Biomedical Microdevices最新文献_第5页

Magnetic moment orientation compensation of a magnetic navigated underactuated spherical capsule robot for all-around observation 全方位观测磁导航欠驱动球形胶囊机器人的磁矩方向补偿。

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2026-04-27 DOI: 10.1007/s10544-026-00811-3

Yongshun Zhang, Yunhui Ma, Yanxia Li, Lin Li

{"title":"Magnetic moment orientation compensation of a magnetic navigated underactuated spherical capsule robot for all-around observation","authors":"Yongshun Zhang, Yunhui Ma, Yanxia Li, Lin Li","doi":"10.1007/s10544-026-00811-3","DOIUrl":"10.1007/s10544-026-00811-3","url":null,"abstract":"<div>\u0000 \u0000 <p>All-around disease screening in any appointed position in 3D regions of the gastrointestinal (GI) tract such as esophagus, stomach and colon is still a pending issue. Based on the rotating magnetic coaxial effect of a suspended magnet actuated by the spatial universal rotating magnetic field (SURMF), a novel underactuated spherical capsule robot(USCR) with fully suspended magnetic ring in term of the gyroscope dynamic balance, along with its lateral drive method using rotating coaxial magnetic moment, are proposed to address orthogonal decoupling of magnetic moments, flexible and efficient posture control with good stability. The underactuated structure facilitates the all around observation mode at a fixed-point and the rolling locomotion mode by the space universal rotating magnetic field (SURMF) axis manipulation, however, magnetic moment orientation deviation and motion path deviation are caused by the slip angle, thus deviation model of the decoupled rotating coaxial magnetic moment is derived, corrected and verified, which lays a foundation for the precise and stable control of the motion path by the slip angle compensation and the application of the rotating coaxial driving theory of the novel capsule.</p>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 2","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermoplastic elastomer based microfluidic gradient generator for cell culture and drug testing 基于热塑性弹性体的微流体梯度发生器，用于细胞培养和药物测试。

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2026-04-25 DOI: 10.1007/s10544-026-00816-y

Kebin Li, Byeong-Ui Moon, Liviu Clime, Ljuboje Lukic, Keith Morton, Lidija Malic, Anu David, Christophe Faure, Teodor Veres

{"title":"Thermoplastic elastomer based microfluidic gradient generator for cell culture and drug testing","authors":"Kebin Li, Byeong-Ui Moon, Liviu Clime, Ljuboje Lukic, Keith Morton, Lidija Malic, Anu David, Christophe Faure, Teodor Veres","doi":"10.1007/s10544-026-00816-y","DOIUrl":"10.1007/s10544-026-00816-y","url":null,"abstract":"<div>\u0000 \u0000 <p>Microfluidic systems are increasingly utilized in preclinical research, however, developing platforms that are compatible with large-scale manufacturing remains a critical challenge. In this regard, we show that thermoplastic elastomer (TPE)-based microfluidic chips could be a viable alternative to traditional poly(dimethylsiloxane) (PDMS) devices for drug testing applications. Microfluidic concentration gradient generators are essential components in these systems, enabling local spatial and temporal control of biochemical stimuli for applications such as cellular response studies and drug screening. TPEs offer key advantages, especially, optical transparency, flexibility, and compatibility with high-throughput fabrication processes compared to PDMS, thereby enhancing commercialization potential. This study demonstrates the design and fabrication of TPE-based microfluidic devices incorporating concentration gradient generators that allow precise control over solute distributions. Gradient formation was validated through numerical modeling and co-flow experiments using fluorescent dyes. The platform supported the co-culture of human lung fibroblast cells and human colon adenocarcinoma cells (HT-29), which exhibited coordinated responses to gradients of fetal bovine serum (FBS) and sepantronimum bromide (YM-155). Performance benchmarks against PDMS chips demonstrated comparable functionality, underscoring the potential of TPE-based devices for future scalable and cost-effective drug testing and cellular assays.</p>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 2","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A dual-Nafion microfluidic preconcentrator with integrated label-free UV absorbance detection on a quartz substrate 在石英衬底上集成无标签紫外吸收检测的双nafion微流控预富集器

