Cancer Control最新文献

{"title":"The Changing Landscape of Second Primary Malignancies in Multiple Myeloma: A SEER Population-Based Study Between Two Therapeutic Eras.","authors":"Weixiang Lu, Xiaoshan Huang, Shengyu Tian, Xiaojie Liang, Guanzhou Ke, Jia Guo, Qingqing Li, Yuquan Huang, Yang Li, Baiwei Luo, Bingyu Lin, Dan Xu, Liang Wang","doi":"10.1177/10732748261432266","DOIUrl":"10.1177/10732748261432266","url":null,"abstract":"<p><p>IntroductionThe introduction of proteasome inhibitors and immunomodulatory agents has significantly improved the prognosis of multiple myeloma (MM). However, the occurrence of second primary malignancies (SPMs) in MM survivors has raised widespread concern.MethodsThis population-based retrospective study using the SEER database analyzed data from 26,869 MM patients (1990-2021) to evaluate changes in SPMs across two therapeutic eras. Patients were stratified into two therapeutic eras based on the year of MM diagnosis: Era-1 (1990-2005; n=12,858) and Era-2 (2006-2021; n=14,011).ResultsAmong 1,346 MM patients who developed SPMs, 670 were in Era-1 and 676 in Era-2. The 15-year cumulative incidence of SPMs was significantly higher in Era-2 (7.7% vs. 4.8%, P < 0.001), an increase driven mainly by solid tumors (6.90% vs. 4.10%, P < 0.001) with no significant change in second hematological malignancies (0.84% vs. 0.67%, P = 0.13). Standardized incidence ratio (SIR) analysis revealed elevated hematological malignancy risk in Era-2 (SIR = 1.71, 95% CI: 1.49-1.96). Median time to SPM was shorter in Era-2 (43.5 vs. 59 months, P < 0.001). Notably, 80% of SPMs in Era-2 occurred within 90 months of MM diagnosis. Overall survival (OS) of SPM patients showed no significant improvement in Era-2 compared to Era-1. Within each diagnostic era, patients who developed SPMs exhibited longer overall survival than those with MM alone; however, this reflects survivor bias, as SPMs can only develop in patients who survive long enough after the initial MM diagnosis. No significant OS differences were observed among SPM patients by race or gender.ConclusionsThe risk of SPMs in MM survivors has significantly increased, and the latency between MM diagnosis and the onset of SPMs was shorter in the Era-2, highlighting the need for enhanced cancer surveillance in MM survivors.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261432266"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12961105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Initiation of Definitive Radiotherapy in Patients With Locally Advanced Head and Neck Cancer.","authors":"Lin-Feng Guo, Li-Mei Lin, Zhen-Zhen Lu, Zhi-Cong Hong, San-Gang Wu","doi":"10.1177/10732748261481970","DOIUrl":"10.1177/10732748261481970","url":null,"abstract":"<p><p>PurposeTo investigate the relationship between time to treatment initiation (TTI) of definitive radiotherapy and survival outcomes in locally advanced head and neck cancers (LAHNC).MethodsWe retrospectively included patients diagnosed between 2005 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database. The multivariate regression analysis, recursive partition analysis, penalized spline function, chi-square test, Kaplan-Meier method, and multivariate Cox proportional-hazards models were used for statistical analyses.ResultsA total of 18657 patients were included. Patients were stratified into 3 groups: no delay (<36 days), at risk of delay (36-61 days), and delay (>61 days). Compared to patients who initiated radiotherapy within 61 days, patients who initiated radiotherapy after 61 days had a higher risk of death in 5-year cancer-specific survival (CSS) (no delay vs. at risk of delay vs. delay: 58.7% vs. 60.5% vs. 50.5%) (P<0.001) and overall survival (OS) (no delay vs. at risk of delay vs. delay: 47.7% vs. 49.5% vs. 39.4%) (P<0.001). Patients in the delay group had worse outcomes in CSS (hazard ratio [HR], 1.209; 95% confidence interval [CI], 1.143-1.278; P<0.001) and OS (HR, 1.199; 95% CI, 1.146-1.256; P<0.001). In patients with oral cavity, oropharyngeal, and laryngeal cancers, the risk of death progressively rose as the treatment was delayed. However, there was no significant difference in the risk among patients with hypopharyngeal cancer.ConclusionsFor patients with LAHNC, delay of definitive radiotherapy leads to inferior survival. Our study highlights that the threshold of 36 and 61 days significantly affects survival and identifies patients experiencing these delays.