Hong Kong Medical Journal最新文献_第6页

Promoting advance care planning in people with early dementia and their family caregivers. 促进早期痴呆患者及其家庭照护者的预先照护规划。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-01

C Y Yeung, H Y L Chan

引用次数: 0

Adrenal insufficiency due to etomidate inhalation via electronic cigarettes: three local cases. 电子烟吸入依托咪酯致肾上腺功能不全3例。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-01 Epub Date: 2025-06-04 DOI: 10.12809/hkmj2412244

Y K Chung, Y T Cheung, C S Y Chan, C C Wong, A C C Fu, Y Y Lam, C Y Lee

引用次数: 0

Effects of nerve sparing on erectile dysfunction and urinary incontinence in robot-assisted radical prostatectomy. 神经保留对机器人辅助根治性前列腺切除术中勃起功能障碍和尿失禁的影响。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-01 Epub Date: 2025-06-10 DOI: 10.12809/hkmj2411709

O W K Tsui, K C H Shing, A P M Lam, S L Ng, S Chun, C F Tsang, T C T Lai, R Na, H L Wong, B S H Ho, A T L Ng

{"title":"Effects of nerve sparing on erectile dysfunction and urinary incontinence in robot-assisted radical prostatectomy.","authors":"O W K Tsui, K C H Shing, A P M Lam, S L Ng, S Chun, C F Tsang, T C T Lai, R Na, H L Wong, B S H Ho, A T L Ng","doi":"10.12809/hkmj2411709","DOIUrl":"10.12809/hkmj2411709","url":null,"abstract":"Introduction: In 2020, there were >1.4 million new prostate cancer cases and >370 000 related deaths reported globally. Robot-assisted radical prostatectomy (RARP) is a surgical method used to eradicate localised prostate cancer. However, erectile dysfunction (ED) and urinary incontinence (UI) are common side-effects. This retrospective cohort study investigated erectile function, urinary continence, and oncological outcomes of nerve sparing (NS) in RARP.Methods: In total, 431 patients who underwent RARP in our institution between January 2018 and April 2023 were recruited; all had attended postoperative follow-up. Regarding ED outcome, patients with a preoperative International Index of Erectile Function-5 (IIEF-5) score of 7 or below 7 were excluded from analysis. Patient demographics, 1-hour pad test results, IIEF-5 questionnaire results, and pathological parameters were analysed.Results: Patients with bilateral NS had a higher mean postoperative IIEF-5 score after 2 months (7.60 vs 3.19 in non-NS patients, P=0.037; 7.60 vs 2.50 in unilateral NS patients, P=0.020) and 3 months (7.40 vs 2.06 in unilateral NS patients; P=0.027). They also had lower mean urine leakage volume in the 1-hour pad test after 1 month (16.40 g vs 49.44 g in non-NS patients, P<0.001; 16.40 g vs 50.82 g in unilateral NS patients, P=0.010) and 2 months (13.60 g vs 35.45 g in non-NS patients; P=0.009). No significant differences were observed in ED or UI between non-NS and unilateral or bilateral NS at 6 and 12 months. There was no correlation between positive surgical margin and NS.Conclusion: Bilateral NS had significant short-term effects on early recovery of erectile function and urinary continence, relative to unilateral NS and non-NS groups, without compromising oncological outcomes.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"218-224"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fragile X syndrome: genetic and clinical profile in the Hong Kong Chinese population. 脆性X染色体综合征：香港华人的遗传和临床特征。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-01 Epub Date: 2025-06-05 DOI: 10.12809/hkmj2411942

C W M Au, H M Luk, S Ho, S W Cheng, S T S Lam, B H Y Chung, S C Chong, I F M Lo

{"title":"Fragile X syndrome: genetic and clinical profile in the Hong Kong Chinese population.","authors":"C W M Au, H M Luk, S Ho, S W Cheng, S T S Lam, B H Y Chung, S C Chong, I F M Lo","doi":"10.12809/hkmj2411942","DOIUrl":"10.12809/hkmj2411942","url":null,"abstract":"Introduction: Fragile X syndrome (FXS) is a common inherited cause of intellectual disability, and FXS testing is recommended as a first-line genetic investigation for global developmental delay or intellectual disability. This retrospective study evaluated the diagnostic yield of FXS testing and clinical features in Chinese patients in Hong Kong.Methods: From 1993 to 2022, 7291 patients referred to the Clinical Genetic Service for neurodevelopmental conditions (eg, developmental delay, autism spectrum disorder, and intellectual disability) underwent FXS testing. In total, 103 individuals from 61 families were confirmed to have an FMR1 full mutation, including 59 index cases and 44 family members. Clinical features of 70 Chinese patients with FXS, including growth, neurobehavioural features, and other co-morbidities, were evaluated.Results: The diagnostic yield of FXS testing was 0.8%. The median age at diagnosis for index cases was 4.1 years, with a trend towards earlier diagnosis in recent years. In 27 families (44.2%), multiple members carried a full mutation. Prenatal diagnosis was arranged in 11% of families. Developmental delay was observed in all males, compared with 45.0% of females. Intellectual disability affected 86.0% of males but only 30.0% of females. Common co-morbidities included obesity, autism spectrum disorder, attention-deficit/hyperactivity disorder, epilepsy, gastrointestinal problems, and sleep disturbances. Features such as strabismus, scoliosis, and mitral valve prolapse were rarely reported.Conclusion: Fragile X syndrome is more than a pure neurodevelopmental disorder. Our findings highlight the importance of early diagnosis and subsequent management, with awareness of relevant surveillance and management guidelines.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"199-207"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barriers and facilitators of implementing post-discharge information summary among healthcare professionals: abridged secondary publication. 在医疗保健专业人员中实施出院后信息汇总的障碍和促进因素：精简的二级出版物。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-01

