Contact Lens & Anterior Eye最新文献

{"title":"Double Iris, A case report","authors":"Ahmed Shakir Ali Al-Wassiti ,&nbsp;Ali Majeed Rashed ,&nbsp;Mohammed Tareq Mutar","doi":"10.1016/j.clae.2025.102423","DOIUrl":"10.1016/j.clae.2025.102423","url":null,"abstract":"<div><div><span>The formation of the iris involves interactions between the neural ectoderm, neural crest-derived cells, and the </span>mesoderm. This report describes the occurrence of double iris in a patient and describes the clinical profile for him.</div><div>The study presents a case of 31-year-old male with a history of blurred vision in the left eye since childhood. His left eye (OS) was amblyopic with a VA of 6/60.</div><div><span><span>There was hypermetropia in the left eye and intraocular pressure (IOP) was within the normal range. </span>Anterior chamber<span> (AC) showed no signs of inflammation, and the vitreous was clear. The slit lamp examination revealed double iris bilaterally that was confirmed using an </span></span>optical coherence tomography.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 5","pages":"Article 102423"},"PeriodicalIF":3.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient considerations versus actual reasons for contact lens cessation: Insights from a survey-based study","authors":"Antonio Ballesteros-Sánchez,&nbsp;Joan Gispets,&nbsp;Aurora Torrents","doi":"10.1016/j.clae.2025.102421","DOIUrl":"10.1016/j.clae.2025.102421","url":null,"abstract":"<div><h3>Purpose</h3><div>To analyze and compare non-contact lens-related and contact lens-related reasons influencing cessation considerations in current contact lens wearers (CLWs) with the actual reasons for cessation reported by discontinued CLWs.</div></div><div><h3>Methods</h3><div>This was an cross-sectional study with face-to-face survey administered to current and discontinued CLWs by trained optometrists at the General Óptica centers across Spain. The survey included basic demographic information, and explored both non-contact lens-related and contact lens-related reasons that led current CLWs to consider cessation or resulted in cessation among discontinued CLWs.</div></div><div><h3>Results</h3><div>A total of 1266 surveys, including 764 from current CLWs and 502 from discontinued CLWs, were included. Regarding non-contact lens-related reasons for cessation, discontinued CLWs more frequently reported a <em>“Preference for wearing spectacles”</em> (13.1 % vs. 3.8 %, <em>P</em> &lt; 0.05) and <em>“Recommendation by an eye care practitioner”</em> (5.2 % vs. 0.6 %, <em>P</em> &lt; 0.05), while current CLWs more often cited <em>“Refractive surgery”</em> (15.8 % vs. 9.4 %, <em>P</em> &lt; 0.05). For contact lens-related reasons for cessation, discontinued CLWs more frequently reported <em>“Difficulty handling contact lenses”</em> (10.6 % vs. 1.9 %, <em>P</em> = 0.001), whereas current CLWs more commonly cited <em>“Contact lens-related ocular symptoms”</em> (57.6 % vs. 43.8 %, <em>P</em> &lt; 0.05). Agreement between groups was generally low for all reasons analyzed, ranging from −0.115 to 0.103.</div></div><div><h3>Conclusions</h3><div>The reasons for cessation from the perspective of current and discontinued CLWs yield different results. By addressing the reasons considered by current CLWs, while taking into account the reasons most strongly associated with cessation in discontinued CLWs, eye care practitioners could proactively prevent CL cessation.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 5","pages":"Article 102421"},"PeriodicalIF":3.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REPLY TO Effectiveness of orthokeratology and myopia control spectacles in a real-world setting in China","authors":"Bi Yang ,&nbsp;Longqian Liu ,&nbsp;Pauline Cho","doi":"10.1016/j.clae.2025.102420","DOIUrl":"10.1016/j.clae.2025.102420","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 4","pages":"Article 102420"},"PeriodicalIF":4.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing medicinal maggot excretions/secretions for the ocular surface: A mini review","authors":"Ebenezer Owusu,&nbsp;Rachel L. Redfern","doi":"10.1016/j.clae.2025.102422","DOIUrl":"10.1016/j.clae.2025.102422","url":null,"abstract":"<div><div><span>Ophthalmology<span> could significantly benefit from the therapeutic potential of medicinal maggots<span><span><span>, which have been extensively utilized in dermatology for </span>wound healing and infection management. This article reviews the evidence supporting the potential translation of maggot excretions/secretions (ES) for treating </span>ocular surface </span></span></span>wounds and infections. It examines the challenges associated with treating ocular surface wounds and infections, the established role of medicinal maggots in chronic skin wound care, and the composition and biological properties of maggot ES. Furthermore, recent research on the impact of maggot ES on the ocular surface is highlighted, along with future research directions necessary to effectively harness its bioactive components for ocular surface-related treatments.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 5","pages":"Article 102422"},"PeriodicalIF":3.