Hong Kong Medical Journal最新文献

Aggressive renal angiomyolipoma with renal vein and inferior vena cava thrombus: a case report. 伴有肾静脉和下腔静脉血栓的侵袭性肾血管肌脂肪瘤：病例报告。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-08-22 DOI: 10.12809/hkmj2311235

P H W Lo, H M Kwok, F H Ng, H Y Lo, J K F Ma

引用次数: 0

Protein induced by vitamin K absence-II for the surveillance and monitoring of hepatocellular carcinoma in Hong Kong. 香港用于监测肝细胞癌的维生素 K 缺乏诱导蛋白-II。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-10-16 DOI: 10.12809/hkmj2411783

R N S Lui, L L Y Mak, K N Kung, C M Leung, R S T Li, Y K Ma, C K M Ng, H L Y Chan, M F Yuen, G L H Wong, J Fung

引用次数: 0

Factors affecting human papillomavirus vaccine acceptance among parents of Primary 4 to 6 boys and girls in Hong Kong. 影响香港小学四至六年级男女学生家长接受人类乳突病毒疫苗的因素。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2024-10-01 DOI: 10.12809/hkmj2311144

J K P Chu, C W Sing, Y Li, P H Wong, E Y T So, I C K Wong

{"title":"Factors affecting human papillomavirus vaccine acceptance among parents of Primary 4 to 6 boys and girls in Hong Kong.","authors":"J K P Chu, C W Sing, Y Li, P H Wong, E Y T So, I C K Wong","doi":"10.12809/hkmj2311144","DOIUrl":"https://doi.org/10.12809/hkmj2311144","url":null,"abstract":"Introduction: Human papillomavirus (HPV) poses a substantial but underestimated healthcare burden in Hong Kong. This study investigated factors affecting parental acceptance of HPV vaccination after the introduction of an immunisation programme for primary school girls. We assessed parental perceptions and related factors concerning HPV vaccination for both boys and girls.Methods: We conducted a cross-sectional survey between December 2021 and February 2022 among parents of Primary 4 to 6 students in Hong Kong. Our self-administered online survey collected data regarding socio-demographic characteristics, awareness and knowledge of HPV vaccination, attitudes towards HPV vaccination, and acceptance of HPV vaccination. Characteristics were compared between boys' parents and girls' parents. Factors associated with vaccine acceptance were analysed by multivariate logistic regression.Results: We observed high awareness of HPV vaccination among boys' parents and girls' parents; however, they demonstrated relatively poor knowledge of HPV and the HPV vaccine. An alarming low HPV vaccination uptake rate was also observed. Attitudes towards the HPV vaccine were similar between parent groups. A majority of parents believed that the HPV vaccine was safe and effective in preventing infection. Parents of boys showed lower HPV vaccine acceptance. Factors associated with acceptance differed between parent groups.Conclusion: High awareness of HPV and HPV vaccine is predictive of vaccine acceptance. Boys' parents are less likely to accept HPV vaccination and emphasis should be placed on addressing potential HPV vaccine hesitancy in this group. Public education should also aim to raise awareness of government vaccination programme, and implementation of catch-up vaccination programme to school children beyond primary school should be considered.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paracetamol-induced hepatotoxicity after normal therapeutic doses in the Hong Kong Chinese population. 香港华人服用正常治疗剂量扑热息痛后引起的肝中毒。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-10-10 DOI: 10.12809/hkmj2311194

W H Tsang, C K Chan, M L Tse

{"title":"Paracetamol-induced hepatotoxicity after normal therapeutic doses in the Hong Kong Chinese population.","authors":"W H Tsang, C K Chan, M L Tse","doi":"10.12809/hkmj2311194","DOIUrl":"10.12809/hkmj2311194","url":null,"abstract":"Introduction: Paracetamol is generally safe at normal therapeutic doses of ≤4 g/day in adults. However, paracetamol-induced hepatotoxicity after normal therapeutic doses use has been reported. We investigated the epidemiology of this adverse drug reaction in the Hong Kong Chinese population.Methods: This territory-wide retrospective observational study included adult patients with suspected paracetamol-induced hepatotoxicity after normal therapeutic doses use from January 2011 to June 2022. We evaluated the demographic characteristics; paracetamol dose, duration, and reason for use; preexisting hepatotoxicity risk factors; laboratory findings; and their relationship with clinical outcomes.Results: We identified 76 patients (median age: 74 years, 23 males) with suspected paracetamolinduced hepatotoxicity after normal therapeutic doses use. There were 14 cases with significant clinical outcomes (five deaths and nine cases of acute hepatic failure), with an incidence of 1.2 cases per year. For patients with significant clinical outcomes, they were significantly older (age >80 years), had a lower body weight (<50 kg), exposed to longer durations (>2 days) and higher daily doses (>3 g), and with higher proportion of malnutrition.Conclusion: Paracetamol-induced hepatotoxicity can occur at normal therapeutic doses in the Hong Kong Chinese population. The identified risk factors are consistent with international guidelines regarding susceptible patients. Considering the widespread local use of paracetamol and low incidence of severe hepatotoxicity, the current dosage recommendations are considered safe for the general population. For susceptible patients, a reduced maximum dose of ≤3 g/day is recommended, with liver function and serum paracetamol monitoring in place.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and severity of asthma among school children in Hong Kong. 香港学童的哮喘发病率和严重程度。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2024-10-01 DOI: 10.12809/hkmj2310882

