Current Opinion in Supportive and Palliative Care最新文献_第2页

Cancer cachexia: exploring parallels with other paraneoplastic syndromes. 癌症恶病质：探索与其他副肿瘤综合征的相似之处。

IF 1.9 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2025-04-24 DOI: 10.1097/SPC.0000000000000762

Michael S Yule, Amy Ireland, Barry J A Laird, Richard J E Skipworth

{"title":"Cancer cachexia: exploring parallels with other paraneoplastic syndromes.","authors":"Michael S Yule, Amy Ireland, Barry J A Laird, Richard J E Skipworth","doi":"10.1097/SPC.0000000000000762","DOIUrl":"https://doi.org/10.1097/SPC.0000000000000762","url":null,"abstract":"Purpose of review: Cancer cachexia (CC) is a paraneoplastic syndrome (PNS) that is characterised by anorexia, weight loss, fatigue and reduced function. This review explores the molecular drivers of CC and other PNS, identifying shared pathways and highlighting unexplored gaps in research.Recent findings: Recent studies have provided further evidence of pro-inflammatory cytokines, such as interleukin-6 and tumour necrosis factor-α, as central players in both CC and PNS, emphasising their role in systemic effects like muscle wasting, lipolysis and pyrexia. Despite these overlaps between syndromes, cytokine profiles vary across different cancer types with one study highlighting that the interplay between multiple cytokines likely plays a more significant role in cancer phenotypes than individual cytokines. Mediators, such as parathyroid hormone related peptide and vascular endothelial growth factor, which are typically associated with malignant hyperkalaemia and hypertrophic osteoarthropathy respectively, have also been linked to cachexia, suggesting a shared role.Summary: This review highlights the overlap between CC and other PNS. Exploring these shared mechanisms can bridge research gaps and improve CC treatment strategies. Similar insights may be gained by examining other conditions which overlap with CC such as eating disorders, bariatric surgery and sepsis.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world implementation of geriatric assessment in cancer care among older adults: the role of implementation science frameworks. 现实世界中老年人癌症护理中老年评估的实施：实施科学框架的作用。

IF 1.9 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2025-03-01 Epub Date: 2025-01-30 DOI: 10.1097/SPC.0000000000000740

Irene Blackberry, Jennifer Boak, Tshepo Rasekaba, Christopher Steer

{"title":"Real-world implementation of geriatric assessment in cancer care among older adults: the role of implementation science frameworks.","authors":"Irene Blackberry, Jennifer Boak, Tshepo Rasekaba, Christopher Steer","doi":"10.1097/SPC.0000000000000740","DOIUrl":"10.1097/SPC.0000000000000740","url":null,"abstract":"Purpose of review: The evidence supporting geriatric assessment (GA) in cancer care is well established, and GA is recommended by the American Society of Clinical Oncology, the International Society of Geriatric Oncology, and other oncology bodies. However, effective implementation of GA remains inadequate. Using selected papers indexed in Medline from the most recent 18 months to July 2024, including two outstanding interest papers, this review aimed to describe enablers and barriers to GA implementation in oncology and contrasts implementation with and without an implementation science framework. Finally, we make recommendations on applying an implementation science framework to facilitate integrating GA in oncology.Recent findings: Implementation science frameworks have been widely employed in health services research, but their use in geriatric oncology, particularly to guide GA implementation and evaluation, is limited. Lack of time in busy practices coupled with workforce shortages adds to the challenges of GA implementation and adoption. A variety of screening and assessment tools such as the G8, electronic rapid fitness assessment, and Eastern Cooperative Oncology Group are often used in lieu of geriatrician review and to streamline GA. When effectively implemented in oncology, GA informs care and treatment decisions for improved outcomes.Summary: Despite the benefits for older adults, embedding GA into routine clinical practice is critical yet not common practice. The variety of available GA tools, logistics, and individual beliefs are some of the identified barriers to GA adoption in oncology. Enablers include organization readiness, adaptability, communication, and the use of multidisciplinary teams. Further research is needed to examine how implementation science frameworks could provide guidance and structure for successful GA implementation in oncology.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":"19 1","pages":"12-18"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Buprenorphine: an old dog with new tricks. 丁丙诺啡：老狗耍新把戏。

IF 1.9 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2025-03-01 Epub Date: 2025-01-30 DOI: 10.1097/SPC.0000000000000743

Ai Deen Ng, Andrew Dickman

引用次数: 0

Social determinants of health and health outcomes in older cancer survivors. 老年癌症幸存者健康和健康结果的社会决定因素。

IF 1.9 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2025-03-01 Epub Date: 2025-01-21 DOI: 10.1097/SPC.0000000000000746

