Journal of Bone Oncology最新文献

{"title":"#2. Homing of intestinal NK and Th1 cells to the tumor site restrains melanoma bone growth in a gut microbiome dependent manner","authors":"Subhashis Pal , Daniel S. Perrien , Tetsuya Yumoto , Roberta Faccio , M. Neale Weitzmann , Roberto Pacifici","doi":"10.1016/j.jbo.2024.100540","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100540","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000204/pdfft?md5=82641d0e9bf9fd46d27224e42a1c2b5b&pid=1-s2.0-S2212137424000204-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140640856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#23. Elucidating the role of bone marrow stiffness in estrogen signaling in metastatic breast cancer to the bone","authors":"Logan Northcutt , Marjan Rafat , Julie Rhoades","doi":"10.1016/j.jbo.2024.100561","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100561","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000411/pdfft?md5=c82ea7ec49ae643b4c42a230af793e4e&pid=1-s2.0-S2212137424000411-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140641237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemotherapy-induced adipocyte senescence triggers bone loss through RANKL-mediated osteoclastogenesis","authors":"Ganesh Kumar Raut , Zhangting Yao , Xianmin Luo , Qihao Ren , Taylor Malachowski , Douglas V. Faget , Sheila A. Stewart","doi":"10.1016/j.jbo.2024.100531","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100531","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000113/pdfft?md5=edddc45f36a73b9ca40e86258e6d049a&pid=1-s2.0-S2212137424000113-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140640977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The roles of the FL/FLT3 axis in the development of cancer-induced bone pain mediated by prostate cancer","authors":"Yang Yu, Sun Hee Park, Jenna Ollodart, Kelly Contino, Laiton R Steele, Yusuke Shiozawa","doi":"10.1016/j.jbo.2024.100530","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100530","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000101/pdfft?md5=22c4d7782b3061db048533fa2de94844&pid=1-s2.0-S2212137424000101-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140641068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#12. Potential role of bone metastasis-associated fibroblasts in prostate cancer-induced bone pain","authors":"Jenna Ollodart, Kelly Contino, Yang Yu, Sun Park, Laiton Steele, Yusuke Shiozawa","doi":"10.1016/j.jbo.2024.100550","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100550","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000307/pdfft?md5=e0cd4354805abbdb1e0c9dbcbf4e0343&pid=1-s2.0-S2212137424000307-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140641072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#35. Defining short-form RON mediated anti-tumor immunity in breast cancer bone metastasis","authors":"Clint H. Valencia, Jaime Fornetti, Alana L. Welm","doi":"10.1016/j.jbo.2024.100573","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100573","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000538/pdfft?md5=bbca3b5e148431ff5ae39ced9c0dfb46&pid=1-s2.0-S2212137424000538-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140640910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Senolytics deplete senescent osteocytes and improve bone health in metastatic breast cancer","authors":"J. Kaur , M. Adhikari , H.M. Sabol , A. Anloague , S. Khan , L. Barnes , J.B. Stambough , M. Palmieri , O. ReyesCastro , E. Ambrogini , M. Almeida , C.A. O'Brien , I. Nookaew , J. Delgado-Calle","doi":"10.1016/j.jbo.2024.100533","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100533","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000137/pdfft?md5=88cb75778b9b7ff39b39dc48c21d00cd&pid=1-s2.0-S2212137424000137-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140640930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#40. Bone metastatic cancer derived stem cell factor induces sensory nerve sprouting in vitro and pain behavior in vivo through c-kit receptor activation","authors":"Kelly F. Contino, Jenna Ollodart, Sun H. Park, Yang Yu, Laiton Steele, Yusuke Shiozawa","doi":"10.1016/j.jbo.2024.100578","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100578","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000587/pdfft?md5=407f952e387cfca89db6243ecd929b60&pid=1-s2.0-S2212137424000587-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140641192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomics model based on MRI to differentiate spinal multiple myeloma from metastases: A two-center study","authors":"Jiashi Cao ,&nbsp;Qiong Li ,&nbsp;Huili Zhang ,&nbsp;Yanyan Wu ,&nbsp;Xiang Wang ,&nbsp;Saisai Ding ,&nbsp;Song Chen ,&nbsp;Shaochun Xu ,&nbsp;Guangwen Duan ,&nbsp;Defu Qiu ,&nbsp;Jiuyi Sun ,&nbsp;Jun Shi ,&nbsp;Shiyuan Liu","doi":"10.1016/j.jbo.2024.100599","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100599","url":null,"abstract":"<div><h3>Purpose</h3><p>Spinal multiple myeloma (MM) and metastases are two common cancer types with similar imaging characteristics, for which differential diagnosis is needed to ensure precision therapy. The aim of this study is to establish radiomics models for effective differentiation between them.</p></div><div><h3>Methods</h3><p>Enrolled in this study were 263 patients from two medical institutions, including 127 with spinal MM and 136 with spinal metastases. Of them, 210 patients from institution I were used as the internal training cohort and 53 patients from Institution II were used as the external validation cohort. Contrast-enhanced T1-weighted imaging (CET1) and T2-weighted imaging (T2WI) sequences were collected and reviewed. Based on the 1037 radiomics features extracted from both CET1 and T2WI images, Logistic Regression (LR), AdaBoost (AB), Support Vector Machines (SVM), Random Forest (RF), and multiple kernel learning based SVM (MKL-SVM) were constructed. Hyper-parameters were tuned by five-fold cross-validation. The diagnostic efficiency among different radiomics models was compared by accuracy (ACC), sensitivity (SEN), specificity (SPE), area under the ROC curve (AUC), YI, positive predictive value (PPV), negative predictive value (NPY), and F1-score.</p></div><div><h3>Results</h3><p>Based on single-sequence, the RF model outperformed all other models. All models based on T2WI images performed better than those based on CET1. The efficiency of all models was boosted by incorporating CET1 and T2WI sequences, and the MKL-SVM model achieved the best performance with ACC, AUC, and F1-score of 0.862, 0.870, and 0.874, respectively.</p></div><div><h3>Conclusions</h3><p>The radiomics models constructed based on MRI achieved satisfactory diagnostic performance for differentiation of spinal MM and metastases, demonstrating broad application prospects for individualized diagnosis and treatment.</p></div>","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000794/pdfft?md5=4f9ab1e548cbf7fe90a8832ffc632b6a&pid=1-s2.0-S2212137424000794-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140346923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#28. Identification of key proteins within prostate cancer derived exosomes and their role in priming the pre-metastatic niche","authors":"Steven L. Wood ,&nbsp;Ana Lopez-Guajardo ,&nbsp;Maria R. Oliva ,&nbsp;Mark Collins ,&nbsp;Khoa Pham ,&nbsp;Mark Dunning ,&nbsp;Emily V. Chambers ,&nbsp;Janet E. Brown","doi":"10.1016/j.jbo.2024.100566","DOIUrl":"https://doi.org/10.1016/j.jbo.2024.100566","url":null,"abstract":"","PeriodicalId":48806,"journal":{"name":"Journal of Bone Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212137424000460/pdfft?md5=932c37acb0b0363bc2dd0ca2a5d10ce5&pid=1-s2.0-S2212137424000460-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140641063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}