Brazilian Journal of Otorhinolaryngology最新文献

{"title":"Moving past the usual suspects: a new framework for aural fullness","authors":"Roseli Saraiva Moreira Bittar , Lucas Resende Lucinda Mangia , Raquel Mezzalira","doi":"10.1016/j.bjorl.2026.101767","DOIUrl":"10.1016/j.bjorl.2026.101767","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 3","pages":"Article 101767"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146081491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there any relationship between the menopause transition and dizziness?","authors":"Lucas Resende Lucinda Mangia ,&nbsp;Roseli Saraiva Moreira Bittar","doi":"10.1016/j.bjorl.2026.101763","DOIUrl":"10.1016/j.bjorl.2026.101763","url":null,"abstract":"<div><h3>Objectives</h3><div>This review aims to study the impact of menopause transition on the vestibular system.</div></div><div><h3>Methods</h3><div>A broad systematic search of biomedical databases was performed. Papers investigating the effects of changes in female sex hormones on the vestibular physiology or the relationship between these changes in midlife women and vestibular manifestations were reviewed. Data from basic science, epidemiological studies and clinical investigations were organized and elaborated. The authors also addressed the gaps and limitations of current literature.</div></div><div><h3>Results</h3><div>Hormonal modifications during menopause transition seem to affect the vestibular system. Accordingly, epidemiological investigations describe a remarkable prevalence of vestibular disorders in climacteric women. However, clinical studies exploring this relationship are scarce, and little is known about the clinical and pathophysiological aspects of these diseases. The predisposition to vestibular disturbances during the menopause transition might be the result of an intricate combination of hormonal effects in the nervous system. These effects encompass changes in energy metabolism, immune and inflammatory regulation, modulation of several neurotransmitter systems, integrity of microcirculation and neuroprotection and neuroplasticity pathways. As a result, structural consequences within the inner ear, changes in the transduction and modulation of peripheral signals and dysregulation of central vestibular circuits may occur. Additionally, patients may present with signs of disturbances in sensory processing or difficulties in recovering from functional damages to the vestibular system. These events may contribute to the manifestation of individual vulnerabilities, causing sensory complaints, and the onset or worsening of vestibular problems. Preliminary data also corroborate the impact of menopause transition in specific vestibular diseases.</div></div><div><h3>Conclusion</h3><div>There is a theoretical basis for understanding the menopause transition as a facilitating condition for vestibular symptoms and diseases. However, clinical studies addressing these issues are scarce. Exploring them is a promising field of investigation that could lead to improvement in care for vestibular patients.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 3","pages":"Article 101763"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoma in the hypopharynx: a case report","authors":"Diego Guzman Rodrigues ,&nbsp;Rynat Dasaev Oliveira Chagas ,&nbsp;Natália Matos Muricy ,&nbsp;Raissa Damasceno Barreto da Silva","doi":"10.1016/j.bjorl.2026.101764","DOIUrl":"10.1016/j.bjorl.2026.101764","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 3","pages":"Article 101764"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of comprehensive sequential therapy for salivary duct carcinoma with HER2 gene amplification: a case report","authors":"Yu Zhang ,&nbsp;Chenke Wei ,&nbsp;Wei Shang ,&nbsp;Zongxuan He","doi":"10.1016/j.bjorl.2026.101765","DOIUrl":"10.1016/j.bjorl.2026.101765","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 3","pages":"Article 101765"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilobed flap for lower lip reconstruction: A two-case series and technical considerations","authors":"Victor Bandini Vieira,&nbsp;Giovana Cruz Corsi,&nbsp;Rafael Pereira de Souza,&nbsp;Rafael De Cicco","doi":"10.1016/j.bjorl.2025.101738","DOIUrl":"10.1016/j.bjorl.2025.101738","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101738"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The