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261481970"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13498790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148800471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom Management and Quality of Life in Oncology Patients With Inoperable Wounds: Comparison of Two Dressing Approaches.","authors":"Hande Cengiz Açıl, Taner Demirci, Alper Erkin, Cenk Sunu, Ayşe Çelik Yılmaz, Dilek Aygin","doi":"10.1177/10732748261491712","DOIUrl":"https://doi.org/10.1177/10732748261491712","url":null,"abstract":"<p><p>IntroductionMalignant or inoperable wounds are among the most challenging conditions in oncology and palliative care. These wounds are associated with complex symptoms such as infection, necrosis, heavy exudate, malodor, and pain, all of which negatively affect patients' physical, psychosocial, and functional well-being, and significantly reduce quality of life. Despite various wound care approaches in clinical practice, studies focusing on symptom burden and quality of life remain limited. This study aimed to evaluate symptom burden and quality of life in oncology patients with inoperable wounds.MethodsThis prospective comparative study was conducted with patients admitted to the Wound Care Clinic of Sakarya University Training and Research Hospital between December 2023 and June 2024. A total of 33 patients were allocated according to the treatment strategy applied in routine clinical practice. Two patients in the PHMB group died during follow-up, resulting in a final analytic sample of 31 patients (PARAF, n = 16; PHMB, n = 15). The control group received PHMB-containing dressings, while the experimental group was treated with boric acid powder and paraffin-impregnated tulle dressing (PARAF). Data were collected using the Patient Information Form, Wound Care Form, and Edmonton Symptom Assessment Scale. Inflammatory markers (C-reactive protein and erythrocyte sedimentation rate), symptom outcomes (odor, pain), and mortality were assessed at week 1, month 1, and month 3.ResultsNo significant difference was found between groups in terms of wound size. Although changes in inflammatory parameters were observed during follow-up, no statistically significant differences were found between groups regarding wound size, ESAS scores, or overall Wound-QoL-17 scores. An isolated statistically significant difference was observed in one Wound-QoL-17 item at the first-month assessment; however, this finding should be interpreted cautiously given the multiple comparisons. Overall, both dressing approaches demonstrated comparable outcomes in symptom management and quality of life during follow-up. No deaths occurred in the PARAF group, whereas two patients in the PHMB group died during follow-up.ConclusionAlthough no differences in wound size were observed between the two methods, slight improvements in symptoms and quality of life were noted. This suggests that palliative dressing approaches, even if they do not directly accelerate wound healing, can contribute to enhancing patients' daily functioning and overall comfort.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261491712"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Comparison of Abiraterone Acetate Versus Docetaxel in Combination With Androgen Deprivation Therapy for Metastatic Hormone-Sensitive Prostate Cancer: A Retrospective Cohort Study From Vietnam.","authors":"Hang Nguyen, Hoa Nguyen, Hau Xuan Nguyen, Minh Truong, Tri Ngo","doi":"10.1177/10732748261481960","DOIUrl":"10.1177/10732748261481960","url":null,"abstract":"<p><p>IntroductionThe optimal choice between docetaxel and abiraterone in combination with androgen deprivation therapy (ADT) for metastatic hormone-sensitive prostate cancer (mHSPC) remains uncertain due to the lack of direct randomized trials. Real-world data, particularly from developing countries, are limited. This study aimed to compare the effectiveness of docetaxel versus abiraterone in combination with ADT and to identify prognostic factors associated with survival outcomes in a Vietnamese population.MethodsWe conducted a retrospective cohort study of patients with mHSPC treated at Vietnam National Cancer Hospital between January 2021 and December 2025. Eligible patients received first-line ADT combined with either docetaxel or abiraterone acetate. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method and compared using the log-rank test. Cox proportional hazards models were applied to evaluate prognostic factors.ResultsBaseline characteristics were generally comparable. Abiraterone was associated with a higher rate of deep prostate-specific antigen (PSA) response at 6 months (PSA≤0.2 ng/mL: 43.7% vs. 16.7%, p=0.002). After a median follow-up of 28.6 months, the median OS was 41.4 months in the docetaxel group and 44.6 months in the abiraterone group. Median PFS was 23.6 and 29.6 months, respectively, with no statistically significant differences between groups. In multivariable analysis, baseline PSA>100 ng/mL (HR 1.98, p=0.01, 95% CI: 1.15-3.42) and PSA>0.2 ng/mL at 6 months (HR 3.93, p<0.001, 95% CI: 1.82-8.49) were independent predictors of worse PFS. PSA>0.2 ng/mL at 6 months was also associated with inferior OS (HR 2.66, p=0.03, 95% CI: 1.09-6.47).ConclusionIn this real-world Vietnamese cohort, docetaxel and abiraterone combined with ADT provided comparable survival outcomes in mHSPC. Although abiraterone achieved deeper PSA responses, this did not translate into a survival advantage. Baseline PSA and 6-month PSA response were strong prognostic factors, underscoring the clinical value of PSA kinetics in risk stratification and treatment monitoring.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261481960"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13500956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148800380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Communicating Cancer Prevention: Comparative Effects of Four Educational Materials on Prevention Beliefs, Information Overload, and Intentions.","authors":"Mona Illmann, Florian Herbolsheimer, Alexander Haussmann, Karen Steindorf","doi":"10.1177/10732748261493130","DOIUrl":"https://doi.org/10.1177/10732748261493130","url":null,"abstract":"<p><p>IntroductionPublic awareness of modifiable cancer risk factors remains limited, and fatalistic prevention beliefs and cancer information overload may hinder information seeking and engagement in preventive behaviors. Brief communication interventions may help address these barriers, but evidence comparing different communication strategies in cancer prevention remains scarce. This randomized study evaluated the effects of four theory-based intervention materials on cancer prevention beliefs, cancer information overload, and prevention-related intentions.MethodsIn a population-based online study, 1,191 adults from Stuttgart, Germany, were randomly assigned to one of four intervention conditions that varied by presentation modality (audiovisual animation vs. text) and mode (narrative vs. non-narrative) or to a control condition. Interventions were self-developed based on the Protection Motivation Theory, addressing modifiable cancer prevention behaviors, particularly physical activity and healthy diet. Cancer prevention beliefs and cancer information overload were assessed pre- and post-intervention using items from the Health Information National Trends Survey; behavioral intentions were assessed post-intervention. Baseline-adjusted ANCOVAs and robust linear models were used.ResultsAudiovisual and narrative materials showed small advantages over text-based and non-narrative materials for the belief that cancer risk can be reduced (<i>F</i>(1,892)=7.33, <i>p</i>=.007, <i>ηp</i>^<i>2</i>=.007; <i>F</i>(1,892)=6.71, <i>p</i>=.010, <i>ηp</i>²=.005, respectively). Narrative materials were associated with comparatively higher perceived cancer information overload than non-narrative materials (<i>F</i>(1,856)=11.90, <i>p</i><.001, <i>ηp</i>²=.02). Compared with the control condition, all four intervention conditions were associated with stronger behavioral intentions (all <i>p</i> ≤ .009), with no significant differences between the intervention conditions.ConclusionBrief theory-based cancer prevention materials can positively influence prevention-related beliefs, perceived information overload, and behavioral intentions. The findings suggest a trade-off in cancer prevention communication: audiovisual and narrative materials showed advantages in strengthening prevention-related beliefs, whereas non-narrative materials were associated with lower perceived cancer information overload. All intervention conditions were associated with stronger intentions, highlighting the potential of diverse theory-based communication strategies to promote cancer-preventive behaviors.