Brazilian Journal of Otorhinolaryngology最新文献

{"title":"Hidden in plain sight: why diagnosing asymptomatic congenital cytomegalovirus (cCMV) changes everything","authors":"Vagner Antonio Rodrigues Silva, Nicolau Moreira Abrahão, Arthur Menino Castilho","doi":"10.1016/j.bjorl.2025.101728","DOIUrl":"10.1016/j.bjorl.2025.101728","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101728"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative proteomics analysis to identify biomarkers of refractory benign paroxysmal positional vertigo","authors":"Liang Xia ,&nbsp;Kexin Song ,&nbsp;Lili Xiao ,&nbsp;Yi Chen ,&nbsp;Hui Li ,&nbsp;Yanmei Feng","doi":"10.1016/j.bjorl.2026.101771","DOIUrl":"10.1016/j.bjorl.2026.101771","url":null,"abstract":"<div><h3>Objective</h3><div>Benign Paroxysmal Positional Vertigo (BPPV) is transient vertigo and paroxysmal nystagmus induced by changes in head position. This study was conducted to investigate the differential expression of serum proteins in patients with refractory BPPV and to screen for diagnostic biomarkers.</div></div><div><h3>Methods</h3><div>Serum samples were collected from patients with BPPV; tandem mass tag-based quantitative proteomics technology was used to detect and quantify the serum proteins of 30 individuals with refractory BPPV and 30 control volunteers. Bioinformatics analysis of differentially expressed proteins was performed using hierarchical clustering, gene ontology annotation, Kyoto Encyclopedia of Genes and Genomes analysis, and protein-protein interaction network analysis.</div></div><div><h3>Results</h3><div>A total of 769 proteins were identified, and 57 differentially expressed proteins were screened between the two groups; 15 proteins were upregulated, whereas 42 were downregulated. Five differentially expressed proteins were chosen for parallel reaction monitoring analysis to confirm the results. Apolipoprotein A-I, apolipoprotein A-II, apolipoprotein C-III, fibrinogen gamma chain, and fructose-bisphosphate aldolase B were the five potential candidate biomarker proteins.</div></div><div><h3>Conclusions</h3><div>This is the first quantitative proteomic study to reveal diagnostic biomarkers in patients with BPPV using tandem mass tag labeling technology. The identified differential proteins may improve the understanding of the pathogenesis and molecular mechanism of BPPV.</div></div><div><h3>Level of evidence</h3><div>Level 4.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101771"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Causal analysis of the impact of serum 25-hydroxyvitamin D levels on laryngeal cancer","authors":"Hinpetch Daungsupawong ,&nbsp;Viroj Wiwanitkit","doi":"10.1016/j.bjorl.2026.101759","DOIUrl":"10.1016/j.bjorl.2026.101759","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101759"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to teach otologic surgery to the next generation?","authors":"Amanda Sampaio Almeida,&nbsp;José Ricardo Gurgel Testa","doi":"10.1016/j.bjorl.2025.101749","DOIUrl":"10.1016/j.bjorl.2025.101749","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101749"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-199a-5p inhibits malignant progression and enhances cisplatin sensitivity of nasopharyngeal carcinoma by targeting SLC1A5","authors":"Anchi Sun ,&nbsp;Rongrong Lv ,&nbsp;Zhiwei Xing ,&nbsp;Yifan He ,&nbsp;Xiaomin Wang ,&nbsp;Hui Li ,&nbsp;Qianqian Shao","doi":"10.1016/j.bjorl.2025.101739","DOIUrl":"10.1016/j.bjorl.2025.101739","url":null,"abstract":"<div><h3>Objective</h3><div>The prevalence of Nasopharyngeal Carcinoma (NPC) is increasing, and the mortality of patients with cisplatin resistance is high. In this study, we aimed to elucidate several potential mechanisms of miR-199a-5p in regulating the progression and cisplatin resistance of NPC.</div></div><div><h3>Methods</h3><div>Relevant datasets were downloaded from the Gene Expression Omnibus (GEO) database to verify miR-199a-5p expression in NPC. The miR-199a-5p level was evaluated by RT-qPCR, and the prognostic significance was analyzed by K–M curve. Cell proliferation, migration, invasion and apoptosis were detected in vitro. The contents of Epithelial-Mesenchymal Transition (EMT) protein, apoptosis protein and SLC1A5 protein were detected by Western immunoblotting. DLR assay elucidated that miR-199a-5p targets SLC1A5. The effect of miR-199a-5p on subcutaneous tumor in nude mice was detected in vivo.</div></div><div><h3>Results</h3><div>We found that miR-199a-5p was differentially expressed in nasopharyngeal carcinoma, and patients with high expression showed good prognosis. It was also found to be associated with cisplatin resistance and showed low expression in HNE1/DDP cells. The up-regulation of miR-199a-5p can inhibit the proliferation, migration and invasion of NPC cells, and enhance cell apoptosis. The mechanism may be achieved by targeting SLC1A5.</div></div><div><h3>Conclusion</h3><div>The high expression of miR-199a-5p can inhibit SLC1A5 and thus the progression of NPC. At the same time, the high expression of miR-199a-5p can increase the sensitivity of NPC to cisplatin.