Journal of Endocrinological Investigation最新文献

{"title":"Emotional dysregulation, obsessive-compulsive traits, and eating disorders: three constructs for one spectrum?","authors":"Silvia Tempia Valenta, Valentina Beghelli, Federica Marcolini, Magda Rosinska, Diana De Ronchi, Fernando Fernandez-Aranda, Anna Rita Atti","doi":"10.1007/s40618-025-02617-1","DOIUrl":"10.1007/s40618-025-02617-1","url":null,"abstract":"<p><strong>Purpose: </strong>Dysfunctional eating behaviors are associated with emotional dysregulation and obsessive-compulsive symptoms. Traditionally, obsessiveness has been linked to anorexia nervosa (AN), while dysregulation has been associated with bulimia nervosa (BN) and binge eating disorder (BED). However, this dichotomous view fails to account for the frequent diagnostic crossover observed among individuals with eating disorders (EDs). This study aimed to identify specific clusters in individuals with EDs based on emotional dysregulation, obsessive-compulsive symptoms, eating symptoms, and body uneasiness.</p><p><strong>Methods: </strong>An observational cross-sectional study was conducted at the ED Unit of Clinical Psychiatry, Bologna, Italy. Participants (N = 360) completed the Difficulties in Emotion Regulation Scale (DERS), Obsessive Compulsive Inventory-Revised (OCI-R), Eating Disorders Examination Questionnaire (EDE-Q), and Body Uneasiness Test (BUT). Hierarchical and two-step cluster analyses were applied. Cluster differences were examined using Kruskal-Wallis tests and post-hoc comparisons.</p><p><strong>Results: </strong>The analysis identified three clusters with increasing levels of emotional dysregulation, obsessive-compulsive symptoms, eating symptoms, and body uneasiness (Cluster size ratio = 2.04; Silhouette = 0.30). Symptom severity ranged from more functional (Cluster 1) to moderate (Cluster 2) to more dysfunctional (Cluster 3).</p><p><strong>Conclusion: </strong>This study identified three clusters representing a progressive gradient in the symptoms assessed, challenging the traditional dichotomy linking obsessiveness solely to AN and dysregulation solely to BN/BED.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"2097-2110"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protect the pituitary stalks in craniopharyngioma resection by endoscopic endonasal approach.","authors":"Lei Cao, Wentao Wu, Jintian Xu, Zisu Zhai, Siming Ru, Fangzheng Liu, Kefan Cai, Youchao Xiao, Ning Qiao, Lu Jin, Songbai Gui","doi":"10.1007/s40618-025-02616-2","DOIUrl":"10.1007/s40618-025-02616-2","url":null,"abstract":"<p><strong>Objectives: </strong>Craniopharyngiomas are benign tumors originating from Rathke's pouch, typically located near the pituitary stalk. Preservation of the pituitary stalk is critical for maintaining pituitary function. We aimed to assess whether preoperative MRI, including diffusion tensor imaging (DTI), can accurately predict the tumor-stalk relationship to guide surgical planning.</p><p><strong>Methods: </strong>This study included 82 patients with primary craniopharyngiomas. All patients underwent MRI, including conventional imaging and DTI, to assess the tumor-stalk relationship. Clinical data, including demographics, clinical presentation, extent of tumor resection, pituitary stalk preservation, endocrine outcomes, and postoperative complications were collected.</p><p><strong>Results: </strong>In this study, the stalk was preserved in 50 patients (61%) and sacrificed in 32 patients (39%). The results showed that pituitary stalk preservation did not significantly increase the risk of tumor recurrence but was associated with a reduced risk of permanent diabetes insipidus (DI) (36% vs. 87.5%, P<0.01) and hypopituitarism (56% vs. 75%, P<0.01) during a mean follow-up period of 58.8 months. Male gender, elevated preoperative prolactin levels, and preoperative DI were factors associated with stalk sacrifice. Stalk preservation was more frequently achieved in peripheral-type tumors compared to central-type tumors. DTI, in combination with conventional MRI, provided greater accuracy in predicting the tumor-stalk relationship than conventional MRI alone. Successful preservation was linked to ≥ 22 stalk fibers (AUC = 0.783, P < 0.01) and ≥ 8.5 mm fiber length (AUC = 0.708, P < 0.01) on DTI.</p><p><strong>Conclusions: </strong>Preoperative MRI, particularly DTI, effectively predicts tumor-stalk topography for surgical planning. Peripheral-type tumors or those with higher stalk fiber counts/lengths are more amenable to preservation, reducing permanent DI risk. These findings support tailored approaches to optimize endocrine outcomes while maintaining oncological safety.