Brazilian Journal of Otorhinolaryngology最新文献

New onset migraines after maxillary antrostomy for silent sinus syndrome treated with rimegepant: A rare case report

IF 1.7 4区医学

Brazilian Journal of Otorhinolaryngology Pub Date : 2025-04-03 DOI: 10.1016/j.bjorl.2025.101580

Aishwarya Aggarwal , Yasemin Akinci , Brian L. Gerhardstein

引用次数: 0

Prolonged noise exposure-induced auditory threshold shifts in wistar rats: Proposal of an experimental exposure protocol based on noise dose

IF 1.7 4区医学

Brazilian Journal of Otorhinolaryngology Pub Date : 2025-04-02 DOI: 10.1016/j.bjorl.2025.101570

Ana Carolina Odorizzi Zica , Gabriela Ribeiro Novanta , Maria Luiza Queiroz Sampaio , Rafael Rocha de Andrade , Lucieny Silva Martins Serra , André Luiz Lopes Sampaio

{"title":"Prolonged noise exposure-induced auditory threshold shifts in wistar rats: Proposal of an experimental exposure protocol based on noise dose","authors":"Ana Carolina Odorizzi Zica , Gabriela Ribeiro Novanta , Maria Luiza Queiroz Sampaio , Rafael Rocha de Andrade , Lucieny Silva Martins Serra , André Luiz Lopes Sampaio","doi":"10.1016/j.bjorl.2025.101570","DOIUrl":"10.1016/j.bjorl.2025.101570","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of the present study was to evaluate the effects of different doses of broadband white noise in a group of Wistar rats.</div></div><div><h3>Methods</h3><div>The sample consisted of 6 male Wistar rats. The animals went through sequential exposures at the intensity of 95 dB for 60 min, 100 dB for 60 min and 100 dB for 120 min. Audiological evaluation was performed by Distortion Product Otoacoustic Emissions (DPOAE) exams at frequencies from 2 to 12 KHz, after each exposure/pause protocol. Statistical analysis was performed based on the values found in the DPOAE and Signal-to-Noise Ratio (S/N) in the nine exams performed over 50 days of research.</div></div><div><h3>Results</h3><div>The study concluded that there was a compound threshold shift induced by long-term sequential noise exposure at the intensity of 100 dB for 60 min and for 120 min, with a “plateau/’ observed in the DPOAE and S/N results that coincide with the exposure period of 6 days at the intensity of 100 dB for 120 min.</div></div><div><h3>Conclusion</h3><div>Thus, we established the proposal of an exposure protocol for research with wistar rats exposed to noise.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 4","pages":"Article 101570"},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Definitive treatment in squamous cell carcinoma of head and neck: A retrospective analysis of chemoradiotherapy in a university hospital setting

IF 1.7 4区医学

Brazilian Journal of Otorhinolaryngology Pub Date : 2025-04-02 DOI: 10.1016/j.bjorl.2025.101576

Hádila Silva Veras Sousa , Vivian Naomi Horita , Davi Magalhães Leite Novaes , Matheus Yung Perin , Daniel Naves Araújo Teixeira , Joyce Gruenwaldt , Eduardo Baldon Pereira , Carlos Takahiro Chone , Gustavo Jacob Lourenço , Ligia Traldi Macedo , Carmen Silvia Passos Lima

{"title":"Definitive treatment in squamous cell carcinoma of head and neck: A retrospective analysis of chemoradiotherapy in a university hospital setting","authors":"Hádila Silva Veras Sousa , Vivian Naomi Horita , Davi Magalhães Leite Novaes , Matheus Yung Perin , Daniel Naves Araújo Teixeira , Joyce Gruenwaldt , Eduardo Baldon Pereira , Carlos Takahiro Chone , Gustavo Jacob Lourenço , Ligia Traldi Macedo , Carmen Silvia Passos Lima","doi":"10.1016/j.bjorl.2025.101576","DOIUrl":"10.1016/j.bjorl.2025.101576","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate toxicities, tumor control, Event-Free Survival (EFS) and Overall Survival (OS) of patients with locoregionally advanced Head and Neck Squamous Cell Carcinoma (HNSCC) treated with definitive platinum-based Chemoradiation (CTRT).</div></div><div><h3>Methods</h3><div>A total of 233 patients underwent treatment with RT plus weekly or every three weeks Cisplatin (CDDP) or Carboplatin (Carbo). Toxicity and response to treatment were classified using conventional criteria. Kaplan-Meier, log-rank test, and Cox regression (univariate and multivariate) were used to assess patient survival.</div></div><div><h3>Results</h3><div>Half of patients presented toxicities grade 3 or 4, with nausea/vomiting and nephrotoxicity being more common in RT and CDDP group and anemia and neutropenia in RT and Carbo group. Complete or partial response was observed in 75% of patients, and the distinct protocols did not alter the treatment response. Two-year EFS and OS probabilities were 43.3% and 66.0%, respectively. Active smoking, an ECOG score of 2 or higher, stage IV tumor, and treatment with RT and Carbo were independent prognostic factors for poorer outcomes. Patients of these groups had approximately double chance of relapse and progression to death compared to others.</div></div><div><h3>Conclusion</h3><div>Our data indicate definitive treatment with RT and CDDP as the best treatment for locoregionally advanced HNSCC treated in Brazilian public hospitals. However, prospective randomized studies are required to establish the ideal treatment for those patients.</div></div><div><h3>Level of evidence</h3><div>3.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 4","pages":"Article 101576"},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isotretinoin use in rhinoplasty patients