</div></div><div><h3>Level of evidence</h3><div>Level 5.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101739"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of triglyceride and cholesterol with vestibular vertigo: Evidence from univariable and multivariable mendelian randomization and mediation analysis","authors":"Ying Mu ,&nbsp;Yacheng Lu ,&nbsp;Wei Fu","doi":"10.1016/j.bjorl.2025.101747","DOIUrl":"10.1016/j.bjorl.2025.101747","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to use Mendelian Randomization (MR) method to explore the potential causal association of triglyceride and cholesterol on the risk of vestibular vertigo and potential mediating factors.</div></div><div><h3>Methods</h3><div>We extracted genetic variants associated with triglyceride and cholesterol from the genome-wide association study. Univariable two-sample MR were performed to evaluate the effects of triglyceride and cholesterol on the vestibular vertigo. Besides, Multivariate MR (MVMR) was used to estimate direct effects of triglyceride and cholesterol on the vestibular vertigo after adjusting for potential mediating factors. We also performed that a two-step mediation MR framework to elucidate potential mediators and to estimate the proportion of the association mediated.</div></div><div><h3>Results</h3><div>Genetically predicted triglyceride and cholesterol were positively associated with the risk of vestibular vertigo. In the MVMR analysis, causal associations between triglyceride and cholesterol with vestibular vertigo remained stable and robust after adjusting for body mass index, hypertension, and type 2 diabetes, whereas the association between triglyceride and cholesterol and the risk of vestibular vertigo became nonsignificant after adjusting for vitamin D. In the mediation analysis, we found that the causal effect of cholesterol on vestibular vertigo might partly mediated by vitamin D.</div></div><div><h3>Conclusion</h3><div>The present study provides robust evidence that genetically predicted triglyceride and cholesterol are independently causally associated with the risk of vestibular vertigo. Vitamin D also was found to mediate the causal pathways between cholesterol and vestibular vertigo.</div></div><div><h3>Level of evidence</h3><div>Level III.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101747"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Chinese herbal medicine in allergic rhinitis: a meta‐analysis","authors":"Huazhen Zhu ,&nbsp;Yongyu Wang ,&nbsp;Haoen Zhang ,&nbsp;Qi Kang ,&nbsp;Lei Xu ,&nbsp;Ji Chen ,&nbsp;Chen Chen ,&nbsp;Jianqing Tao","doi":"10.1016/j.bjorl.2026.101769","DOIUrl":"10.1016/j.bjorl.2026.101769","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the clinical efficacy of Chinese Herbal Medicine (CHM) in treating Allergic Rhinitis (AR) through meta‐analysis.</div></div><div><h3>Methods</h3><div>A meta‐analysis was conducted using a random effects model to explore the impact of CHM on response rates, nasal symptom scores, quality of life, blood Immunoglobulin E (IgE) levels, and adverse reactions.</div></div><div><h3>Results</h3><div>A total of 1,326 articles were retrieved, of which 12 studies were included. The meta‐analysis showed that the response rate in the experimental group was higher than in the control group (p &lt; 0.001). The adverse reaction rate was lower in the experimental group compared with the control group (p = 0.003). Subgroup analysis by publication year indicated that studies published in 2024 and 2023 showed lower nasal congestion scores in the experimental group compared with the control group (p &lt; 0.0001); nasal itching scores were lower in the experimental group than in the control group (p &lt; 0.0001). Subgroup analysis by age revealed that the 30+ and 40+ age groups had lower nasal itching scores, sneezing scores and rhinorrhea scores in the experimental group compared with the control group (p &lt; 0.0001). Blood IgE levels were also lower in the experimental group compared with the control group (p = 0.002). Scores for the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) were lower in the experimental group (p &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>The current evidence suggests that CHM can enhance the efficacy of AR treatment, improve patients’ quality of life, and result in a lower rate of adverse reactions.</div></div><div><h3>Level of evidence</h3><div>I.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101769"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Image-guided protocol with a guide-marker for bone conduction hearing implant placement estimation","authors":"Renata Tadeu Ramirez Garcia ,&nbsp;Antonio Carlos dos Santos ,&nbsp;Fabiana Danieli-Hyppolito ,&nbsp;Miguel Angelo Hyppolito","doi":"10.1016/j.bjorl.2025.101748","DOIUrl":"10.1016/j.bjorl.2025.101748","url":null,"abstract":"<div><h3>Objective</h3><div>To propose a protocol for image-guided implant placement estimation, combining 3D reconstruction of preoperative Computed Tomography (CT) images and a guide-marker, for individuals undergoing percutaneous Bone Conduction Hearing Devices (BCHD).