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"2053-2065"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of thyroid function in non-basal ganglia intracerebral hemorrhage prognosis.","authors":"Yiting Xu, Zirui Xu, Yang Chen, Junjie Yang, Kezheng Li, Yinuo Chen, Jiali Xie, Chunyang Pang, Lingfei Gao, Mengwan Song, Huan Yu, Binbin Deng, Huanjie Huang","doi":"10.1007/s40618-025-02603-7","DOIUrl":"10.1007/s40618-025-02603-7","url":null,"abstract":"<p><strong>Purpose: </strong>Thyroid function disorders serve as unfavorable prognosis predictors for numerous diseases. However, their role in predicting intracerebral hemorrhage outcome is unclear. This study investigated the prognostic potential of thyroid function parameters for intracerebral hemorrhage.</p><p><strong>Methods: </strong>Admissions for intracerebral hemorrhage caused by hypertension were retrospectively enrolled to determine thyroid function levels. Patients were subjected to three month- and three year-follow up to assess short- and long-term prognosis, respectively.</p><p><strong>Results: </strong>Elevated levels of thyroxine and decreased levels of free triiodothyronine (fT3) are associated with unfavorable short-term prognosis in non-basal ganglia intracerebral hemorrhage patients. The levels of thyroid stimulating hormone and free tetraiodothyronine did not exhibit any significant change. This alteration in thyroid function was not observed in basal-ganglia intracerebral hemorrhage patients. Furthermore, the inclusion of thyroxine and fT3 enhanced the prognostic power of the traditional model (NIHSS only) in predicting short-term outcomes. Among patients 55 years or older, subgroup analyses results are consistent with previous findings. Additionally, our clinical model is also applicable towards predicting the long-term prognosis of non-basal ganglia intracerebral hemorrhage.</p><p><strong>Conclusion: </strong>Thyroid function concentrations, especially the levels of thyroxine and fT3, could serve as key prognostic predictors for non-basal ganglia cerebral hemorrhage, especially among the middle-aged and elderly groups.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"2013-2026"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From pathology to symbol: the cultural reconstruction of Thyroid Eye Disease in ancient Chinese figures-case studies of Shu King Wang Jian and General Zhang Fei.","authors":"Chunhui Yang, Ruili Wei","doi":"10.1007/s40618-025-02599-0","DOIUrl":"10.1007/s40618-025-02599-0","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"2197-2198"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a nomogram based on METS-IR and SPISE index for predicting mild cognitive impairment in type 2 diabetes mellitus.","authors":"Niu Tong, Liu Kunyu, Zhou Xueling, Sun Ruoyu, Niu Diejing, Wang Shaohua, Yuan Yang","doi":"10.1007/s40618-025-02629-x","DOIUrl":"10.1007/s40618-025-02629-x","url":null,"abstract":"<p><strong>Background: </strong>Insulin resistance (IR) is central to metabolic syndrome and contributes to the development of type 2 diabetes mellitus (T2DM) as well as mild cognitive impairment (MCI). Several low-cost surrogate markers have been proposed to assess IR, such as the triglyceride-glucose (TyG) index, TyG-BMI, TG/HDL-C, metabolic score for insulin resistance (METS-IR), and single-point insulin sensitivity estimator (SPISE). This study aimed to develop nomogram models integrating these indices with clinical data to predict MCI in patients with T2DM.</p><p><strong>Methods: </strong>A total of 600 patients diagnosed with T2DM were recruited. Demographic, clinical, and biochemical parameters were documented, and cognitive performance was assessed using the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE). Logistic regression analyses identified predictors of MCI, and receiver operating characteristic (ROC) curves evaluated their predictive accuracy. Two nomogram models were constructed: Model 1 included METS-IR, age, sex, education level, and hypertension; Model 2 substituted SPISE for METS-IR, retaining other clinical variables.</p><p><strong>Results: </strong>All IR surrogate indices were significantly associated with MCI and reduced MMSE scores (P < 0.001). METS-IR and SPISE exhibited higher predictive accuracy (AUC: METS-IR = 0.809, SPISE = 0.805) compared to TyG, TyG-BMI, and TG/HDL-C, particularly among female participants. Nomogram models demonstrated robust predictive performance (AUC: Model 1 = 0.846; Model 2 = 0.838).