Hong Kong Medical Journal最新文献_第2页

1,4-Butanediol: legal date rape drug on the loose.

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-02-01 Epub Date: 2025-02-11 DOI: 10.12809/hkmj2412268

C W Yeung, T M Han, K Y C Yu, M L Chen, Y K Chong

引用次数: 0

Strengthening lung cancer screening in Hong Kong: policy, innovation, and collaborative approaches for early detection and improved outcomes.

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-02-01 DOI: 10.12809/hkmj245173

H H F Loong, A D L Sihoe, D Y T Cheung, Y T Cheung, D C L Lam, J S K Au, M S C Li, A J Y Lim, J Y T Li, W T Brown, M C S Wong

引用次数: 0

Clinical errors and mistakes: civil or criminal liability?

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-02-01 Epub Date: 2025-02-07 DOI: 10.12809/hkmj255171

A Lee, M A Anawis, R G Beran, T Cheung, C Ho, H Kim

引用次数: 0

Use of pronase in screening for early cancers of the upper gastrointestinal tract.

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-02-01 DOI: 10.12809/hkmj2411578

Z Wu, S Li, L Lu, Z Zhang, G Wang, T Qin, G Zhao, J Liu

{"title":"Use of pronase in screening for early cancers of the upper gastrointestinal tract.","authors":"Z Wu, S Li, L Lu, Z Zhang, G Wang, T Qin, G Zhao, J Liu","doi":"10.12809/hkmj2411578","DOIUrl":"https://doi.org/10.12809/hkmj2411578","url":null,"abstract":"Introduction: This study aimed to investigate the effectiveness of pronase in improving the detection rate of early cancer and enhancing visual field clarity during gastroscopy in China.Methods: In total, 1450 patients who participated in an early diagnosis and treatment programme of upper gastrointestinal cancer in Wuwei, Gansu Province between 2020 and 2021 were enrolled. Cluster randomisation was utilised at the community level. All patients underwent endoscopy and biopsy. The experimental group (n=725) received pronase granules and dimethicone prior to gastroscopy; the control group (n=725) received dimethicone alone. Endoscopic visibility scores, examination durations, and lesion detection rates were recorded for both groups.Results: Visibility scores for all regions of the stomach were significantly lower in the experimental group than in the control group (P<0.001). This finding remained consistent after adjustment for confounding factors in multiple linear regression analysis. The detection rate of precancerous lesions and early cancer was significantly higher in the experimental group than in the control group (77.5% vs 62.5%; P<0.001). Binary logistic regression analysis indicated that the likelihood of detecting early cancer was greater in the experimental group, with an odds ratio of 3.840 (95% confidence interval=1.204-12.241; P=0.023). Also, average gastroscopy time was significantly shorter in the experimental group than in the control group (6.52±2.51 min vs 10.03±1.23 min, t=33.81; P=0.001).Conclusion: The administration of pronase prior to gastroscopy enhances visual field clarity, reduces examination time, and increases the detection rates of precancerous lesions and early cancer.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":"31 1","pages":"41-47"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence, risk factors, and outcomes of systemic sclerosis-associated interstitial lung disease in a Chinese population.

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-02-01 Epub Date: 2025-02-12 DOI: 10.12809/hkmj2411807

D T H Chan, L H P Tam, T T O Lam, J So, L Y Ho, L S Tam, H So

{"title":"Prevalence, risk factors, and outcomes of systemic sclerosis-associated interstitial lung disease in a Chinese population.","authors":"D T H Chan, L H P Tam, T T O Lam, J So, L Y Ho, L S Tam, H So","doi":"10.12809/hkmj2411807","DOIUrl":"10.12809/hkmj2411807","url":null,"abstract":"Introduction: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is a leading cause of mortality among systemic sclerosis (SSc) patients. This multicentre cohort study sought to determine the prevalence of SSc-ILD, identify risk factors for ILD development in SSc patients, and explore poor prognostic factors in SSc-ILD patients.Methods: Medical records were retrospectively reviewed for Chinese patients who met the 2013 American College of Rheumatology/European League Against Rheumatism classification criteria for SSc. Univariable and multivariable analyses were performed to compare SSc patients with and without ILD, as well as SSc-ILD patients with and without disease progression. Survival analysis was also conducted.Results: The study cohort comprised 223 SSc patients with a median follow-up duration of 8.1 years. The prevalence of ILD was 49.8%. A history of bibasal crackles (hazard ratio [HR]=2.813; P=0.001) was independently associated with ILD development. Among ILD patients, 64.1% exhibited progressive disease. An elevated C-reactive protein (CRP) level at ILD diagnosis (HR=1.064; P=0.002) constituted an independent predictor of ILD progression. The overall mortality rate was 24.2% and pneumonia was the most common cause of death. Predictors of mortality included age at SSc diagnosis (HR=1.101; P=0.002), history of smoking (HR=5.173; P=0.028), and CRP level at SSc diagnosis (HR=1.103; P=0.009).Conclusion: Interstitial lung disease was prevalent among SSc patients in this cohort and the majority exhibited disease progression. Comprehensive clinical assessment, supported by investigations such as CRP level measurement, is essential to identify predictors of poor prognosis.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"16-23"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Success rate of induction of labour in twin pregnancies relative to singleton pregnancies in a predominantly Chinese population.

