Pain in patients with multiple inherited osteochondromas: Incidence and potential prognostic factors. A retrospective cohort study

IF 3.4 2区 医学 Q2 Medicine
Morena Tremosini , Mattia Morri , Cristiana Forni , Elena Pedrini , Marina Mordenti , Maria Gnoli , Alessia Di Cecco , Alice Moroni , Luca Sangiorgi
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引用次数: 0

Abstract

Purpose

the purpose of this study was to describe the baseline characteristics, presenting phenotype and treatment interventions for patients diagnosed with multiple osteochondromas who presented with severe pain symptoms.

Methods

a retrospective single-centre cohort study was conducted at a Rare Skeletal Disorders Department. Pain symptomatology was measured at the first visit, pain level was reported, varying from 0, absence of pain to 10, maximum pain. Baseline characteristics, pathology phenotype using IOR classification and treatments performed/ongoing as medical, surgical and conservative therapies were collected.

Results

a total of 152 patients were enrolled, with a median pain score of 0 and the 25th and 75th percentiles of 0 and 4, respectively. A percentage of 25.7 % (95 % CI of 19.3–33.3) presented at the first visit with moderate/severe pain. Multiple logistic regression confirmed that age was the only factor to be significantly associated with moderate/severe pain and IOR classification was not able to provide a description of the pathology that was associated with a major pain score.

Conclusion

from the early stages of multiple osteochondromas diagnosis, pain symptoms must be carefully assessed. An increase in age is associated with a worsening of pain; IOR classification of the multiple osteochondromas phenotype does not currently allow an association between the various classes and pain. A re-evaluation of the classification in this light could be an important new element for clinical practice.
多发性遗传性骨软骨瘤患者的疼痛:发病率和潜在的预后因素。回顾性队列研究
目的本研究的目的是描述伴有严重疼痛症状的多发性骨软骨瘤患者的基线特征、表现表型和治疗干预措施。方法采用回顾性单中心队列研究,在某罕见骨骼疾病科进行。首次就诊时测量疼痛症状,报告疼痛程度,从0(无疼痛)到10(最大疼痛)不等。收集基线特征、IOR分类的病理表型和已经/正在进行的药物、手术和保守治疗。结果共纳入152例患者,疼痛评分中位数为0,第25百分位和第75百分位分别为0和4。第一次就诊时出现中度/重度疼痛的比例为25.7% (95% CI为19.3-33.3)。多重逻辑回归证实,年龄是唯一与中度/重度疼痛显著相关的因素,IOR分类不能提供与重度疼痛评分相关的病理描述。结论从早期诊断多发骨软骨瘤开始,就必须认真评估疼痛症状。年龄的增长与疼痛的恶化有关;多发性骨软骨瘤表型的IOR分类目前不允许不同类型和疼痛之间的关联。在这种情况下,重新评估分类可能是临床实践的重要新元素。
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来源期刊
CiteScore
7.20
自引率
2.90%
发文量
50
审稿时长
34 days
期刊介绍: The Journal of Bone Oncology is a peer-reviewed international journal aimed at presenting basic, translational and clinical high-quality research related to bone and cancer. As the first journal dedicated to cancer induced bone diseases, JBO welcomes original research articles, review articles, editorials and opinion pieces. Case reports will only be considered in exceptional circumstances and only when accompanied by a comprehensive review of the subject. The areas covered by the journal include: Bone metastases (pathophysiology, epidemiology, diagnostics, clinical features, prevention, treatment) Preclinical models of metastasis Bone microenvironment in cancer (stem cell, bone cell and cancer interactions) Bone targeted therapy (pharmacology, therapeutic targets, drug development, clinical trials, side-effects, outcome research, health economics) Cancer treatment induced bone loss (epidemiology, pathophysiology, prevention and management) Bone imaging (clinical and animal, skeletal interventional radiology) Bone biomarkers (clinical and translational applications) Radiotherapy and radio-isotopes Skeletal complications Bone pain (mechanisms and management) Orthopaedic cancer surgery Primary bone tumours Clinical guidelines Multidisciplinary care Keywords: bisphosphonate, bone, breast cancer, cancer, CTIBL, denosumab, metastasis, myeloma, osteoblast, osteoclast, osteooncology, osteo-oncology, prostate cancer, skeleton, tumour.
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