IF 1.7 4区医学

Brazilian Journal of Otorhinolaryngology Pub Date : 2025-03-26 DOI: 10.1016/j.bjorl.2025.101592

Jholbert Cardoso Santana, Hugo Valter Ramos Lisboa, Leandro Azevedo de Camargo, Ricardo Araújo Meira Almeida, Lourival Mendes Bueno

{"title":"Isotretinoin use in rhinoplasty patients","authors":"Jholbert Cardoso Santana, Hugo Valter Ramos Lisboa, Leandro Azevedo de Camargo, Ricardo Araújo Meira Almeida, Lourival Mendes Bueno","doi":"10.1016/j.bjorl.2025.101592","DOIUrl":"10.1016/j.bjorl.2025.101592","url":null,"abstract":"<div><h3>Objective</h3><div>Presenting evidence available on perioperative isotretinoin application in, and benefits for, thick-skinned patients subjected to rhinoplasty.</div></div><div><h3>Methods</h3><div>Analysis was applied to articles available in the following databases: Cochrane, PubMed, ScienceDirect and Scielo. The analyzed corpus comprised studies published from 2004 to 2023 focused on investigating thick-skinned patients subjected to rhinoplasty and treated with isotretinoin. Inappropriate and unrelated methodologies were excluded from the analysis.</div></div><div><h3>Results</h3><div>Initially, 1,214 articles were collected, but this number dropped to 617 after duplicates’ removal. Twenty (20) articles remained in the corpus after inclusion criteria application, but 10 of them were excluded from the analysis based on exclusion criteria. Finally, 10 articles were selected for review purposes: 1 experience report, 2 case studies, 3 narrative reviews and 4 clinical trials.</div></div><div><h3>Conclusions</h3><div>The current findings suggested aesthetic improvements in patients treated with isotretinoin, although its long-term benefits remain uncertain. Thus, further research on this topic should be conducted.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 4","pages":"Article 101592"},"PeriodicalIF":1.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal study of hearing preservation and electrocochleography after cochlear implantation in adults 成人人工耳蜗植入术后听力保护和耳电图纵向研究

IF 1.7 4区医学

Brazilian Journal of Otorhinolaryngology Pub Date : 2025-03-26 DOI: 10.1016/j.bjorl.2025.101584

Marianne Schleich , John J. Galvin III , Fabrice Micaletti , David Bakhos

{"title":"Longitudinal study of hearing preservation and electrocochleography after cochlear implantation in adults","authors":"Marianne Schleich , John J. Galvin III , Fabrice Micaletti , David Bakhos","doi":"10.1016/j.bjorl.2025.101584","DOIUrl":"10.1016/j.bjorl.2025.101584","url":null,"abstract":"<div><h3>Objectives</h3><div>Electrocochleography (ECOG) is a composite objective measure of the cochlea and the cochlear nerve responses. The objectives of this study were to investigate the evolution of ECOG after cochlear implantation and compare them with audiometric thresholds over a 12-month period.</div></div><div><h3>Methods</h3><div>A prospective monocentric study was conducted in Advanced Bionics cochlear implant recipients. Audiometric thresholds were recorded preoperatively and at 1-, 3-, 6-, and 12-months post cochlear implantation; ECOGs were recorded perioperatively after the electrode array insertion and at 1-, 3-, 6-, and 12-months post cochlear implantation. Cochlear Microphonic (CM) responses were measured by an apical electrode of the cochlear implant. Postoperative behavioral and ECOG thresholds were compared using Pearson correlation analyses.</div></div><div><h3>Results</h3><div>A total of 17 patients were included. At 1-year, residual hearing (≤90 dB HL at 500 Hz) was preserved for 4 out of 17 patients. Significant correlations were observed between perioperative ECOG and preoperative audiometric thresholds (<em>p</em> = 0.008), and between ECOG and audiometric thresholds at 3-months postoperative (<em>p</em> = 0.002).</div></div><div><h3>Conclusion</h3><div>ECOG can reflect changes in cochlear responses during and after implantation and may help to predict deterioration of residual hearing.</div></div><div><h3>Level of evidence</h3><div>Level 3.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 4","pages":"Article 101584"},"PeriodicalIF":1.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of the adjunctive use of photobiomodulation therapy in olfactory disorders in post-COVID-19 patients: A randomized controlled trial