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-02-01 Epub Date: 2025-02-12 DOI: 10.12809/hkmj2311333

C K Wong, C M W Hung, V K S Ng, W K Yung, W C Leung, W L Lau

{"title":"Success rate of induction of labour in twin pregnancies relative to singleton pregnancies in a predominantly Chinese population.","authors":"C K Wong, C M W Hung, V K S Ng, W K Yung, W C Leung, W L Lau","doi":"10.12809/hkmj2311333","DOIUrl":"10.12809/hkmj2311333","url":null,"abstract":"Introduction: This study assessed the efficacy of induction of labour in twin pregnancies relative to singleton pregnancies within a predominantly Chinese patient population.Methods: This retrospective case-matched cohort study included patients with twin pregnancies who underwent induction of labour at our institution in Hong Kong between 2012 and 2020. Patients with twin pregnancies were matched one-to-one with singleton pregnancies based on parity, maternal age, and the indication for induction of labour. The primary outcome was the mode of delivery. Secondary outcomes included the time from oxytocin infusion to delivery, indications for caesarean or instrumental delivery, and maternal and neonatal outcomes.Results: In total, 160 women with twin pregnancies met the inclusion criteria and were matched with 160 singleton pregnancies. Caesarean section was performed in 42 patients (26.3%) with twin pregnancies and 27 patients (16.9%) with singleton pregnancies undergoing induction of labour. Patients with twin pregnancies had a significantly higher risk of caesarean section relative to those with singleton pregnancies (odds ratio=2.14, 95% confidence interval =1.14-4.04; P=0.024). Internal podalic version was required in 13.6% of cases for the vaginal delivery of the second twin. There was no significant difference between the groups in the time from oxytocin administration to vaginal delivery (P=0.143).Conclusion: Despite a higher induction failure rate, about three quarters of twin pregnancy patients achieved successful vaginal deliveries. Our findings inform decision making for patients and obstetricians, emphasising the importance of training for internal podalic version to aid second twin delivery and reduce caesarean rates in twin pregnancies.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"24-31"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urgent call for comprehensive reform of rare disease care in Hong Kong.

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-02-01 Epub Date: 2025-02-18 DOI: 10.12809/hkmj2412032

R S K Chang, D Y H Yap, K Y Chan, C Y Wong, M L Chan

引用次数: 0

Dermatomyositis following COVID-19 vaccination.

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2025-02-01 Epub Date: 2025-02-10 DOI: 10.12809/hkmj2411797

T K Kong

引用次数: 0

Disabilities and professional training: a tripartite consensus statement by the Hong Kong Academy of Medicine and the two medical schools in Hong Kong. 残疾与专业培训：香港医学专科学院与香港两所医学院的三方共识声明。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2024-12-20 DOI: 10.12809/hkmj245174

G K K Leung

引用次数: 0

2024 Hong Kong College of Obstetricians and Gynaecologists Guidelines for cervical cancer prevention and screening. 2024香港妇产科学院子宫颈癌预防及筛检指引。

IF 3.1 4区医学

Hong Kong Medical Journal Pub Date : 2024-12-01 Epub Date: 2024-12-03 DOI: 10.12809/hkmj2411547

S F Ngu, A N Y Cheung, K K Jong, J Y P Law, A Y Lee, J H S Lee, W H Li, V Ma, G C Y Wong, R W C Wong, K K L Chan

{"title":"2024 Hong Kong College of Obstetricians and Gynaecologists Guidelines for cervical cancer prevention and screening.","authors":"S F Ngu, A N Y Cheung, K K Jong, J Y P Law, A Y Lee, J H S Lee, W H Li, V Ma, G C Y Wong, R W C Wong, K K L Chan","doi":"10.12809/hkmj2411547","DOIUrl":"10.12809/hkmj2411547","url":null,"abstract":"Primary prevention of cervical cancer is best achieved by vaccinating girls with a prophylactic human papillomavirus (HPV) vaccine. Despite the high efficacy of such vaccines, cervical cancer screening remains necessary because current vaccines do not offer full protection. Secondary prevention via cervical screening should target all women from age 25 years or at the onset of sexual activity, whichever occurs later, until age 64 years. Screening is recommended at 3-year intervals after two consecutive normal annual cytology results, or at 5-year intervals using HPV-based testing (either HPV co-test with cytology or HPV stand-alone). Women who have undergone hysterectomy with cervix removal for benign disease and have no prior history of cervical dysplasia can discontinue screening. Women with HPV-positive, cytology-negative co-test results should either undergo repeat co-testing in 12 months or immediate HPV16/18 genotyping. Immediate referral of women with positive stand-alone HPV test results for colposcopy without further triage is not recommended. A second triage test using cytology, genotyping for HPV16/18, or p16/Ki-67 dual-stain should be conducted to accurately identify women at high risk for high-grade lesions who thus require colposcopy referral. Women with HPV-positive, cytology-positive co-test results, or high-grade abnormal cytology results should be referred for colposcopy. Treatment with a loop electrosurgical excision procedure is recommended for women with high-grade squamous intraepithelial lesions (HSILs). After HSIL treatment, long-term follow-up with HPV-based testing over 25 years is preferred. When cytology results show atypical glandular cells, colposcopy and sampling of the endocervix and endometrium are recommended.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"488-497"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0