Brazilian Journal of Otorhinolaryngology最新文献

{"title":"Functional and esthetic outcomes of redundante rhinoplasty for internal nasal valve dysfunction in Asian patients","authors":"Hahn Jin Jung ,&nbsp;Min Woo Park ,&nbsp;Woo Sub Shim ,&nbsp;Jee Hye Wee","doi":"10.1016/j.bjorl.2024.101430","DOIUrl":"https://doi.org/10.1016/j.bjorl.2024.101430","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to use validated measures to evaluate the functional and esthetic outcomes in patients who underwent functional rhinoplasty for Internal Nasal Valve Dysfunction (INVD) in Korea.</p></div><div><h3>Methods</h3><p>A retrospective review of consecutive patients who underwent functional rhinoplasty for INVD confirmed by endoscopic findings and the modified Cottle test between 2016 and 2018 was performed. Nasal obstruction was assessed with the Visual Analog Scale (VAS) and nasal obstruction symptom evaluation (NOSE) scale. Acoustic rhinometry was performed pre- and post-operatively. The Minimal Cross-Sectional Area (MCA) of the nose was measured. Objective assessment of the esthetic outcomes was performed with the Objective Rhinoplasty Outcome Score (OROS), which assesses tip rotation, projection, width, dorsal height, width, length, symmetry, and the overall result.</p></div><div><h3>Results</h3><p>Fifty-seven patients (46 men and 11 women; mean age, 30.5 ± 12.3 years) who underwent functional rhinoplasty were included in this study. The VAS and NOSE scores indicated functional improvement in all cases (all <em>p</em> &lt; 0.001). There were no significant between-group differences (VAS score, <em>p</em> = 0.274; NOSE score, <em>p</em> = 0.952). The objective functional outcomes evaluated using MCA on the concave (<em>p</em> = 0.478) and convex (<em>p</em> = 0.631) sides did not differ significantly pre- and post-operatively. The subjective evaluation of esthetic satisfaction revealed no between-group difference. Moreover, 31 out of 44 patients (70.5%) with static INVD and nine out of 14 patients (64.3%) with dynamic or combined INVD showed excellent outcomes. Regarding objective esthetic outcomes, scores for the eight factors were &gt;3, and there was no significant difference between the two groups (all <em>p</em> &gt; 0.05).</p></div><div><h3>Conclusions</h3><p>Functional rhinoplasty, including extracorporeal septoplasty and spreader grafting, may be a viable option for correcting INVD with functional and esthetic improvement. Dynamic INVD is less prevalent among Asians, and there was no significant difference in the surgical outcomes compared with those of static INVD.</p></div><div><h3>Level of Evidence</h3><p>Level 4.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 4","pages":"Article 101430"},"PeriodicalIF":2.2,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000454/pdfft?md5=0448f4ff0512a90bf4d4a7e3cd96c5e8&pid=1-s2.0-S1808869424000454-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140542352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic thyroidectomy via chest-collarbone approach versus conventional open thyroidectomy: a retrospective comparative study","authors":"Yuming Lou,&nbsp;Lutong Liu,&nbsp;Miaomiao Jin,&nbsp;Bifei Fu,&nbsp;Chaoyang Xu,&nbsp;Xiaofeng Lu","doi":"10.1016/j.bjorl.2024.101429","DOIUrl":"https://doi.org/10.1016/j.bjorl.2024.101429","url":null,"abstract":"<div><h3>Objective(s)</h3><p>Endoscopic thyroidectomy, such as axillary, areola and transoral approaches, offer the advantage of a good cosmetic outcome, but it requires a wider dissection field compared to open thyroidectomy. Recently, chest-collarbone approach thyroidectomy has been widely developed in China because of its shorter anatomical route compared to other endoscopic approaches. This study retrospectively evaluated endoscopic thyroidectomy via chest-collarbone approach in patients with thyroid nodules to determine its feasibility.