Brazilian Journal of Otorhinolaryngology最新文献

{"title":"Patients’ satisfaction and efficacy of modern conventional hearing aids: A comprehensive analysis of the self-reported user experiences in adult people","authors":"Daniele Portelli ,&nbsp;Cosimo Galletti ,&nbsp;Sabrina Loteta ,&nbsp;Leonard Freni ,&nbsp;Francesco Ciodaro ,&nbsp;Angela Alibrandi ,&nbsp;Giuseppe Alberti","doi":"10.1016/j.bjorl.2025.101565","DOIUrl":"10.1016/j.bjorl.2025.101565","url":null,"abstract":"<div><h3>Objective</h3><div>Hearing loss is a widespread condition that impacts the quality of life, affecting communication, social interactions, and cognitive functions. This study aimed to evaluate the subjective benefit and satisfaction of using hearing aids among patients since the adoption rate of hearing aids remains low.</div></div><div><h3>Methods</h3><div>The study retrospectively analysed data from 133 patients with hearing aids, using the Abbreviated Profile of Hearing Aid Benefit (APHAB) and the Satisfaction with Amplification in Daily Life (SADL) questionnaires. Patients were divided into two groups based on this median age and sex for comparative analysis. The Mann Whitney test was applied with references to numerical parameters (APHAB and SADL) to assess differences between male vs female subjects and adults vs elderly. The Spearman correlation test was applied to assess the possible correlation between APHAB and SADL. A <em>p-</em>value lower than 0.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>Results indicated no significant gender differences in most APHAB and SADL subscales, except for the SADL “personal image” subscale, which showed lower scores for women (<em>p</em> =  0.023). Age-based comparison revealed no significant differences in APHAB scores; the SADL scores showed significant differences in the “positive effect” (<em>p</em> = 0.013), “negative features” (<em>p</em> = 0.005), and overall scores (<em>p</em> = 0.039), with lower satisfaction in older patients. Correlation analysis identified a positive relationship between the SADL “negative features” and APHAB “aversiveness” subscales (<em>p</em> = 0.042, correlation coefficient ρ = 0.176).</div></div><div><h3>Conclusions</h3><div>The study highlights the importance of addressing subjective perceptions and aesthetic concerns in hearing aid adoption, emphasizing the need for personalized rehabilitation strategies to improve patient outcomes and satisfaction.</div></div><div><h3>Level of evidence</h3><div>Level 3.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 3","pages":"Article 101565"},"PeriodicalIF":1.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143196935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The important role of cuproptosis and cuproptosis-related genes in the development of thyroid carcinoma revealed by transcriptomic analysis and experiments","authors":"Yani Liu ,&nbsp;Yanyan He ,&nbsp;Shizhen Lei","doi":"10.1016/j.bjorl.2025.101560","DOIUrl":"10.1016/j.bjorl.2025.101560","url":null,"abstract":"<div><h3>Objective</h3><div>Programmed Cell Death (PCD) processes have been suggested to play a role in the development of cancers. The study aimed to investigate the enrichment of different types of PCD and identify important PCD-related genes in Thyroid Carcinoma (THCA).</div></div><div><h3>Methods</h3><div>The whole study is based on transcriptomic analysis and Immunohistochemistry (IHC) experiments. For transcriptomic analysis, the transcriptomic data of THCA (n = 493) and normal thyroid samples (n = 58) was used. The enrichment score of different types of PCD in THCA samples was calculated and the most enriched PCD process was identified. Then the expression of PCD-related genes in control and THCA samples were compared and the association between cuproptosis and characteristics of Tumor Microenvironment (TME) in THCA tissues was explored. IHC experiment was performed to confirm gene expressions in THCA and para-tumor samples.</div></div><div><h3>Results</h3><div>Enrichment analysis showed that cuproptosis was the most enriched type of PCD process and associated with malignancy in THCA. The expression of a cuproptosis-related gene, CDKN2A, was found and confirmed to be higher in THCA than normal samples and associated with poor outcomes and higher clinical stages of patients with THCA. Moreover, CDKN2A expression was associated with immunosuppressive TME in THCA.</div></div><div><h3>Conclusion</h3><div>Our findings indicated the important role of cuproptosis and a cuproptosis-related gene, CDKN2A, in the development and progression of THCA, which might provide novel insights into the understanding of pathophysiology of THCA.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 3","pages":"Article 101560"},"PeriodicalIF":1.