Hong Kong Medical Journal最新文献

{"title":"Severe amyloid-related imaging abnormalities associated with lecanemab in Hong Kong: a case report.","authors":"S S W Wong, K K Yam, B L H Ng, F H N Chu, E Y L Chu, H K F Mak, P K C Chiu, Y F Shea","doi":"10.12809/hkmj2513587","DOIUrl":"10.12809/hkmj2513587","url":null,"abstract":"","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"249-251"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148158608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative real-world analysis of stereotactic body radiotherapy versus conventional radiotherapy for Chinese patients with low- to intermediate-risk localised prostate cancer.","authors":"B H W Lam, E K H Chan, O L Wong, C F Chan, A C C Chen, L L Chan, D R Johnson, D C M Lam, K C W Wong, J J S Suen, D M C Poon","doi":"10.12809/hkmj2514055","DOIUrl":"10.12809/hkmj2514055","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated the 5-year biochemical progression-free survival (bPFS) rate and late toxicities associated with conventional radiotherapy (CRT) and stereotactic body radiotherapy (SBRT) in Chinese patients with low-to intermediate-risk prostate cancer.</p><p><strong>Methods: </strong>A retrospective analysis was conducted in patients with low- to intermediate-risk prostate cancer who received CRT (76 Gy in 38 fractions) or SBRT (36.25 Gy in 5 fractions) between 2015 and 2019 at a hospital in Hong Kong. The primary endpoint was 5-year bPFS. Post-radiotherapy biochemical recurrence was defined according to the Phoenix criteria. Secondary endpoints included clinician-reported late gastrointestinal (GI) and genitourinary (GU) toxicities, graded according to CTCAE (Common Terminology Criteria for Adverse Events) version 5.0.</p><p><strong>Results: </strong>In total, 130 patients met the inclusion criteria: 99 (76.2%) received CRT and 31 (23.8%) received SBRT. After median follow-up of 65.7 months for CRT and 78.0 months for SBRT, the 5-year bPFS rates were 88.2% (95% confidence interval [95% CI]=76.6%-100%) for SBRT and 90.3% (95% CI=84.0%-97.1%) for CRT (P=0.9). Twenty-two (22.2%) patients in the CRT group and four (12.9%) in the SBRT group experienced grade ≥2 GU toxicities (P=0.258). For grade ≥2 GI toxicities, 29 (29.3%) patients in the CRT group and five (16.1%) in the SBRT group were affected (P=0.146). The incidence of these toxicities peaked between 2 and 3 years after treatment.</p><p><strong>Conclusion: </strong>In this study, CRT and SBRT demonstrated comparable long-term effectiveness for low- to intermediate-risk prostate cancer; SBRT appeared to be associated with a non-significantly lower incidence of late GI and GU toxicities.</p>","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"234-242"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional outcomes following mechanical thrombectomy beyond 6 hours after acute ischaemic stroke.","authors":"C H Ho, K F Cheng, I H W Cheung, M S Chi, O M Y Choi, W W S Ho, G K K Lau, R Lee, W M Lui, Y H Mak, K C Teo, A C O Tsang, C P Tsang, M Y Tse, J T F Zhuang, G K K Leung","doi":"10.12809/hkmj2514653","DOIUrl":"10.12809/hkmj2514653","url":null,"abstract":"<p><strong>Introduction: </strong>Mechanical thrombectomy (MT) within 6 hours is the standard treatment for large vessel occlusion stroke. However, the benefit-to-risk ratio of MT becomes increasingly unfavourable in the extended 6- to 24-hour window; current guidelines recommend cerebral perfusion studies (CPS) for patient selection. Although recent trials of extended-window MT have shown promising results, challenges may arise in real-world implementation where CPS are not readily available. This single-centre retrospective review included patients who underwent extended-window MT with or without prior CPS in Hong Kong.</p><p><strong>Methods: </strong>This study included 480 patients who underwent MT at Queen Mary Hospital between January 2019 and January 2025. Primary outcomes were 3-month modified Rankin Scale, door-to-groin puncture time, recanalisation rate, procedural complications and mortality. Secondary outcomes included differences in 3-month functional status between patients who underwent MT with or without prior CPS.</p><p><strong>Results: </strong>Among the 51 patients who underwent extended-window MT, 37 (72.5%) had anterior circulation stroke. The overall complication rate was 7.8%. Cerebral perfusion studies were performed to guide selection in 15 patients (40.5%) with anterior circulation strokes and were associated with a significantly higher rate of functional independence at 3 months compared with selection based on clinical judgement alone (66.7% vs 27.3%; P=0.018). Use of CPS was also associated with a longer door-to-puncture time (167 vs 89.5 min; P<0.001).</p><p><strong>Conclusion: </strong>Cerebral perfusion studies improve patient selection for extended-window MT. Favourable functional outcomes were achieved in a substantial proportion of patients selected on the basis of clinical criteria alone. The study findings provide evidence supporting clinical service development to facilitate CPS adoption and extended-window MT in Hong Kong.</p>","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"200-207"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148273449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-cultural translation into Chinese and psychometric evaluation of a screening tool for benign prostatic enlargement.","authors":"C F Ng, C K Chan, S K K Yuen, H S W Kwok, I P H Wu, J Wang, F P T Lai, A K L Lo, A Q Liu, P K F Chiu, J Y C Teoh","doi":"10.12809/hkmj2513308","DOIUrl":"10.12809/hkmj2513308","url":null,"abstract":"<p><strong>Introduction: </strong>We conducted a study to linguistically translate and psychometrically validate a translated and culturally adapted Chinese version of the European 3-item benign prostatic hyperplasia (BPH) screening tool (TOOL), then assess its diagnostic accuracy for identifying BPH with a prostate volume above 40 mL.