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Menopause age and cancer risk is influenced by rare genetic variants 绝经年龄和癌症风险受罕见基因变异的影响
IF 12.5 1区 生物学
Nature Structural & Molecular Biology Pub Date : 2024-11-13 DOI: 10.1038/s41594-024-01434-z
Michelle Korda
{"title":"Menopause age and cancer risk is influenced by rare genetic variants","authors":"Michelle Korda","doi":"10.1038/s41594-024-01434-z","DOIUrl":"10.1038/s41594-024-01434-z","url":null,"abstract":"","PeriodicalId":49141,"journal":{"name":"Nature Structural & Molecular Biology","volume":"31 11","pages":"1646-1647"},"PeriodicalIF":12.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane 出版商更正：RING E3 泛素连接酶 TRIM72 在膜上的结构和活化。
IF 12.5 1区 生物学
Nature Structural & Molecular Biology Pub Date : 2024-10-28 DOI: 10.1038/s41594-024-01429-w
Si Hoon Park, Juhyun Han, Byung-Cheon Jeong, Ju Han Song, Se Hwan Jang, Hyeongseop Jeong, Bong Heon Kim, Young-Gyu Ko, Zee-Yong Park, Kyung Eun Lee, Jaekyung Hyun, Hyun Kyu Song
{"title":"Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane","authors":"Si Hoon Park, Juhyun Han, Byung-Cheon Jeong, Ju Han Song, Se Hwan Jang, Hyeongseop Jeong, Bong Heon Kim, Young-Gyu Ko, Zee-Yong Park, Kyung Eun Lee, Jaekyung Hyun, Hyun Kyu Song","doi":"10.1038/s41594-024-01429-w","DOIUrl":"10.1038/s41594-024-01429-w","url":null,"abstract":"","PeriodicalId":49141,"journal":{"name":"Nature Structural & Molecular Biology","volume":"31 11","pages":"1810-1810"},"PeriodicalIF":12.5,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41594-024-01429-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis 作者更正：自身免疫性脑炎中抗体介导的 NMDA 受体聚集和内吞的结构基础
IF 12.5 1区 生物学
Nature Structural & Molecular Biology Pub Date : 2024-10-25 DOI: 10.1038/s41594-024-01410-7
Han Wang, Chun Xie, Bo Deng, Jinjun Ding, Na Li, Zengwei Kou, Mengmeng Jin, Jie He, Qinrui Wang, Han Wen, Jinbao Zhang, Qinming Zhou, Sheng Chen, Xiangjun Chen, Ti-Fei Yuan, Shujia Zhu
{"title":"Author Correction: Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis","authors":"Han Wang, Chun Xie, Bo Deng, Jinjun Ding, Na Li, Zengwei Kou, Mengmeng Jin, Jie He, Qinrui Wang, Han Wen, Jinbao Zhang, Qinming Zhou, Sheng Chen, Xiangjun Chen, Ti-Fei Yuan, Shujia Zhu","doi":"10.1038/s41594-024-01410-7","DOIUrl":"10.1038/s41594-024-01410-7","url":null,"abstract":"","PeriodicalId":49141,"journal":{"name":"Nature Structural & Molecular Biology","volume":"31 11","pages":"1809-1809"},"PeriodicalIF":12.5,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41594-024-01410-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clamping Pol ε to the leading strand 将 Pol ε 夹在前导链上
IF 12.5 1区 生物学
Nature Structural & Molecular Biology Pub Date : 2024-10-22 DOI: 10.1038/s41594-024-01416-1
Noopur Singh, Erik Johansson
{"title":"Clamping Pol ε to the leading strand","authors":"Noopur Singh, Erik Johansson","doi":"10.1038/s41594-024-01416-1","DOIUrl":"10.1038/s41594-024-01416-1","url":null,"abstract":"Two recent studies provide structural insights into how human DNA polymerase ε (Pol ε) interacts with PCNA to form a processive holoenzyme on the leading strand. A series of cryo-EM images offer structural information on the proofreading process, showing how DNA is transferred between the polymerase and exonuclease sites in human Pol ε.","PeriodicalId":49141,"journal":{"name":"Nature Structural & Molecular Biology","volume":"31 11","pages":"1644-1645"},"PeriodicalIF":12.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cohesin closes the door on coexpression 聚合素关闭了共表达之门
IF 12.5 1区 生物学
Nature Structural & Molecular Biology Pub Date : 2024-10-15 DOI: 10.1038/s41594-024-01404-5