J W C H Cheng, Y P Tsang, Y Y Lam, A K Y Chu, C S Y Ng, C H Y Chan, Y L Fung, P S Y Chau, D C K Luk

{"title":"Prevalence and severity of asthma among school children in Hong Kong.","authors":"J W C H Cheng, Y P Tsang, Y Y Lam, A K Y Chu, C S Y Ng, C H Y Chan, Y L Fung, P S Y Chau, D C K Luk","doi":"10.12809/hkmj2310882","DOIUrl":"https://doi.org/10.12809/hkmj2310882","url":null,"abstract":"Introduction: This study presents contemporary epidemiological data regarding the prevalence and severity of asthma and wheezing among children in Hong Kong, which provides an update to the results of the International Study of Asthma and Allergies in Childhood (ISAAC) conducted in 1994-1995 and 2001-2003.Methods: This cross-sectional investigation was based on the ISAAC study protocol. Responses from 1100 children aged 6 to 7 years (Primary 1-2) and 1048 children aged 13 to 14 years (Secondary 2-3) in Hong Kong between September 2020 and August 2021 were analysed. Sex differences within each age-group were assessed using Chi squared and independent t tests. Demographic information was entered into hierarchical logistic regression models to identify potential predictive factors associated with asthma severity. Annual change in prevalence was calculated via division of the prevalence by the number of years between surveys. Logistic regression modelling was conducted to identify risk factors associated with asthma severity.Results: The prevalences of current wheezing were 6.19% and 4.97% in the primary and secondary school groups, respectively. The prevalences of asthma ever were 5.55% and 6.12%, whereas those of wheezing ever were 20.38% and 12.05%, in the primary and secondary school groups, respectively.Conclusion: Asthma severity and prevalence have decreased in Hong Kong since 1994-1995. A followup study will explore the protective and risk factors contributing to these trends.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can we eliminate mother-to-child transmission of hepatitis B virus in Hong Kong by 2030? 到 2030 年，我们能否在香港消除乙型肝炎病毒的母婴传播？

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2024-10-01 DOI: 10.12809/hkmj245165

W C Leung, M C S Wong

引用次数: 0

2024 Hong Kong College of Obstetricians and Gynaecologists guideline on antenatal screening and management of hepatitis B for prevention of mother-to-child transmission. 2024 香港妇产科医学院关于预防母婴传播的乙型肝炎产前筛查和管理指南。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-04-30 DOI: 10.12809/hkmj2311218

K W Cheung, P L So, L L Y Mak, F N Y Yu, W L Cheung, S L Mok, T Y Leung, M T Y Seto

引用次数: 0

Validation of diagnostic coding for chronic obstructive pulmonary disease in an electronic health record system in Hong Kong. 香港电子健康记录系统中慢性阻塞性肺病诊断编码的验证。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-08-29 DOI: 10.12809/hkmj2210657

W C Kwok, T C C Tam, C W Sing, E W Y Chan, C L Cheung

{"title":"Validation of diagnostic coding for chronic obstructive pulmonary disease in an electronic health record system in Hong Kong.","authors":"W C Kwok, T C C Tam, C W Sing, E W Y Chan, C L Cheung","doi":"10.12809/hkmj2210657","DOIUrl":"10.12809/hkmj2210657","url":null,"abstract":"Introduction: Electronic health record databases can facilitate epidemiology research regarding diseases such as chronic obstructive pulmonary disease (COPD), a common medical condition worldwide. We aimed to assess the validity of International Classification of Diseases, 9th Revision (ICD-9) code algorithms for identifying COPD in Hong Kong's territory-wide electronic health record system, the Clinical Data Analysis and Reporting System (CDARS).Methods: Adult patients diagnosed with COPD at all public hospitals in Hong Kong and specifically at Queen Mary Hospital from 2011 to 2020 were identified using the ICD-9 code 496 (Chronic airway obstruction, not elsewhere classified) within the CDARS. Two respiratory specialists reviewed clinical records and spirometry results to confirm the presence of COPD in a randomly selected group of cases.Results: During the study period, 93 971 and 2479 patients had the diagnostic code for COPD at all public hospitals in Hong Kong and specifically at Queen Mary Hospital, respectively. Two hundred cases were randomly selected from Queen Mary Hospital for validation using medical records and spirometry results. The overall positive predictive value was 81.5% (95% confidence interval=76.1%-86.9%). We also developed an algorithm to identify COPD cases in our cohort.Conclusion: This study represents the first validation of ICD-9 coding for COPD in the CDARS. Our findings demonstrated that the ICD-9 code 496 is a reliable indicator for identifying COPD cases, supporting the use of the CDARS database for further clinical research concerning COPD.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of paracetamol in clinical consultations: are current prescribing practices safe? 在临床会诊中使用扑热息痛：目前的处方做法安全吗？

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2024-10-01 DOI: 10.12809/hkmj245164

B H M Ma, M C S Wong

引用次数: 0

Sodium nitrite-induced methemoglobinaemia: a case report. 亚硝酸钠诱发高铁血红蛋白血症：病例报告。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-10-09 DOI: 10.12809/hkmj2311153

C Y Yeung, H G Lam, F L Lee, F K C Chu, C K Chan

引用次数: 0