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2026-04-23 DOI: 10.1007/s10544-026-00814-0

Dong-Li Li, Cheng-Yeh Ke, Chun-Ping Jen

{"title":"A dual-Nafion microfluidic preconcentrator with integrated label-free UV absorbance detection on a quartz substrate","authors":"Dong-Li Li, Cheng-Yeh Ke, Chun-Ping Jen","doi":"10.1007/s10544-026-00814-0","DOIUrl":"10.1007/s10544-026-00814-0","url":null,"abstract":"<div>\u0000 \u0000 <p>A dual-Nafion microfluidic preconcentrator with integrated label-free ultraviolet absorbance detection on a quartz substrate is presented for stable electrokinetic protein enrichment and real-time monitoring. The device employs a symmetric dual-membrane architecture to spatially confine the ion-concentration-polarization enrichment zone, thereby suppressing axial migration and improving operational stability compared with conventional single-Nafion configurations. Integration of a UV-transparent quartz substrate and a chromium-defined optical window enables background-suppressed, on-chip absorbance detection at 280 nm without fluorescent labeling. Device performance was characterized using bovine serum albumin as a model protein under controlled electrokinetic conditions, where real-time absorbance measurements demonstrated stable enrichment behavior over a wide concentration range, yielding enrichment factors of approximately 39-fold, 3960-fold, and 4380-fold from initial concentrations of 1 µM, 10 nM, and 1 nM, respectively, within 30 min of operation. Compared with a previously reported single-Nafion glass-based device, the dual-Nafion platform exhibits enhanced enrichment efficiency and extends reliable operation into the low-nanomolar regime. These results highlight the advantages of combining a symmetric dual‑Nafion architecture with quartz‑based, label‑free UV absorbance detection for reproducible electrokinetic preconcentration, and demonstrate the feasibility of using this integrated platform as a front‑end module for downstream biosensing and analytical systems.</p>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 2","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147738444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A CFD-driven supervised learning framework for rapid DLD microfluidic chip optimization in CTC separation CTC分离中快速优化DLD微流控芯片的cfd驱动监督学习框架

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2026-04-23 DOI: 10.1007/s10544-026-00813-1

Tanbir Sarowar, Elizabeth Chen, Xiaolin Chen

{"title":"A CFD-driven supervised learning framework for rapid DLD microfluidic chip optimization in CTC separation","authors":"Tanbir Sarowar, Elizabeth Chen, Xiaolin Chen","doi":"10.1007/s10544-026-00813-1","DOIUrl":"10.1007/s10544-026-00813-1","url":null,"abstract":"<div>\u0000 \u0000 <p>Circulating tumor cells (CTCs) provide critical diagnostic information for cancer detection and monitoring, yet their isolation from whole blood remains technically challenging due to their extreme rarity. Deterministic lateral displacement (DLD) microfluidics offers label-free, size-based separation but requires precise geometric optimization, a process traditionally requiring complex and computationally expensive iterative simulations. Here we present a computational supervised machine learning framework, trained on validated CFD simulation data, that accelerates DLD device design by over three orders of magnitude compared to iterative CFD-based optimization. We generated 8.9 million particle trajectory data points through validated computational fluid dynamics simulations spanning 896 device configurations, systematically varying period number (<i>N</i> = 3–48) and particle diameter (1–14 μm). Four supervised regression algorithms, Gradient Boosting, k-Nearest Neighbors, Random Forest, and Multi-Layer Perceptron were trained to predict particle trajectories as functions of design parameters. Random Forest achieved the highest predictive accuracy (R² = 0.958) with an inference time of 89 ms per design candidate, enabling real-time interactive design exploration. The models, through prediction of the particle trajectories, successfully captured the deterministic zigzag-to-bumped mode transition and accurately identified the critical diameter range. This data-driven approach significantly reduces the reliance on repeated CFD simulations during design optimization, compressing the design exploration cycle from weeks to seconds while maintaining accuracy consistent with the underlying validated simulations. The presented framework provides a generalizable computational methodology that integrates physics-based simulations with supervised learning to accelerate microfluidic device design, offering a potential foundation for future clinical diagnostic applications.</p>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 2","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147738072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical biosensing using particle diffusometry on thermoplastic microfluidic chips bonded using direct and indirect chip bonding methods 热塑性微流控芯片上的粒子扩散光学生物传感，采用直接和间接的芯片键合方法。

