Mechanistic insights into bone destruction in multiple myeloma: Cellular and molecular perspectives

IF 3.4 2区医学 Q2 Medicine

Journal of Bone Oncology Pub Date : 2025-03-04 DOI:10.1016/j.jbo.2025.100668

Oxana Lungu , Denise Toscani , Nicola Giuliani

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Abstract

Multiple myeloma (MM) is a hematological malignancy that leads to significant bone destruction, resulting in debilitating pain and skeletal-related events. The pathophysiology of osteolytic bone destruction in MM involves complex interactions between malignant plasma cells (PCs) and the bone marrow (BM) microenvironment. This review aims to provide a comprehensive synthesis of the cellular and molecular pathways underlying MM-associated bone disease. We discuss the role of osteoclast (OC), osteoblast (OB), osteocytes, along with the complex interactions between immune cells and the BM microenvironment in shaping disease progression. Additionally, we explore the molecular signaling pathways involved in bone disease as well as the influence of inflammatory cytokines, and the role of the metabolic alterations that characterize the MM BM. We also explore novel therapeutic strategies targeting these pathways to improve clinical outcomes. Understanding these mechanisms is crucial for the development of more effective treatments to prevent bone damage in MM patients.

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多发性骨髓瘤的骨破坏机制：细胞和分子的观点

多发性骨髓瘤（MM）是一种血液系统恶性肿瘤，可导致严重的骨破坏，导致衰弱性疼痛和骨骼相关事件。MM的骨溶解性破坏的病理生理涉及恶性浆细胞（PCs）和骨髓（BM）微环境之间复杂的相互作用。本综述旨在提供mm相关骨病的细胞和分子途径的综合。我们讨论了破骨细胞（OC）、成骨细胞（OB）、骨细胞的作用，以及免疫细胞和骨细胞微环境之间复杂的相互作用在形成疾病进展中的作用。此外，我们还探讨了骨病的分子信号通路，炎症细胞因子的影响，以及表征MM - BM的代谢改变的作用。我们还探索针对这些途径的新治疗策略，以改善临床结果。了解这些机制对于开发更有效的治疗方法来预防MM患者的骨损伤至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Bone Oncology ONCOLOGY-

CiteScore

7.20

自引率

2.90%

发文量

审稿时长

34 days

期刊介绍： The Journal of Bone Oncology is a peer-reviewed international journal aimed at presenting basic, translational and clinical high-quality research related to bone and cancer. As the first journal dedicated to cancer induced bone diseases, JBO welcomes original research articles, review articles, editorials and opinion pieces. Case reports will only be considered in exceptional circumstances and only when accompanied by a comprehensive review of the subject. The areas covered by the journal include: Bone metastases (pathophysiology, epidemiology, diagnostics, clinical features, prevention, treatment) Preclinical models of metastasis Bone microenvironment in cancer (stem cell, bone cell and cancer interactions) Bone targeted therapy (pharmacology, therapeutic targets, drug development, clinical trials, side-effects, outcome research, health economics) Cancer treatment induced bone loss (epidemiology, pathophysiology, prevention and management) Bone imaging (clinical and animal, skeletal interventional radiology) Bone biomarkers (clinical and translational applications) Radiotherapy and radio-isotopes Skeletal complications Bone pain (mechanisms and management) Orthopaedic cancer surgery Primary bone tumours Clinical guidelines Multidisciplinary care Keywords: bisphosphonate, bone, breast cancer, cancer, CTIBL, denosumab, metastasis, myeloma, osteoblast, osteoclast, osteooncology, osteo-oncology, prostate cancer, skeleton, tumour.