IF 1.7 4区医学

Brazilian Journal of Otorhinolaryngology Pub Date : 2025-03-26 DOI: 10.1016/j.bjorl.2025.101583

Patricia Costa Oliveira , Luisa Oliveira Correia , Natalia Medeiros Dias Lopes , Gabriel Rodrigues Suassuna , Richard L. Doty , Fabio de Rezende Pinna , Richard Louis Voegels , Marco Aurelio Fornazieri

{"title":"Efficacy of the adjunctive use of photobiomodulation therapy in olfactory disorders in post-COVID-19 patients: A randomized controlled trial","authors":"Patricia Costa Oliveira , Luisa Oliveira Correia , Natalia Medeiros Dias Lopes , Gabriel Rodrigues Suassuna , Richard L. Doty , Fabio de Rezende Pinna , Richard Louis Voegels , Marco Aurelio Fornazieri","doi":"10.1016/j.bjorl.2025.101583","DOIUrl":"10.1016/j.bjorl.2025.101583","url":null,"abstract":"<div><h3>Objectives</h3><div>Photobiomodulation Therapy (PBMT) is a non-invasive treatment that uses photons from the red to infrared spectrum to modulate cellular processes with anti-inflammatory and regenerative properties. This study aimed to evaluate the use of PBMT applied intranasally in patients with an impaired sense of smell after COVID-19. Methods: This proof-of-concept study was a randomized, placebo-controlled clinical trial that recruited 81 patients with olfactory disorders after SARS-CoV-2 infection (1–12 months), randomly assigned to 3 groups: controls, red light and infrared light exposure groups. PBMT was applied twice a week for five weeks, associated with prednisolone 40 mg for five days and olfactory training for 90 days from the first day of laser application. UPSIT® and subjective chemosensory scores were the outcomes collected before the first session and three months thereafter.</div></div><div><h3>Results</h3><div>Compared to controls, patients undergoing infrared PBMT showed more improvement in UPSIT® scores (+4.6 points, 95% CI: 1.5–7.8, <em>p</em> = 0.004) and a tendency towards reporting a better subjective smell score at the three-month follow-up. Response rates were 26.1% (95% CI: 6.7–45.5), 43.5% (95% CI: 21.6–65.4), and 68% (95% CI: 48.3–87.7) in the control, red and infrared groups, respectively. No major adverse events were reported.</div></div><div><h3>Conclusion</h3><div>Therapy with PBMT in the infrared frequency appears to be a safe option in treating post-COVID olfactory disorders when combined with a five-day use of systemic corticosteroid and 90 days of olfactory training.</div></div><div><h3>Level of evidence</h3><div>2.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 4","pages":"Article 101583"},"PeriodicalIF":1.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the frontal recess pneumatization pattern in patients with chronic frontal sinusopathy

IF 1.7 4区医学

Brazilian Journal of Otorhinolaryngology Pub Date : 2025-03-26 DOI: 10.1016/j.bjorl.2025.101593

Krystal Calmeto Negri , Rogério Hamerschmidt , Cassio Iwamoto , Carolina Rodrigues Laranjeira Vilar

