Brazilian Journal of Otorhinolaryngology最新文献

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Impact of prosthesis position on hearing outcomes in otosclerosis patients based on ultra-high-resolution CT 基于超高分辨率CT的假体位置对耳硬化患者听力结果的影响
IF 1.8 4区 医学
Brazilian Journal of Otorhinolaryngology Pub Date : 2025-07-29 DOI: 10.1016/j.bjorl.2025.101688
Chen Yang , Heyu Ding , Ting Zhang , Pengfei Zhao , Zhenchang Wang , Shusheng Gong , Jing Xie
{"title":"Impact of prosthesis position on hearing outcomes in otosclerosis patients based on ultra-high-resolution CT","authors":"Chen Yang ,&nbsp;Heyu Ding ,&nbsp;Ting Zhang ,&nbsp;Pengfei Zhao ,&nbsp;Zhenchang Wang ,&nbsp;Shusheng Gong ,&nbsp;Jing Xie","doi":"10.1016/j.bjorl.2025.101688","DOIUrl":"10.1016/j.bjorl.2025.101688","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to explore the impact of prosthesis position on hearing outcomes in otosclerosis patients based on Ultra-High-Resolution CT (U-HRCT).</div></div><div><h3>Methods</h3><div>We retrospectively reviewed medical records of 142 patients (182 ears) who underwent stapedotomy. We compared preoperative with postoperative hearing results. An experienced radiologist extracted data about stapes prostheses from U-HRCT images, including absolute insertion depth, relative insertion depth, angle between the prosthesis and incus, angle between the prosthesis and footplate, and the relative position of the hook clamped onto the long process of incus. We analyzed potential relationships between the imaging data and postoperative hearing outcomes.</div></div><div><h3>Results</h3><div>We obtained satisfactory hearing results from 129 ears postoperatively. 119 ears (92.2%) presented Air-Bone Gaps (ABG) in the 0–20 dB range. We observed statistically significant differences between mean pre- and post-operative ABG at different frequencies (0.5, 1, 2, and 4 kHz). The best results occurred at 2 kHz (98.5%). We found that the observed values for prosthesis insertion depth (mean 0.6 mm, relative depth: mean 23%) and mean angle between the prosthesis and incus (mean 91.2 °) were safe and effective. We also found that the mean angle between prosthesis and footplate was related to postoperative ABG (p = 0.049). The hook position on the long process of incus (relative distance of 10.5%) is also a crucial factor in determining postoperative hearing results (p = 0.726).</div></div><div><h3>Conclusion</h3><div>Prosthesis position and postoperative hearing outcomes are related. Postoperative imaging evaluation is especially important for patients who did not benefit substantially from stapes surgery.</div></div><div><h3>Level of evidence</h3><div>Level 3.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 6","pages":"Article 101688"},"PeriodicalIF":1.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicopathological analysis of hyalinizing clear cell carcinoma in the head and neck 头颈部透明细胞癌的临床病理分析
IF 1.8 4区 医学
Brazilian Journal of Otorhinolaryngology Pub Date : 2025-07-29 DOI: 10.1016/j.bjorl.2025.101676
Xiaoli Zhao, Donglin Ma, Yahui Li, Dongmei Yang, Yingshi Piao
{"title":"Clinicopathological analysis of hyalinizing clear cell carcinoma in the head and neck","authors":"Xiaoli Zhao,&nbsp;Donglin Ma,&nbsp;Yahui Li,&nbsp;Dongmei Yang,&nbsp;Yingshi Piao","doi":"10.1016/j.bjorl.2025.101676","DOIUrl":"10.1016/j.bjorl.2025.101676","url":null,"abstract":"<div><h3>Objective</h3><div>To study clinicopathological features and differential diagnosis of hyalinizing clear cell carcinoma in the head and neck.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed patients with hyalinizing clear cell carcinoma in the head and neck, who underwent surgical resection in Beijing Tongren Hospital affiliated to Capital Medical University from January 2014 to May 2024. The clinical features of HCCC were analyzed by computed tomography and magnetic resonance imaging. Tumor sections were further characterized using hematoxylin and eosin staining, immunohistochemistry, and fluorescence in situ hybridization.