George Andrew S. Inglis
{"title":"Cohesin closes the door on coexpression","authors":"George Andrew S. Inglis","doi":"10.1038/s41594-024-01404-5","DOIUrl":"10.1038/s41594-024-01404-5","url":null,"abstract":"","PeriodicalId":49141,"journal":{"name":"Nature Structural & Molecular Biology","volume":"31 10","pages":"1463-1463"},"PeriodicalIF":12.5,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142439142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into reproduction-regulating NOD-like receptors 对生殖调节 NOD 样受体的深入了解
IF 12.5 1区 生物学
Nature Structural & Molecular Biology Pub Date : 2024-10-08 DOI: 10.1038/s41594-024-01383-7
Inga V. Hochheiser, Matthias Geyer
{"title":"Insights into reproduction-regulating NOD-like receptors","authors":"Inga V. Hochheiser, Matthias Geyer","doi":"10.1038/s41594-024-01383-7","DOIUrl":"10.1038/s41594-024-01383-7","url":null,"abstract":"An understudied subset of NOD-like receptors are involved in the reproductive system, and their dysfunction can cause infertility. The recently obtained structures of the core subcortical maternal complex assembled around one of them, NLRP5, provide important insight into this building block of early embryo cytoplasmic lattices.","PeriodicalId":49141,"journal":{"name":"Nature Structural & Molecular Biology","volume":"31 11","pages":"1641-1643"},"PeriodicalIF":12.5,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142325384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cryo-EM structure of the human subcortical maternal complex and the associated discovery of infertility-associated variants 人类皮层下母体复合体的低温电子显微镜结构及不孕症相关变体的发现
IF 12.5 1区 生物学
Nature Structural & Molecular Biology Pub Date : 2024-10-08 DOI: 10.1038/s41594-024-01396-2
Pengliang Chi, Guojin Ou, Sibei Liu, Qianhong Ma, Yuechao Lu, Jinhong Li, Jialu Li, Qianqian Qi, Zhuo Han, Zihan Zhang, Qingting Liu, Li Guo, Jing Chen, Xiang Wang, Wei Huang, Lei Li, Dong Deng
{"title":"Cryo-EM structure of the human subcortical maternal complex and the associated discovery of infertility-associated variants","authors":"Pengliang Chi, Guojin Ou, Sibei Liu, Qianhong Ma, Yuechao Lu, Jinhong Li, Jialu Li, Qianqian Qi, Zhuo Han, Zihan Zhang, Qingting Liu, Li Guo, Jing Chen, Xiang Wang, Wei Huang, Lei Li, Dong Deng","doi":"10.1038/s41594-024-01396-2","DOIUrl":"10.1038/s41594-024-01396-2","url":null,"abstract":"The functionally conserved subcortical maternal complex (SCMC) is essential for early embryonic development in mammals. Reproductive disorders caused by pathogenic variants in NLRP5, TLE6 and OOEP, three core components of the SCMC, have attracted much attention over the past several years. Evaluating the pathogenicity of a missense variant in the SCMC is limited by the lack of information on its structure, although we recently solved the structure of the mouse SCMC and proposed that reproductive disorders caused by pathogenic variants are related to the destabilization of the SCMC core complex. Here we report the cryogenic electron microscopy structure of the human SCMC and uncover that the pyrin domain of NLRP5 is essential for the stability of SCMC. By combining prediction of SCMC stability and in vitro reconstitution, we provide a method for identifying deleterious variants, and we successfully identify a new pathogenic variant of TLE6 (p.A396T). Thus, on the basis of the structure of the human SCMC, we offer a strategy for the diagnosis of reproductive disorders and the discovery of new infertility-associated variants. On the basis of the assembly mechanism and structures of the human subcortical maternal complex, the authors provide a strategy for the diagnosis of reproductive disorders and the discovery of new infertility-associated SCMC variants.","PeriodicalId":49141,"journal":{"name":"Nature Structural & Molecular Biology","volume":"31 11","pages":"1798-1807"},"PeriodicalIF":12.5,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142384213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher Correction: Structural basis of LRPPRC–SLIRP-dependent translation by the mitoribosome 出版商更正：mitoribosome依赖LRPPRC-SLIRP翻译的结构基础。
