Journal of Bone Oncology最新文献

{"title":"Incidence, Risk Factors, and Survival of Bone Metastases and Skeletal-Related Events in Melanoma Patients: A Systematic Review and Quality Assessment of 29 Studies","authors":"Michelle R. Shimizu ,&nbsp;Olaf N. van de Langerijt ,&nbsp;Daniel Torres ,&nbsp;Tom de Groot ,&nbsp;Olivier Q. Groot","doi":"10.1016/j.jbo.2024.100603","DOIUrl":"10.1016/j.jbo.2024.100603","url":null,"abstract":"<div><h3>Background</h3><p>Skeletal metastases make up 17% of all metastases from advanced-stage melanoma. Bone metastases are associated with increased morbidity and mortality and decreased quality of life due to their association with skeletal-related events (SREs), including pathological fracture, spinal cord compression, hypercalcemia, radiotherapy, and surgery. The study aimed to determine the incidence of bone metastases and SREs in melanoma, identify possible risk factors for the development of bone metastases and SREs, and investigate survival rates in this patient population.</p></div><div><h3>Methods</h3><p>A computer-based literature search was conducted using Pubmed, Embase, and Cochrane Central Register of Controlled Trials up to July 2023. The Newcastle-Ottawa Quality Assessment Scale (NOS) was utilized for quality assessment. Study characteristics, patient information, risk factors for developing bone metastases and SREs, and characteristics for survival were recorded.</p></div><div><h3>Results</h3><p>We included 29 studies. The average bone metastasis-free interval ranged from four to 72 months. Incidence of bone metastases varied from 2 % to 49 % across 14 studies. 69 % (20/29) of studies described the location of bone metastases, with 24 % (7/29) focusing solely on spinal metastases. In one study, 129 SREs were recorded in 71 % (59/83) of the patient cohort, with various manifestations. The use of bone-directed agents was independently associated with lower risk of SREs. Survival after detection of bone metastasis ranged from three to 13 months. Factors associated with survival included clinical, tumor-related, and treatment features.</p></div><div><h3>Conclusion</h3><p>This review highlights the notable prevalence and risk factors of developing bone metastases and subsequent SREs in patients with melanoma. The surge in bone metastases poses a challenge in complication management, given the high prevalence of SREs. While this study offers a comprehensive overview of the incidence, risk factors, and outcomes associated with bone metastases and SREs in melanoma patients that may guide patient and physician decision-making, a notable gap lies in the limited availability of high-quality data and the heterogeneous design of the existing literature. Future research should address predictive factors for bone metastases and SREs in melanoma to facilitate patient and physician decision-making and ultimately improve outcomes in this patient population.</p></div>","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000836/pdfft?md5=41f31a2ffea4ebb37db7f3d04deceb85&pid=1-s2.0-S2212137424000836-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140769005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversine inhibits proliferation and induces apoptosis of human osteosarcoma cells through targeting MEK1","authors":"Xianlong Chen ,&nbsp;Yeyin Zhong ,&nbsp;Simiao Wang ,&nbsp;Shujie Xu ,&nbsp;Junyuan Chen ,&nbsp;Xin Cheng ,&nbsp;Xuesong Yang","doi":"10.1016/j.jbo.2024.100601","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100601","url":null,"abstract":"<div><p>Reversine, or 2-(4-morpholinoanilino)-6-cyclohexylaminopurine, is a 2,6-disubstituted purine derivative. This small molecule shows anti-tumor potential by playing a central role in the inhibition of several kinases related to cell cycle regulation and cytokinesis. In this study, systematic review demonstrated the feasibility and pharmacological mechanism of anti-tumor effect of reversine. Firstly, we grafted MNNG/HOS, U-2 OS, MG-63 osteosarcoma cell aggregates onto chicken embryonic chorioallantoic membrane (CAM) to examine the tumor volume of these grafts after reversine treatment. Following culture, reversine inhibited the growth of osteosarcoma cell aggregates on CAM significantly. <em>In vitro</em> experiment, reversine suppressed osteosarcoma cell viability, colony formation, proliferation, and induced apoptosis and cell cycle arrest at G₀-G₁ phase. Scratch wound assay demonstrated that reversine restrained cell migration. Reversine increased the protein expression of E-cadherin. The mRNA expression of Rac1, RhoA, CDC42, PTK2, PXN, N-cadherin, Vimentin in MNNG/HOS, U-2 OS and MG-63 cells were suppressed and PTEN increased after reversine treatment. Network pharmacology prediction, molecular docking and systematic review revealed MEK1 can be used as an effective target for reversine to inhibit osteosarcoma. Western blot results show the regulation of MEK1 and ERK1/2 by reversine was not consistent in different osteosarcoma cell lines, but we found that reversine significantly inhibited the protein expression of MEK1 in MNNG/HOS, U-2 OS and MG-63. All these suggested that reversine can exert its anti-tumor effect by targeting the expression of MEK1.