{"title":"胆固醇依赖性转移性的标志物","authors":"Yuqi Wang, Xi Wang, Charles J. David, Yilong Zou","doi":"10.1038/s41594-025-01626-1","DOIUrl":null,"url":null,"abstract":"How metabolic fitness in cancer clones is established and selected during dissemination and colonization remains enigmatic. A study in Nature now shows that disseminated pancreatic cancer cells bifurcate to seed the lung or liver on the basis of PCSK9 levels and the availability of microenvironmental cholesterol.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"27 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A marker for sterol-dependent metastatic tropism\",\"authors\":\"Yuqi Wang, Xi Wang, Charles J. David, Yilong Zou\",\"doi\":\"10.1038/s41594-025-01626-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"How metabolic fitness in cancer clones is established and selected during dissemination and colonization remains enigmatic. A study in Nature now shows that disseminated pancreatic cancer cells bifurcate to seed the lung or liver on the basis of PCSK9 levels and the availability of microenvironmental cholesterol.\",\"PeriodicalId\":18822,\"journal\":{\"name\":\"Nature structural & molecular biology\",\"volume\":\"27 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature structural & molecular biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41594-025-01626-1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-025-01626-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
How metabolic fitness in cancer clones is established and selected during dissemination and colonization remains enigmatic. A study in Nature now shows that disseminated pancreatic cancer cells bifurcate to seed the lung or liver on the basis of PCSK9 levels and the availability of microenvironmental cholesterol.
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