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143196937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of an active middle ear implant in congenital middle ear malformations: A contemporary review","authors":"Vagner Antonio Rodrigues da Silva ,&nbsp;Henrique Furlan Pauna ,&nbsp;Guilherme Correa Guimarães ,&nbsp;Joel Lavinsky ,&nbsp;Thomas E. Linder ,&nbsp;Arthur Menino Castilho","doi":"10.1016/j.bjorl.2025.101562","DOIUrl":"10.1016/j.bjorl.2025.101562","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate hearing outcomes and postoperative complications among patients with middle and external ear malformations undergoing active middle ear implantation with Vibrant Soundbridge® (VSB).</div></div><div><h3>Methods</h3><div>Review of the literature. Studies published in English, Portuguese, or Spanish at the following databases: PubMed, MEDLINE, Scopus, Web of Science, EMBASE, and Cochrane Library were searched. The search strategy yielded a total of 141 potentially relevant studies. Of these, ten were included in this analysis.</div></div><div><h3>Results</h3><div>The mean preoperative air conduction threshold was 66.7 ± 6.2 dB. The mean air-bone gap was 46 ± 7.7 dB. VSB implantation resulted in mean hearing gain of 40.5 ± 7.1 dB in the air-conduction thresholds among the evaluated frequencies. The speech recognition index if the Floating Mass Transducer (FMT) was placed in the short process was 86.0% ± 9.6%, with significant difference when compared to long process coupling (<em>p</em> = 0.035) and the round window coupling (<em>p</em> =  0.048).</div></div><div><h3>Conclusion</h3><div>Bone conduction thresholds did not worsen in any of the studies included in the present review. VSB implantation resulted in a mean hearing gain of 40 dB at air conduction thresholds.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 3","pages":"Article 101562"},"PeriodicalIF":1.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143196938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochlear implantation and cognitive function in the older adult population: current state of the art and future perspectives","authors":"Tinne Vandenbroeke ,&nbsp;Ellen Andries ,&nbsp;Marc J.W. Lammers ,&nbsp;Anouk Hofkens-Van den Brandt ,&nbsp;Griet Mertens ,&nbsp;Vincent Van Rompaey","doi":"10.1016/j.bjorl.2024.101544","DOIUrl":"10.1016/j.bjorl.2024.101544","url":null,"abstract":"<div><h3>Objectives</h3><div>Hearing loss is associated with increased cognitive decline and incident dementia in older adults. Given the rapidly rising incidence of dementia, management of modifiable risk factors such as hearing loss, is essential to mitigate the impact on the individual and society in general. In this narrative review, we discuss the current state-of-art with respect to studying cognitive function before and after cochlear implantation in the elderly population. Future perspectives are considered to shed light into the pathophysiology of cognitive decline due to hearing loss and how objective measures may contribute to this field.</div></div><div><h3>Methods</h3><div>The existing literature on cochlear implantation and cognition is reviewed. The potential limitations and objective measures for cognitive functioning are discussed. Relevant studies were identified through a broad search of academic databases, including Pubmed and Web of Science. Given the narrative nature of this review, no strict inclusion or exclusion criteria were applied, allowing for a broad overview of the current state-of-the-art literature on the effects of cochlear implantation on cognitive functioning, the challenges of studying cognition in this population and future research directions.</div></div><div><h3>Results</h3><div>Multiple studies have been able to demonstrate an improvement of cognitive functioning in older adults with severe-to-profound hearing loss after cochlear implantation. However, it is important to consider the challenges of studying cognition in this population. Evoked response potentials might have potential as an objective marker for cognition in this study population.</div></div><div><h3>Conclusion</h3><div>Although there is no standardized study protocol to investigate cognition after cochlear implantation, a significant improvement in cognition is observed in the majority of studies one year after cochlear implantation. The identification of an objective marker of cognitive functioning will help unravel how cochlear implantation affects cognition.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 3","pages":"Article 101544"},"PeriodicalIF":1.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LAMB1 promotes proliferation and metastasis in nasopharyngeal carcinoma and shapes the immune-suppressive tumor microenvironment","authors":"Enzi Feng ,&nbsp;Xinyu Yang ,&nbsp;Jie Yang,&nbsp;Qianqian Qu,&nbsp;Xiaojiang Li","doi":"10.1016/j.bjorl.2024.101551","DOIUrl":"10.1016/j.bjorl.2024.101551","url":null,"abstract":"<div><h3>Objective</h3><div>Laminin subunit Beta-1 (LAMB1), a component of the extracellular matrix, has been reported to be implicated in the development and progression of cancer. However, the role of LAMB1 in Nasopharyngeal Carcinoma (NPC) remains unknown.