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2026-04-20 DOI: 10.1007/s10544-026-00810-4

Julio A. Rivera-De Jesus, Alexander B. Memmer, Dong Hoon Lee, Tamara L. Kinzer-Ursem, Steven T. Wereley, Jacqueline C. Linnes, Melinda A. Lake-Speers

{"title":"Optical biosensing using particle diffusometry on thermoplastic microfluidic chips bonded using direct and indirect chip bonding methods","authors":"Julio A. Rivera-De Jesus, Alexander B. Memmer, Dong Hoon Lee, Tamara L. Kinzer-Ursem, Steven T. Wereley, Jacqueline C. Linnes, Melinda A. Lake-Speers","doi":"10.1007/s10544-026-00810-4","DOIUrl":"10.1007/s10544-026-00810-4","url":null,"abstract":"<div>\u0000 \u0000 <p>Thermoplastics offer a scalable and cost-effective platform for fabricating microfluidic devices for point-of-care (POC) diagnostics. Among them, cyclic olefin polymer (COP) stands out due to its exceptional optical clarity, making it suitable for fluorescence-based biosensing. However, bonding COP layers without compromising mechanical strength or imaging quality remains a challenge. This study systematically evaluates four bonding techniques: thermal bonding, solvent bonding, UV-curable adhesives, and pressure-sensitive adhesives (PSA), using standardized 180-degree peel tests to quantify bond strength. PSA bonding exhibited the highest adhesion (0.2–0.8 N/mm), while thermal and solvent bonds were notably weaker (<0.05 N/mm). Plasma treatment improved bond strength and uniformity across most methods. We demonstrate the utility of these bonding techniques by fabricating multilayer microfluidic chips compatible with particle diffusometry (PD), an optical biosensing method that detects <i>Vibrio cholerae</i> DNA via changes in nanoparticle motion. Chips were assessed for both mechanical robustness and image intensity suitability for smartphone-based PD measurements. This work provides practical design criteria for selecting prototyping-compatible bonding strategies in the development of low-cost, optically clear microfluidic diagnostic platforms.</p>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 2","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10544-026-00810-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparative study of COVID-19 point-of-care detection across human biofluids using MEMS-based near-infrared spectroscopy and machine learning 基于mems的近红外光谱和机器学习在人体生物体液中检测COVID-19的比较研究

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2026-04-13 DOI: 10.1007/s10544-026-00806-0

Ahmed Abdelkhalik, Mazen Erfan, Bassem Mortada, Mohamed Gaber, Moataz Bellah Abdelaleem, Hala Hafez, Samia A. Girgis, Ossama Mansour, Bassam Saadany, Yasser M. Sabry, Diaa Khalil