</div></div><div><h3>Results</h3><div>There were 4 male and 5 female cases in 9 patients. The age range was 28–84 years-old, the middle age was 60 years-old. 9 patients, 5 in the nasopharynx, 2 in the base of the tongue, and 2 in the oropharynx. At the cellular level, the HCCC tumors were composed of transparent and eosinophilic cells (in various ratios), which were typically arranged into nests, cords, and trabeculae, and embedded in a glassy hyaline substance. Immunohistochemical evaluation showed positivity for CK7, P63, P40, CK5/6, and negativity for S100, SMA, GFAP, and calponin. Fluorescence in situ hybridization revealed EWSR1 rearrangement in all the nine patients evaluated.</div></div><div><h3>Conclusions</h3><div>Hyalinizing clear cell carcinoma is a rare low-grade salivary gland carcinoma that mostly occurs in the minor salivary glands. They had an indolent disease course, with few metastases. Our study shows that the above combination of analytical techniques can be used to accurately characterize and diagnose HCCC.</div></div><div><h3>Level of evidence</h3><div>Level 1.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 6","pages":"Article 101676"},"PeriodicalIF":1.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sequential flaps reconstruction in head and neck cancer: A systematic review 序贯皮瓣重建头颈癌:系统回顾
IF 1.8 4区 医学
Brazilian Journal of Otorhinolaryngology Pub Date : 2025-07-29 DOI: 10.1016/j.bjorl.2025.101693
Yu Xiong , Zepeng Xu , Mailudan Ainiwaer , Zheng Jiang , Fei Chen
{"title":"Sequential flaps reconstruction in head and neck cancer: A systematic review","authors":"Yu Xiong ,&nbsp;Zepeng Xu ,&nbsp;Mailudan Ainiwaer ,&nbsp;Zheng Jiang ,&nbsp;Fei Chen","doi":"10.1016/j.bjorl.2025.101693","DOIUrl":"10.1016/j.bjorl.2025.101693","url":null,"abstract":"<div><h3>Objectives</h3><div>For patients with Head and Neck Cancer (HNC), flap reconstruction is one of the treatment modalities for large head and neck defects. While most patients achieve satisfactory outcomes with a single flap, some may require a second or additional flaps due to various reasons. The aim of our study was to systematically review the relevant articles and investigate the application of sequential flaps in reconstruction of patients with HNC.</div></div><div><h3>Methods</h3><div>Two authors independently screened articles from PubMed, EBSCO, and Web of Science. Studies were included if they reported at least one of the following outcomes: duration of operation or hospitalization, flap-related postoperative complications, flap success rate, and follow-up outcomes.</div></div><div><h3>Results</h3><div>A total of 17 articles were included, comprising 832 patients and 1037 flaps (excluding the number of flaps used in initial reconstructions). The overall flap failure rate was 5.4%. Among the 314 flap-related postoperative complications, the most common were revision (5.8%), complete flap necrosis (5.2%), and arterial or venous thrombosis (3.3%).</div></div><div><h3>Conclusion</h3><div>Sequential flaps are an optional and effective reconstructive modality for HNC patients. However, prospective studies are needed to explore prognostic-related risk factors and better determine the suitability of sequential flaps for individual patients. Additionally, since reconstruction impacts both aesthetics and function, it is crucial to emphasize during preoperative discussions that postoperative outcomes may not fully align with patient expectations.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 6","pages":"Article 101693"},"PeriodicalIF":1.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of nigella sativa oil on healing in nasal septum perforations 黑草油对鼻中隔穿孔愈合的影响
IF 1.8 4区 医学
Brazilian Journal of Otorhinolaryngology Pub Date : 2025-07-29 DOI: 10.1016/j.bjorl.2025.101678
Ahmet Koder , Onur Ersoy
{"title":"The effect of nigella sativa oil on healing in nasal septum perforations","authors":"Ahmet Koder ,&nbsp;Onur Ersoy","doi":"10.1016/j.bjorl.2025.101678","DOIUrl":"10.1016/j.bjorl.2025.101678","url":null,"abstract":"<div><h3>Objective</h3><div>Nasal Septal Perforation (NSP) is a challenging condition with limited treatment options, often resulting in symptoms like nasal obstruction and epistaxis. Nigella Sativa Oil (NSO), known for its anti-inflammatory and regenerative properties, has shown promise in promoting wound healing. This study aims to investigate the effects of NSO on the wound healing process in an experimental NSP model using rats, exploring its potential as a therapeutic agent for NSP treatment.