Brazilian Journal of Otorhinolaryngology最新文献

{"title":"Association between hepatitis B and C viruses and head and neck lymphoma: A case-control study.","authors":"Wan-Hsun Tsai, Ching-Chih Lee, Ting-Shou Chang","doi":"10.1016/j.bjorl.2025.101701","DOIUrl":"https://doi.org/10.1016/j.bjorl.2025.101701","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess the relationship between Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) infections and Head and Neck (H&N) lymphoma in a region where HBV and HCV are highly prevalent.</p><p><strong>Methods: </strong>Patients diagnosed with H&N lymphoma between 2013 and 2022 at our institution were eligible for the study, with exclusion criteria applied to patients with a history of recurrence, other cancers, HIV infections, organ transplantation, and those below 18-years of age. The first and the second control group comprised outpatients and patients diagnosed with Head and Neck Squamous Cell Carcinoma (HNSCC) who were gender and age-matched at the same hospital. Logistic regression analysis, which was adjusted for sex, age, smoking, alcohol consumption, Rheumatoid Arthritis (RA), and Systemic Lupus Erythematosus (SLE), was utilized to estimate the Odds Ratio (OR) and 95% Confidence Interval (95% CI) for HBV and HCV infection status.</p><p><strong>Results: </strong>From 2013 to 2022, 304 patients with H&N lymphoma were identified. After excluding those with a history of other cancers or recurrences, 262 patients remained. The first control group included 1048 matched outpatients. Additionally, 262 patients diagnosed with HNSCC during the same period were selected as the second control group. Of the 242 Non-Hodgkin Lymphoma (NHL) patients, 102 had Extranodal Lymphoma (ENL). Of these ENL patients, 49 tested positive for HBV and 17 for HCV. After controlling for the confounding factors, NHL patients with HBsAg positivity had a significantly higher prevalence rate than healthy controls, particularly among B-cell Lymphoma and Diffuse Large B-Cell Lymphoma (DLBCL) patients. Furthermore, there were no significant differences in HCV infections between the three groups.</p><p><strong>Conclusions: </strong>In conclusion, the study found a significant link between HBV infection and H&N NHL, particularly DLBCL in Taiwan. However, no significant link was discovered between HCV infection and H&N lymphoma. These findings suggest a potential role for HBV in the development of H&N NHL and DLBCL.</p><p><strong>Level of evidence: 4: </strong></p>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":" ","pages":"101701"},"PeriodicalIF":1.8,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of inner ear abnormalities on middle ear mechanics: Findings from adults with MD and LVAS","authors":"Wen Jiang ,&nbsp;Yi Mu ,&nbsp;Huan Lin ,&nbsp;Chanfeng Shen ,&nbsp;Huiying Zhang ,&nbsp;Fei Zhao ,&nbsp;Yuehua Qiao ,&nbsp;Xuanyi Li ,&nbsp;Wen Liu","doi":"10.1016/j.bjorl.2025.101673","DOIUrl":"10.1016/j.bjorl.2025.101673","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the clinical significance of WAI as a predictive marker for MD and LVAS among adults.</div></div><div><h3>Methods</h3><div>Participants included 110 ears with MD, 18 ears with LVAS, and 92 normal ears (control group) recruited from clinical audiology settings. The outcome measures included Wideband Energy Absorbance (WBA), Resonance Frequency (RF), admittance Magnitude (YM), and phase Angle (YA). Propensity Score Matching (PSM) was conducted to treat the group imbalance.</div></div><div><h3>Results</h3><div>Compared with the control group, The MD group exhibited significantly lower WBA between 1587 and 4000 Hz (p &lt; 0.05), while the LVAS group showed lower WBA between 1000 and 2520 Hz (p &lt; 0.05). The MD and LVAS groups had lower RF (p &lt; 0.05), while they had higher YM at low frequencies (226 and 678 Hz for MD, and 1000 Hz for LVAS, p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>This study showed that LVAS has a lower WBA at middle frequencies, whereas MD has a lower WBA at middle and high frequencies. These findings suggest that WAI may serve as a predictive marker for MD and LVAS. However, further studies are needed to explore its diagnostic utility in Third Mobile Window Abnormalities (TMWA).</div></div><div><h3>Level of evidence</h3><div>IV: Retrospective cohort study.