{"title":"A comparative study of COVID-19 point-of-care detection across human biofluids using MEMS-based near-infrared spectroscopy and machine learning","authors":"Ahmed Abdelkhalik, Mazen Erfan, Bassem Mortada, Mohamed Gaber, Moataz Bellah Abdelaleem, Hala Hafez, Samia A. Girgis, Ossama Mansour, Bassam Saadany, Yasser M. Sabry, Diaa Khalil","doi":"10.1007/s10544-026-00806-0","DOIUrl":"10.1007/s10544-026-00806-0","url":null,"abstract":"<div>\u0000 \u0000 <p>This study explores the use of near-infrared (NIR) spectroscopy in the 1.3–2.6 μm wavelength range, employing a handheld miniaturized microelectromechanical systems (MEMS)-based spectrometer for the rapid, non-invasive detection of COVID-19 from various biofluids. A total of 238 samples—including nasopharyngeal (NSP) swabs, nasal swabs, and saliva—from both COVID-19 positive and negative individuals are analysed. Machine learning algorithms process the spectral data to develop predictive models for the disease classification. Models based on a single biofluid achieve detection accuracies between 75% and 80%, while combining scans from multiple biofluids of the same individual improves accuracy to 88%. The study highlights trade-offs between sample accessibility and diagnostic performance. Overall, the findings demonstrate that NIR spectroscopy serves as a viable low-cost, portable, and rapid point-of-care (POC) solution, with strong potential for scalable mass screening—particularly in resource-limited settings.</p>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 2","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microarchitectonics of single-pore hollow polymeric micromotors based on polyaminoester/polycaprolactone for co-delivery of doxorubicin and curcumin against gastric cancer 基于聚胺酯/聚己内酯的单孔中空聚合物微电机的微结构研究，用于联合递送阿霉素和姜黄素抗胃癌。

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2026-04-11 DOI: 10.1007/s10544-026-00808-y

Hesam Layegh, Sepideh Khoee

{"title":"Microarchitectonics of single-pore hollow polymeric micromotors based on polyaminoester/polycaprolactone for co-delivery of doxorubicin and curcumin against gastric cancer","authors":"Hesam Layegh, Sepideh Khoee","doi":"10.1007/s10544-026-00808-y","DOIUrl":"10.1007/s10544-026-00808-y","url":null,"abstract":"<div><p>Micromotors have garnered significant interest due to their autonomous locomotion and capabilities for active transport at the micro and nanoscale. This study presents a novel synthesis method for producing single-pore hollow polymeric microspheres (SHPMS) using a dendron-polymer conjugate derived from polyaminoester and polycaprolactone, characterized by its pH-responsiveness and amphiphilicity. The conjugate serves as a partial emulsifier in a one-step water-in-oil-in-water (W/O/W) double emulsion process, allowing for precise morphological control over the microspheres, including adjustments to pore size and internal architecture. Following synthesis, platinum nanoparticles were loaded into the SHPMs, yielding self-propelled micromotors capable of propulsion via the catalytic decomposition of hydrogen peroxide. These micromotors were tailored for the co-delivery of doxorubicin (DOX) and curcumin (CURC) to enhance therapeutic efficacy against gastric adenocarcinoma (AGS and MKN-45) cells. Drug release studies showed excellent pH-responsiveness with markedly increased DOX release in acidic environments. Cytotoxicity assays revealed that the micromotor system exhibited significantly enhanced anticancer activity compared to free DOX, due to the synergistic effects of curcumin as a natural P-glycoprotein (P-gp) inhibitor. This combination not only reduced the required DOX concentration but also maintained therapeutic activity.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 2","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147661962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of droplet size on the encapsulation efficiency of microparticles in passive microfluidic systems 无源微流控系统中液滴尺寸对微粒封装效率的影响。

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2026-03-31 DOI: 10.1007/s10544-026-00795-0

Risa Fujita, Masashi Kobayashi, Takashi Tanii, Masahiro Furuya, Shuichi Shoji, Daiki Tanaka