E L Y Wong, K S Tang, D Dong, P K H Mo, A W L Cheung, E K Yeoh

引用次数: 0

Initiation of statin therapy in patients with diabetes mellitus: a target trial emulation study (abridged secondary publication). 他汀类药物在糖尿病患者中的起始治疗：一项目标试验模拟研究（次要出版物节略）。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-01

E Y F Wan, W Xu, A H Y Mok, W Y Chin, E Y T Yu, C S L Chui, E W Y Chan, I C K Wong, C L K Lam, G Danaei

引用次数: 0

Rethink personalised sudden cardiac death risk assessment in non-dilated left ventricular cardiomyopathy: a case report. 重新考虑非扩张型左室心肌病个体化心源性猝死风险评估：1例报告。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-01 Epub Date: 2025-04-14 DOI: 10.12809/hkmj2412128

K W C Lun, J C Y Lee, E C Y Wong, M K Y Lee, D P H Lee

引用次数: 0

The role of primary care doctors in addressing the health impact of poverty in Hong Kong. 初级保健医生在处理香港贫穷对健康的影响方面的角色。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-01 Epub Date: 2025-06-03 DOI: 10.12809/hkmj2412155

J E Parry, M Vanstone, M Grignon, J R Dunn

引用次数: 0

Rat hepatitis E virus and genotype 4 hepatitis E virus infections among immunocompromised persons and patients with hepatitis in Hong Kong: abridged secondary publication. 大鼠戊型肝炎病毒和基因4型戊型肝炎病毒在香港免疫功能低下者和肝炎患者中的感染：次要出版物节略。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-01

S Sridhar, C C Y Yip, P C Y Woo, K Y Yuen

引用次数: 0

Evaluation of the safety and efficacy of the Sentire Surgical System (C1000) for robot-assisted radical prostatectomy. Sentire Surgical System （C1000）用于机器人辅助根治性前列腺切除术的安全性和有效性评估。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-01 Epub Date: 2025-06-04 DOI: 10.12809/hkmj2412169

C F Ng, C H Yee, P K F Chiu, M H M Tam, F P T Lai

{"title":"Evaluation of the safety and efficacy of the Sentire Surgical System (C1000) for robot-assisted radical prostatectomy.","authors":"C F Ng, C H Yee, P K F Chiu, M H M Tam, F P T Lai","doi":"10.12809/hkmj2412169","DOIUrl":"10.12809/hkmj2412169","url":null,"abstract":"Introduction: This prospective clinical study evaluated the clinical safety and efficacy of the Sentire Surgical System (C1000), a locally developed robotic surgical platform, in performing radical prostatectomy in Hong Kong.Methods: This was a single-centre, single-arm study. Adult patients with a clinical diagnosis of localised prostate cancer planned for surgical treatment were invited to participate. Surgery was performed using the Sentire C1000 system following the standard approach. The primary endpoints were the conversion rate and the incidence of perioperative complications within 30 days. Secondary outcomes, including perioperative, pathological, oncological, and functional outcomes at 1 month after surgery, were also assessed.Results: From August 2022 to September 2023, 20 patients were recruited. All procedures were performed without conversion. There were no intraoperative complications related to the robotic device. Minor surgical complications (Grade I-II according to the Clavien-Dindo Classification) occurred in seven patients and were managed conservatively. The mean total operative time was 184.5 minutes (standard deviation=30.0). The median estimated blood loss was 175.0 mL (interquartile range [IQR]=100.0-275.0). The median length of hospital stay was 3.0 days (IQR=2.0-4.0). Seventeen patients achieved undetectable levels of prostate-specific antigen at 1 month after surgery.Conclusion: These initial results support the Sentire Surgical System (C1000), Hong Kong's first locally developed multidisciplinary robotic surgical platform, as a safe and effective option for radical prostatectomy, with clinical performance and outcomes comparable to existing robotic systems.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"192-198"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0