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 1","pages":"Article 101673"},"PeriodicalIF":1.8,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expectations Questionnaire for Adults with Cochlear Implants (EQA-CI): Translation, adaptation and cross-cultural validation to Brazilian Portuguese","authors":"Ingrid Barros Da Silva Santana ,&nbsp;Fernanda Ferreira Caldas ,&nbsp;Carolina Costa Cardoso ,&nbsp;Francisco Wallison Lucena da Silva ,&nbsp;Rayssa Pacheco Brito Dourado ,&nbsp;Fayez Bahmad Jr","doi":"10.1016/j.bjorl.2025.101717","DOIUrl":"10.1016/j.bjorl.2025.101717","url":null,"abstract":"<div><h3>Objective</h3><div>To translate, culturally adapt and validate the <em>Cuestionário de Expectativas</em> (CEA) for the Brazilian context, with focus on assessing the expectations of patients during pre-surgical stage.</div></div><div><h3>Methods</h3><div>An analytical and descriptive study was carried out, including translation, back-translation, adaptation and validation of the CEA. The process involved 119 participants who answered the questionnaire, allowing the analysis of understanding of the items using the Content Validity Index (CVI) and Exploratory Factor Analysis (EFA). Reliability was assessed with Cronbach's Alpha, McDonald's Omega and Composite Reliability coefficients, using Item Response Theory (IRT).</div></div><div><h3>Results</h3><div>The questionnaire had a total CVI of 0.974, indicating good comprehension by the participants, as well as high values for three internal consistency coefficients (⍺ = 0.828; ω = 0.854; CC = 0.900). The instrument showed great consistency indices and validity measures to be applied on a large scale.</div></div><div><h3>Conclusion</h3><div>The validity and reliability of the instrument were confirmed. Therefore, the instrument was translated, adapted and validated for Brazilian Portuguese.</div></div><div><h3>Levels of evidence</h3><div>Step 2.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 1","pages":"Article 101717"},"PeriodicalIF":1.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Otoprotective effect of the use of antioxidants on noise exposure in experimental studies with rodents – A systematic review with meta-analysis","authors":"Gabriela Guenther Ribeiro Novanta ,&nbsp;Ana Carolina Odorizzi Zica ,&nbsp;Maria Luiza Queiroz Sampaio ,&nbsp;Camila de Castro Corrêa ,&nbsp;Lucieny Silva Martins Serra ,&nbsp;Andre Luiz Lopes Sampaio","doi":"10.1016/j.bjorl.2025.101696","DOIUrl":"10.1016/j.bjorl.2025.101696","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the occurrence of otoprotective effect of the use of antioxidants on noise exposure in experimental models with rodents through a systematic review.</div></div><div><h3>Methods</h3><div>An electronic search was conducted in EMBASE, LILACS, PubMed/Medline, Scopus, Web of Science databases, and in the grey literature of articles published up to June 2022. In the PICO strategy, the studied population consisted of rodent animals exposed to high levels of sound pressure, the intervention consisted of the use of antioxidants, the comparison with the concomitant use of placebo and the results of audiological tests such as Evoked Otoacoustic Emissions and Brainstem Auditory Evoked Potential and the results of histological and immunohistochemical evaluations were collected as outcomes. The analysis of the numerical data was performed according to the Review Manager (Cochrane), using the mean difference as a measure of effect.</div></div><div><h3>Results</h3><div>35 studies were included in the qualitative synthesis and 27 in the quantitative synthesis. The analysis carried out by CAMARADES indicates that most of the included studies demonstrate methodological quality, and the SYRCLE RoB risk of bias assessment protocol revealed a high risk of bias in all eligible studies. In the analysis of the meta-analysis, the effect generated by the use of antioxidants was notorious in comparison with groups that were exposed to the same noise, without the use of antioxidant. Using the ABR responses at the most commonly used frequencies of 2,000–32,000 Hz as outcomes, it was possible to observe in all analyses an otoprotective effect caused by the use of the antioxidant.</div></div><div><h3>Conclusion</h3><div>This systematic review with meta-analysis demonstrated the variable otoprotective effect of the use of antioxidants on exposure to sound pressure levels in experimental studies with rodents, despite the high risk of bias and great heterogeneity of the selected studies.