{"title":"Effect of droplet size on the encapsulation efficiency of microparticles in passive microfluidic systems","authors":"Risa Fujita, Masashi Kobayashi, Takashi Tanii, Masahiro Furuya, Shuichi Shoji, Daiki Tanaka","doi":"10.1007/s10544-026-00795-0","DOIUrl":"10.1007/s10544-026-00795-0","url":null,"abstract":"<div>\u0000 \u0000 <p>Droplet microfluidic technologies are widely used in single-cell analysis, in which passive encapsulation methods are commonly used to isolate individual cells or particles. In these systems, the number of particles per droplet is assumed to follow a Poisson distribution. However, the extent to which droplet size affects encapsulation behavior under passive conditions is poorly understood. In this study, we systematically investigated the effect of droplet diameter on single-particle encapsulation fidelity by generating agarose droplets 30, 50, and 100 μm using a flow-focusing microfluidic device. Fluorescent beads were encapsulated at a concentration corresponding to a mean occupancy of 1, and encapsulation statistics were analyzed across droplet sizes. The 30 and 50 μm droplets exhibited encapsulation distributions closely aligned with the Poisson model, whereas 100 μm droplets showed a large excess of empty droplets and substantial deviation from the expected profile. To examine whether comparable size-dependent trends are observed in a biological sample, green fluorescent protein-expressing <i>Escherichia coli</i> were encapsulated in droplets of the same sizes. The 30 μm droplets consistently showed the closest agreement with Poisson statistics, whereas the 50 and 100 μm droplets showed comparable encapsulation fidelity, with moderate deviations and a modest increase in empty droplets at the largest diameter. These findings indicate that smaller droplets provide robust stochastic encapsulation in passive systems, while larger droplets may exhibit reduced fidelity depending on particle type. Our results suggest that droplet size is an important factor to consider when designing simplified and reliable microfluidic systems for biological applications.</p>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 2","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10544-026-00795-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-generation wearable, ingestible, and implantable bioelectronics for health monitoring, therapy, and human-machine interaction 用于健康监测、治疗和人机交互的下一代可穿戴、可摄取和可植入的生物电子学。

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2026-03-24 DOI: 10.1007/s10544-026-00809-x

Madhurendra Mishra, Krishnesh Krishnakumar Nair, Hannah Susan Regi, Aakifah Minhaj, Divyansh Shetty, Anoushka Martin, Adarsh Ganesan

{"title":"Next-generation wearable, ingestible, and implantable bioelectronics for health monitoring, therapy, and human-machine interaction","authors":"Madhurendra Mishra, Krishnesh Krishnakumar Nair, Hannah Susan Regi, Aakifah Minhaj, Divyansh Shetty, Anoushka Martin, Adarsh Ganesan","doi":"10.1007/s10544-026-00809-x","DOIUrl":"10.1007/s10544-026-00809-x","url":null,"abstract":"<div>\u0000 \u0000 <p>The development of wearable and ingestible bioelectronic systems has advanced healthcare by facilitating continuous physiological monitoring and targeted medical therapies. This review presents a comprehensive overview of recent advances in next-generation bioelectronic technologies that integrate sensing, wireless communication and intelligent data processing within minimally invasive architectures. Our study investigates new technologies that monitor human physiology and biochemistry through ingestible capsules, microneedle interfaces, smart epidermal patches, wearable ultrasound devices and contactless sensing systems that measure multiple biological signals in real time. The therapeutic bioelectronic devices combine sensing capabilities with controlled actuation functions for use in wound healing, neuro-rehabilitation and prosthetic control. The review investigates current progress in wearable human-machine interfaces that use electronic skins, soft bio-integrated sensors and neuromorphic components to transform human body signals into machine-readable commands. The research study also focuses on artificial intelligence and machine learning integration that makes bioelectronic systems more intelligible and adaptive to different situations, allowing for enhanced personalized healthcare and advanced human-machine interaction.</p>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 2","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enzymatic assay in a lab-on-a-disk format to measure free piperacillin concentration in serum 酶测定法在实验室磁盘格式测量游离哌拉西林浓度在血清中。

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2026-03-17 DOI: 10.1007/s10544-026-00807-z

Olivier Verlaine, Ana Amoroso, Maxence Remy, Stéphanie Wautier, Raphaël Robiette, Bernard Joris, Tristan Gilet

引用次数: 0