Zachary Siegel, Ashley Smith-Nuñez, Marquita W Lewis

{"title":"Social determinants of health and health outcomes in older cancer survivors.","authors":"Zachary Siegel, Ashley Smith-Nuñez, Marquita W Lewis","doi":"10.1097/SPC.0000000000000746","DOIUrl":"10.1097/SPC.0000000000000746","url":null,"abstract":"Purpose of the review: Today, two-thirds of all cancer survivors are at least 65 years old. Older cancer survivors have complex care needs, and addressing their social determinants of health (SDoH) is critical for improving and managing survivorship outcomes for this uniquely vulnerable population, yet research specifically examining these associations remains limited and emergent. To this end, we describe the emergent body of evidence on the associations between SDoH domains and older cancer survivors' outcomes.Recent findings: Despite the limited investigations of SDoH on the health outcomes of older cancer survivors, there were measures representing all domains of SDoH - health care access and quality, education access and quality, neighborhood and built environment, social and community context, and economic stability. We reviewed another determinant, Digital Environment and Engagement, as they are highly relevant to older cancer survivors' care. Studies primarily investigated outcomes such as the use of or delays in treatment and variables related to care coordination. Generally, poorer access to resources such as income, social networks, and quality health care facilities predicted poorer health outcomes.Summary: We reviewed studies that revealed that SDoH significantly impacts older cancer survivors' health outcomes. Our description informs future interventions and policies to improve their care.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":" ","pages":"19-24"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of precision radiotherapy for the management of cancer-related pain in the abdomen. 精确放疗在治疗癌性腹痛中的应用。

IF 1.9 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2025-03-01 Epub Date: 2024-12-12 DOI: 10.1097/SPC.0000000000000738

Aisling M Glynn, Yaacov R Lawrence, Laura A Dawson, Aisling S Barry

{"title":"The use of precision radiotherapy for the management of cancer-related pain in the abdomen.","authors":"Aisling M Glynn, Yaacov R Lawrence, Laura A Dawson, Aisling S Barry","doi":"10.1097/SPC.0000000000000738","DOIUrl":"10.1097/SPC.0000000000000738","url":null,"abstract":"Purpose of review: Abdominal pain due to cancer is a significant and debilitating symptom for cancer patients, which is commonly undertreated. Radiotherapy (RT) for the management of abdominal cancer pain is underused, with limited awareness of its benefit. This review presents a discussion on current precision RT options for the management of cancer pain in the abdomen.Recent findings: Precision RT focuses on delivering targeted and effective radiation doses while minimizing damage to surrounding healthy tissues. In patients with primary or secondary liver cancer, RT has been shown to significantly improve liver related cancer pain in the majority of patients. Also, symptom sequelae of tumour thrombus may be relieved with the use of palliative RT. Similarly, single dose, high precision stereotactic RT to the celiac plexus has been shown to significantly improve pain in patients with pancreatic cancer. Pain response for adrenal metastases has been less commonly investigated, but small series suggest that stereotactic body RT may reduce or alleviate pain.Summary: RT is an effective option for the treatment of abdominal cancer pain. RT should be considered within the multidisciplinary treatment armamentarium, and may be successfully integrated, alone or in conjunction with other treatment modalities, in abdominal cancer-related pain.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":" ","pages":"51-58"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Palliative radiotherapy for the hemostasis of bleeding tumors: an overview of the most recent literature. 姑息性放疗用于出血肿瘤的止血：最新文献综述。

IF 1.9 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2025-03-01 Epub Date: 2025-01-30 DOI: 10.1097/SPC.0000000000000741

Manuel Guhlich, Pieter Verschuren, Eva Oldenburger

{"title":"Palliative radiotherapy for the hemostasis of bleeding tumors: an overview of the most recent literature.","authors":"Manuel Guhlich, Pieter Verschuren, Eva Oldenburger","doi":"10.1097/SPC.0000000000000741","DOIUrl":"10.1097/SPC.0000000000000741","url":null,"abstract":"Purpose of review: Palliative radiotherapy is frequently applied for various indications, with hemostasis being a quite common one. However, while bleeding can occur at different sites and arise from various primary tumor types, clear guidelines for administering hemostatic radiotherapy are lacking. Additionally, most available data on hemostatic radiotherapy are retrospective, and often studies do not focus on hemostasis specifically. This review provides an overview of the most recent data on hemostatic radiotherapy to identify any research trends and focus areas for this specific topic.Recent findings: This review confirms the value of radiation for tumor bleeding. Unfortunately, research in hemostatic radiotherapy predominantly continues to focus on retrospective analyses of treated patients. However, at least two prospective trials specifically investigating hemostasis have been published recently, both conducted in low-income countries.Summary: Radiotherapy is an effective and well-tolerated treatment for bleeding tumors. As the incidence of advanced cancer rises in low- and middle-income countries, where resources are limited, further research should focus on hypofractionated regimens. Additionally, there is a need for comprehensive descriptions of contouring and treatment planning to optimize outcomes in these settings.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":"19 1","pages":"33-40"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Palliative radiation therapy for locally advanced breast cancer. 局部晚期乳腺癌的姑息放射治疗。