</div></div><div><h3>Level of Evidence</h3><div>1.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 1","pages":"Article 101696"},"PeriodicalIF":1.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogenic/Progestin therapy and the development of Vestibular Schwannoma: A systematic review and meta-analysis","authors":"Maria Vitória Graça Couto de Campos Amaral,&nbsp;Fayez Bahmad Jr","doi":"10.1016/j.bjorl.2025.101706","DOIUrl":"10.1016/j.bjorl.2025.101706","url":null,"abstract":"<div><h3>Objective</h3><div>Compare the risk of developing Vestibular schwannoma in patients prescribed Hormone Therapy (HT).</div></div><div><h3>Methods</h3><div>We performed a systematic review in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA), the search was conducted in English, and we included all the studies that met the following criteria: (a) Participants who presented with VS; (b) Patients prescribed Hormone Replacement Therapy (HRT); (c) Prospective, retrospective or case-control study.</div></div><div><h3>Results</h3><div>Of the 146 articles, four met the inclusion criteria and were included in the systematic review and meta-analysis. Two studies documented an increased relative risk of Vestibular schwannoma in patients that had ever used hormone replacement therapy, another study found an incidence rate 2.2 times higher than the expected incidence rate and the other study indicated a 10% increased odds of the Vestibular Schwannoma in patients who have ever used hormone replacement therapy.</div></div><div><h3>Conclusion</h3><div>The use of hormone replacement therapy was associated with an increased relative risk of Vestibular Schwannoma but also demonstrated a lack of a definitive association.</div></div><div><h3>Level of evidence</h3><div>Level 1.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 1","pages":"Article 101706"},"PeriodicalIF":1.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram for predicting overall and cancer-specific survival in patients with postoperative follicular thyroid cancer","authors":"Xin Liu ,&nbsp;Suidan Chen ,&nbsp;Cangui Wu","doi":"10.1016/j.bjorl.2025.101719","DOIUrl":"10.1016/j.bjorl.2025.101719","url":null,"abstract":"<div><h3>Objectives</h3><div>In this research, nomograms were constructed from clinical variables in patients with postoperative Follicular Thyroid Cancer (FTC) to predict the survival of FTC patients.</div></div><div><h3>Methods</h3><div>Adult patients surgically treated for FTC from 2004 to 2015 were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Significant clinical variables were screened using univariate analysis and further screened with multivariate Cox regression analysis, which were used to construct nomogram models for Overall Survival (OS) and Cancer-Specific Survival (CSS).</div></div><div><h3>Results</h3><div>Age, sex, marital status, tumor size, glandular invasion status, N stage and M stage were identified as the clinical variables affecting the OS in FTC patients. Additionally, all variables, except sex, were found to have an impact on the CSS in FTC patients. The c-index shows agreement between the predicted results and the actual observed results, and the calibration curve of the probability of survival also shows agreement between the predicted plot and the actual observations.</div></div><div><h3>Conclusions</h3><div>Our study successfully built a nomogram of OS and CSS for FTC patients who had undergone surgery.</div></div><div><h3>Level of evidence</h3><div>IV: Retrospective cohort study.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 1","pages":"Article 101719"},"PeriodicalIF":1.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian randomization and FinnGen analysis of the causal relationship between 473 gut microbiota species and chronic sinusitis","authors":"Chenguang Zhang ,&nbsp;Yicong Wang ,&nbsp;Chenghao Hu ,&nbsp;Bin Guo ,&nbsp;Huwei Jiang ,&nbsp;Chunlong Zhao ,&nbsp;Yuwen Wang","doi":"10.1016/j.bjorl.2025.101711","DOIUrl":"10.1016/j.bjorl.2025.101711","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the causal associations between Gut Microbiota (GM) and Chronic Sinusitis (CRS) using Mendelian Randomization (MR).