Cancer Control最新文献

{"title":"A Cross-Sectional Analysis of 2017-2022 National Immunization Survey: Sociodemographic Disparities Associated With Human Papillomavirus Vaccine Initiation and Completion Series Among US Adolescents.","authors":"Atinuke Ibrahim-Ojoawo, Nicolette Powe, Richard Rogers, Ken Learman, Heather Hefner","doi":"10.1177/10732748241293674","DOIUrl":"10.1177/10732748241293674","url":null,"abstract":"<p><strong>Objective: </strong>The introduction of the Human Papillomavirus (HPV) vaccine has led to future decline in prevalence of HPV-causing cancers; however, disparities in early HPV vaccine uptake and coverage may contribute to persistent inequalities in HPV-related cancers in the United States. We assess the current trend of sociodemographic factors significantly associated with the initiation and Up To Date (UTD) HPV vaccine series among adolescents in the U.S.</p><p><strong>Methods: </strong>The retrospective National Immunization Survey-Teen data were analyzed for a cohort of adolescents aged 13-17 years who initiated HPV vaccine and completed the series from 2017 to 2022. A multivariable logistic regression estimated the correlation of sociodemographic variables to determine the odds of HPV vaccine initiation and completion as the outcomes.</p><p><strong>Results: </strong>There were 3.2% and 5% surge in HPV vaccine initiation and UTD, respectively, with teens' mean age of 14.98 over the years. The unvaccinated dropped by 5.6%, and those not UTD declined by 4.6% in the HPV vaccine series during this period. The proportion of teens who initiated and completed the vaccine series were mostly older female teens, non-Hispanics, regularly insured with private coverage, raised by educated older mothers, above poverty status, and living in the South. The adjusted multivariable logistic regression shows the odds of initiating and completing increases over the years, and older teens are more likely to initiate the HPV vaccine and complete the vaccine series. However, boys with non-Medicaid coverage/uninsured in the South have lower odds to initiate and complete the vaccine.</p><p><strong>Conclusion: </strong>Improved HPV vaccine uptake and UTD were found in older females, insured with Medicaid, and from highly educated mothers in the Northeast. Findings underscore the importance of effective strategies to address current HPV vaccination disparities among identified teens with lower uptake and UTD that may reduce future burden of HPV-related cancers in the U.S.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Advances in Mitochondrial Research in Cancer.","authors":"Zhiru Li, Wu Zhang, Shaowei Guo, Guoyan Qi, Jiandi Huang, Jin Gao, Jing Zhao, Lin Kang, Qingxia Li","doi":"10.1177/10732748241299072","DOIUrl":"10.1177/10732748241299072","url":null,"abstract":"<p><strong>Background: </strong>Abnormalities in mitochondrial structure or function are closely related to the development of malignant tumors. Mitochondrial metabolic reprogramming provides precursor substances and energy for the vital activities of tumor cells, so that cancer cells can rapidly adapt to the unfavorable environment of hypoxia and nutrient deficiency. Mitochondria can enable tumor cells to gain the ability to proliferate, escape immune responses, and develop drug resistance by altering constitutive junctions, oxidative phosphorylation, oxidative stress, and mitochondrial subcellular relocalization. This greatly reduces the rate of effective clinical control of tumors.</p><p><strong>Purpose: </strong>Explore the major role of mitochondria in cancer, as well as targeted mitochondrial therapies and mitochondria-associated markers.</p><p><strong>Conclusions: </strong>This review provides a comprehensive analysis of the various aspects of mitochondrial aberrations and addresses drugs that target mitochondrial therapy, providing a basis for clinical mitochondria-targeted anti-tumor therapy.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Patient-Centered Communication on Patient Engagement, Health-Related Quality of Life, Service Quality Perception and Patient Satisfaction in Patients with Cancer: A Cross-Sectional Study in Türkiye.","authors":"Cuma Çakmak, Özgür Uğurluoğlu","doi":"10.1177/10732748241236327","DOIUrl":"10.1177/10732748241236327","url":null,"abstract":"<p><strong>Introduction: </strong>Patient-centered communication is a type of communication that takes place between the provider and the patient.</p><p><strong>Objectives: </strong>It is aimed to reveal the effects of patient-centered communication on patient engagement, health-related quality of life, perception of service quality and patient satisfaction.