Hong Kong Medical Journal最新文献_第3页

D-lactic acidosis in short bowel syndrome: are probiotics friend or foe? A case report. 短肠综合征d -乳酸酸中毒：益生菌是敌是友？一份病例报告。

IF 2.6 4区医学

Hong Kong Medical Journal Pub Date : 2025-08-01 Epub Date: 2025-07-17 DOI: 10.12809/hkmj2412534

B P Y Leung, B S Y Tsui, I Kan

引用次数: 0

Flu-based and PD1-based vaccines for SARS-CoV-2: abridged secondary publication. 针对SARS-CoV-2的基于流感和基于pd1的疫苗：次要出版物摘要。

IF 2.6 4区医学

Hong Kong Medical Journal Pub Date : 2025-08-01

K Y Yuen, I F N Hung, H Chen, Z Chen

引用次数: 0

Machine learning model for prediction of coronavirus disease 2019 within 6 months after three doses of BNT162b2 in Hong Kong. 在香港注射三剂BNT162b2后6个月内预测2019冠状病毒病的机器学习模型。

IF 2.6 4区医学

Hong Kong Medical Journal Pub Date : 2025-08-01 Epub Date: 2025-06-23 DOI: 10.12809/hkmj2411879

J T Tan, R Zhang, K H Chan, J Qin, I F N Hung, K S Cheung

{"title":"Machine learning model for prediction of coronavirus disease 2019 within 6 months after three doses of BNT162b2 in Hong Kong.","authors":"J T Tan, R Zhang, K H Chan, J Qin, I F N Hung, K S Cheung","doi":"10.12809/hkmj2411879","DOIUrl":"10.12809/hkmj2411879","url":null,"abstract":"Introduction: We aimed to develop a machine learning (ML) model to predict the risk of coronavirus disease 2019 (COVID-19) among three-dose BNT162b2 vaccine recipients in Hong Kong.Methods: A total of 304 individuals who had received three doses of BNT162b2 were recruited from three vaccination centres in Hong Kong between May and August 2021. The dataset was randomly divided into training (n=184) and testing (n=120) sets in a 6:4 ratio. Demographics, co-morbidities and medications, blood tests (complete blood count, liver and renal function tests, glycated haemoglobin level, lipid profile, and presence of hepatitis B surface antigen), and controlled attenuation parameter (CAP) were used to develop six ML models (logistic regression, linear discriminant analysis, random forest, naïve Bayes, neural network [NN], and extreme gradient boosting models) to predict COVID-19 risk. Model performance was assessed using area under the receiver operating characteristic curve (AUC), sensitivity, specificity, and positive predictive value (PPV) and negative predictive value (NPV).Results: Among the study population (median age: 50.9 years [interquartile range=43.6-57.8]; men: 30.9% [n=94]), 27 participants (8.9%) developed COVID-19 within 6 months. Fifteen clinical variables were used to train the models. The NN model achieved the best performance, with an AUC of 0.74 (95% confidence interval [95% CI]=0.60-0.88). Using the optimal cut-off value based on the maximised Youden index, sensitivity, specificity, PPV, and NPV were 90% (95% CI=55%-100%), 58% (95% CI=48%-68%), 16% (95% CI=8%-29%), and 98% (95% CI=92%-100%), respectively. The top predictors in the NN model include age, prediabetes/diabetes, CAP, alanine aminotransferase level, and aspartate aminotransferase level.Conclusion: An NN model integrating 15 clinical variables effectively identified individuals at low risk of COVID-19 following three doses of BNT162b2.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"296-304"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strengthening service integration of non-locally trained healthcare professionals through crew resource management: longitudinal measures and beyond. 通过人员资源管理加强非本地培训医护专业人员的服务整合：纵向措施及其他措施。

IF 2.6 4区医学

Hong Kong Medical Journal Pub Date : 2025-08-01 Epub Date: 2025-07-11 DOI: 10.12809/hkmj2513451

E H K So, V K L Cheung, L H Chan, J W H Yip, P K Wong, S H K Cheung, N H Chia, G W Y Ng

引用次数: 0

Enhancing cost-effectiveness considerations in the adoption of new drugs in Hong Kong. 加强在香港采用新药时的成本效益考虑。

IF 2.6 4区医学

Hong Kong Medical Journal Pub Date : 2025-08-01 Epub Date: 2025-07-23 DOI: 10.12809/hkmj2412259

B H K Yip, J N M Lui, E H H Yiu, K P Tsang, D A Goldstein, H H F Loong, R S M Wong, V W Y Lee

引用次数: 0

Primary cervical intradural extramedullary malignant melanoma: a case report. 原发性宫颈硬膜内髓外恶性黑色素瘤1例。

IF 2.6 4区医学

Hong Kong Medical Journal Pub Date : 2025-08-01 Epub Date: 2025-08-04 DOI: 10.12809/hkmj2412434

L Tang, H Liu, J Zheng, F Wang, M Wang, Y Zhou, M Chen, J He, Y Chen

引用次数: 0

It's time to re-examine medical professionalism in medical education. 是时候重新审视医学教育中的医学专业精神了。

IF 2.6 4区医学

Hong Kong Medical Journal Pub Date : 2025-08-01 Epub Date: 2025-07-11 DOI: 10.12809/hkmj2412468