</div></div><div><h3>Methods</h3><div>Twenty-two male Sprague Dawley rats were randomly assigned to two groups. Each subject had a Nasal Septal Perforation (NSP) approximately 2 mm in diameter created. NSO (study group) and saline (control group) were applied topically once a day for 14 days. At the end of the 14th day, the rats were sacrificed, and their nasal septa were excised for macroscopic and histopathological examination. Immunohistochemically Vascular Endothelial Growth Factor (VEGF) and Proliferating Nuclear Cell Antigen (PCNA) parameters examined. Tissue morphology was evaluated, collagen density was measured. The macroscopic closure rate of the NSPs and the histopathological parameters were analyzed statistically.</div></div><div><h3>Results</h3><div>NSO group showed significantly higher collagen density, surface morphology score, International Cartilage Repair Society (ICRS) matrix examination score, PCNA immunoreactivity and macroscopic closure rate of NSPs compared to the saline group (p &lt; 0.05). In terms of VEGF immunoreactivity, no difference was detected between both groups (p &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Locally administered NSO may enhance wound healing in the nasal septum within an experimental NSP model, suggesting that NSO could be an effective alternative or adjunctive treatment for NSP, promoting better clinical outcomes.</div></div><div><h3>Level of evidence</h3><div>Level 3.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 6","pages":"Article 101678"},"PeriodicalIF":1.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer stem cell biomarkers in locally advanced head and neck squamous cell carcinoma 局部晚期头颈部鳞状细胞癌的肿瘤干细胞生物标志物
IF 1.8 4区 医学
Brazilian Journal of Otorhinolaryngology Pub Date : 2025-07-29 DOI: 10.1016/j.bjorl.2025.101689
Miguel Caballero-Borrego , Juan J. Grau , Neus Basté , Paola C. Castillo , Cristina Teixido , Izaskun Valduvieco , Isabel Vilaseca
{"title":"Cancer stem cell biomarkers in locally advanced head and neck squamous cell carcinoma","authors":"Miguel Caballero-Borrego ,&nbsp;Juan J. Grau ,&nbsp;Neus Basté ,&nbsp;Paola C. Castillo ,&nbsp;Cristina Teixido ,&nbsp;Izaskun Valduvieco ,&nbsp;Isabel Vilaseca","doi":"10.1016/j.bjorl.2025.101689","DOIUrl":"10.1016/j.bjorl.2025.101689","url":null,"abstract":"<div><h3>Objectives</h3><div>To analyze the presence of cancer stem cells markers in consecutive patients with locally advanced Head and Neck Squamous Cell Carcinoma (HNSCC) and establish their suitability as a prognostic biomarker in samples from routine practice.</div></div><div><h3>Methods</h3><div>Retrospective study of 104 consecutive patients with locally advanced HNSCC treated with definitive surgery and adjuvant chemoradiotherapy. Immunohistochemical expression of CD44, HLA-I, pan-cytokeratin, and phosphorylated Epidermal Growth Factor Receptor (p-EGFR) were evaluated in surgical specimens. Overall Survival (OS) and Disease-Free Survival (DFS) rates were calculated based on clinical characteristics and the total positive score (for tumor marker expression). Hazard ratios were calculated by Cox multivariate analysis.</div></div><div><h3>Results</h3><div>After a median follow-up of 50-months, higher OS rates were observed for patients without cervical node pathological involvement (p &lt; 0.001), patients with HLA-I overexpression and a total positive score ≥ 15% (p = 0.017), and patients with low CD44 expression and a total positive score ≤ 60% (p = 0.022). Grouping by p-EGFR (p = 0.648) or pan-cytokeratin (p = 0.477) expression did not show statistical differences in OS. None of the biomarkers were associated with different DFS rates. Cox multivariate analysis revealed that positive cervical nodes (HR = 1.294; 95% CI 1.025–1.634; p = 0.030) and the expressions of HLA (HR = 0.373; 95% CI 0.168‒0.829; p = 0.015) and CD44 (HR = 2.170; 95% CI 1.031–4.569; p = 0.041) were independently associated with OS.</div></div><div><h3>Conclusion</h3><div>Nodal involvement, HLA-I overexpression, and decreased CD44 expression are independent prognostic factors of survival in patients with locally advanced HNSCC.</div></div><div><h3>Level of evidence</h3><div>III.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 6","pages":"Article 101689"},"PeriodicalIF":1.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The agger nasi approach to the uncinate process: From top to bottom 钩交过程的agger nasi方法:从上到下
IF 1.8 4区 医学