</p></div><div><h3>Methods</h3><p>A total of 46 patients with thyroid disease who underwent endoscopic thyroidectomy between January 2022 and December 2022 were enrolled in the study and randomly matched to patients with thyroid disease who underwent open thyroidectomy at the same time based on nodule size and pathology. Postoperative bleeding, hoarseness situation, hospital stay, postoperative drainage volume, laryngeal nerve palsy, hypoparathyroidism and wound infection were assessed in both groups.</p></div><div><h3>Results</h3><p>Forty-four patients underwent endoscopic thyroidectomy successfully and two patients changed to open thyroidectomy. The amount of postoperative drainage for the endoscopic thyroidectomy group was 102.78 ± 28.04 mL, and which was 71.91 ± 19.20 for open thyroidectomy group (<em>p</em> &lt; 0.001). The postoperative hospital stay for the endoscopic thyroidectomy group was 8.78 ± 2.57 days, and which was 7.22 ± 1.13 for open thyroidectomy group (<em>p</em> &lt; 0.001). There was no significant difference in postoperative bleeding, hoarseness situation, and wound infection between the two groups. Laryngeal nerve palsy, supraclavicular nerve injury and hypoparathyroidism were not observed in any patient during this study.</p></div><div><h3>Conclusion</h3><p>Chest-collarbone endoscopic thyroid surgery is acceptable. This treatment improves in a good cosmetic outcome in patients with thyroid disease. To assess patients with preoperative nodule size and nature of the case is the impact of the success rate, which is particularly important.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 4","pages":"Article 101429"},"PeriodicalIF":2.2,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000442/pdfft?md5=d38911fd27cad8331dd9bdf9c6edff2f&pid=1-s2.0-S1808869424000442-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140557885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic cervical thymic cyst with thyroglossal duct cyst","authors":"Weiyao Chen ,&nbsp;Juxing Sun ,&nbsp;Yanqiu Zhou ,&nbsp;Mengyin Li ,&nbsp;Shaohua Wang ,&nbsp;Xinxin Yang ,&nbsp;Xiaoyu Li","doi":"10.1016/j.bjorl.2024.101431","DOIUrl":"https://doi.org/10.1016/j.bjorl.2024.101431","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 4","pages":"Article 101431"},"PeriodicalIF":2.2,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000466/pdfft?md5=03148e7256bf55e06b789cb8e1bae51f&pid=1-s2.0-S1808869424000466-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140543528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Degree of swallowing impairment in the elderly: clinical and instrumental assessment","authors":"Tatiane Totta Salgado ,&nbsp;Cris Magna dos Santos Oliveira ,&nbsp;Marina Gatti ,&nbsp;Roberta Gonçalves da Silva ,&nbsp;Heitor Marques Honório ,&nbsp;Giédre Berretin-Felix","doi":"10.1016/j.bjorl.2024.101426","DOIUrl":"10.1016/j.bjorl.2024.101426","url":null,"abstract":"<div><h3>Objective</h3><p>To classifying the degree of swallowing impairment in the elderly, comparing clinical and instrumental assessment.</p></div><div><h3>Methods</h3><p>This is a cross-sectional study with quantitative and qualitative analysis of clinical and instrumental assessment of 37 elderly, aged 60–82 years, of both genders without neurological, oncological or systemic diseases, participated in this study. All participants were submitted to clinical evaluation and their results compared through fiberoptic endoscopic evaluation of swallowing considering liquid, pudding and solid food consistencies. Data were analyzed descriptively and statistically using the analysis of variance test (two-way ANOVA) and Tukey's <em>post hoc</em> test (<em>p</em> &lt;  0.05).</p></div><div><h3>Results</h3><p>In the clinical evaluation there was a higher occurrence of moderate swallowing impairment, followed by functional swallowing, while in fiberoptic endoscopic evaluation of swallowing the severity of the impairment was greater for moderate and mild degrees. There was no statistical difference between the clinical and instrumental evaluation methods. However, there was a significant interaction between the variables, with a difference for liquid consistency in the instrumental evaluation method.