</div></div><div><h3>Methods</h3><div>Fifty-one subjects aged 6- to 75-years undergoing percutaneous BCHD surgery were included. Three optional implant points were estimated and marked using a guide-marker, and compared with preoperative CT images to define optimal placement. A peer validation was conducted by two independent reviewers to assess the replicability of the protocol in clinical practice.</div></div><div><h3>Results</h3><div>Bilateral CT images were obtained from all 51 subjects, and a total of 54 BCHD surgeries were performed. Relevant findings, including mastoid cells (19.6%), cranial suture lines (27.5%), perforating vessels (13.7%), bone surface irregularities (1.9%), venous lakes (9.8%), and fixation plates (3.9%) were identified in 52.9% of subjects, and they affected the implant placement in 37.3% of cases. There was moderate agreement between the reviewers regarding implant placement in both right and left ears, and in relation to the actual implant placement performed during the surgical procedure.</div></div><div><h3>Conclusion</h3><div>The image-guided implant placement estimation, combining 3D reconstruction of preoperative Computed Tomography (CT) images and a guide-marker, has proven reliable and effective for estimating optimal implant placement in subjects undergoing percutaneous BCHD surgery, thereby constituting a valuable tool for clinical practice.</div></div><div><h3>Level of evidence</h3><div>2.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101748"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram for predicting cognitive impairment in middle-aged and elderly individuals with self-reported hearing loss: Insights from the longitudinal CHARLS cohort","authors":"Cheng Li ,&nbsp;Yan Mei ,&nbsp;Wei Li ,&nbsp;Dan Liu","doi":"10.1016/j.bjorl.2025.101751","DOIUrl":"10.1016/j.bjorl.2025.101751","url":null,"abstract":"<div><h3>Objective</h3><div>To develop and evaluate a predictive model for cognitive impairment, assessed by a brief cognitive test, among middle-aged and older adults with self-reported hearing loss, aiming to facilitate early identification and targeted intervention in high-risk populations.</div></div><div><h3>Methods</h3><div>This study utilized data from the 2011–2018 waves of the China Health and Retirement Longitudinal Study, including 1,093 individuals aged 45 and above with self-reported hearing impairment but normal cognition at baseline. The average follow-up duration was 5.2-years. Cognitive impairment was defined as a total cognitive score at least one standard deviation below the mean for the corresponding age group. Univariate and multivariate Cox proportional hazards models were used to identify independent predictors, and a nomogram was constructed based on significant variables. Model performance was assessed using calibration curves, time-dependent Concordance indices (C-index), and the Area Under the receiver operating Characteristic Curve (AUC). Risk stratification analysis was conducted across various sociodemographic subgroups.</div></div><div><h3>Results</h3><div>During follow-up, 152 individuals (13.9%) developed cognitive impairment. Higher education level, urban residence, and participation in leisure social activities (e.g., playing mahjong) were independently associated with lower risk of cognitive impairment. The nomogram demonstrated good discriminative performance, with AUCs of 0.728, 0.762, and 0.768, and corresponding time-dependent C-indices of 0.719, 0.761, and 0.767 at 3-, 5-, and 6-year follow-up points, respectively. Calibration plots indicated good agreement between predicted and observed risks. Risk scores varied significantly across subgroups defined by sex, age, education level, and residential location. Kaplan–Meier analyses confirmed the model’s effective risk stratification capability.</div></div><div><h3>Conclusion</h3><div>This study presents the first predictive model tailored to cognitive risk heterogeneity among older adults with self-reported hearing loss. By incorporating a brief cognitive test, the nomogram demonstrated reliable performance and holds potential for use in risk stratification, population screening, and personalized preventive interventions.</div></div><div><h3>Level of evidence</h3><div>2 ‒ Prospective cohort study based on the longitudinal CHARLS data.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101751"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous intraparotid and intratemporal facial nerve schwannoma: resection of the lesion and nerve reconstruction with cross-face technique ‒ Case report","authors":"José Fernando Polanski ,&nbsp;Anelyse Pulner Agulham ,&nbsp;Beatriz Alvarez Mattar ,&nbsp;Anne Karoline Groth ,&nbsp;Marja Cristiane Reksidler","doi":"10.1016/j.bjorl.2026.101761","DOIUrl":"10.1016/j.bjorl.2026.101761","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101761"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}