胆固醇依赖性转移性的标志物

IF 10.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2025-07-11 DOI:10.1038/s41594-025-01626-1

Yuqi Wang, Xi Wang, Charles J. David, Yilong Zou

{"title":"胆固醇依赖性转移性的标志物","authors":"Yuqi Wang, Xi Wang, Charles J. David, Yilong Zou","doi":"10.1038/s41594-025-01626-1","DOIUrl":null,"url":null,"abstract":"How metabolic fitness in cancer clones is established and selected during dissemination and colonization remains enigmatic. A study in Nature now shows that disseminated pancreatic cancer cells bifurcate to seed the lung or liver on the basis of PCSK9 levels and the availability of microenvironmental cholesterol.","PeriodicalId":49141,"journal":{"name":"Nature Structural & Molecular Biology","volume":"32 8","pages":"1331-1333"},"PeriodicalIF":10.1000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A marker for sterol-dependent metastatic tropism\",\"authors\":\"Yuqi Wang, Xi Wang, Charles J. David, Yilong Zou\",\"doi\":\"10.1038/s41594-025-01626-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"How metabolic fitness in cancer clones is established and selected during dissemination and colonization remains enigmatic. A study in Nature now shows that disseminated pancreatic cancer cells bifurcate to seed the lung or liver on the basis of PCSK9 levels and the availability of microenvironmental cholesterol.\",\"PeriodicalId\":49141,\"journal\":{\"name\":\"Nature Structural & Molecular Biology\",\"volume\":\"32 8\",\"pages\":\"1331-1333\"},\"PeriodicalIF\":10.1000,\"publicationDate\":\"2025-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Structural & Molecular Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.nature.com/articles/s41594-025-01626-1\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Structural & Molecular Biology","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41594-025-01626-1","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

癌症克隆在传播和定植过程中如何建立和选择代谢适应度仍然是一个谜。《自然》杂志上的一项研究表明，播散性胰腺癌细胞在PCSK9水平和微环境胆固醇可用性的基础上分化为肺或肝脏。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A marker for sterol-dependent metastatic tropism

查看原文本刊更多论文

A marker for sterol-dependent metastatic tropism

How metabolic fitness in cancer clones is established and selected during dissemination and colonization remains enigmatic. A study in Nature now shows that disseminated pancreatic cancer cells bifurcate to seed the lung or liver on the basis of PCSK9 levels and the availability of microenvironmental cholesterol.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.