IF 1.9 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2025-03-01 Epub Date: 2024-12-12 DOI: 10.1097/SPC.0000000000000739

Stephen L B Ciocon, Cecília F P M Sousa, Gustavo N Marta, Jennifer Y Y Kwan

{"title":"Palliative radiation therapy for locally advanced breast cancer.","authors":"Stephen L B Ciocon, Cecília F P M Sousa, Gustavo N Marta, Jennifer Y Y Kwan","doi":"10.1097/SPC.0000000000000739","DOIUrl":"10.1097/SPC.0000000000000739","url":null,"abstract":"Purpose of review: Globally, breast cancer is the most commonly diagnosed cancer in women. Locally advanced breast cancers (LABCs) may necessitate palliative radiation therapy (RT) due to the severity of the patients' symptoms, inoperability, or other reasons precluding curative-intent treatment such as poor performance status and patient comorbidities. This review aims to discuss current evidence on palliative RT in LABC.Recent findings: Advanced targeted RT techniques have led to improvements in local control with reduced treatment-related toxicities. Emerging short-course palliative RT prescriptions offer feasible options that avoid delay in systemic therapy. Additionally, recent studies also highlight approaches for integrating palliative RT with systemic therapies.Summary: Palliative RT plays a vital role in managing symptoms and enhancing quality of life for LABC patients. However, there is currently no consensus on the optimal prescriptions for palliative RT in these patients. Standardized reporting of palliative RT studies is needed for robust comparison of efficacy and toxicity between various treatment regimens. Furthermore, future research on the optimal integration of RT with novel systemic agents is needed.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":" ","pages":"41-50"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing care for older adults with cancer: addressing key challenges and emerging insights. 促进老年癌症患者的护理：解决关键挑战和新见解。

IF 1.9 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2025-03-01 Epub Date: 2025-01-30 DOI: 10.1097/SPC.0000000000000748

Schroder Sattar

引用次数: 0

Medication management: supportive care medications in older adults with cancer. 药物管理：老年癌症患者的支持性护理药物。

IF 1.9 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2025-03-01 Epub Date: 2025-01-30 DOI: 10.1097/SPC.0000000000000742

Darren J Walsh, Chloé Herledan

引用次数: 0

Blood-based biomarkers of frailty in older patients with cancer. 老年癌症患者虚弱的血液生物标志物。

IF 1.9 4区医学

Current Opinion in Supportive and Palliative Care Pub Date : 2025-03-01 Epub Date: 2025-01-30 DOI: 10.1097/SPC.0000000000000747

Baran Akagunduz, Yakup Ergün, Dig dem Dog An Akagündüz, Nergis Akbas, Dilara Akagündüz, Aziz Karaog Lu, Pinar Soysal

{"title":"Blood-based biomarkers of frailty in older patients with cancer.","authors":"Baran Akagunduz, Yakup Ergün, Dig dem Dog An Akagündüz, Nergis Akbas, Dilara Akagündüz, Aziz Karaog Lu, Pinar Soysal","doi":"10.1097/SPC.0000000000000747","DOIUrl":"10.1097/SPC.0000000000000747","url":null,"abstract":"Purpose of review: This review aims to evaluate the current evidence on blood-based biomarkers for frailty detection in older cancer patients. It explores the potential of various biomarkers, including inflammatory markers and microRNAs (miRNAs), to serve as indicators of frailty and examines the limitations of existing studies. The review also highlights the need for further research to validate these biomarkers and improve their clinical applicability.Recent findings: Recent studies have examined blood biomarkers associated with frailty in older cancer patients. Findings suggest that elevated granulocyte levels and lower macrophage-derived stem cells and regulatory T cells are linked to frailty. Inflammatory biomarkers such as interleukin-6 and specific miRNAs, as well as higher neutrophil-to-lymphocyte ratios, have also been identified as potential indicators of frailty. While these biomarkers show promise, no single marker has proven sufficient, and combining them may improve frailty detection. Further research is needed to validate their clinical usefulness in this population.Summary: Blood-based biomarkers show potential for detecting frailty in older patients with cancer, but further research is needed, particularly beyond an inflammatory focus and with more robust study designs.","PeriodicalId":48837,"journal":{"name":"Current Opinion in Supportive and Palliative Care","volume":"19 1","pages":"25-32"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0