</p><p><strong>Method: </strong>The study was conducted by applying multiple regression analysis to the data obtained from 312 patients with cancer treated in a training and research hospital affiliated to the Ministry of Health in Diyarbakır, Türkiye.</p><p><strong>Results: </strong>More than half of the patients were female and had stage 4 cancer. Different types of cancer were detected (breast cancer, cancer of the digestive organs, lymphatic and hematopoietic cancer, cancer of the genital organs, cancer of the respiratory organs, etc.). It can be stated that the average values obtained by patients from patient-centered communication and its sub-dimensions are high. There are positive, moderate and low and significant relationships between the overall patient-centered communication and patient engagement, patient satisfaction, service quality perception and quality of life. It was statistically revealed that patient-centered communication positively affected patient engagement, health-related quality of life, service quality perception, and patient satisfaction<b>.</b></p><p><strong>Conclusion: </strong>Patient-centered communication positively affects various short and medium-term health outcomes and this study offers suggestions for improving patient-provider communication.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10901059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139974158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Analysis of the Efficacy of Oral Dexamethasone in Combination With Docetaxel Plus Ramucirumab Therapy for Previously Treated Lung Cancer.","authors":"Kosuke Hamai, Ryo Katsura, Shinya Miyake, Suguru Fujita, Shinpei Tada, Tetsu Hirakawa, Sayaka Ueno, Takuya Tanimoto, Nobuhisa Ishikawa","doi":"10.1177/10732748241274615","DOIUrl":"10.1177/10732748241274615","url":null,"abstract":"<p><strong>Introduction: </strong>Docetaxel plus ramucirumab (DTX + RAM) therapy is a standard treatment for previously treated lung cancer, but many adverse events have been reported. This retrospective study was conducted to examine if the side effects of DTX + RAM therapy can be minimized by the combined use of oral dexamethasone (DEX), and to assess the therapeutic effect of DTX + RAM in patients with recurrent lung cancer.</p><p><strong>Methods: </strong>Forty patients with relapsed non-small cell lung cancer who underwent DTX + RAM therapy were divided into two groups based on the concomitant use of oral DEX, and the therapeutic effects and toxicities in the two groups were compared.</p><p><strong>Results: </strong>The objective response rate (ORR) was significantly better in the DEX group (<i>P</i> = 0.0203). The median progression-free survival (PFS) was 5.20 months vs 2.87 months (<i>P</i> = 0.064) in the DEX and non-DEX groups, respectively. However, the median overall survival (OS) was significantly better in the DEX group (15.17 months vs 7.37 months, <i>P</i> = 0.0317). The frequency of fluid retention within six months of the start of treatment was 10.0% vs 42.5% in the DEX and non-DEX groups, respectively, with the fluid retention rate being significantly higher in the non-DEX group (<i>P</i> = 0.039).<b>Conclusion:</b> Concomitant use of oral DEX during DTX + RAM therapy may facilitate the long-term continuation of treatment and contribute to OS prolongation.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Rehabilitation Exercises Effectively Improve Chronic Cough After Surgery for Non-small Cell Lung Cancer.","authors":"Nanzhi Luo, Fuqiang Dai, Xintian Wang, Binbin Hu, Lin Zhang, Kejia Zhao","doi":"10.1177/10732748241255824","DOIUrl":"10.1177/10732748241255824","url":null,"abstract":"<p><strong>Introduction: </strong>Cough is a major complication after lung cancer surgery, potentially impacting lung function and quality of life. However, effective treatments for managing long-term persistent postoperative cough remain elusive. In this study, we investigated the potential of a pulmonary rehabilitation training program to effectively address this issue.</p><p><strong>Methods: </strong>Between January 2019 and December 2022, a retrospective review was conducted on patients with non-small cell lung cancer (NSCLC) who underwent lobectomy and lymph node dissection via video-assisted thoracoscopic surgery (VATS) at Daping hospital. Based on their postoperative rehabilitation methods, the patients were categorized into 2 groups: the traditional rehabilitation group and the pulmonary rehabilitation group. All patients underwent assessment using the Leicester cough questionnaire (LCQ) on the third postoperative day. Additionally, at the 6-month follow-up, patients' LCQ scores and lung function were re-evaluated to assess the long-term effects of the pulmonary rehabilitation training programs.