</div></div><div><h3>Methods</h3><div>Three NPC datasets were utilized to identify LAMB1 as a targeted gene. The correlation between LAMB1 expression and clinical characteristics, prognosis was explored. KEGG and GO enrichment analyses were conducted to investigate LAMB1’s functions in NPC. The CIBERSORT, xCell, MCPCOUNTER, and EPIC methods were used to assess the Cancer-Associated Fibroblasts (CAFs) and immune cells infiltration. We predicted LAMB1’s effect on treatment using TIDE, CTRP, and CellMine databases. Finally, Western blot, CCK-8, Transwell, and Wound scratch were employed to validate LAMB1’s effect on NPC cells.</div></div><div><h3>Results</h3><div>LAMB1 was highly expressed in NPC. High-expression LAMB1 was correlated with poorer progression-free survival and impeded the infiltration of CD4⁺ T-cells, CD8⁺ T-cells and dendritic cells. It also diminished the expression of HLA and suppressed T-cells stimulation. Differential expressed cytokines and involved pathways were divergent across different level of fibroblasts infiltration. At high level of fibroblasts, LAMB1 indirectly inhibited immune cells by remolding extracellular matrix. But at low level of fibroblasts, LAMB1 directly suppressed immune response. Tumors with high LAMB1 level had weak responses to immunotherapy. In vitro experiment, LAMB1 significantly suppressed HLA-1 and enhanced the proliferation, migration, and invasion capabilities of NPC cells.</div></div><div><h3>Conclusion</h3><div>High expression of LAMB1 is significantly associated with an immune-suppressive tumor microenvironment in NPC. LAMB1 enhances the proliferation, migration and invasion of NPC cells. These findings suggest that LAMB1 may serve as a prognostic biomarker for predicting NPC progression and a potential therapeutic target to enhance the efficacy of existing immunotherapies.</div></div><div><h3>Level of evidence</h3><div>3.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 2","pages":"Article 101551"},"PeriodicalIF":1.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CircRNA-miRNA-mRNA regulatory network in high-altitude hypobaric hypoxia-induced hearing impairment and hearing acclimatization","authors":"Danzeng Awang ,&nbsp;Kanzi Danzeng ,&nbsp;Tianheng Wang ,&nbsp;Quzong Deji ,&nbsp;Mengting Huang ,&nbsp;Hailong Ren ,&nbsp;Xinzhu Liu ,&nbsp;Binghan Zhao ,&nbsp;Lanzi Gongga","doi":"10.1016/j.bjorl.2024.101557","DOIUrl":"10.1016/j.bjorl.2024.101557","url":null,"abstract":"<div><h3>Objective</h3><div>High altitude hypobaric hypoxia can induce hearing impairment and hearing acclimatization, but few studies have been performed to decipher the potential transition between the two states. To decipher transition-related circular RNAs (circRNAs)-microRNAs (miRNAs)-messenger RNA (mRNAs) regulatory network.</div></div><div><h3>Methods</h3><div>Wistar rats were airlifted from plain to high altitude and maintained for 30 days and 60 days. Hearing acclimatization was determined using the Auditory Brainstem Response (ABR) test. Cochlea tissues were isolated, and high-throughput circRNA analysis and mRNAs-sequencing were performed. Differentially Expressed circRNAs (DEcircRNAs) and Differentially Expressed mRNAs (DEmRNAs) were obtained, and circRNA-miRNA and miRNA-mRNA regulation were predicted. A circRNA-miRNA-mRNA competing endogenous RNA (ceRNA) network was also constructed. The DEmRNAs in this network were functionally annotated using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses based on Metascape.</div></div><div><h3>Results</h3><div>The ABR assay indicated that hearing impairment happened on day 30 and hearing acclimatization occurred on day 60. Hearing impairment-related circRNAs (64 upregulated and 147 downregulated) and genes (572 upregulated and 757 downregulated) were identified. Hearing acclimatization-related circRNAs (79 upregulated and 142 downregulated) and genes (690 upregulated and 751 downregulated) were also identified. Hearing impairment and hearing acclimatization ceRNA networks were also constructed after integrating the predicted miRNA regulation analyses. Anterograde trans-synaptic signaling (GO:0098916) and negative regulation of cellular response to growth factor stimulus (GO:0090288) were regulated by hearing impairment ceRNA networks, and embryonic organ development (GO:0048568) was regulated by hearing acclimatization ceRNA networks.</div></div><div><h3>Conclusion</h3><div>Hearing impairment- and hearing acclimatization-associated circRNAs and ceRNA networks were identified, which contribute new knowledge to our understanding of acclimatization transition.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 2","pages":"Article 101557"},"PeriodicalIF":1.