</p></div><div><h3>Conclusion</h3><p>Healthy elderly have different degree of swallowing impairment according to food consistency. The clinical assessment using a scale that considers the physiological changes of the elderly, presented results similar to those found in the instrumental examination.</p></div><div><h3>Level of Evidence</h3><p>2.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 4","pages":"Article 101426"},"PeriodicalIF":2.2,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000417/pdfft?md5=cc62e4c1a8f90d37859ce30ac541f4b2&pid=1-s2.0-S1808869424000417-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical experience of an adhesive bone conduction hearing system in children with congenital single-sided deafness","authors":"Yujie Liu ,&nbsp;Wenxi Qiu ,&nbsp;Lin Yang ,&nbsp;Yuan Wang ,&nbsp;Jikai Zhu ,&nbsp;Mengshuang Lv ,&nbsp;Shouqin Zhao","doi":"10.1016/j.bjorl.2024.101427","DOIUrl":"10.1016/j.bjorl.2024.101427","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aimed to investigate the effects of an adhesive bone conduction device (aBCD) in children with congenital single-sided deafness (SSD). Specifically, we examined whether the aBCD elicits improvement in the speech perception ability of children with congenital SSD and whether using this device would adversely affect the horizontal localisation abilities of these children.</p></div><div><h3>Methods</h3><p>Thirteen school-aged children with SSD and seven children with Normal Hearing (NH) were included in this study. Speech perception in noise was measured using the Mandarin Speech Test Materials and sound localisation performance was evaluated using broadband noise stimuli (0.5–20 kHz), randomly played from seven loudspeakers at different stimulus levels (65-, 70-, and 75-dB SPL).</p></div><div><h3>Results</h3><p>All children with SSD showed inferior speech perception and sound localisation performance compared with children with NH. The aBCD use remarkably improved the speech perception abilities of these children under quiet and noise conditions; however, their sound localisation abilities neither improved nor deteriorated.</p></div><div><h3>Conclusion</h3><p>This study reveals the effectiveness and safety of a non-surgical aBCD in paediatric patients with SSD. Our results provide a theoretical basis for early hearing intervention with an aBCD in children with congenital SSD who are temporarily unable to undergo ear surgery.</p></div><div><h3>Level of evidence</h3><p>Level 3.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 4","pages":"Article 101427"},"PeriodicalIF":2.2,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000429/pdfft?md5=53517e890f42109c749d3db0e6309068&pid=1-s2.0-S1808869424000429-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140398825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative complications in cochlear implant surgery and their possible risk factors","authors":"Vanessa Ribeiro Orlando ,&nbsp;Oswaldo Laércio Mendonça Cruz","doi":"10.1016/j.bjorl.2024.101428","DOIUrl":"10.1016/j.bjorl.2024.101428","url":null,"abstract":"<div><h3>Objective</h3><p>This is a retrospective analysis of the major and minor complications of cochlear implants, as well as the Risk Factors (RF) involved.</p></div><div><h3>Methods</h3><p>We analyzed the medical records of patients submitted to cochlear implants at public University from 2006 to July 2019, and list here the major and minor complications found, and their risk factors.</p></div><div><h3>Results</h3><p>There were 193 ears, 100 (51.3%) from females and 93 (48.2%) from males, with a mean age of 23.63 years. In 54 of them (28%), there were alterations seen in the Temporal Bone CT scan, and 44 (22.8%) in the brain MRI. There were 158 (81.9%) insertions performed; 127 (65.8%) of them through the round window. There were 78 complications: 19 (9.8%) major and 56 (29%) minor complications. Among the major complications, there were 3 (1.6%) Surgical Site infections (SS); 5 (2.6%) hematomas/seromas; 5 (2.6%) electrode extrusion; 5 (2.6%) device faults; 1 (0.5%) wrong path. Among the minor complications, there were 6 (3.1%) Acute Otitis Media (AOM); 9 (4.7%) SS infections; 4 (2.1%) facial paresis; 17 (8.8%) vertigos; 9 (4.7%) with tinnitus. The most important RF was age. Patients younger than 2.5 years had more major complications: SS infection (<em>p</em> = 0.018) and electrode extrusion (<em>p</em> = 0.017). There was a higher rate of vertigo in adults (<em>p</em> = 0.003), and it was more often associated with comorbidities (<em>p</em> = 0.008). The insertion route, the presence of changes in CT and MRI and the CI brand used did not impact the number of complications.