Brazilian Journal of Otorhinolaryngology Pub Date : 2025-07-29 DOI: 10.1016/j.bjorl.2025.101675
Miguel Soares Tepedino , Luziana de Lima Ramalho , Leonardo Balsalobre , Andrea Santos Dumont Costa Curta , Debora de Carvalho Garcez , Rogerio Pezato
{"title":"The agger nasi approach to the uncinate process: From top to bottom","authors":"Miguel Soares Tepedino ,&nbsp;Luziana de Lima Ramalho ,&nbsp;Leonardo Balsalobre ,&nbsp;Andrea Santos Dumont Costa Curta ,&nbsp;Debora de Carvalho Garcez ,&nbsp;Rogerio Pezato","doi":"10.1016/j.bjorl.2025.101675","DOIUrl":"10.1016/j.bjorl.2025.101675","url":null,"abstract":"<div><h3>Objective</h3><div>To describe a novel endoscopic approach to the Uncinate Process (UP) via the agger nasi region and evaluate its anatomical basis and clinical outcomes.</div></div><div><h3>Methods</h3><div>This study comprised two components. In the imaging study, 51 paranasal sinus CT scans were analyzed to measure the distance between the UP and the medial orbital wall at the agger nasi and ethmoid infundibulum regions, using standardized coronal and axial planes. In the clinical study, 53 patients with chronic rhinosinusitis underwent uncinectomy through the agger nasi approach. Pre- and postoperative SNOT-22 scores were compared after 6-months of follow-up, and complications were recorded.</div></div><div><h3>Results</h3><div>The distance from the UP to the orbit was significantly greater at the agger nasi region compared to the ethmoid infundibulum on both sides (p &lt; 0.001). Clinically, the agger nasi approach allowed consistent identification of the maxillary sinus ostium and preservation of key anatomical structures. There was a significant improvement in SNOT-22 scores postoperatively (p &lt; 0.001), with no major complications observed.</div></div><div><h3>Conclusion</h3><div>The agger nasi approach to the UP is a safe, reproducible, and effective technique. The greater distance from the UP to the orbit in this region may reduce the risk of orbital injury and facilitate complete identification of the natural drainage pathway of the maxillary sinus.</div></div><div><h3>Level of evidence</h3><div>3.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 6","pages":"Article 101675"},"PeriodicalIF":1.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical outcomes of high-frequency electrocautery surgery and proton pump inhibitor therapy for refractory laryngeal contact granuloma 高频电切联合质子泵抑制剂治疗难治性喉部接触性肉芽肿的临床效果
IF 1.8 4区 医学
Brazilian Journal of Otorhinolaryngology Pub Date : 2025-07-29 DOI: 10.1016/j.bjorl.2025.101690
Zelong Wang, Xianbin Lan, Yuan Fang, Shaoping Peng, Riqun Jin, Dongming Deng, Zhiheng Song
{"title":"Clinical outcomes of high-frequency electrocautery surgery and proton pump inhibitor therapy for refractory laryngeal contact granuloma","authors":"Zelong Wang,&nbsp;Xianbin Lan,&nbsp;Yuan Fang,&nbsp;Shaoping Peng,&nbsp;Riqun Jin,&nbsp;Dongming Deng,&nbsp;Zhiheng Song","doi":"10.1016/j.bjorl.2025.101690","DOIUrl":"10.1016/j.bjorl.2025.101690","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the clinical efficacy of high-frequency electrocautery under electronic laryngoscopy combined with acid-suppressing drugs (Proton Pump Inhibitor, PPI) in the treatment of Refractory Laryngeal Contact Granuloma (RLCG).</div></div><div><h3>Methods</h3><div>A total of 42 patients with RLCG, treated at our hospital from January 2019 to January 2024 were included in this study. The patients underwent high-frequency electrocautery to excise laryngeal granulomas under local anesthesia using electronic laryngoscopy, followed by PPI therapy. Follow-up started one-month post-surgery and lasted for 6–12 months (average of 8.5 months), to assess the cure rate and overall efficacy.</div></div><div><h3>Results</h3><div>The cure rate was 76.19%, and the overall efficacy rate was 92.86%. On average, each patient underwent 1.79 procedures. The combined treatment of high-frequency electrocautery under local anesthesia with electronic laryngoscopy and PPI therapy demonstrated significant therapeutic effects for RLCG. The treatment was simple, well-tolerated by patients, cost-effective, and resulted in rapid symptom improvement, all without the need for general anesthesia or intubation.</div></div><div><h3>Conclusion</h3><div>The combined approach of high-frequency electrocautery under local anesthesia with electronic laryngoscopy and PPI therapy is effective in treating refractory laryngeal contact granuloma. This method offers the advantages of a straightforward surgical procedures, high patient tolerance, low cost, quick symptom relief, and no requirement for general anesthesia or intubation.</div></div><div><h3>Level of evidence</h3><div>Level 4-Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 6","pages":"Article 101690"},"PeriodicalIF":1.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional outcomes of otosclerosis surgery 耳硬化手术的功能结局
