对抗癌症相关恶病质/组织损耗的有希望的临床前方法

IF 2 4区医学 Q3 HEALTH CARE SCIENCES & SERVICES

Current Opinion in Supportive and Palliative Care Pub Date : 2025-09-01 Epub Date: 2025-07-29 DOI:10.1097/SPC.0000000000000763

Savannah A Epstein, Aneesha Dasgupta, Jason D Doles

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引用次数: 0

摘要

综述的目的：强调有前途的临床前工作，寻求针对癌症相关的组织/肌肉萎缩。最近的发现：这篇叙述性综述探讨了癌症恶病质生物学的最新创新和新兴/未充分研究的方面，突出了三个关键领域的代表性研究：(a)针对已建立的消耗途径的新策略，(b)多模式/组合治疗方法，以及(c)涉及组织间通信的机制。摘要：虽然不是详尽的，但这篇综述强调了临床前研究的三个关键领域，这些领域有可能为未来旨在减轻癌症患者恶病质和组织消耗的临床试验提供信息和启发。

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Promising preclinical approaches to combating cancer-associated cachexia/tissue wasting.

Purpose of review: To highlight promising pre-clinical work seeking to target cancer-associated tissue/muscle wasting.

Recent findings: This narrative review explores recent innovations and emerging/understudied aspects of cancer cachexia biology, highlighting representative studies across three key areas: (a) novel strategies for targeting established wasting pathways, (b) multimodal/combinatorial therapeutic approaches, and (c) mechanisms involving inter-tissue communication.

Summary: Though not exhaustive, this review highlights three key areas of pre-clinical research with the potential to inform and inspire future clinical trials aimed at mitigating cachexia and tissue wasting in cancer patients.

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来源期刊

Current Opinion in Supportive and Palliative Care HEALTH CARE SCIENCES & SERVICES-

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： A reader-friendly resource, Current Opinion in Supportive and Palliative Care provides an up-to-date account of the most important advances in the field of supportive and palliative care. Each issue contains either two or three sections delivering a diverse and comprehensive coverage of all the key issues, including end-of-life management, gastrointestinal systems and respiratory problems. Current Opinion in Supportive and Palliative Care is an indispensable journal for the busy clinician, researcher or student.