</p></div><div><h3>Conclusion</h3><p>Among the minor complications, those involving the vestibular system were the most common, especially in adults with comorbidities. Regarding major complications, there was an emphasis on SS infections, hematomas, seromas, electrode extrusion, especially in children under two years of age. There were implanted device faults (2.6%), with none of the brands evaluated standing out.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 4","pages":"Article 101428"},"PeriodicalIF":2.2,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000430/pdfft?md5=6d46d624c937e8dae924abf3cbec6d91&pid=1-s2.0-S1808869424000430-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochlear implantation outcomes in children with multiple disabilities: a topic that’s worth revisiting","authors":"Goh Bee-See ,&nbsp;Nur Af’Idah Mohd Zulkefli ,&nbsp;Asma Abdullah ,&nbsp;Cila Umat ,&nbsp;Norazlin Kamal Nor ,&nbsp;Juriza Ismail ,&nbsp;Stephen J. O’Leary","doi":"10.1016/j.bjorl.2024.101423","DOIUrl":"10.1016/j.bjorl.2024.101423","url":null,"abstract":"<div><h3>Objectives</h3><p>To determine the benefits of cochlear implantation in hearing loss children with multiple disabilities (MD) in terms of auditory outcomes, speech performance, and their quality of life.</p></div><div><h3>Methods</h3><p>This was a cross sectional study from January 2019 to December 2020 in which thirty-one children with hearing loss and multiple disabilities were evaluated. Their improvement in auditory and speech performances were assessed using Categories of Auditory Performance version II (CAP-II) and the Speech Intelligibility Rating (SIR) scales. The assessment was done at 6-month intervals, with the baseline evaluation done at least six months after activation of the implant. Parents were asked to fill the Parents Evaluation of Aural/Oral Performance of Children (PEACH) diary and Perceived Benefit Questionnaire (PBQ) to evaluate the child’s quality of life.</p></div><div><h3>Results</h3><p>All 31 children have Global Developmental Delay (GDD), with 11 having an additional disability. Both mean CAP-II and SIR scores showed significant improvement with increased hearing age (<em>p</em> &lt; 0.05) after 6-month intervals. In addition, 20 out of 31 children (64.5%) have achieved verbal communication after implantation. The mean PEACH score in quiet was significantly better than in noise (<em>p</em> = 0.007) and improved with the increased of hearing age. The majority of parents (96%‒100%) perceived a cochlear implant as beneficial to their child in terms of auditory response, awareness, interaction, communication, and speech development.</p></div><div><h3>Conclusions</h3><p>Cochlear implantation had shown benefits in children with multiple disabilities. Outcome measures should not only focus on auditory and speech performances but the improvement in quality of life. Hence, individualized each case with realistic expectation from families must be emphasized in this group of children.</p></div><div><h3>Level of evidence</h3><p>Level 3.