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic and audiological determinants of hearing loss in high-risk neonates","authors":"Yanan Shi ,&nbsp;Naiyao Zhang ,&nbsp;Na Du ,&nbsp;Tongxi Zheng ,&nbsp;Ying Yu ,&nbsp;Youjin Li","doi":"10.1016/j.bjorl.2024.101541","DOIUrl":"10.1016/j.bjorl.2024.101541","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to investigate the correlation between prevalent risk factors for high-risk neonates in neonatal intensive care unit and their hearing loss, and to examine the audiological features and genetic profiles associated with different deafness mutations in our tertiary referral center. This research seeks to deepen our understanding of the etiology behind congenital hearing loss.</div></div><div><h3>Methods</h3><div>We conducted initial hearing screenings, including automated auditory brainstem response, distortion product otoacoustic emission, and acoustic immittance on 443 high-risk neonates within 7 days after birth and 42 days (if necessary) after birth. Neonates who failed initial screenings underwent further diagnostic tests at 3 months. The risk factors were analyzed retrospectively by Chi-Square test and stepwise logistic regression. Genetic analysis involved a deafness sequencing panel targeting 19 pathogenic variants across four genes (GJB2, GJB3, SLC26A4, and MT-RNR), applied to both the study cohort and a larger hearing screening cohort of 14863 neonates from our center and different medical centers in the same region.</div></div><div><h3>Results</h3><div>Out of the 443 high-risk neonates, 222 failed their diagnostic hearing tests. Logistic regression identified preterm birth, neonatal hyperbilirubinemia and advanced maternal age (≧35 yr) as significant risk factors for hearing loss. Genetic screening of 33 neonates who failed the diagnostic tests revealed that 7 (21.21%) carried at least one pathogenic variant, with identified 1 homozygotes and 3 heterozygotes in the GJB2, 1 homozygotes and 1 heterozygotes in the SLC26A4 gene, and 1 homoplasmic variant in the MT-RNR (12SrRNA). In the larger hearing screening cohort, 497 (3.34%) were genetically positive for deafness mutations, among whom 29 had the diagnostic hearing tests and 7 eventually diagnosed with hearing loss. Of the rest 468 neonates who didn’t have the diagnostic tests, 445 (95.09%) passed the hearing screening tests.</div></div><div><h3>Conclusion</h3><div>Preterm birth, neonatal hyperbilirubinemia and advanced maternal age are critical risk factors for hearing impairment in high-risk neonates. Mutations such as c.235delC in GJB2 and c.919-2A&gt;G in SLC26A4 are the most common. Long-term follow-up of neonates carrying heterozygous variants, particularly in genes like GJB3, is necessary to understand their progression and hearing outcomes. This study highlights the importance of deafness gene screening in neonates to ensure accurate diagnosis and effective intervention.</div></div><div><h3>Level of evidence</h3><div>Level 3.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 2","pages":"Article 101541"},"PeriodicalIF":1.7,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Otomycosis risk after non-suppurative middle ear surgery","authors":"Fatih Gul ,&nbsp;Ozgenur Kocak ,&nbsp;Ali Ozturk ,&nbsp;Mehmet Ali Babademez","doi":"10.1016/j.bjorl.2024.101552","DOIUrl":"10.1016/j.bjorl.2024.101552","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was to investigate the risk factors that may cause postoperative otomycosis in patients undergoing Chronic Nonsuppurative Otitis Media (CNSOM) surgery.</div></div><div><h3>Methods</h3><div>In this retrospective study, 409 out of 523 patients met the inclusion criteria. 44 patients diagnosed with otomycosis CNSOM were analyzed. Perioperative factors were analyzed to determine the potential risks of otomycosis. The primary factors identified as contributing to otomycosis were firmly adherent cerumen, tympano-meatal flap positioning, and Diabetes Mellitus (DM). The study analyzed the patients’ follow-up six months after the surgical procedure. Otomycosis occurring within 30-days of surgery was classified as “early otomycosis”, while those occurring later were classified as “late otomycosis”.</div></div><div><h3>Results</h3><div>Graft success at 6-months showed no significant difference between otomycosis and non-otomycosis groups. We found that the presence of DM, tympano-meatal flap positioning, and firmly adhered cerumen removal were significantly associated with the development of otomycosis. The logistic regression model was significant and explained 9.2% of the variation. Overall, individuals with the presence of advancement flap, DM, and cerumen removal status were respectively 2.0, 2.8, and 2.1 times more likely to have otomycosis. DM was the only risk factor identified in all three patients who developed late otomycosis.