emerging role of anti-thymic stromal lymphopoietin monoclonal antibody (Tezepelumab) in comorbid and non-comorbid CRSwNP patients: a scoping review","authors":"Antonio Moffa ,&nbsp;Eugenio de Corso ,&nbsp;Domiziana Nardelli ,&nbsp;Antonella Loperfido ,&nbsp;Jacopo Galli ,&nbsp;Peter Baptista ,&nbsp;Manuele Casale","doi":"10.1016/j.bjorl.2026.101768","DOIUrl":"10.1016/j.bjorl.2026.101768","url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review aims to evaluate the effectiveness of Tezepelumab, a monoclonal antibody targeting the thymic stromal lymphopoietin, in patients affected by chronic rhinosinusitis with nasal polyposis, both with and without comorbid asthma.</div></div><div><h3>Methods</h3><div>A systematic search of the literature was conducted across PubMed, SCOPUS, and Google Scholar databases until April 2025. Studies were selected based on predefined inclusion criteria, focusing on adult patients with clinically diagnosed chronic rhinosinusitis with nasal polyps who received Tezepelumab treatment for at least four weeks and reported validated clinical outcomes. Studies involving patients receiving prior standard treatment and comorbid asthma were included. Outcome measures included sinonasal symptom scores, imaging scores, pulmonary function tests, quality of life assessments, systemic corticosteroid use, and the need for surgical intervention. Study selection, data extraction, and quality assessment were conducted independently by two reviewers.</div></div><div><h3>Result</h3><div>Out of 221 screened records, three randomized controlled trials involving a total of 691 patients met the eligibility criteria. Tezepelumab treatment resulted in significant improvements in nasal symptom scores, including reductions in nasal congestion and loss of smell, as well as improved quality of life and sleep-related symptoms. Objective assessments showed a reduction in polyp size and radiological scores, with fewer patients requiring systemic corticosteroids or surgical intervention compared to placebo. Improvements were also observed in lung function and disease control among patients with comorbid asthma. The effect size exceeded minimal clinically important difference thresholds across key outcome measures.</div></div><div><h3>Conclusion</h3><div>Tezepelumab demonstrated consistent and clinically meaningful benefits in the treatment of chronic rhinosinusitis with nasal polyps, including symptom relief, reduced polyp burden, and decreased need for corticosteroids or surgery. Its upstream mechanism offers potential advantages over existing biologic therapies. Further long-term and real-world studies are needed to confirm its role in clinical practice and define ideal patient selection strategies.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101768"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discriminative validity and diagnostic accuracy of Horus® posturographic parameters in individuals with and without vestibulopathy","authors":"Maria Clara Peixoto Marinheiro ,&nbsp;Ana Clara Teixeira Fernandes ,&nbsp;Luana Dantas da Silva ,&nbsp;Adriana Guedes Carlos ,&nbsp;José Diniz Júnior ,&nbsp;Juliana Maria Gazzola ,&nbsp;Vanessa Regiane Resqueti","doi":"10.1016/j.bjorl.2025.101746","DOIUrl":"10.1016/j.bjorl.2025.101746","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the discriminative validity and diagnostic accuracy of posturographic parameters from the Horus® in individuals with and without vestibulopathy.</div></div><div><h3>Methods</h3><div>This is a methodological study of discriminative validity and diagnostic accuracy. 153 individuals aged 40–79, of both sexes, were included and divided into Group 1 (with vestibular dysfunction) and Group 2 (without vestibular dysfunction). Instruments on clinical characterization, cognition, physical activity level, and posturography were applied. Discriminative validity was assessed with nonparametric multivariate analyses, the Mann-Whitney test, controlled with Holm adjustment and rank-biserial correlation to estimate effect size. Sensitivity, specificity, area under the curve, and cutoff points were calculated using ROC curves.