IF 1.7 4区 医学
Brazilian Journal of Otorhinolaryngology Pub Date : 2025-07-11 DOI: 10.1016/j.bjorl.2025.101679
Nadia Romdhane, Dorra Chiboub, Amal Nessib, Ameni Amri, Ines Hariga, Chiraz Chaouch Mbarek
{"title":"Functional outcomes of otosclerosis surgery","authors":"Nadia Romdhane,&nbsp;Dorra Chiboub,&nbsp;Amal Nessib,&nbsp;Ameni Amri,&nbsp;Ines Hariga,&nbsp;Chiraz Chaouch Mbarek","doi":"10.1016/j.bjorl.2025.101679","DOIUrl":"10.1016/j.bjorl.2025.101679","url":null,"abstract":"<div><h3>Objectives</h3><div>The objectives of this work were to evaluate the results of otosclerosis surgery and to study the predictors of its functional success.</div></div><div><h3>Methods</h3><div>Our study was retrospective on 322 patients, equivalent to 418 ears operated in the otolaryngology and head and neck surgery department, from January 2000 to December 2020.</div></div><div><h3>Results</h3><div>Hearing success was noted in 89.5% of patients considering the Postoperative Residual Air Bone Gap (PRABG) ≤10 dB criterion; in 94.3% of patients according to the conductive gain ≥20 dB criterion; in 96.4% of patients based on the improvement of cochlear reserve criterion; in 88.8% according to the Air Bone Gap improvement (ABGi) ≥70% criterion and in 81.8% considering all these criteria. The short, medium and long-term postoperative tonal audiometries could be superimposed, reflecting the stability of the hearing results. A regression of tinnitus has been reported in 79.2% of cases. The independent predictors of hearing success were the Aubry's audiometric stages I and II, mean preoperative air curve &gt;40 dB and platinotomy. The independent predictors of tinnitus regression retained were male sex, no exposure to loud noise and Veillon radiological stages I and II.</div></div><div><h3>Conclusion</h3><div>The identification of factors influencing the functional results of surgery allows a better selection of candidates for the intervention and more relevant information for patients.</div></div><div><h3>Level of evidence</h3><div>Level 3: Non-randomized controlled cohort or follow-up study.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 6","pages":"Article 101679"},"PeriodicalIF":1.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of ApoE and Spp1 in the cochlea and auditory cortex of age-related hearing loss mice ApoE和Spp1在老年性听力损失小鼠耳蜗和听觉皮层的表达
IF 1.7 4区 医学
Brazilian Journal of Otorhinolaryngology Pub Date : 2025-07-09 DOI: 10.1016/j.bjorl.2025.101674
Yingxue Yuan , Junhong Zhang , Jingyi Zhao , Xiru Zhang , Zhixin Cao
{"title":"Expression of ApoE and Spp1 in the cochlea and auditory cortex of age-related hearing loss mice","authors":"Yingxue Yuan ,&nbsp;Junhong Zhang ,&nbsp;Jingyi Zhao ,&nbsp;Xiru Zhang ,&nbsp;Zhixin Cao","doi":"10.1016/j.bjorl.2025.101674","DOIUrl":"10.1016/j.bjorl.2025.101674","url":null,"abstract":"<div><h3>Objective</h3><div>Screen for differential proteins in the cochlea of mice associated with Age-Related Hearing Loss (ARHL), analyze and validate the expression of specific differential proteins and genes in the cochlea and auditory cortex of ARHL mice, and preliminarily explore their potential mechanisms of action.</div></div><div><h3>Methods</h3><div>ABR (Auditory Brainstem Response) hearing tests were conducted to select 15-month-old C57BL/6 mice with significantly decreased hearing as the experimental group and 2-month-old mice with normal hearing as the control group. Cochleae were dissected, and unlabeled quantitative proteomics was employed to identify and analyze differentially expressed proteins in the inner ear of the two groups of mice. Key node proteins were selected via the STRING database and Cytoscape analysis. The expression of two selected proteins, ApoE and Spp1, in the cochlea was detected using qRT-PCR, Western blot, and immunofluorescence techniques, and their expression in the auditory cortex of the brain was further explored.