</p><p><strong>Methods: </strong>The study was conducted in two phases. The first phase involved a rigorous translation process performed by skilled multilingual translators using forward and backward translation techniques. The second phase focused on psychometric validation and was conducted in urology units across our hospital network.</p><p><strong>Results: </strong>Sixty-six male patients of Chinese ethnicity, aged 18 to 90 years, who presented with lower urinary tract symptoms for at least 4 weeks were recruited. The study evaluated the TOOL's reliability, internal consistency, and validity, including convergent, concurrent, and criterion validity. Statistical analyses demonstrated strong internal consistency (Cronbach's alpha=0.890) and substantial test-retest reliability (intra-class correlation coefficient=0.715). The screening tool demonstrated moderate to strong correlations with both the International Prostate Symptom Score and prostate volume, supporting its validity. Furthermore, responsiveness analysis showed significant reductions in TOOL scores after surgery. The combination of the screening tool (cut-off: ≥3) and prostate-specific antigen level (cut-off: >2.35 μg/L) exhibited high sensitivity and specificity for detecting prostate volume above 40 mL (sensitivity: 92%, specificity: 73%; area under the receiver operating characteristic curve=0.842).</p><p><strong>Conclusion: </strong>These findings support the reliability and validity of the TOOL as a culturally adapted instrument for evaluating lower urinary tract symptoms in Chinese-speaking populations. Its use may improve the management of BPH.</p>","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"217-224"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148273437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragmatic pacing for ventilator weaning in a patient with cervical spine injury in Hong Kong: a case report.","authors":"E Y K Cham, P K N Lam, K S H Chok, D Y C Chan, D T M Chan","doi":"10.12809/hkmj2513718","DOIUrl":"10.12809/hkmj2513718","url":null,"abstract":"","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"255-257"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholera outbreak in 1932 and a public education pamphlet on the prevention of cholera.","authors":"D C Lung, K K W To","doi":"10.12809/hkmj-hkmms202606","DOIUrl":"https://doi.org/10.12809/hkmj-hkmms202606","url":null,"abstract":"","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":"32 3","pages":"279-280"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148320120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney health for all: caring for people, protecting the planet.","authors":"R Vanholder, D Abdellatif, A C Soares Dos Santos, R Correa-Rotter, N Gopalakrishnan, B Wang, S Roumeliotis, A Balducci, A Haris, M Yadla, L Hsiao","doi":"10.12809/hkmj265192","DOIUrl":"10.12809/hkmj265192","url":null,"abstract":"<p><p>The current kidney care model-focused on late-stage disease and in-centre haemodialysis-is unsustainable because of costs, environmental burden, poor outcomes and reduced quality of life. The 78th World Health Assembly's recognition of kidney disease as a serious health threat presents a critical opportunity to reshape kidney care. Aligned with this, the 2026 World Kidney Day theme, 'Kidney Health for All: Caring for People, Protecting the Planet', calls for systematic change. A sustainable model must prioritise early detection and prevention, reducing the need for kidney replacement therapy. Transplantation and home dialysis benefit people with kidney failure, the environment and society. Dialysis itself must become more eco-friendly without compromising care quality, recognising that planetary perturbations in turn affect kidney health. Conservative care should also be considered, particularly for elderly and frail patients, if the quality-of-life benefits outweigh those offered by dialysis. Achieving this shift requires coordinated action across all stakeholders; education and engagement of the public, policymakers and health professionals to raise awareness about the threat of kidney disease; and an urgent move towards patient-centred care.</p>","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"196.e1-196.e10"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148303625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical aspects of interpreting N-terminal pro-B-type natriuretic peptide levels in diagnosing Kawasaki disease.","authors":"E C T So, A F C Lo, G C F Mok, H S H S Lam, M C Yam, E L W Fung, A M Li","doi":"10.12809/hkmj2513677","DOIUrl":"https://doi.org/10.12809/hkmj2513677","url":null,"abstract":"","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":"32 3","pages":"243-245"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148320069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic volume overload and congestive heart failure during transurethral resection of the prostate treated with high-dose nitroglycerin: a case report.","authors":"H Jia, Q Zheng, Z Wang, Z Dong","doi":"10.12809/hkmj2513455","DOIUrl":"10.12809/hkmj2513455","url":null,"abstract":"","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"252-254"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital plexiform neurofibroma with sphenoid dysplasia: pulsatile exophthalmos in neurofibromatosis type 1.","authors":"R Luan, L Zhu, T Lin","doi":"10.12809/hkmj2513959","DOIUrl":"10.12809/hkmj2513959","url":null,"abstract":"","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"262.e1-262.e2"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148228841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}