</div></div><div><h3>Results</h3><div>The final sample included 78 individuals in Group 1 and 75 in Group 2, with mean ages of 59.36 and 56.48 years, respectively. Significant differences were found between the groups for all dependent variables related to confidence ellipse/limit of stability and mediolateral velocity (p &lt; 0.001), with moderate to large differences (ES &gt; 0.28) and in most of the anteroposterior velocity and sensory analysis (p &lt; 0.005), with small to moderate differences (ES: &gt;0.11 and &lt;0.43). The ROC curve analysis revealed that confidence ellipse/limit of stability and mediolateral velocity exhibited high specificity (84% and 80%) and moderate sensitivity (52.6% and 53.85%). The Vestibular Function parameter demonstrated good sensitivity (70%) and moderate specificity (60.8%), while the Composite Balance Index showed a sensitivity of 79.5% and specificity of 64%.</div></div><div><h3>Conclusion</h3><div>Horus® posturographic parameters demonstrated moderate to good discriminative ability to differentiate individuals with and without vestibular dysfunction, with high sensitivity for vestibular function and the Composite Balance Index.</div></div><div><h3>Level of evidence</h3><div>3 (cross-sectional study).</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101746"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explainable machine learning model for predicting hearing recovery in unilateral sudden sensorineural hearing loss","authors":"Jueting Wu ,&nbsp;Ruru Chen ,&nbsp;Yaxuan Liu ,&nbsp;Feng Zhao ,&nbsp;Huiying Chen ,&nbsp;Xiaoyu Lin ,&nbsp;Jiping Su","doi":"10.1016/j.bjorl.2025.101730","DOIUrl":"10.1016/j.bjorl.2025.101730","url":null,"abstract":"<div><h3>Objective</h3><div>Sudden Sensorineural Hearing Loss (SSNHL) is routinely encountered in otolaryngology clinics. The prognosis of SSNHL varies dramatically and depends on multiple influence factors. This study aimed to develop an explainable Machine Learning (ML) model with easily accessible features to predict the prognosis of SSNHL.</div></div><div><h3>Methods</h3><div>This bi-center retrospective study included 534 patients with SSNHL. We randomly split the data into training and validation sets. Univariate analysis and Least Absolute Shrinkage and Selection Operator (LASSO) regression were employed to select predominant features, including demographic, disease-specific characteristics, and laboratory items. We evaluated the performance of five ML models constructed with six crucial variables using the Area Under the receiver operating characteristic Curve (AUC), accuracy, specificity, sensitivity, and F1 scores. These models were further calibrated by calibration curve and Brier score. Clinical utility was evaluated by Decision Curve Analysis (DCA). The Shapley Additive Explanations (SHAP) method was applied to interpret feature contribution and explain the ML models.</div></div><div><h3>Results</h3><div>The Random Forest (RF) model reached the highest AUC of 0.998. Its accuracy, sensitivity, specificity, and F1 score were 0.981, 0.963, 0.989, and 0.967, respectively. DCA curve analysis revealed a comparable net benefit of the models. The SHAP method revealed that the primary features were degree of hearing loss, audiogram type, age, Mean Corpuscular Volume (MCV), onset to treatment, and serum Albumin (ALB) accordingly.</div></div><div><h3>Conclusions</h3><div>The explainable ML model was superb in predicting hearing outcome and providing information on feature contributions. Clinicians can better understand the contributors to hearing recovery and guide aural rehabilitation using the SHAP method.</div></div><div><h3>Level of evidence</h3><div>Level 3.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101730"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brazilian Academy of Paediatric Otorhinolaryngology Task Force – lingual frenulum disorders in childhood – evidence-based recommendations","authors":"Juliana Alves de Sousa Caixeta ,&nbsp;Debora Bressan Pazinatto ,&nbsp;Rita Carolina Pozzer Krumenauer Padoin ,&nbsp;José Faibes Lubianca Neto ,&nbsp;Melissa Ameloti Gomes Avelino ,&nbsp;Vitor Guo Chen ,&nbsp;Trissia Maria Farah Vazzoler ,&nbsp;Leticia Teixeira Castellano ,&nbsp;Sulene Pirana ,&nbsp;Carolina Sponchiado Miura ,&nbsp;Edio Júnior Cavallaro Magalhães ,&nbsp;Rodrigo Guimarães Pereira","doi":"10.1016/j.bjorl.2026.101762","DOIUrl":"10.1016/j.bjorl.2026.101762","url":null,"abstract":"<div><h3>Objective</h3><div>To provide evidence-based recommendations for the diagnosis, assessment of functional impact, and management of altered lingual frenulum in children.