</div></div><div><h3>Results</h3><div>Label-free quantitative proteomics identified 115 differentially expressed proteins in the cochlea of 15-month-old ARHL mice compared to 2-month-old hearing-normal mice, including 42 upregulated and 73 downregulated proteins. GO and KEGG enrichment analyses revealed significant enrichment of differentially expressed proteins in functions and signaling pathways associated with neurodegenerative diseases and neurotransmission. Protein-Protein Interaction (PPI) analysis using the STRING database and Cytoscape selection identified ApoE and Spp1 as key hub proteins. Validation via qRT-PCR, Western blot, and immunofluorescence demonstrated that both ApoE and Spp1 were highly expressed in the cochlea and auditory cortex of the ARHL mice compare to 2-month-old hearing-normal mice.</div></div><div><h3>Conclusion</h3><div>ApoE and Spp1 are upregulated in the cochlea of ARHL mice, particularly in spiral ganglion neurons, and in the auditory cortex, suggesting their potential involvement in the pathogenesis and progression of ARHL through the modulation of auditory neural conduction systems.</div></div><div><h3>Level of evidence</h3><div>Level 2.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 6","pages":"Article 101674"},"PeriodicalIF":1.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of tinnitus with obstructive sleep apnea and rapid eye movement-related obstructive sleep apnea in similar hearing threshold groups 耳鸣与阻塞性睡眠呼吸暂停和快速眼动相关阻塞性睡眠呼吸暂停在相似听力阈组的关联
IF 1.7 4区 医学
Brazilian Journal of Otorhinolaryngology Pub Date : 2025-07-08 DOI: 10.1016/j.bjorl.2025.101661
Sun Choi , Seok Hyun Park , Su Yeon Kim , Su Kyoung Park , Sang Chul Park , Jiwon Chang
{"title":"Association of tinnitus with obstructive sleep apnea and rapid eye movement-related obstructive sleep apnea in similar hearing threshold groups","authors":"Sun Choi ,&nbsp;Seok Hyun Park ,&nbsp;Su Yeon Kim ,&nbsp;Su Kyoung Park ,&nbsp;Sang Chul Park ,&nbsp;Jiwon Chang","doi":"10.1016/j.bjorl.2025.101661","DOIUrl":"10.1016/j.bjorl.2025.101661","url":null,"abstract":"<div><h3>Objectives</h3><div>Obstructive sleep apnea, a multisystem disease, affects cochlear and vestibular functions due to chronic intermittent hypoxia and recurrent oxygen desaturation. During rapid eye movement sleep, the muscle tone of the upper airway decreases more, and the cardiovascular complication risk is higher than that during non-rapid eye movement sleep. We analyzed whether tinnitus was associated with obstructive sleep apnea and rapid eye movement-related obstructive sleep apnea in patients with similar hearing thresholds.</div></div><div><h3>Methods</h3><div>We evaluated patients with obstructive sleep apnea without (24 patients; group 1) and with (27 patients; group 2) tinnitus. All participants underwent pure-tone audiometry, tinnitus tests, polysomnography, and sleep questionnaires.</div></div><div><h3>Results</h3><div>The sleep efficiency (86.23% ± 10.38% vs. 81.27% ± 8.10%) and Epworth Sleepiness Scale (8.50 ± 4.31 vs. 5.15 ± 2.82) values were higher in group 2 versus group 1. In patients with rapid eye movement-related obstructive sleep apnea, the sleep efficiency value was higher in group 2 (90.55% ± 4.61%) versus group 1 (78.13% ± 11.70%). However, in patients with obstructive sleep apnea and rapid eye movement-related obstructive sleep apnea, medication use that might affect sleep was higher in group 2 (44.4% and 54.4%, respectively) versus group 1 (16.7% and 28.6%, respectively).</div></div><div><h3>Conclusions</h3><div>We evaluated the relationship between tinnitus and obstructive sleep apnea or rapid eye movement-related obstructive sleep apnea in groups with similar hearing thresholds for the first time. The presence of tinnitus in patients with obstructive sleep apnea with similar hearing thresholds was more closely related to subjective parameters than to objective parameters. Patients with tinnitus had poorer sleep quality than those without tinnitus.</div></div><div><h3>Level of evidence</h3><div>4.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 5","pages":"Article 101661"},"PeriodicalIF":1.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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