IF 12.5 1区 生物学
Nature Structural & Molecular Biology Pub Date : 2024-09-19 DOI: 10.1038/s41594-024-01402-7
Vivek Singh, J. Conor Moran, Yuzuru Itoh, Iliana C. Soto, Flavia Fontanesi, Mary Couvillion, Martijn A. Huynen, L. Stirling Churchman, Antoni Barrientos, Alexey Amunts
{"title":"Publisher Correction: Structural basis of LRPPRC–SLIRP-dependent translation by the mitoribosome","authors":"Vivek Singh, J. Conor Moran, Yuzuru Itoh, Iliana C. Soto, Flavia Fontanesi, Mary Couvillion, Martijn A. Huynen, L. Stirling Churchman, Antoni Barrientos, Alexey Amunts","doi":"10.1038/s41594-024-01402-7","DOIUrl":"10.1038/s41594-024-01402-7","url":null,"abstract":"","PeriodicalId":49141,"journal":{"name":"Nature Structural & Molecular Biology","volume":"31 11","pages":"1809-1809"},"PeriodicalIF":12.5,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41594-024-01402-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Unwinding of a eukaryotic origin of replication visualized by cryo-EM 作者更正：用低温电子显微镜观察真核生物复制起源的开卷。
IF 12.5 1区 生物学
Nature Structural & Molecular Biology Pub Date : 2024-09-09 DOI: 10.1038/s41594-024-01398-0
Sarah S. Henrikus, Marta H. Gross, Oliver Willhoft, Thomas Pühringer, Jacob S. Lewis, Allison W. McClure, Julia F. Greiwe, Giacomo Palm, Andrea Nans, John F. X. Diffley, Alessandro Costa
{"title":"Author Correction: Unwinding of a eukaryotic origin of replication visualized by cryo-EM","authors":"Sarah S. Henrikus, Marta H. Gross, Oliver Willhoft, Thomas Pühringer, Jacob S. Lewis, Allison W. McClure, Julia F. Greiwe, Giacomo Palm, Andrea Nans, John F. X. Diffley, Alessandro Costa","doi":"10.1038/s41594-024-01398-0","DOIUrl":"10.1038/s41594-024-01398-0","url":null,"abstract":"","PeriodicalId":49141,"journal":{"name":"Nature Structural & Molecular Biology","volume":"31 11","pages":"1808-1808"},"PeriodicalIF":12.5,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41594-024-01398-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142165965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamics of an epigenetic regulator on chromatin observed at the single-molecule level 在单分子水平上观察染色质上表观遗传调节因子的动态变化
IF 12.5 1区 生物学
Nature Structural & Molecular Biology Pub Date : 2024-08-22 DOI: 10.1038/s41594-024-01374-8
{"title":"Dynamics of an epigenetic regulator on chromatin observed at the single-molecule level","authors":"","doi":"10.1038/s41594-024-01374-8","DOIUrl":"10.1038/s41594-024-01374-8","url":null,"abstract":"Methyl-CpG-binding protein 2 (MeCP2) is a master regulator of neuronal gene expression, and its genetic mutations cause the neurodevelopmental disorder Rett syndrome. Single-molecule experiments have enabled the direct visualization of the dynamics of MeCP2 on DNA, shedding light on how the specific chromatin context tunes MeCP2 function.","PeriodicalId":49141,"journal":{"name":"Nature Structural & Molecular Biology","volume":"31 11","pages":"1648-1649"},"PeriodicalIF":12.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142021862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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