</p><p><strong>Results: </strong>Among the 276 patients meeting the inclusion criteria, 195 (70.7%) were in the traditional rehabilitation group, while 81 (29.3%) participated in the pulmonary rehabilitation group. The pulmonary rehabilitation group showed a significantly lower incidence of cough on the third postoperative day (16.0% vs 29.7%, <i>P</i> = .018) and higher LCQ scores in the somatic dimension (5.09 ± .81 vs 4.15 ± 1.22, <i>P</i> = .007) as well as in the total score (16.44 ± 2.86 vs 15.11 ± 2.51, <i>P</i> = .018, whereas there were no significant differences in psychiatric and sociological dimensions. At the 6-month follow-up, the pulmonary rehabilitation group continued to have a lower cough incidence (3.7% vs 12.8%, <i>P</i> = .022) and higher LCQ scores across all dimensions: somatic (6.19 ± .11 vs 5.75 ± 1.20, <i>P</i> = .035), mental (6.37 ± 1.19 vs 5.85 ± 1.22, <i>P</i> = .002), sociological (6.76 ± 1.22 vs 5.62 ± 1.08, <i>P</i> < .001), and total (18.22 ± 2.37 vs 16.21 ± 2.53, <i>P</i> < .001). Additionally, lung function parameters including FVC, FVC%, FEV1, FEV1%, MVV, MVV%, DLCO SB, and DLCO% were all significantly higher in the pulmonary rehabilitation group compared to the traditional group.</p><p><strong>Conclusion: </strong>Pulmonary rehabilitation exercises significantly reduced the incidence of postoperative cough and improved cough-related quality of life in patients undergoing lobectomy, with sustained benefits observed at the 6-month follow-up. Additionally, these exercises demonstrated superior lung function outcomes compared to traditional rehabilitation methods.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>KRAS</i>, <i>NRAS</i> and <i>BRAF</i> Mutational Profile of Colorectal Cancer in a Series of Moroccan Patients.","authors":"Sara El Zaitouni, Abdelilah Laraqui, Meriem Ghaouti, Asmae Benzekri, Fouad Kettani, Tahar Bajjou, Yassine Sekhsokh, Soukaina Benmokhtar, Meryem Jafari, Walid Baba, Mohamed Oukabli, Hicham El Annaz, Rachid Abi, Mohamed Rida Tagajdid, Safae El Kochri, Idriss Amine Lahlou, Rabii Ameziane El Hassani, Khalid Ennibi","doi":"10.1177/10732748241262179","DOIUrl":"10.1177/10732748241262179","url":null,"abstract":"<p><strong>Objectives: </strong>The present study aimed to evaluate the frequencies of <i>KRAS</i>, <i>NRAS,</i> and <i>BRAF</i> mutations and their possible associations with clinicopathological features in 249 Moroccan patients with colorectal cancer (CRC).</p><p><strong>Methods: </strong>A retrospective investigation of a cohort of formalin-fixed paraffin-embedded tissues of 249 patients with CRC was screened for <i>KRAS</i>/<i>NRAS</i>/<i>BRAF</i> mutations using Idylla™ technology and pyrosequencing.</p><p><strong>Results: </strong><i>KRAS</i>, <i>NRAS,</i> and <i>BRAF</i> mutations were revealed in 46.6% (116/249), 5.6% (14/249), and 2.4% (6/249) of patients. <i>KRAS</i> exon 2 mutations were identified in 87.9% of patients (102/116). <i>KRAS</i> G12D and G12 C were the most frequent, at 32.8% and 12.93%, respectively. Among the patients with <i>KRAS</i> exon 2 wild-type (wt), 27.6% (32/116) harbored additional <i>KRAS</i> mutations. Concurrent <i>KRAS</i> mutations were identified in 9.5% (11/116); including six in codon 146 (A146P/T/V), three in codon 61 (Q61H/L/R), one in codon 12 (G12 A and Q61H), and one in codon 13 (G13D and Q61 L). Among the <i>NRAS</i> exon 2 wt patients, 64.3% (9/14) harbored additional <i>NRAS</i> mutations. Concurrent <i>NRAS</i> mutations were identified in 28.6% (4/14) of <i>NRAS</i>-mutant patients. Since 3.2% wt <i>KRAS</i> were identified with <i>NRAS</i> mutations, concomitant <i>KRAS</i> and <i>NRAS</i> mutations were identified in 2.4% (6/249) of patients. <i>KRAS</i> mutations were higher in the >50-year-old age-group (<i>P</i> = .031), and the tumor location was revealed to be significantly associated with <i>KRAS</i> mutations (<i>P</i> = .028) predominantly in left colon (27.5%) and colon (42.2%) locations. <i>NRAS</i> mutations were most prevalent in the left colon (42.8%) and in well-differentiated tumors (64.2%).</p><p><strong>Conclusion: </strong>Detection of <i>KRAS</i> mutations, particularly the G12 C subtype, may be significant for patients with CRC and has possible therapeutic implications. However, rare <i>KRAS</i> concomitant mutations in CRC patients suggest that each individual may present distinct therapeutic responses. <i>KRAS</i> testing alongside the identification of other affected genes in the same patient will make the treatments even more personalized by contributing more accurately to the clinical decision process. Overall, early diagnosis using novel molecular techniques may improve the management of CRC by providing the most efficient therapies for Moroccan patients.