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of definition of meibomian gland dysfunction on the frequency of MGD in dry eye disease from the DREAM© study","authors":"Divya Jagadeesh ,&nbsp;Meng C. Lin ,&nbsp;Fiona Stapleton ,&nbsp;Jocelyn He ,&nbsp;Gui-Shuang Ying ,&nbsp;Penny Asbell","doi":"10.1016/j.clae.2025.102416","DOIUrl":"10.1016/j.clae.2025.102416","url":null,"abstract":"<div><h3>Purpose</h3><div>Meibomian gland dysfunction (MGD) is a common disease, yet there is no standard clinical definition. This study explored the frequency and characteristics of MGD in dry eye disease (DED) using different clinical definitions.</div></div><div><h3>Methods</h3><div>A secondary analysis of data collected from the DREAM© study participants (n = 535) with moderate-to-severe DED was undertaken. Three common MG clinical features; plugging, secretion quality, and MG atrophy grade, either separately or in combination were used to create MGD definitions. The frequency of MGD, defined by the per eye findings, was reported. Demographic characteristics were compared between those with and without MGD.</div></div><div><h3>Results</h3><div>The frequency of MGD in DED varied from 12 % (gland plugging, plus poor secretion quality plus gland atrophy) to 55 % (gland plugging alone) of eyes. Older age was associated with MGD when atrophy-based definitions were used (<em>p</em> &lt; 0.001) but was not associated with MGD definitions using plugging or secretion quality <em>(p</em> &gt; 0.05). After adjustment for age and between-eye correlations, MGD frequency was higher in women for definitions based on lower lid gland atrophy (adjusted <em>p</em> &lt; 0.05). Hispanic or Latino ethnicity was more commonly associated with MGD than other ethnicities (adjusted <em>p</em> &lt; 0.001), for definitions based on plugging and secretion quality.</div></div><div><h3>Conclusion</h3><div>The frequency of MGD in DED varied with MGD definition. The highest frequency occurred where MGD was defined as lower eyelid gland plugging. Gland atrophy increased with age. The variation in disease frequency has implications for clinical diagnosis and determining efficacy assessment in intervention studies.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 5","pages":"Article 102416"},"PeriodicalIF":3.7,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of 265 nm ultraviolet C light in the treatment of multi-drug resistant Pseudomonas aeruginosa keratitis in vitro and in an in vivo murine model","authors":"Lakshminarayanan Gowtham ,&nbsp;Esther Sheba ,&nbsp;Savitri Sharma ,&nbsp;Dilip Kumar Mishra ,&nbsp;Bhupesh Bagga","doi":"10.1016/j.clae.2025.102417","DOIUrl":"10.1016/j.clae.2025.102417","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluated the <em>in vitro</em> and <em>in vivo</em> efficacy of 265 nanometer (nm) ultraviolet C (UVC) light using 1.93 mW/cm² against multi-drug-resistant (MDR) <em>Pseudomonas aeruginosa</em> (<em>P. aeruginosa</em>) keratitis.</div></div><div><h3>Methods</h3><div>The effect of UVC light was studied on two clinical isolates of <em>P. aeruginosa</em>. Isolate 1 was ciprofloxacin-susceptible, and isolate 2 was MDR (but ceftazidime-susceptible). For the <em>in vitro</em> evaluation, <em>P. aeruginosa</em> isolates (100 μl, 1*10⁸ CFU/ml) were spread on Muller-Hinton solid agar surface and exposed to UVC light for 1, 5, 10, 15, and 30 seconds (s). For the <em>in vivo</em> study, the right eyes of C57BL mice were infected with the <em>P. aeruginosa</em> isolates (5 μL, 1*10⁸ CFU/ml) in two sets with isolates 1 and 2, respectively. The first set (n = 24) was randomized into four groups: a) untreated, b) UVC light 15 s exposure twice daily for two days, c) topical ciprofloxacin 0.3 %w/v twice daily for two days, d) topical ciprofloxacin 0.3 %w/v two-hourly for two days. The second set with MDR <em>P. aeruginosa</em> (n = 24) was treated similarly except for group d (which received topical ceftazidime 5 %w/v two hourly for two days). The left eyes were used to evaluate the safety of applied treatments without inducing infection. At 48 hours (hrs), eyes were enucleated and subjected to microbiological and histopathology analysis.</div></div><div><h3>Results</h3><div><em>In vitro</em>, the UVC light exposure resulted in a clear inhibition area for exposures of 15 and 30 s. In the <em>in vivo</em> murine model, UVC light prevented overall clinical severity (p &lt; 0.05) at 24 and 48 hrs by both isolates. Microbiological assessment at 48 hrs showed no growth of organisms in UVC light-treated corneas of either of the sets, similar to an observed treatment with ciprofloxacin (set 1) and ceftazidime (set 2).</div></div><div><h3>Conclusion</h3><div>265 nm UVC light showed an exposure-dependent <em>in vitro</em> bactericidal effect on <em>P. aeruginosa</em>. The <em>in vivo</em> studies showed that UVC light eliminated both strains of <em>P. aeruginosa</em> with an equivalent efficacy.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 4","pages":"Article 102417"},"PeriodicalIF":4.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vision in times of war: Managing keratoconus in children and the role of omega-3 and vitamins in supporting eye health","authors":"V. Tepleshniuk ,&nbsp;Y. Barinov","doi":"10.1016/j.clae.2025.102411","DOIUrl":"10.1016/j.clae.2025.102411","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 4","pages":"Article 102411"},"PeriodicalIF":4.