</div></div><div><h3>Conclusion</h3><div>This study found that compromised epithelial integrity in the external auditory canal, non-epithelial areas, and reduced blood circulation were independent risk factors for postoperative otomycosis.</div></div><div><h3>Level of evidence</h3><div>4.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 2","pages":"Article 101552"},"PeriodicalIF":1.7,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experts' discussion: implications of the World Health Organization's World report on hearing for the cochlear implant field","authors":"Wolf-Dieter Baumgartner ,&nbsp;Javier Gavilán ,&nbsp;Abdelhamid Benghalem ,&nbsp;Suela Sallavaci ,&nbsp;Gunesh Rajan ,&nbsp;Ranjith Rajeswaran ,&nbsp;Mario Zernotti ,&nbsp;Shelly Chadha","doi":"10.1016/j.bjorl.2024.101556","DOIUrl":"10.1016/j.bjorl.2024.101556","url":null,"abstract":"<div><h3>Objective</h3><div>This review aims to analyse the implications of the World Health Organization's 2021 world report on hearing, with a particular focus on the cochlear implant field. The objective is to understand the challenges and opportunities highlighted in the report and propose viable solutions for effective implementation within the cochlear implant community.</div></div><div><h3>Methods</h3><div>Following the release of the World Health Organization's world report on hearing, cochlear implant professionals explored and discussed the implications of the report with examples from various countries to understand the disparities in access, reimbursement policies, and social stigma associated with hearing loss.</div></div><div><h3>Results</h3><div>The world hearing report identifies hearing loss as a major global health issue, with an estimate of 1.5 billion people currently affected and a projected increase to 2.5 billion by 2050. Key challenges in the cochlear implantation field include disparities in access to services, particularly in low- and middle-income countries, lack of reimbursement policies in many regions, and the social stigma surrounding hearing loss.</div></div><div><h3>Conclusion</h3><div>A multi-faced approach is needed to address the rising prevalence of hearing loss and policy makers must prioritize ear and hearing care as a public health concern. Organizations like the HEARRING group can promote education, awareness, and training, and act as advocates for changes in healthcare systems to expand access to hearing care services.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 2","pages":"Article 101556"},"PeriodicalIF":1.7,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dupilumab on otitis media associated with eosinophilic chronic rhinosinusitis","authors":"Seiichiro Kamimura,&nbsp;Keisuke Ishitani,&nbsp;Ryota Morozumi,&nbsp;Eiji Kondo,&nbsp;Takahiro Azuma,&nbsp;Go Sato,&nbsp;Yoshiaki Kitamura","doi":"10.1016/j.bjorl.2024.101555","DOIUrl":"10.1016/j.bjorl.2024.101555","url":null,"abstract":"<div><h3>Objective</h3><div>Eosinophilic Otitis Media (EOM) is an intractable disease caused by type 2 inflammation, such as Eosinophilic Chronic Rhinosinusitis (ECRS) and bronchial asthma. Biologics have recently been used to treat ECRS and bronchial asthma. Biologics are not indicated for EOM; however, because approximately 10% of ECRS cases has concomitant EOM, concomitant EOM improvement has been observed when dupilumab is administered for ECRS. Therefore, we aimed to investigate the current status of EOM treatment and clarify the effect of dupilumab on EOM.</div></div><div><h3>Method</h3><div>This retrospective study included 25 patients attending our hospital. The disease status of patients with EOM not treated with dupilumab (control) and those treated with dupilumab at the time of evaluation were compared. The EOM disease status was compared using the EOM severity score, temporal bone shadow on Computed Tomography (CT), and standard pure tone audiometry.</div></div><div><h3>Result</h3><div>Twenty-four of the 25 patients with EOM had concomitant ECRS, and 12 were administered with dupilumab. The severity score of EOM, temporal bone CT score, and air conductance hearing were significantly improved after dupilumab administration in 12 patients with EOM. Comparison of EOM patients without dupilumab (control) and those treated with dupilumab at the time of evaluation revealed that the severity score of EOM, temporal bone CT score, and air conduction hearing were significantly better in patients treated with dupilumab.</div></div><div><h3>Conclusion</h3><div>Our study demonstrated that dupilumab was administered to approximately half of the patients with EOM, suggesting that the treatment of EOM has undergone significant changes due to dupilumab administered to ECRS. Our study also suggests that dupilumab is highly effective in patients with EOMs.</div></div><div><h3>Level of evidence</h3><div>4.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 2","pages":"Article 101555"},"PeriodicalIF":1.7,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}