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261493130"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Timing of Specialist Palliative Care and End-Of-Life Healthcare Utilization in Patients With Colorectal Cancer and Related Intestinal Cancers: A Nationwide Register-Based Study.","authors":"Nelli-Sofia Nåhls, Liisa Rautakorpi, Mikko Nuutinen, Tiina Saarto, Timo Carpén","doi":"10.1177/10732748261476336","DOIUrl":"10.1177/10732748261476336","url":null,"abstract":"<p><p>IntroductionPatients with colorectal cancer and other intestinal cancers often experience a high symptom burden and frequently require healthcare services near the end of life (EOL). Early involvement of specialist palliative care (SPC) has been shown to improve quality of life and reduce aggressive EOL care, but data on its timing in this population is limited. This study examined the association between timing of SPC contact and healthcare utilization at the EOL.Patients and MethodsThis nationwide retrospective cohort study included all patients who died from colorectal cancer and other intestinal cancers in Finland in 2019. Data on healthcare use were obtained from national registers. Patients were categorized based on the timing of their first SPC contact into early (>30 days before death) and late or no SPC contact (≤30 days or none). Healthcare utilization in the last month of life was compared between groups, and multivariable logistic regression was used to identify factors associated with acute care.ResultsA total of 1445 patients were included, of whom 339 (23%) received early SPC contact, with a median of 142 days before death. Early SPC contact was associated with fewer emergency department (ED) contacts (43% vs. 54%, p<0.001) and secondary care hospitalizations (21% vs. 49%, p<0.001) and with a lower likelihood of death in hospital (59% vs. 80%, p<0.001). In multivariable analyses, late or no SPC contact was associated with higher odds of ED contacts (odds ratio (OR) 1.613, 95% confidence interval (CI) 1.255-2.074) and hospitalizations (OR 4.029, 95% CI 2.998-5.415).ConclusionsSPC contact occurring more than 30 days before death was associated with lower acute care use and fewer hospital deaths among patients with colorectal cancer and other intestinal cancer. These findings support consideration of earlier integration of SPC in the disease trajectory and warrant further prospective studies evaluating its impact on EOL care and healthcare utilization.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261476336"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global and National Burden of Chronic Obstructive Pulmonary Disease and Tracheal, Bronchus, and Lung Cancer From 1990 to 2021: Comorbidity Burden Analysis Based on the Global Burden of Disease Study 2021.","authors":"Hao Zhou, Zhiheng Dong, Xiaodan Ye","doi":"10.1177/10732748251407363","DOIUrl":"10.1177/10732748251407363","url":null,"abstract":"<p><p>IntroductionQuantifying disease burden plays a critical role in informing prevention strategies and optimizing health resource allocation. While existing studies have separately described the global epidemiological landscapes of chronic obstructive pulmonary disease (COPD) and tracheal, bronchus, and lung cancer (LC), there is a notable absence of comprehensive analysis on the combined burden of LC-COPD. Addressing this gap is essential for improving disease management and policy development.MethodsData on age-standardized incidence, death, prevalence, and disability-adjusted life year (DALY) rates (ASIR, ASDR, ASPR, and ASDALYR per 100 000) from 1990 to 2021, in global, regional, and national/territorial hierarchy, were retrieved from the 2021 Global Burden of Disease Study (GBD 2021). COPD to LC ratios of ASRs (C/L-ASRs) were calculated to describe the relative burden of LC-COPD. With Joinpoint regression, the average annual percentage changes were generated to study epidemiological trends. ASDALYR attributable to four shared risks, were systematically studied.ResultsIn 2021, global ASRs for both COPD and LC declined, yet their combined disease burden remained substantial. Notably, five regions exhibited synchronous increases. Low SDI regions showed severe imbalance-described by a C/L-ASIR of 3.53 in 2021. Age stratification further revealed COPD-dominated mortality in aged ≥ 75 years, particularly among females. Despite a 60.1% global decline since 1990, smoking was still the leading contributor. Household air pollution from solid fuels posed a greater burden than smoking in South Asia and Sub-Saharan Africa. Ambient particulate matter pollution increased LC-related ASDALYRs in almost all regions.ConclusionAlthough the overall burden of LC-COPD is declining, the comorbid population remains large and continues to face healthcare access barriers. This study calls for shifting focus to the shared comorbidity burden, prioritizing the prevention of common risk factors, early identification of comorbidities, and implementing integrated care to optimize resource utilization under constrained conditions.