</div></div><div><h3>Methods</h3><div>Task force members were educated on knowledge synthesis methods, including electronic database search, review and selection of relevant citations, and critical appraisal of selected studies. Articles written in English or Portuguese on ankyloglossia, or lingual frenotomy were eligible for inclusion. The American College of Physicians’ guideline grading system was used for critical appraisal of evidence and recommendations for therapeutic interventions.</div></div><div><h3>Results</h3><div>There are several methods described in the literature for the evaluation of the lingual frenulum, and most of them lack internal or external validation. There are no data supporting a relationship between altered lingual frenulum and dysphagia, orofacial alterations, malocclusion, social limitations, obstructive sleep apnoea, or gastroesophageal reflux. According to the studies, an altered lingual frenulum does not cause speech delay; however, some studies with very low levels of evidence show that an altered lingual frenulum may make the pronunciation of some phonemes more difficult. In children with an altered lingual frenulum, lingual frenotomy may reduce maternal pain during breastfeeding. Therefore, in children with an altered lingual frenulum, lingual frenotomy may be a good therapeutic option when there is a complaint of pain during breastfeeding. There are several surgical techniques described in the literature for the release of the lingual frenulum, as well as different instruments that can be used for this purpose. There is no scientific evidence that one method is superior to another.</div></div><div><h3>Conclusion</h3><div>Lingual frenectomy may improve maternal pain during breastfeeding and may be an option in selected cases of phonetic alterations.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101762"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative proteomics analysis to identify biomarkers of refractory benign paroxysmal positional vertigo","authors":"Liang Xia ,&nbsp;Kexin Song ,&nbsp;Lili Xiao ,&nbsp;Yi Chen ,&nbsp;Hui Li ,&nbsp;Yanmei Feng","doi":"10.1016/j.bjorl.2026.101771","DOIUrl":"10.1016/j.bjorl.2026.101771","url":null,"abstract":"<div><h3>Objective</h3><div>Benign Paroxysmal Positional Vertigo (BPPV) is transient vertigo and paroxysmal nystagmus induced by changes in head position. This study was conducted to investigate the differential expression of serum proteins in patients with refractory BPPV and to screen for diagnostic biomarkers.</div></div><div><h3>Methods</h3><div>Serum samples were collected from patients with BPPV; tandem mass tag-based quantitative proteomics technology was used to detect and quantify the serum proteins of 30 individuals with refractory BPPV and 30 control volunteers. Bioinformatics analysis of differentially expressed proteins was performed using hierarchical clustering, gene ontology annotation, Kyoto Encyclopedia of Genes and Genomes analysis, and protein-protein interaction network analysis.</div></div><div><h3>Results</h3><div>A total of 769 proteins were identified, and 57 differentially expressed proteins were screened between the two groups; 15 proteins were upregulated, whereas 42 were downregulated. Five differentially expressed proteins were chosen for parallel reaction monitoring analysis to confirm the results. Apolipoprotein A-I, apolipoprotein A-II, apolipoprotein C-III, fibrinogen gamma chain, and fructose-bisphosphate aldolase B were the five potential candidate biomarker proteins.</div></div><div><h3>Conclusions</h3><div>This is the first quantitative proteomic study to reveal diagnostic biomarkers in patients with BPPV using tandem mass tag labeling technology. The identified differential proteins may improve the understanding of the pathogenesis and molecular mechanism of BPPV.</div></div><div><h3>Level of evidence</h3><div>Level 4.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101771"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}