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of toric contact lens correction upon functional near visual performance with digital devices","authors":"Scott A. Read,&nbsp;Stephen J. Vincent,&nbsp;Luisa H. Colorado,&nbsp;Joanne M. Wood,&nbsp;Michael J. Collins","doi":"10.1016/j.clae.2025.102415","DOIUrl":"10.1016/j.clae.2025.102415","url":null,"abstract":"<div><h3>Purpose</h3><div>Although it is well known that astigmatism correction with toric contact lenses improves clinical vision measures, their effects on real-world visual performance using digital devices such as smartphones are less well understood. This study aimed to examine how toric soft contact lenses impact functional near visual performance with a smartphone, in comparison to spherical equivalent contact lenses.</div></div><div><h3>Methods</h3><div>Fifteen healthy young adults (mean age 23.6 ± 2.8 years) with low to moderate astigmatism (−0.50 D to −1.50 D) participated in this prospective, repeated measures randomised crossover trial. Either toric or best sphere soft daily disposable contact lenses (lens material Verofilcon A) were worn during two separate study visits. At each visit, near visual acuity (VA) was assessed, and participants performed a reading task on a smartphone with both high and low contrast text displays. A mobile eye tracker was worn during the reading task to track objective measures of visual fatigue such as palpebral aperture height and near focusing demand.</div></div><div><h3>Results</h3><div>Both high and low contrast near VA were significantly better with the toric correction compared to the best sphere (p = 0.001). While reading on a smartphone, the average reading speed was not significantly different between the sphere and toric lenses (p = 0.18). Significantly fewer errors were made while reading with the toric lens compared to the best sphere lens for the low contrast (p = 0.04), but not for high contrast text (p = 0.4). For measures of palpebral aperture height, and focusing demand, a significant lens by time interaction was found (both p &lt; 0.05), with a significantly greater focusing demand and a narrower palpebral aperture observed towards the end of the reading task with the best sphere lens.</div></div><div><h3>Conclusion</h3><div>Significant visual and functional benefits were found for digital near visual tasks associated with toric contact lens correction.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 5","pages":"Article 102415"},"PeriodicalIF":3.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising the methodology for assessing tear meniscus height using digital imaging","authors":"James S. Wolffsohn ,&nbsp;Moonisah Ayaz ,&nbsp;Stefan Bandlitz ,&nbsp;Franziska von der Höh ,&nbsp;Andreas Ebner ,&nbsp;Jennifer P. Craig","doi":"10.1016/j.clae.2025.102419","DOIUrl":"10.1016/j.clae.2025.102419","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine the optimum method for assessing tear meniscus height using digital imaging.</div></div><div><h3>Method</h3><div>The tear meniscus of 38 participants (mean age 32.5 ± 10.6 years, 45 % male) was video recorded three times, each for a period of five seconds following two natural blinks using the Oculus Keratograph 5M, first with infrared and subsequently with visible (white) light. Still images at 0.5 s intervals from the last blink, up to 5 s, were extracted from the video recording and the lower eyelid tear meniscus height was measured using ImageJ at seven locations; immediately below pupil centre and at 1 mm, 3 mm and 6 mm, nasally and temporally. Dryness symptoms were assessed with the Ocular Surface Disease Index (OSDI) and tear film stability with non-invasive tear breakup time with the Oculus Keratograph 5M.</div></div><div><h3>Results</h3><div>A significant difference in the tear meniscus height was measured with infrared (0.29 ± 0.08 mm) compared to white light (0.27 ± 0.08 mm; p &lt; 0.001). Tear meniscus height increased significantly with repeated measurement (first: 0.27 ± 0.08 mm; second 0.27 ± 0.08; 0.28 ± 0.09; p = 0.005). In each case, following a significant decrease immediately after a blink, the tear meniscus height was stable between 1.0 and 2.5 s and increased thereafter (p &lt; 0.001). A consistent tear meniscus height measurement was achieved by measuring within 1 mm of the pupil midline, but increased more peripherally (p &lt; 0.001). Differences in height, while statistically significant, were not clinically significant except in the peripheral measurements.</div></div><div><h3>Conclusion</h3><div>Tear meniscus height should be measured in a consistent manner, either with infrared or white light. A single measurement from the top of the meniscus to the eyelid margin within 1 mm of the pupil midline, from an image captured 1.0 to 2.5 s after two blinks, is sufficient.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 4","pages":"Article 102419"},"PeriodicalIF":4.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the Elimination of Keratoconus in Our Hands?","authors":"Gabriel Fickett,&nbsp;Shehzad A. Naroo","doi":"10.1016/j.clae.2025.102414","DOIUrl":"10.1016/j.clae.2025.102414","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 3","pages":"Article 102414"},"PeriodicalIF":4.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}