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Krüppel-like factor 14 enhances fatty acid oxidation to combat pulmonary fibrosis. kr<s:1> pel样因子14增强脂肪酸氧化以对抗肺纤维化。
IF 5.8 2区 医学
Respiratory Research Pub Date : 2026-04-30 DOI: 10.1186/s12931-026-03662-x
Jingrui Ren, Ruijie Wan, Shuai Zhou, Xinran Ma, Chenxi Zhu, Jinxin Ma, Jianqiao Chen, Limin Zhao, Wenjuan Wu
{"title":"Krüppel-like factor 14 enhances fatty acid oxidation to combat pulmonary fibrosis.","authors":"Jingrui Ren, Ruijie Wan, Shuai Zhou, Xinran Ma, Chenxi Zhu, Jinxin Ma, Jianqiao Chen, Limin Zhao, Wenjuan Wu","doi":"10.1186/s12931-026-03662-x","DOIUrl":"https://doi.org/10.1186/s12931-026-03662-x","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic pulmonary fibrosis (IPF) is a progressive lung disorder with few effective treatments. This study examines how Krüppel-like factor 14 (KLF14) influences fatty acid oxidation (FAO) and fibroblast senescence in IPF.</p><p><strong>Methods: </strong>A rat model of IPF was induced using bleomycin. Expression levels of KLF14, CPT1A, and related proteins were measured using qRT-PCR and Western blot. Lung tissue histology was examined, and cellular senescence was evaluated using SA-β-gal staining. The transcriptional regulation of CPT1A by KLF14 was confirmed through luciferase reporter assays and ChIP.</p><p><strong>Results: </strong>KLF14 expression was significantly downregulated in the IPF model. Overexpression of KLF14 reduced collagen deposition, attenuated fibroblast senescence, and enhanced FAO by upregulating CPT1A. Mechanistically, KLF14 binds to the CPT1A promoter, promoting its transcription.</p><p><strong>Conclusions: </strong>KLF14 enhances FAO through CPT1A activation, offering a novel therapeutic strategy for IPF.</p>","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: A multicenter prospective clinical cohort study of pulmonary cryptococcosis in adult non-HIV-infected patients in a southeastern province of China. 更正：一项中国东南部省份成人非hiv感染患者肺隐球菌病的多中心前瞻性临床队列研究。
IF 5.8 2区 医学
Respiratory Research Pub Date : 2026-04-29 DOI: 10.1186/s12931-026-03624-3
Meiyan Chen, Chen Shuyang, Wang Meng, Wang Huijuan, Zeng Shengyuan, Zhuang Liying, Lai Guoxiang, Yu Zongyang, You Yanjing, Xie Baosong, Yao Xiujuan, Chen Xiangqi, Lin Lan, Lin Qunying, Hu Yuxiong, Xu Liyu, Li Xiaohua, Chen Xiaohong, Wu Danmei, Chen Gongping, Liu Kaixiong, She Hui, Lin Li, Yu Guoqing, Wen Wen
{"title":"Correction: A multicenter prospective clinical cohort study of pulmonary cryptococcosis in adult non-HIV-infected patients in a southeastern province of China.","authors":"Meiyan Chen, Chen Shuyang, Wang Meng, Wang Huijuan, Zeng Shengyuan, Zhuang Liying, Lai Guoxiang, Yu Zongyang, You Yanjing, Xie Baosong, Yao Xiujuan, Chen Xiangqi, Lin Lan, Lin Qunying, Hu Yuxiong, Xu Liyu, Li Xiaohua, Chen Xiaohong, Wu Danmei, Chen Gongping, Liu Kaixiong, She Hui, Lin Li, Yu Guoqing, Wen Wen","doi":"10.1186/s12931-026-03624-3","DOIUrl":"https://doi.org/10.1186/s12931-026-03624-3","url":null,"abstract":"","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":"27 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fungal exposure exacerbates allergen-driven asthma in a two-hit mouse model. 真菌暴露加剧了过敏原驱动的哮喘在一个双重打击小鼠模型。
IF 5.8 2区 医学
Respiratory Research Pub Date : 2026-04-28 DOI: 10.1186/s12931-026-03684-5
Shuya Mei, Lingxiang Zhu, Kui Zhang, Abhimanyu Thakur, Bohao Chen, Xiangdi Mao, Fuyu Duan, Venesa Romero, Yin Chen, Joyce Chen