</div></div><div><h3>Methods</h3><div>Genome-Wide Association Study (GWAS) summary statistics for 473 GM taxa were obtained from MiBioGen consortium. CRS data (22,099 cases vs. 371,520 controls) were sourced from the FinnGen R12 cohort. Causal effects were estimated via Inverse Variance-Weighted (IVW), MR-Egger, weighted median, and Bayesian-weighted MR methods. Sensitivity analyses (heterogeneity and horizontal pleiotropy tests) were performed to validate robustness.</div></div><div><h3>Results</h3><div>IVW analysis identified 20 GM taxa significantly associated with CRS risk (<em>p</em> &lt; 0.05). Of these, 7 taxa (e.g., <em>Francisellales</em>, <em>Roseibacillus</em>, <em>Merdibacter massiliensis</em>) exhibited risk-increasing effects, while 13 taxa (e.g., <em>Firmicutes I</em>, <em>Succinivibrionaceae</em>) showed protective effects. Sensitivity analyses confirmed the absence of significant heterogeneity (Cochran’s <em>Q p</em> &gt; 0.05) or pleiotropy (MR-Egger intercept <em>p</em> &gt; 0.05). Bayesian-weighted MR validated 18 causal relationships (posterior probability &gt; 95%), except for RUG420 sp900317985 and UBA7703 (non-significant).</div></div><div><h3>Conclusions</h3><div>This MR study provides genetic evidence supporting causal roles of specific GM taxa in CRS pathogenesis. These findings highlight the gut-sinus axis as a potential therapeutic target and underscore the utility of large-scale biobanks (e.g., FinnGen) in advancing precision medicine.</div></div><div><h3>Level of evidence</h3><div>Level 5. Mendelian Randomized (MR) studies are second only to randomized controlled trials in terms of the level of evidence.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 1","pages":"Article 101711"},"PeriodicalIF":1.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental comparison of platelet-rich plasma with conventional treatment in rats with acoustic trauma induced hearing loss","authors":"Funda Kutay,&nbsp;Mehmet Ihsan Gülmez,&nbsp;Semsettin Okuyucu","doi":"10.1016/j.bjorl.2025.101712","DOIUrl":"10.1016/j.bjorl.2025.101712","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to test at an experimental level the contributions of traditional treatments with Platelet Rich Plasma (PRP) to the recovery of hearing in hearing loss due to acoustic trauma.</div></div><div><h3>Methods</h3><div>Thirty healthy adult rats were used in the study. Otoacoustic Emission (OAE) measurements were performed before the study. All rats with OAE measurements were exposed to 95 dB pure tone sound at a frequency of 4 kHz for 60-minutes. OAEs of the experimental animals were measured again at the 24th hour and it was determined that acoustic trauma had occurred. The rats were divided into 3 groups of 10, the first group was the control group, the 2nd group was determined as the group in which approximately 0.5 mL of intratympanic PRP was injected for 5 doses with 2 days intervals, and the 3rd group was determined as the group in which approximately 0.5 mL of intratympanic steroid was injected with 2 days intervals. OAE measurements made after 7 and 21 days were evaluated, and the treatments given were compared to the group without treatment.</div></div><div><h3>Results</h3><div>The results obtained from day-by-day and frequency-by-frequency measurements of DPOAE were statistically compared to check whether significant results were obtained. It was determined that better results were obtained in rats with acoustic trauma treated with PRP and prednol compared with acoustic trauma who received no treatment, and close treatment efficacy results were found between PRP and prednol groups.</div></div><div><h3>Conclusion</h3><div>When DPOAE measurements of these three groups at 4 kHz frequency on various days were compared with Group 1, a significant statistical difference was observed in Groups 2 and 3, but no significant difference was found between Groups 2 and 3. It was concluded that PRP is as effective as steroids in the improvement of hearing.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 1","pages":"Article 101712"},"PeriodicalIF":1.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations of gut microbiome in chronic rhinosinusitis: insights from a mendelian randomization study","authors":"Ke-Shuang Wang ,&nbsp;Jun-Hao Tu ,&nbsp;Qian-Xing Wang ,&nbsp;Sui-Zi Zhou ,&nbsp;Jia-Rong Wu ,&nbsp;Qian-Hui Qiu","doi":"10.1016/j.bjorl.2025.101698","DOIUrl":"10.1016/j.bjorl.2025.101698","url":null,"abstract":"<div><h3>Objective</h3><div>Gut microbiome dysbiosis is associated with various diseases. Causal association between Chronic Rhinosinusitis (CRS) and gut microbiome is yet unknown. This study aimed to investigate the potential causal relationship between CRS and gut microbiome dysbiosis.