</p></div>","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000812/pdfft?md5=17b197984c69eab329554364783ee9b3&pid=1-s2.0-S2212137424000812-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140632712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#5. Activating RET mutations in medullary thyroid cancer cells promotes osteoblastic bone metastasis by inhibiting osteoclastogenesis and stimulating osteoblast activity","authors":"Rozita Bagheri-Yarmand,&nbsp;Gabriel M Pagnotti,&nbsp;Trupti Trivedi,&nbsp;Leah Guerra,&nbsp;Joseph L. Kidd,&nbsp;Jade A. Martinez,&nbsp;Jian H. Song,&nbsp;Sua-Hwa Lin,&nbsp;Theresa A. Guise","doi":"10.1016/j.jbo.2024.100543","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100543","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221213742400023X/pdfft?md5=ff2638c34efcdb32e22a5592681c45da&pid=1-s2.0-S221213742400023X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140641137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#18. Inhibition of de novo serine synthesis in osteosarcoma depletes cysteine and drives dependency upon exogenous cystine import through system xCT to maintain redox balance","authors":"Caitlyn Brashears,&nbsp;Toshiano Oyama,&nbsp;Richa Rathore,&nbsp;Brian Van Tine","doi":"10.1016/j.jbo.2024.100556","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100556","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000368/pdfft?md5=8cfc616b936ba392ec5353392654a5ba&pid=1-s2.0-S2212137424000368-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140641152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#50. Investigating the role of EphA2 in breast cancer bone metastasis","authors":"Verra Ngwa ,&nbsp;Dominique Parker ,&nbsp;Xiaoyong Wang ,&nbsp;Deanna Edwards ,&nbsp;Dana Brantley-Sieders ,&nbsp;Julie Rhoades ,&nbsp;Jin Chen","doi":"10.1016/j.jbo.2024.100588","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100588","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221213742400068X/pdfft?md5=8973b8247cad0f830de712fdbcbd138e&pid=1-s2.0-S221213742400068X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140641270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#14. Determining how prostate cancer cell heterogeneity promotes bone metastasis using fluid-walled microfluidics","authors":"Daniele T. Cotton ,&nbsp;Joseph A.E. Morgan ,&nbsp;Alexander Feuerborn ,&nbsp;James R. Edwards ,&nbsp;Srinivasa R. Rao ,&nbsp;Edmond J. Walsh ,&nbsp;Claire M. Edwards","doi":"10.1016/j.jbo.2024.100552","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100552","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000320/pdfft?md5=4213cfb817ef5802d4909dbe3f8e58ee&pid=1-s2.0-S2212137424000320-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140641074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#16. Variable fluid stresses may alter breast cancer expression in a 3D perfusion model of bone metastasis","authors":"Shreya Venkatesh ,&nbsp;Brandon Hayes ,&nbsp;Boyuan Liu ,&nbsp;Nick Bottenus ,&nbsp;Philip Owens ,&nbsp;Maureen Lynch","doi":"10.1016/j.jbo.2024.100554","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100554","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000344/pdfft?md5=0ab4620098a830f14fa81aefdcab95c9&pid=1-s2.0-S2212137424000344-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140641107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#25. Regulation of osteoblast migration, secretome, and metabolic programming by prostate cancer","authors":"Katrina L. Clines,&nbsp;Henry H. Moon,&nbsp;Gregory A. Clines","doi":"10.1016/j.jbo.2024.100563","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100563","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000435/pdfft?md5=3741953afcd19003dc3236c7c763a9f3&pid=1-s2.0-S2212137424000435-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140640711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#4. Elucidating the effect of glutamine metabolism in breast-to-bone metastasis","authors":"Breelyn Karno ,&nbsp;Yoonha Hwang ,&nbsp;Rachelle W. Johnson ,&nbsp;Jin Chen ,&nbsp;Deanna N. Edwards","doi":"10.1016/j.jbo.2024.100542","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100542","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000228/pdfft?md5=eda6ea2df1b8318750eb5ae237c92e2d&pid=1-s2.0-S2212137424000228-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140641136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#24. Mechanical loading-induced changes to the bone microenvironment control bone metastatic breast cancer lesions","authors":"Blayne Sarazin,&nbsp;Emma Briggs,&nbsp;Meredith Provera,&nbsp;Philip Owens,&nbsp;Maureen Lynch","doi":"10.1016/j.jbo.2024.100562","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100562","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000423/pdfft?md5=a6083bd782d90be99644d7752a6a7d35&pid=1-s2.0-S2212137424000423-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140640710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}