Hong Kong Medical Journal最新文献

Medico-socio-legal collaboration in the primary care setting in Hong Kong. 香港基层医疗机构的医学与社会法律合作。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-13 DOI: 10.12809/hkmj255180

E T Y Tse, A Lee, K W Tong, P Lu, J E Parry, C Lw Chan, W C W Wong

引用次数: 0

Stepped care approach to filicides in Hong Kong. 香港对杀婴者采取阶梯式护理方法。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-13 DOI: 10.12809/hkmj2311459

K L Hon, C H Y Chan, K K Y Leung, W F Hui, P Ip

引用次数: 0

Advancing next-generation sequencing access: aspirations for next-generation sequencing policy and patient access in Hong Kong. 推进新一代测序获取：对香港新一代测序政策和患者获取的期望。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-13 DOI: 10.12809/hkmj255177

J Au, R Mok, C Fung, M Tham, Y S Teh, A Sen, W Brown, M C S Wong

引用次数: 0

Living donor renal transplantation in a patient with human immunodeficiency virus: a case report. 人类免疫缺陷病毒患者活体肾移植一例报告。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-12 DOI: 10.12809/hkmj2411809

T L Leung, J M C Chan, I L Y Wong, C K Y Poon, W Lee, K F Yim, O T Y Tsang, S K S Fung, A Cheuk, H L Tang

引用次数: 0

Effects of nerve sparing on erectile dysfunction and urinary incontinence in robot-assisted radical prostatectomy. 神经保留对机器人辅助根治性前列腺切除术中勃起功能障碍和尿失禁的影响。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-10 DOI: 10.12809/hkmj2411709

O W K Tsui, K C H Shing, A P M Lam, S L Ng, S Chun, C F Tsang, T C T Lai, R Na, H L Wong, B S H Ho, A T L Ng

{"title":"Effects of nerve sparing on erectile dysfunction and urinary incontinence in robot-assisted radical prostatectomy.","authors":"O W K Tsui, K C H Shing, A P M Lam, S L Ng, S Chun, C F Tsang, T C T Lai, R Na, H L Wong, B S H Ho, A T L Ng","doi":"10.12809/hkmj2411709","DOIUrl":"https://doi.org/10.12809/hkmj2411709","url":null,"abstract":"Introduction: In 2020, there were >1.4 million new prostate cancer cases and >370 000 related deaths reported globally. Robot-assisted radical prostatectomy (RARP) is a surgical method used to eradicate localised prostate cancer. However, erectile dysfunction (ED) and urinary incontinence (UI) are common side-effects. This retrospective cohort study investigated erectile function, urinary continence, and oncological outcomes of nerve sparing (NS) in RARP.Methods: In total, 431 patients who underwent RARP in our institution between January 2018 and April 2023 were recruited; all had attended postoperative follow-up. Regarding ED outcome, patients with a preoperative International Index of Erectile Function-5 (IIEF-5) score ≤7 were excluded from analysis. Patient demographics, 1-hour pad test results, IIEF-5 questionnaire results, and pathological parameters were analysed.Results: Patients with bilateral NS had a higher mean postoperative IIEF-5 score after 2 months (7.60 vs 3.19 in non-NS patients, P=0.037; 7.60 vs 2.50 in unilateral NS patients, P=0.020) and 3 months (7.40 vs 2.06 in unilateral NS patients; P=0.027). They also had lower mean urine leakage volume in the 1-hour pad test after 1 month (16.40 g vs 49.44 g in non-NS patients, P<0.001; 16.40 g vs 50.82 g in unilateral NS patients, P=0.010) and 2 months (13.60 g vs 35.45 g in non-NS patients; P=0.009). No significant differences were observed in ED or UI between non-NS and unilateral or bilateral NS at 6 and 12 months. There was no correlation between positive surgical margin and NS.Conclusion: Bilateral NS had significant short-term effects on early recovery of erectile function and urinary continence, relative to unilateral NS and non-NS groups, without compromising oncological outcomes.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fragile X syndrome: genetic and clinical profile in the Hong Kong Chinese population. 脆性X染色体综合征：香港华人的遗传和临床特征。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-05 DOI: 10.12809/hkmj2411942