H Ye

引用次数: 0

Importance of surveillance and vaccination in managing respiratory syncytial virus infections among older adults in Hong Kong. 监察及接种疫苗对香港长者呼吸道合胞病毒感染的重要性

IF 2.6 4区医学

Hong Kong Medical Journal Pub Date : 2025-08-01 Epub Date: 2025-07-25 DOI: 10.12809/hkmj255182

J C K Chan, M Y W Kwan, W Lam, C K C Lai, G Waterer, A Cheng, M Wong, K M Sin, K K P Chan, A Lo, M M S Lui, W S Leung, M C S Wong

引用次数: 0

Clinical outcomes after implementation of a lung nodule surveillance programme in Hong Kong. 香港实施肺结节监测计划后的临床结果。

IF 2.6 4区医学

Hong Kong Medical Journal Pub Date : 2025-08-01 Epub Date: 2025-08-06 DOI: 10.12809/hkmj2412168

L Y W Shong, W C Chong, P I Cheang, W C Choy, F K P Chan, W C Kwok, M S M Ip, D C L Lam

{"title":"Clinical outcomes after implementation of a lung nodule surveillance programme in Hong Kong.","authors":"L Y W Shong, W C Chong, P I Cheang, W C Choy, F K P Chan, W C Kwok, M S M Ip, D C L Lam","doi":"10.12809/hkmj2412168","DOIUrl":"10.12809/hkmj2412168","url":null,"abstract":"Introduction: To facilitate early and accurate identification and risk stratification of lung nodules, a surveillance programme was implemented at a tertiary hospital in Hong Kong. This study examined the clinical outcomes of patients recruited during the first year of programme implementation.Methods: This prospective cohort study included patients enrolled in the lung nodule surveillance programme between 1 January 2022 and 31 December 2022. Recruitment criteria included patients attending the respiratory outpatient clinic for lung nodules or lung masses. Patient demographics and clinical outcomes were analysed. Primary outcomes were the number of lung cancer cases detected and their stage at diagnosis. Secondary outcomes included the invasive investigations performed, adverse events related to these procedures, and details of lung cancer treatment and survival.Results: Of the 1471 patients recruited to the programme, 291 (19.8%) underwent invasive investigations, and 133 (9.0%) were diagnosed with lung cancer. Among those diagnosed, 62 (46.6%) had stage I disease and 10 (7.5%) had stage II disease. Overdue scans and missed follow-ups were identified and rescheduled. Significantly better survival was observed in female patients compared with male patients (P=0.037 for progression-free survival and P=0.030 for overall survival), and in patients with early-stage cancer compared with those with late-stage lung cancer (P<0.001). Age was also independently associated with survival outcomes (P<0.001).Conclusion: The implementation of a lung nodule surveillance programme resulted in the detection of early-stage lung cancer in more than half of diagnosed cases, with the potential to improve patient survival.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"277-286"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrum of inherited eye disorders at Hong Kong Children's Hospital: insights into the local genetic landscape and experience with ocular genetic services. 香港儿童医院的遗传性眼病谱：了解本地遗传情况及眼科遗传服务的经验。

IF 2.6 4区医学

Hong Kong Medical Journal Pub Date : 2025-08-01 Epub Date: 2025-08-04 DOI: 10.12809/hkmj2412298

S S W Cheng, S S L Cheung, T C Ko, T L Lee, J C S Yam, H M Luk

{"title":"Spectrum of inherited eye disorders at Hong Kong Children's Hospital: insights into the local genetic landscape and experience with ocular genetic services.","authors":"S S W Cheng, S S L Cheung, T C Ko, T L Lee, J C S Yam, H M Luk","doi":"10.12809/hkmj2412298","DOIUrl":"10.12809/hkmj2412298","url":null,"abstract":"Introduction: Inherited eye disorders (IEDs) are a leading cause of visual impairment. However, local data and information about the genetic landscape of IEDs in Hong Kong remain limited. This study aimed to examine the diagnostic yield, mutational spectrum, and clinical utility of genomic testing in patients with IEDs at a major local centre.Methods: This retrospective observational study included 130 patients with suspected IEDs who attended the genetic counselling clinic at the Department of Clinical Genetics of the Hong Kong Children's Hospital between December 2021 and October 2023. Analyses were conducted on the spectrum of ocular genetic disorders, genetic variants, diagnostic yields, and clinical utility of genomic testing.Results: The overall diagnostic yield of genomic testing was 51.5%. Inherited retinal disorders accounted for approximately 60% of positive results. Patients with syndromic features and a positive family history were significantly more likely to receive a molecular diagnosis (P<0.05). Clinical utility of genomic testing was observed in over 70% of patients with positive results. With genetic counselling, a confirmed molecular diagnosis contributed to disease prognostication, avoided unnecessary investigations, guided clinical management, and facilitated reproductive planning and family cascade screening.Conclusion: There is a growing demand for the application of genomic medicine in patients with IEDs. Genetic testing is widely accepted and demonstrates high diagnostic and clinical utilities. The multidisciplinary team clinic service model is the global trend for integrating genomic testing into routine care. Hong Kong Children's Hospital is implementing this model to meet the evolving needs of this patient population.","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"287-295"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0