Senescence in the bone marrow microenvironment: A driver in development of therapy-related myeloid neoplasms

IF 3.4 2区医学 Q2 Medicine

Journal of Bone Oncology Pub Date : 2024-07-05 DOI:10.1016/j.jbo.2024.100620

Angelo Jose Guilatco , Mithun Vinod Shah , Megan Moore Weivoda

引用次数: 0

Abstract

Therapy-related myeloid neoplasms (t-MN) are a growing concern due to the continued use of cytotoxic therapies to treat malignancies. Cytotoxic therapies have been shown to drive therapy-induced senescence in normal tissues, including in the bone marrow microenvironment (BMME), which plays a crucial role in supporting normal hematopoiesis. This review examines recent work that focuses on the contribution of BMME senescence to t-MN pathogenesis, as well as offers a perspective on potential opportunities for therapeutic intervention.

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骨髓微环境中的衰老：与治疗相关的髓细胞肿瘤发生的驱动因素

由于持续使用细胞毒性疗法治疗恶性肿瘤，与治疗相关的骨髓肿瘤（t-MN）日益受到关注。细胞毒疗法已被证明能促使正常组织，包括骨髓微环境（BMME）发生治疗诱导的衰老，而骨髓微环境在支持正常造血过程中起着至关重要的作用。这篇综述探讨了骨髓微环境衰老对 t-MN 发病机制所起作用的最新研究成果，并对潜在的治疗干预机会进行了展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Bone Oncology ONCOLOGY-

CiteScore

7.20

自引率

2.90%

发文量

审稿时长

34 days

期刊介绍： The Journal of Bone Oncology is a peer-reviewed international journal aimed at presenting basic, translational and clinical high-quality research related to bone and cancer. As the first journal dedicated to cancer induced bone diseases, JBO welcomes original research articles, review articles, editorials and opinion pieces. Case reports will only be considered in exceptional circumstances and only when accompanied by a comprehensive review of the subject. The areas covered by the journal include: Bone metastases (pathophysiology, epidemiology, diagnostics, clinical features, prevention, treatment) Preclinical models of metastasis Bone microenvironment in cancer (stem cell, bone cell and cancer interactions) Bone targeted therapy (pharmacology, therapeutic targets, drug development, clinical trials, side-effects, outcome research, health economics) Cancer treatment induced bone loss (epidemiology, pathophysiology, prevention and management) Bone imaging (clinical and animal, skeletal interventional radiology) Bone biomarkers (clinical and translational applications) Radiotherapy and radio-isotopes Skeletal complications Bone pain (mechanisms and management) Orthopaedic cancer surgery Primary bone tumours Clinical guidelines Multidisciplinary care Keywords: bisphosphonate, bone, breast cancer, cancer, CTIBL, denosumab, metastasis, myeloma, osteoblast, osteoclast, osteooncology, osteo-oncology, prostate cancer, skeleton, tumour.