C W M Au, H M Luk, S Ho, S W Cheng, S T S Lam, B H Y Chung, S C Chong, I F M Lo

{"title":"Fragile X syndrome: genetic and clinical profile in the Hong Kong Chinese population.","authors":"C W M Au, H M Luk, S Ho, S W Cheng, S T S Lam, B H Y Chung, S C Chong, I F M Lo","doi":"10.12809/hkmj2411942","DOIUrl":"https://doi.org/10.12809/hkmj2411942","url":null,"abstract":"Introduction: Fragile X syndrome (FXS) is a common inherited cause of intellectual disability, and FXS testing is recommended as a first-line genetic investigation for global developmental delay or intellectual disability. This retrospective study evaluated the diagnostic yield of FXS testing and clinical features in Chinese patients in Hong Kong.Methods: From 1993 to 2022, 7291 patients referred to the Clinical Genetic Service for neurodevelopmental conditions (eg, developmental delay, autism spectrum disorder, and intellectual disability) underwent FXS testing. In total, 103 individuals from 61 families were confirmed to have an FMR1 full mutation, including 59 index cases and 44 family members. Clinical features of 70 Chinese patients with FXS, including growth, neurobehavioural features, and other co-morbidities, were evaluated.Results: The diagnostic yield of FXS testing was 0.8%. The median age at diagnosis for index cases was 4.1 years, with a trend towards earlier diagnosis in recent years. In 27 families (44.2%), multiple members carried a full mutation. Prenatal diagnosis was arranged in 11% of families. Developmental delay was observed in all males, compared with 45.0% of females. Intellectual disability affected 86.0% of males but only 30.0% of females. Common co-morbidities included obesity, autism spectrum disorder, attention-deficit/hyperactivity disorder, epilepsy, gastrointestinal problems, and sleep disturbances. Features such as strabismus, scoliosis, and mitral valve prolapse were rarely reported.Conclusion: Fragile X syndrome is more than a pure neurodevelopmental disorder. Our findings highlight the importance of early diagnosis and subsequent management, with awareness of relevant surveillance and management guidelines.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adrenal insufficiency due to etomidate inhalation via electronic cigarettes: three local cases. 电子烟吸入依托咪酯致肾上腺功能不全3例。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-04 DOI: 10.12809/hkmj2412244

Y K Chung, Y T Cheung, C S Y Chan, C C Wong, A C C Fu, Y Y Lam, C Y Lee

引用次数: 0

Evaluation of the safety and efficacy of the Sentire Surgical System (C1000) for robot-assisted radical prostatectomy. Sentire Surgical System （C1000）用于机器人辅助根治性前列腺切除术的安全性和有效性评估。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-04 DOI: 10.12809/hkmj2412169

C F Ng, C H Yee, P K F Chiu, M H M Tam, F P T Lai

{"title":"Evaluation of the safety and efficacy of the Sentire Surgical System (C1000) for robot-assisted radical prostatectomy.","authors":"C F Ng, C H Yee, P K F Chiu, M H M Tam, F P T Lai","doi":"10.12809/hkmj2412169","DOIUrl":"https://doi.org/10.12809/hkmj2412169","url":null,"abstract":"Introduction: This prospective clinical study evaluated the clinical safety and efficacy of the Sentire Surgical System (C1000), a locally developed robotic surgical platform, in performing radical prostatectomy in Hong Kong.Methods: This was a single-centre, single-arm study. Adult patients with a clinical diagnosis of localised prostate cancer planned for surgical treatment were invited to participate. Surgery was performed using the Sentire C1000 system following the standard approach. The primary endpoints were the conversion rate and the incidence of perioperative complications within 30 days. Secondary outcomes, including perioperative, pathological, oncological, and functional outcomes at 1 month after surgery, were also assessed.Results: From August 2022 to September 2023, 20 patients were recruited. All procedures were performed without conversion. There were no intraoperative complications related to the robotic device. Minor surgical complications (Grade I-II according to the Clavien-Dindo Classification) occurred in seven patients and were managed conservatively. The mean total operative time was 184.5 minutes (standard deviation=30.0). The median estimated blood loss was 175.0 mL (interquartile range [IQR]=100.0-275.0). The median length of hospital stay was 3.0 days (IQR=2.0-4.0). Seventeen patients achieved undetectable levels of prostate-specific antigen at 1 month after surgery.Conclusion: These initial results support the Sentire Surgical System (C1000), Hong Kong's first locally developed multidisciplinary surgical robotic platform, as a safe and effective option for radical prostatectomy, with clinical performance and outcomes comparable to existing robotic systems.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of primary care doctors in addressing the health impact of poverty in Hong Kong. 初级保健医生在处理香港贫穷对健康的影响方面的角色。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-03 DOI: 10.12809/hkmj2412155

J E Parry, M Vanstone, M Grignon, J R Dunn

引用次数: 0

Respiratory syncytial virus: the battle continues. 呼吸道合胞病毒：战斗仍在继续。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-06-03 DOI: 10.12809/hkmj2513120

J W T Tang

引用次数: 0