{"title":"Fungal exposure exacerbates allergen-driven asthma in a two-hit mouse model.","authors":"Shuya Mei, Lingxiang Zhu, Kui Zhang, Abhimanyu Thakur, Bohao Chen, Xiangdi Mao, Fuyu Duan, Venesa Romero, Yin Chen, Joyce Chen","doi":"10.1186/s12931-026-03684-5","DOIUrl":"https://doi.org/10.1186/s12931-026-03684-5","url":null,"abstract":"","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The allure and pitfalls of physiological quotients in lung function interpretation. 生理商在肺功能解释中的吸引力和缺陷。
IF 5.8 2区 医学
Respiratory Research Pub Date : 2026-04-28 DOI: 10.1186/s12931-026-03666-7
Zhican Liu, Chao Hu, Mingyan Jiang
{"title":"The allure and pitfalls of physiological quotients in lung function interpretation.","authors":"Zhican Liu, Chao Hu, Mingyan Jiang","doi":"10.1186/s12931-026-03666-7","DOIUrl":"10.1186/s12931-026-03666-7","url":null,"abstract":"","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":"27 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tracking the evolution of biomarker efficacy in SARS-CoV-2: a global meta-analyses series. 追踪SARS-CoV-2生物标志物疗效的演变：一项全球荟萃分析系列
IF 5.8 2区 医学
Respiratory Research Pub Date : 2026-04-28 DOI: 10.1186/s12931-026-03656-9
Me Rahman Shuvo, Max Schwiening, Nikos Avramidis, Felipe Soares, Oliver Feng, Susana Abreu, Niki Veale, William Thomas, A A Roger Thompson, Richard J Samworth, Nicholas W Morrell, Malcolm G Semple, Kenneth Baillie, Stefan J Marciniak, Elaine Soon
{"title":"Tracking the evolution of biomarker efficacy in SARS-CoV-2: a global meta-analyses series.","authors":"Me Rahman Shuvo, Max Schwiening, Nikos Avramidis, Felipe Soares, Oliver Feng, Susana Abreu, Niki Veale, William Thomas, A A Roger Thompson, Richard J Samworth, Nicholas W Morrell, Malcolm G Semple, Kenneth Baillie, Stefan J Marciniak, Elaine Soon","doi":"10.1186/s12931-026-03656-9","DOIUrl":"https://doi.org/10.1186/s12931-026-03656-9","url":null,"abstract":"","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Respiratory tract diseases and lung function in coke oven plant workers: a 50-year global systematic evaluation and meta-analysis. 焦炉工厂工人呼吸道疾病和肺功能：50年全球系统评价和荟萃分析
IF 5.8 2区 医学
Respiratory Research Pub Date : 2026-04-28 DOI: 10.1186/s12931-026-03602-9
Amir Hossein Khoshakhlagh, Safiye Ghobakhloo, Marzieh Rahimi, Akram Yazdani, Agnieszka Gruszecka-Kosowska
{"title":"Respiratory tract diseases and lung function in coke oven plant workers: a 50-year global systematic evaluation and meta-analysis.","authors":"Amir Hossein Khoshakhlagh, Safiye Ghobakhloo, Marzieh Rahimi, Akram Yazdani, Agnieszka Gruszecka-Kosowska","doi":"10.1186/s12931-026-03602-9","DOIUrl":"https://doi.org/10.1186/s12931-026-03602-9","url":null,"abstract":"","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adult life course trajectories of lung function and the development of interstitial lung abnormalities: the CARDIA lung study. 肺功能的成人生命历程轨迹和间质性肺异常的发展：CARDIA肺研究。
IF 5.8 2区 医学
Respiratory Research Pub Date : 2026-04-28 DOI: 10.1186/s12931-026-03667-6
Kevin M Grudzinski, Gabrielle Y Liu, Laura A Colangelo, Kavitha C Selvan, Rachel Putman, Gary M Hunninghake, Raul San Jose Estepar, George Washko, Ravi Kalhan, Anthony J Esposito