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 4","pages":"Article 101423"},"PeriodicalIF":2.2,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000387/pdfft?md5=9642ab6014f77aa4832831f554f41096&pid=1-s2.0-S1808869424000387-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140277540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internal jugular vein thrombosis caused by invasive pharyngeal cancer: a case report and literature review","authors":"Filip Tudor ,&nbsp;Andro Košec ,&nbsp;Alan Pegan","doi":"10.1016/j.bjorl.2024.101425","DOIUrl":"10.1016/j.bjorl.2024.101425","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 4","pages":"Article 101425"},"PeriodicalIF":2.2,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000405/pdfft?md5=01cc5e9cd31c11131799246c293265d6&pid=1-s2.0-S1808869424000405-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140281163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic rhinosinusitis possibly associated with decreased lung function in chronic cough patients","authors":"Pengfei Zhao ,&nbsp;Shin Kariya ,&nbsp;Takaya Higaki ,&nbsp;Seiichiro Makihara ,&nbsp;Toru Rikimaru ,&nbsp;Mitsuhiro Okano ,&nbsp;Mizuo Ando","doi":"10.1016/j.bjorl.2024.101424","DOIUrl":"10.1016/j.bjorl.2024.101424","url":null,"abstract":"<div><h3>Objectives</h3><p>The purpose of this study is to investigate the lung function in Chronic Rhinosinusitis (CRS) patients with Chronic Cough (CC).</p></div><div><h3>Methods</h3><p>A total of 1413 CC patients were retrospectively screened and 109 CRS patients with CC were enrolled. Lung function, Lund-Mackay Computed Tomography (CT) score, smoking status, peripheral blood eosinophil count, and immunoglobulin E concentration in serum samples, and Sino-Nasal Outcome Test were examined. Normal control subjects are also recruited.</p></div><div><h3>Results</h3><p>The Forced Expiratory Volume in 1 second (FEV_1.0), Percent Predicted FEV_1.0, and FEV_1.0/Forced Vital Capacity (FVC) ratio in the patients were significantly low as compared with the control subjects. The FEV_1.0/FVC ratio was negatively correlated with the Lund-Mackay CT scores of the patients with a high CT score.</p></div><div><h3>Conclusions</h3><p>The CRS patients with CC should be investigated with lung function. In addition, the multidisciplinary evaluation including a pulmonologist is needed to manage the CRS patients with CC.</p></div><div><h3>Level of evidence</h3><p>Level 4.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 4","pages":"Article 101424"},"PeriodicalIF":2.2,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000399/pdfft?md5=3d0be4a5955f4c8b6dadc16514180564&pid=1-s2.0-S1808869424000399-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive analysis of the immune implication of EPHX4 gene in laryngeal squamous cell carcinoma","authors":"Nimei Shen ,&nbsp;Gang Gao ,&nbsp;Xinhong Lu,&nbsp;Jiaxin Jin,&nbsp;Liwei Lin,&nbsp;Maohua Qian,&nbsp;Yang Qin","doi":"10.1016/j.bjorl.2024.101411","DOIUrl":"10.1016/j.bjorl.2024.101411","url":null,"abstract":"<div><h3>Objectives</h3><p>The role of Epoxide Hydrolase-4 (EPHX4), a member of epoxide hydrolase family, has not been investigated in cancer. The purpose of this article is to explore the application value of EPHX4 in laryngeal cancer and its relationship with immune infiltration.</p></div><div><h3>Methods</h3><p>We observed that EPHX4 expression and its survival assays in laryngeal cancer specimens based on The Cancer Genome Atlas (TCGA) cohorts. We also analyzed the correlation between immune cell infiltration levels and EPHX4 gene copy number in laryngeal cancer. Finally, we conducted in vitro assay to evaluate the functions of EPHX4 in laryngeal cancer cell line.</p></div><div><h3>Results</h3><p>EPHX4 is highly expressed in laryngeal cancer specimens and has a poor prognosis. EPHX4 related immune cell analysis showed that it participated in NK Natural killer cell mediated cytotoxicity. Finally, Cell experiments indicate that EPHX4 could promote laryngeal cancer cell line proliferation, colony formation and invasion.</p></div><div><h3>Conclusions</h3><p>Our research results suggest that EPHX4 may be a potential immunotherapy target for laryngeal cancer. The nominated immune signature is a helpful and promising prognostic indicator in laryngeal cancer.</p></div><div><h3>Levels of Evidence</h3><p>Level 3.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 4","pages":"Article 101411"},"PeriodicalIF":2.2,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000260/pdfft?md5=f5082510a8df9f5ecbd2384820688771&pid=1-s2.0-S1808869424000260-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140270382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}