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome Dysbiosis, Dietary Intake and Lifestyle-Associated Factors Involve in Epigenetic Modulations in Colorectal Cancer: A Narrative Review.","authors":"Genevieve Kwao-Zigah, Antionette Bediako-Bowan, Pius Agyenim Boateng, Gloria Kezia Aryee, Stacy Magdalene Abbang, Gabriel Atampugbire, Osbourne Quaye, Emmanuel A Tagoe","doi":"10.1177/10732748241263650","DOIUrl":"10.1177/10732748241263650","url":null,"abstract":"<p><p><b>Background:</b> Colorectal cancer is the second cause of cancer mortality and the third most commonly diagnosed cancer worldwide. Current data available implicate epigenetic modulations in colorectal cancer development. The health of the large bowel is impacted by gut microbiome dysbiosis, which may lead to colon and rectum cancers. The release of microbial metabolites and toxins by these microbiotas has been shown to activate epigenetic processes leading to colorectal cancer development. Increased consumption of a 'Westernized diet' and certain lifestyle factors such as excessive consumption of alcohol have been associated with colorectal cancer.<b>Purpose:</b> In this review, we seek to examine current knowledge on the involvement of gut microbiota, dietary factors, and alcohol consumption in colorectal cancer development through epigenetic modulations.<b>Methods:</b> A review of several published articles focusing on the mechanism of how changes in the gut microbiome, diet, and excessive alcohol consumption contribute to colorectal cancer development and the potential of using these factors as biomarkers for colorectal cancer diagnosis.<b>Conclusions:</b> This review presents scientific findings that provide a hopeful future for manipulating gut microbiome, diet, and alcohol consumption in colorectal cancer patients' management and care.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11186396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Impact of Neoadjuvant Chemotherapy in Localized or Locoregionally Advanced Gallbladder Cancer: A Population-Based and Propensity Score Matched SEER Analysis.","authors":"Yi-Chen Xiong, Zi-Yi Yang, Albie Gong, Zi-You Wu, Shi-Lei Liu, Yi-di Zhu, Xiao-Ling Song, Bing-Feng Chu, Xiang-Song Wu, Wei Gong","doi":"10.1177/10732748241271682","DOIUrl":"10.1177/10732748241271682","url":null,"abstract":"<p><strong>Background: </strong>The effect of neoadjuvant chemotherapy (NACT) in gallbladder cancer (GBC) patients remains controversial. The aim of this study was to assess the impact of NACT on overall survival (OS) and cancer specific survival (CSS) in patients with localized or locoregionally advanced GBC, and to explore possible protective predictors for prognosis.</p><p><strong>Methods: </strong>Data for patients with localized or locoregionally advanced GBC (i.e., categories cTx-cT4, cN0-2, and cM0) from 2004 to 2020 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Patients in the NACT and non-NACT groups were propensity score matched (PSM) 1:3, and the Kaplan-Meier method and log-rank test were performed to analyze the impact of NACT on OS and CSS. Univariable and multivariable Cox regression models were applied to identify the possible prognostic factors. Subgroup analysis was conducted to identify patients who would benefit from NACT.</p><p><strong>Results: </strong>Of the 2676 cases included, 78 NACT and 234 non-NACT patients remained after PSM. In localized or locoregionally advanced GBC patients, the median OS of the NACT and non-NACT was 31 and 16 months (log-rank <i>P</i> < 0.01), and the median CSS of NACT and non-NACT was 32 and 17 months (log-rank <i>P</i> < 0.01), respectively. Longer median OS (31 vs 17 months, log-rank <i>P</i> < 0.01) and CSS (32 vs 20 months, log-rank <i>P</i> < 0.01) was associated with NACT compared with surgery alone. Multivariable Cox regression analysis showed that NACT, stage, and surgery type were prognostic factors for OS and CSS in GBC patients. Subgroup analysis revealed that the survival hazard ratios (HRs) of NACT vs non-NACT for localized or locoregionally advanced GBC patients were significant in most subgroups.</p><p><strong>Conclusions: </strong>NACT may provide therapeutic benefits for localized or locoregionally advanced GBC patients, especially for those with advanced stage, node-positive, poorly differentiated or undifferentiated disease. NACT combined with radical surgery was associated with a survival advantage. Therefore, NACT combined with surgery may provide a better treatment option for resectable GBC patients.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11312743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of Prognostic Nomogram for Male Breast Cancer Patients: A Surveillance, Epidemiology and End Results Database Analysis.","authors":"Zhongjing Ma, Mengyao Xu, Jingjiao Zhang, Jia Li, Fengqi Fang","doi":"10.1177/10732748241270628","DOIUrl":"10.1177/10732748241270628","url":null,"abstract":"<p><strong>Background: </strong>Male breast cancer (MBC) represents a rare subtype of breast cancer, with limited prognostic factor studies available. The purpose of this research was to develop a unique nomogram for predicting MBC patient overall survival (OS) and breast cancer-specific survival (BCSS).