{"title":"Adult life course trajectories of lung function and the development of interstitial lung abnormalities: the CARDIA lung study.","authors":"Kevin M Grudzinski, Gabrielle Y Liu, Laura A Colangelo, Kavitha C Selvan, Rachel Putman, Gary M Hunninghake, Raul San Jose Estepar, George Washko, Ravi Kalhan, Anthony J Esposito","doi":"10.1186/s12931-026-03667-6","DOIUrl":"10.1186/s12931-026-03667-6","url":null,"abstract":"","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":"27 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Respiratory-physiology modeling of therapeutic hydrogen inhalation: defining the fraction of inspired hydrogen (FiH2) and flow-rate requirements. 治疗性氢气吸入的呼吸生理学建模：定义吸入氢气的比例（FiH2）和流量要求。
IF 5.8 2区 医学
Respiratory Research Pub Date : 2026-04-28 DOI: 10.1186/s12931-026-03664-9
Tyler W LeBaron, Kinji Ohno, Cordélia Salomez-Ihl, Philippe Cinquin, François Boucher, Motoaki Sano, John N Kheir
{"title":"Respiratory-physiology modeling of therapeutic hydrogen inhalation: defining the fraction of inspired hydrogen (FiH<sub>2</sub>) and flow-rate requirements.","authors":"Tyler W LeBaron, Kinji Ohno, Cordélia Salomez-Ihl, Philippe Cinquin, François Boucher, Motoaki Sano, John N Kheir","doi":"10.1186/s12931-026-03664-9","DOIUrl":"https://doi.org/10.1186/s12931-026-03664-9","url":null,"abstract":"","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of blood protein-metabolic profiles via machine learning to enable the accurate early detection of non-small cell lung cancer. 通过机器学习整合血液蛋白代谢谱，实现非小细胞肺癌的准确早期检测。
IF 5.8 2区 医学
Respiratory Research Pub Date : 2026-04-27 DOI: 10.1186/s12931-026-03686-3
HuiYing Shi, JiaMing Sun, HuiMin Wei, Jun Tang, XiaoLei Zhou, HongSa Li, JiongRan Wang, LiFeng Li, Fang Sun, JunWei Zhao, ShuLin Zhang
{"title":"Integration of blood protein-metabolic profiles via machine learning to enable the accurate early detection of non-small cell lung cancer.","authors":"HuiYing Shi, JiaMing Sun, HuiMin Wei, Jun Tang, XiaoLei Zhou, HongSa Li, JiongRan Wang, LiFeng Li, Fang Sun, JunWei Zhao, ShuLin Zhang","doi":"10.1186/s12931-026-03686-3","DOIUrl":"https://doi.org/10.1186/s12931-026-03686-3","url":null,"abstract":"","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unsupervised comprehensive CT imaging clusters reveal distinct morphological phenotypes in asthma: insights from two prospective cohorts. 无监督的综合CT成像簇揭示哮喘的不同形态表型：来自两个前瞻性队列的见解。
IF 5.8 2区 医学
Respiratory Research Pub Date : 2026-04-27 DOI: 10.1186/s12931-026-03691-6
Yusuke Hayashi, Naoya Tanabe, Atsuyasu Sato, Tsunahiko Hirano, Hiroshi Iwamoto, Tomoki Maetani, Yusuke Shiraishi, Ryo Sakamoto, Hironobu Sunadome, Ayumi Fukatsu-Chikumoto, Toshihito Otani, Naoko Higaki, Yoshihiro Amano, Tamio Okimoto, Mayuka Yamane, Akihito Yokoyama, Hiroshi Date, Susumu Sato, Noboru Hattori, Kazuto Matsunaga, Toyohiro Hirai
{"title":"Unsupervised comprehensive CT imaging clusters reveal distinct morphological phenotypes in asthma: insights from two prospective cohorts.","authors":"Yusuke Hayashi, Naoya Tanabe, Atsuyasu Sato, Tsunahiko Hirano, Hiroshi Iwamoto, Tomoki Maetani, Yusuke Shiraishi, Ryo Sakamoto, Hironobu Sunadome, Ayumi Fukatsu-Chikumoto, Toshihito Otani, Naoko Higaki, Yoshihiro Amano, Tamio Okimoto, Mayuka Yamane, Akihito Yokoyama, Hiroshi Date, Susumu Sato, Noboru Hattori, Kazuto Matsunaga, Toyohiro Hirai","doi":"10.1186/s12931-026-03691-6","DOIUrl":"https://doi.org/10.1186/s12931-026-03691-6","url":null,"abstract":"","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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