undergoing endovascular treatment.MethodsPatients undergoing endovascular interventions for unruptured intracranial aneurysms, using either flow diverter placement or coil embolization, were enrolled. Blood samples were collected before the intervention and during a follow-up period between 6 and 18 months. Total mRNA/miRNA was isolated from plasma, followed by RNA-seq analysis. Gene Ontology analysis was used to identify pathways linked to altered miRNA expression.ResultsTwenty-three patients participated, with 13 (56.5%) undergoing flow diversion and 10 (43.5%) coil embolization. The median follow-up sample collection time was 10.70 months (SEM ± 1.32). No significant differences in angiographic occlusion were noted between intervention groups. Differentially expressed miRNAs were not identified between groups at baseline. However, at follow-up, 39 miRNAs were upregulated and 41 were downregulated, independent of intervention. Notably, three miRNAs (miR-4746-5p, miR-4685-3p, and miR-490-3p) were downregulated in the flow diversion group compared to the coil embolization group. Bioinformatics analysis revealed associations with upregulated fluid shear stress, p53, adherens junction pathways, along with downregulated apoptosis pathways.ConclusionsThis study suggests that fluid shear stress and apoptosis may influence aneurysm healing or thromboembolic events in flow diverter-treated patients. Further research is warranted to elucidate the functional significance of these findings in treatment outcomes, providing valuable insights for improved patient care in intracranial aneurysm management.</p>","PeriodicalId":49174,"journal":{"name":"Interventional Neuroradiology","volume":" ","pages":"2537-2543"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuhai Long, Sun Yu, Chengcheng Shi, Ji Ma, Zhen Li, Jingliang Cheng, Yuncai Ran, Xinwei Han, Tengfei Li
{"title":"Diluted contrast media combined with high-resolution C-arm CT for evaluating apposition of flow diversions in a porcine model.","authors":"Shuhai Long, Sun Yu, Chengcheng Shi, Ji Ma, Zhen Li, Jingliang Cheng, Yuncai Ran, Xinwei Han, Tengfei Li","doi":"10.1177/15910199241261763","DOIUrl":"10.1177/15910199241261763","url":null,"abstract":"<p><p>BackgroundIn intracranial stenting, good stent apposition is crucial, and high-resolution C-arm computer tomography (CT) is utilized to assess whether stent apposition is complete. This study was aimed at finding optimal hypertonic or isotonic contrast media injection concentration for high-resolution C-arm CT to assess apposition of flow diversion (FD) after carotid artery stenting in swine.MethodsTwelve FD stents were implanted into the left carotid artery of Bama swine through the endovascular method. During high-resolution C-arm CT scanning, 6%, 8%, 10%, 12%, and 14% dilution percentages of hypertonic contrast media (iopromide 370 mg/ml) and 10%, 12%, 14%, 16%, and 18% dilution percentages of isotonic contrast media (iodixanol 320 mg/ml) were separately injected. A radiologist and a neuro-interventional specialist evaluated and qualitatively scored the post-processed images, and intravascular ultrasound (IVUS) was used to verify the accuracy of these images.ResultsOverall, 12 FD stents were implanted into the left common carotid artery of 12 swine, with a technical success rate of 100%. The best reconstructed images used to observe stent apposition were achieved with iopromide diluted to a concentration of 12% (all <i>P</i> < .05) or iodixanol diluted to a concentration of 16% (all <i>P</i> < .05). Malapposition was noted in one case, and good apposition was noted in 11 cases. These results were consistent with IVUS observations.ConclusionInjecting iopromide or iodixanol diluted to 12% or 16% during high-resolution C-arm CT scanning, respectively, can help evaluate FD stent apposition and obtain optimal image quality.</p>","PeriodicalId":49174,"journal":{"name":"Interventional Neuroradiology","volume":" ","pages":"2096-2102"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}