Synthesis and active manipulation of magnetic liquid beads

IF 3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Biomedical Microdevices Pub Date : 2024-05-06 DOI:10.1007/s10544-024-00708-z

Ajeet Singh Yadav, Fariba Malekpour Galogahi, Aditya Vashi, Du Tuan Tran, Gregor S. Kijanka, Haotian Cha, Kamalalayam Rajan Sreejith, Nam-Trung Nguyen

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Abstract

We report the fabrication and characterisation of magnetic liquid beads with a solid magnetic shell and liquid core using microfluidic techniques. The liquid beads consist of a fluorinated oil core and a polymer shell with magnetite particles. The beads are generated in a flow-focusing polydimethylsiloxane (PDMS) device and cured by photo polymerisation. We investigated the response of the liquid beads to an external magnetic field by characterising their motion towards a permanent magnet. Magnetic sorting of liquid beads in a channel was achieved with 90% efficiency. The results show that the liquid beads can be controlled magnetically and have potential applications in digital microfluidics including nucleic acid amplification, drug delivery, cell culture, sensing, and tissue engineering. The present paper also discusses the magnetophoretic behaviour of the liquid bead by varying its mass and magnetite concentration in the shell. We also demonstrated the two-dimensional self-assembly of magnetic liquid beads for potential use in digital polymerase chain reaction and digital loop mediated isothermal amplification.

Graphical abstract

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磁性液体珠的合成与活性操作。

我们报告了利用微流体技术制造和表征具有固体磁性外壳和液体内核的磁性液体珠的情况。这种液体磁珠由氟化油芯和含有磁铁矿颗粒的聚合物外壳组成。磁珠在聚二甲基硅氧烷（PDMS）流动聚焦装置中生成，并通过光聚合固化。我们研究了液体珠对外部磁场的反应，确定了它们向永久磁铁运动的特征。在一个通道中实现了液态珠的磁分选，效率高达 90%。结果表明，液态珠可以通过磁力控制，并有望应用于数字微流控技术，包括核酸扩增、药物输送、细胞培养、传感和组织工程。本文还讨论了通过改变液体珠子的质量和外壳中磁铁矿的浓度来实现其磁导行为。我们还展示了磁性液体珠的二维自组装，可用于数字聚合酶链式反应和数字环介导等温扩增。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Microdevices 工程技术-工程：生物医学

CiteScore

6.90

自引率

3.60%

发文量

审稿时长

6 months

期刊介绍： Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.