</div></div><div><h3>Methods</h3><div>We used Genome-Wide Association Study (GWAS) data from FinnGen database for CRS. The Dutch Microbiome Project study provided data on gut microbiota species. A total of 334,182 individuals were included. Two-sample bidirectional Mendelian Randomization (MR) analysis was used to investigate causal relationship between CRS and gut microbiome. The main methods of evaluation were Inverse Variance Weighting (IVW), weighted median, weighted mode, and MR-Egger regression. Sensitivity analyses were performed to assess heterogeneity and pleiotropy.</div></div><div><h3>Results</h3><div>Forward MR analysis indicated CRS is potentially linked to decreased risk of <em>Haemophilus parainfluenzae</em> (OR = 0.79, 95% CI 0.66‒0.94, <em>p</em> = 0.009) and increased risk of Bilophila’s (OR = 1.14, 95% CI 1.02–1.27, <em>p</em> = 0.023) within the gut. Reduced risks in gut microbiota-related pathways like UDP<em>-N-</em>acetyl-<span>d</span>-glucosamine biosynthesis I (OR = 0.85, 95% CI 0.77‒0.94, <em>p</em> = 0.002) and increased risk in pathway NAD biosynthesis I from aspartate (OR = 1.14, 95% CI 1.03–1.27, <em>p</em> = 0.010) were also linked to CRS. Reverse MR analyses, we obtained no positive results (<em>p</em> &gt; 0.05/412).</div></div><div><h3>Conclusion</h3><div>This study reveals CRS exerts a causal impact on shifts within the composition of the gut microbiome and also links to the changes of gut microbiota-related metabolic pathways. The risk of changes in gut microbiota should be of greater concern in patients with CRS than in the general population.</div></div><div><h3>Level of evidence</h3><div>Mendelian Randomized (MR) studies are second only to randomized controlled trials in terms of the level of evidence.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 1","pages":"Article 101698"},"PeriodicalIF":1.8,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis on the plane and mechanism of tongue-originated obstruction in Obstructive Sleep Apnea Syndrome (OSAS) patients with macroglossia","authors":"Min Huang ,&nbsp;Guohao Chen","doi":"10.1016/j.bjorl.2025.101709","DOIUrl":"10.1016/j.bjorl.2025.101709","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the plane and related mechanisms of tongue-originated obstruction in Obstructive Sleep Apnea Syndrome (OSAS) patients with macroglossia, utilizing pharyngeal Magnetic Resonance Imaging (MRI) in combination with Upper Airway Pressure Monitoring (UAPM).</div></div><div><h3>Methods</h3><div>Nineteen OSAS patients with macroglossia and 19 healthy controls were enrolled in this study. Every case was examined by pharyngeal MRI and Polysomnogram (PSG). The minimum Retropalatal Space (RP), the minimum Retrolingual Space (RL), soft palate thickness and the minimum space from the dorsal tongue to the soft palate (TP) were measured on a midsagittal plane. UAPM was measured only in the OSAS group. The differences of results between groups were statistically analyzed.</div></div><div><h3>Results</h3><div>Both UAPM and pharyngeal MRI indicated that the obstruction plane was present in patients with OSAS along the velopharyngeal plane. The mean values of both RP and RP/RL of patients with OSAS in this study were significantly smaller than control group values (<em>p</em> &lt; 0.05). There was no significant difference in RL and soft palate thickness across the two groups (<em>p</em> &gt; 0.05). The value of TP in both groups was close to 0, showing no significant difference between groups (<em>p</em> &gt; 0.05).</div></div><div><h3>Conclusions</h3><div>The velopharyngeal plane was the most common site demonstrating obstructive etiology in OSAS patients with macroglossia. The related mechanism is suspected to include the backward movement of the soft palate caused by the high arch and the fall of the middle segment of the hypertrophic tongue. These findings may inform tongue-related surgical site decision-making for OSAS patients with macroglossia.</div></div><div><h3>Level of evidence</h3><div>IV: Retrospective cohort study.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 1","pages":"Article 101709"},"PeriodicalIF":1.8,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}