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748251407363"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12957602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Cure: Psychosocial Care and the Quality of Life of Filipino Children With Cancer.","authors":"Rowalt Alibudbud","doi":"10.1177/10732748261438535","DOIUrl":"10.1177/10732748261438535","url":null,"abstract":"","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261438535"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147533963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the Role of Oncology Nursing in Low- and Middle-Income Countries: An Urgent Imperative.","authors":"Linh Thuy Khanh Tran, Phuong Thi Ngoc Nguyen, Winnie Kwok-Wei So, Eric Ngo, PhuongThao D Le","doi":"10.1177/10732748261441921","DOIUrl":"10.1177/10732748261441921","url":null,"abstract":"<p><p>Cancer disproportionately affects low- and middle-income countries (LMICs), where shortages of oncology specialists and limited system capacity constrain the delivery of comprehensive cancer care. This Perspective argues that expanding oncology nursing roles offers a pragmatic and cost-effective strategy to strengthen cancer care in resource-constrained settings. Oncology nurses contribute across advanced clinical practice, care coordination, psychosocial support, health behavior change, and leadership in research and quality improvement. Evidence increasingly supports nurse-led models as effective in improving continuity of care, symptom management, and patient-centered outcomes, particularly in community-based settings. However, the integration of advanced oncology nursing in many LMICs remains fragmented and under-recognized. We call for systematic incorporation of oncology nursing into national cancer control strategies through standardized competency frameworks, structured education pathways, and regulatory support that enable advanced practice oncology nurses. The coordinated implementation of these measures can create a self-reinforcing system in which regulation, education, universal health coverage integration, and research collectively enable equitable, efficient, and continuously improving oncology care-supporting progress toward SDG3 and ensuring that high-quality cancer care becomes a standard rather than a privilege in LMICs.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261441921"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival and Treatment Patterns in Vulvar Paget's Disease: Evidence From SEER.","authors":"Lele Chang, Yaxin Kang, Jing Liu, Cuibo Lin, Qin Xu","doi":"10.1177/10732748261450261","DOIUrl":"10.1177/10732748261450261","url":null,"abstract":"<p><p>IntroductionVulvar Paget's disease (VPD) is a rare condition, and a comprehensive analysis of its clinical and pathological characteristics, treatment approaches, and prognosis has not yet been conducted.MethodsWe conducted a retrospective population-based cohort study using publicly available, de-identified data from the Surveillance, Epidemiology, and End Results (SEER) database. Patients diagnosed with VPD between 2004 and 2021were included. Kaplan-Meier and Cox models assessed impacts on overall and cancer-specific survival. Propensity score matching (PSM) balanced surgical and non-surgical groups.Results1,778 patients with VPD were included. Most patients were women aged ≥50 years (96.5%) and of White race (81.7%). The labium majus was the most commonly specified tumor site (203/1,778, 11.4%), although most cases were recorded as vulva, NOS. A total of 1,374 patients underwent surgical treatment. After PSM, surgery remained associated with improved survival. A generally similar trend was observed across subgroups, although not all subgroup comparisons reached statistical significance.ConclusionBased on the SEER database, this study found that surgery was beneficial for improving the prognosis of VPD patients, especially for those who were elderly.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261450261"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13180072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}