</p><p><strong>Methods: </strong>From 2010 to 2020, clinical characteristics of male breast cancer patients were obtained from the Surveillance, Epidemiology and End Results (SEER) database. Following univariate and multivariate analyses, nomograms for OS and BCSS were created. Kaplan-Meier plots were further generated to illustrate the relationship between independent risk variables and survival. The nomogram's ability to discriminate was measured by employing the area under a time-dependent receiver operating characteristic curve (AUC) and calibration curves. Additionally, when the nomogram was used to direct clinical practice, we also used decision curve analysis (DCA) to evaluate the clinical usefulness and net clinical benefits.</p><p><strong>Results: </strong>A total of 2143 patients were included in this research. Univariate and multivariate analysis showed that age, grade, surgery, chemotherapy status, brain metastasis status, subtype, marital status, race, and AJCC-T, AJCC-N, and AJCC-M stages were significantly correlated with OS. Lung metastasis, age, marital status, grade, surgery, and AJCC-T, AJCC-N, and AJCC-M stages were significantly correlated with BCSS. By comprising these variables, a predictive nomogram was constructed in the SEER cohort. Then, it could be validated well in the validation cohort by receiver operating characteristics (ROCs) curve and calibration plot. Furthermore, the nomogram demonstrated better decision curve analysis (DCA) results, indicating the ability to forecast survival probability with greater accuracy.</p><p><strong>Conclusion: </strong>We created and validated a unique nomogram that can assist clinicians in identifying MBC patients at high risk and forecasting their OS/BCSS.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11311147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Diagnostic Nomogram Incorporating Prognostic Nutritional Index for Predicting Vaginal Invasion in Stage IB - IIA Cervical Cancer.","authors":"Ning Xie, Jie Lin, Haijuan Yu, Li Liu, Sufang Deng, Linying Liu, Yang Sun","doi":"10.1177/10732748241278479","DOIUrl":"10.1177/10732748241278479","url":null,"abstract":"<p><strong>Introduction: </strong>With the advancements in cancer prevention and diagnosis, the proportion of newly diagnosed early-stage cervical cancers has increased. Adjuvant therapies based on high-risk postoperative histopathological factors significantly increase the morbidity of treatment complications and seriously affect patients' quality of life.</p><p><strong>Objectives: </strong>Our study aimed to establish a diagnostic nomogram for vaginal invasion (VI) among early-stage cervical cancer (CC) that can be used to reduce the occurrence of positive or close vaginal surgical margins.</p><p><strong>Methods: </strong>We assembled the medical data of early-stage CC patients between January 2013 and December 2021 from the Fujian Cancer Hospital. Data on demographics, laboratory tests, MRI features, physical examination (PE), and pathological outcomes were collected. Univariate and multivariate logistic regression analyses were employed to estimate the diagnostic variables for VI in the training set. Finally, the statistically significant factors were used to construct an integrated nomogram.</p><p><strong>Results: </strong>In this retrospective study, 540 CC patients were randomly divided into training and validation cohorts according to a 7:3 ratio. Multivariate logistic analyses showed that age [odds ratio (OR) = 2.41, 95% confidence interval (CI), 1.29-4.50, <i>P</i> = 0.006], prognostic nutritional index (OR = 0.18, 95% CI, 0.04-0.77, <i>P</i> = 0.021), histological type (OR = 0.28, 95% CI, 0.08-0.94, <i>P</i> = 0.039), and VI based on PE (OR = 3.12, 95% CI, 1.52-6.45, <i>P</i> = 0.002) were independent diagnostic factors of VI. The diagnostic nomogram had a robust ability to predict VI in the training [area under the receiver operating characteristic curve (AUC) = 0.76, 95% CI: 0.70-0.82] and validation (AUC = 0.70, 95% CI: 0.58-0.83) cohorts, and the calibration curves, decision curve analysis, and confusion matrix showed good prediction power.</p><p><strong>Conclusion: </strong>Our diagnostic nomograms could help gynaecologists quantify individual preoperative VI risk, thereby optimizing treatment options, and minimizing the incidence of multimodality treatment-related complications and the economic burden.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}