{"title":"Analysis of the frontal recess pneumatization pattern in patients with chronic frontal sinusopathy","authors":"Krystal Calmeto Negri , Rogério Hamerschmidt , Cassio Iwamoto , Carolina Rodrigues Laranjeira Vilar","doi":"10.1016/j.bjorl.2025.101593","DOIUrl":"10.1016/j.bjorl.2025.101593","url":null,"abstract":"<div><h3>Objectives</h3><div>To analyze the pneumatization pattern of the frontal recess using CT scans and to determine the prevalence of frontoethmoidal cells and their possible correlation with the development of sinusopathy.</div></div><div><h3>Methods</h3><div>By means of a retrospective, analytical and cross-sectional study, 300 CT scans of patients with clinical suspicion of chronic rhinosinusitis were examined, separately on the right and left sides, totaling a sample of 600 paranasal sinuses, with regard to the presence of frontal cells, the presence of blockage or veiling of the recess and frontal sinus.</div></div><div><h3>Results</h3><div>Frontoethmoidal cells were present in 85.8% of cases; the most frequent cells were supra bulla cells, in 43.8%, and the least frequent were supraorbital ethmoid cells, in 11% of cases. There was a 35% prevalence of supra-Agger cells, 15.8% of supra-Agger frontal cells, 20.2% of supra bulla frontal cells and 12.3% of frontal septal cells. A significant relationship was found between the presence of supra-Agger frontal cells and supra bulla frontal cells and the development of sinusopathy.</div></div><div><h3>Conclusion</h3><div>The supra-Agger frontal cells and supra bulla frontal cells, when present in the frontal recess, predispose to the development of frontal sinusopathy. Therefore, preoperative tomographic analysis allows a three-dimensional anatomical understanding of the recess and frontal sinus based on determining the pneumatization pattern of this region.</div></div><div><h3>Level of evidence</h3><div>Level 3.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 4","pages":"Article 101593"},"PeriodicalIF":1.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital glossocervical fistula of presumed branchial origin: A unique anatomical pathway

IF 1.7 4区医学

Brazilian Journal of Otorhinolaryngology Pub Date : 2025-03-24 DOI: 10.1016/j.bjorl.2025.101567

Kento Koda , Kenji Kondo , Yuki Saito , Tatsuya Yamasoba

引用次数: 0

The pitfalls of positional dizziness: Not everything is crystal

IF 1.7 4区医学

Brazilian Journal of Otorhinolaryngology Pub Date : 2025-03-22 DOI: 10.1016/j.bjorl.2025.101575

Lucas Resende Lucinda Mangia , Raquel Mezzalira , Roseli Saraiva Moreira Bittar

引用次数: 0

Quality-of-life assessment instruments for patients with vestibular schwannoma: A systematic review

IF 1.7 4区医学

Brazilian Journal of Otorhinolaryngology Pub Date : 2025-03-21 DOI: 10.1016/j.bjorl.2025.101585

Katarzyna Bieńkowska, Barbara Kostecka, Andrzej Kokoszka

{"title":"Quality-of-life assessment instruments for patients with vestibular schwannoma: A systematic review","authors":"Katarzyna Bieńkowska, Barbara Kostecka, Andrzej Kokoszka","doi":"10.1016/j.bjorl.2025.101585","DOIUrl":"10.1016/j.bjorl.2025.101585","url":null,"abstract":"<div><h3>Objective</h3><div>The European Association of Neuro-Oncology (EANO) indicated that different study designs and methodologies led to inconsistent conclusions about treatment methods and QoL in patients with Vestibular Schwannoma (VS). This study systematically reviews recent findings about QoL assessment instruments for patients with VS and provides recommendations for the measurement of QoL with standardized psychometric tools.</div></div><div><h3>Methods</h3><div>This study was conducted based on the PRISMA 2020 guideline for reporting systematic reviews. The key words used were as follows: quality of life, health-related quality of life, vestibular schwannomas, acoustic neuroma. Studies were included when the following eligibility criteria were met.</div></div><div><h3>Results</h3><div>Our search finally yielded 48 articles published in years 2014–2024 that measured QoL in patients with VS using standardized psychometric tools. The studies examined various dimensions of QoL. The most frequently used disease-specific questionnaire was the Penn Acoustic Neuroma Quality of Life (PANQOL). As a generic tool, authors preferred to use the Short-Form 36-Item Health Survey (SF-36).</div></div><div><h3>Conclusion</h3><div>Recent findings and data on Quality of Life (QoL) tools for patients with VS emphasize the importance of using standardized and disease specific tool like PANQOL, due to their frequent use and large amount of patient data. Although the SF-36 is commonly used for general assessments, it may not be sensitive enough for a complete QoL evaluation and should not be the only tool used. The GBI is effective for assessing changes after specific medical treatments. Using methods similar to those in past studies helps medical professionals make reliable conclusions about QoL and evaluate the effects of different treatments in VS patients.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 3","pages":"Article 101585"},"PeriodicalIF":1.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0