Effect of 0.01% atropine eye drops combined with different optical treatments to control low myopia in Chinese children

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye Pub Date : 2025-02-01 DOI:10.1016/j.clae.2024.102317

Xindan Cao , Ziqi Guo , Zhiyuan Wei , Hongfei Ming , Bing Ma , Yue Zhao , Yue Zhang , Lei Guo , Cheng Peng

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引用次数: 0

Abstract

Purpose

To investigate the efficacy and safety of 0.01% atropine (AT) in combination with different optical treatments for controlling myopia in Chinese children.

Methods

This retrospective study analyzed 341 Chinese children aged 6–11 years with myopia between −0.50 D and −3.0 D between January 2022 and May 2023. The fast-progressing, myopic children received three optical treatments combined with 0.01 % atropine: 75 children with single-vision spectacles and atropine (SV + AT), 162 children with defocus-incorporated multi-segment spectacles and atropine (DIMS + AT), or 104 children with orthokeratology and atropine (OK + AT). The changes in spherical equivalent refraction (SER), axial length (AL), intraocular pressure (IOP), and amplitude of accommodation (AMP) were observed at 6-month and 1-year intervals.

Results

After controlling for baseline variables, at 6 months, the increase in adjusted AL was significantly greater in the SV + AT group than in the DIMS + AT group (difference = 0.13 mm, 95 % CI: 0.07–0.20, P < 0.05) and in the OK + AT group (difference = 0.09 mm, 95 % CI: 0.09–0.17, P < 0.05). A more significant progression in adjusted SER was also observed in the SV + AT group than in the DIMS group (difference = −0.20D, 95 % CI: −0.29 to −0.11, P < 0.05). At 12 months, the greatest increase in adjusted AL was observed in the SV + AT group, with a statistically significant difference of 0.24 mm (95 % CI: 0.19–0.29, P < 0.05) compared with the DIMS group and a difference of 0.19 mm (95 % CI: 0.13–0.25, P < 0.05) compared with the OK + ST group. Similarly, a more significant progression in adjusted SER was observed in the SV + AT group than in the DIMS group (difference = −0.36 D, 95 % CI: −0.48 to −0.24, P < 0.05).

Conclusions

This study suggested that 0.01% atropine combined with DIMS or orthokeratology may be viable for controlling low myopia in fast-progressing, myopic children.

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0.01% 阿托品滴眼液联合不同光学疗法控制中国儿童低度近视的效果。

目的：探讨0.01%阿托品（AT）联合不同光学疗法控制中国儿童近视的有效性和安全性：这项回顾性研究分析了 2022 年 1 月至 2023 年 5 月间 341 名近视度数在-0.50 D 至-3.0 D 之间的 6-11 岁中国儿童。这些近视度数进展较快的儿童接受了三种光学治疗和 0.01 % 阿托品治疗：75 名儿童接受了单光眼镜和阿托品治疗（SV + AT），162 名儿童接受了散焦入射多片式眼镜和阿托品治疗（DIMS + AT），或 104 名儿童接受了角膜矫形术和阿托品治疗（OK + AT）。每隔 6 个月和 1 年观察一次球面等效屈光度（SER）、轴向长度（AL）、眼压（IOP）和调节幅度（AMP）的变化：在控制基线变量后，6 个月时，SV + AT 组调整后轴长的增加明显大于 DIMS + AT 组（差异 = 0.13 mm，95 % CI：0.07-0.20，P < 0.05）和 OK + AT 组（差异 = 0.09 mm，95 % CI：0.09-0.17，P < 0.05）。与 DIMS 组相比，SV + AT 组的调整后 SER 也有更明显的增长（差异 = -0.20D，95 % CI：-0.29 至 -0.11，P <0.05）。在 12 个月时，SV + AT 组的调整后 AL 值增幅最大，差异为 0.24 mm（95 % CI：0.19-0.29，P），具有显著的统计学意义：这项研究表明，0.01% 阿托品与 DIMS 或角膜矫形术结合使用，可有效控制进展迅速的近视儿童的低度近视。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Lens & Anterior Eye OPHTHALMOLOGY-

CiteScore

7.60

自引率

18.80%

发文量

198

审稿时长

55 days

期刊介绍： Contact Lens & Anterior Eye is a research-based journal covering all aspects of contact lens theory and practice, including original articles on invention and innovations, as well as the regular features of: Case Reports; Literary Reviews; Editorials; Instrumentation and Techniques and Dates of Professional Meetings.