</p><p><strong>Conclusions: </strong>Nomogram models incorporating METS-IR or SPISE alongside key clinical parameters effectively predicted the risk of MCI among patients with T2DM. These indices notably outperformed other surrogate markers, highlighting their clinical value for early assessment of cognitive risk.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"2151-2165"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycemia risk index (GRI): a metric designed to facilitate the interpretation of continuous glucose monitoring data: a narrative review.","authors":"Philippe Oriot, Gaëtan Prévost, Jean-Christophe Philips, Noemie Klipper Dit Kurz, Michel P Hermans","doi":"10.1007/s40618-025-02609-1","DOIUrl":"10.1007/s40618-025-02609-1","url":null,"abstract":"<p><p>The Glycemia Risk Index (GRI) is a novel composite metric that integrates both hypoglycemia and hyperglycemia episodes to provide a comprehensive view of glycemic control in individuals with type 1 or type 2 diabetes. Unlike traditional metrics such as HbA₁c or time-in-range (TIR), the GRI highlights extreme glycemic excursions and aligns more closely with clinical perceptions of glycemic risk. It correlates well with other CGM-derived indicators and has demonstrated relevance in various settings, including the management of individuals using hybrid closed-loop systems. In individuals with HbA₁c ≤ 7%, the GRI can reveal hidden risks not captured by HbA₁c alone, highlighting its added value in routine clinical assessment. Despite these strengths, the GRI has limitations. It was developed using CGM data from healthy adults on intensive insulin therapy, limiting generalization to other populations. Unlike HbA₁c or TIR, it is not yet validated against hard clinical outcomes. As CGM technology evolves, the GRI holds promise as a valuable tool, provided its current limitations are addressed through further research and clinical integration.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1995-2000"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic markers in pheochromocytomas/paragangliomas: the role of histopathology, SDHB, MAML3 and MCM6 expression.","authors":"Emel Yaldır, Balça Begüm Cengiz, Osman Furkan Mülkem, Muzaffer Bilgin, Mustafa Fuat Açıkalın","doi":"10.1007/s40618-025-02610-8","DOIUrl":"10.1007/s40618-025-02610-8","url":null,"abstract":"<p><strong>Objective: </strong>There are currently no definitive prognostic markers that accurately predict malignant behavior in pheochromocytoma/paraganglioma (PCC/PGL). While metastasis develops in only 10-15% of adrenal-origin, this rate can rise up to 50% in those with extra-adrenal localization. This study aims to investigate the potential predictive effect of known histopathological features in PCC/PGL, alongside SDHB, S100, Ki-67 proliferation index, and the expression of MAML3 and MCM6 in predicting metastatic disease.</p><p><strong>Methods: </strong>The specimens of 71 patients who were diagnosed with PCC/PGL and underwent total excision between 2010 and 2021 were re-examined. Demographic, clinical, and histopathological data, as well as immunohistochemical results for Ki-67, S100, SDHB, MCM6, and MAML3, were recorded.</p><p><strong>Results: </strong>While distant organ metastasis was observed in 3.4% (n = 1/29) of PCC and 21.2% (n = 7/33) of head and neck PGL, this rate was found to be significantly higher at 66.7% (n = 6/9) in abdominal PGL (p < 0.001). No MAML3 overexpression was observed in any of the cases. Distant organ metastasis was more frequently detected in cases with MCM6 overexpression.</p><p><strong>Conclusions: </strong>Although there is still no definitive feature that predicts metastasis, in line with the literature, extra-adrenal localization, vascular invasion, capsular invasion, nuclear pleomorphism, hyperchromasia, and confluent necrosis were found to be associated with distant organ metastasis in our study. Additionally, in the multivariate analysis, larger tumor size (> 5.1 cm), the presence of > 3/10 HPF mitosis, and SDHB loss were associated with lower metastasis-free survival. While no conclusions could be drawn regarding MAML3, the prognostic value of MCM6 appears promising.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"2077-2086"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of shear wave elastography in diagnosing sarcopenia in patients with type 2 diabetes.","authors":"Li An, Jinjun Shi, Ye Pan, Yu Ding, Wei Gao, Liqun Ren, Jing Wang, Yao Wang","doi":"10.1007/s40618-025-02623-3","DOIUrl":"10.1007/s40618-025-02623-3","url":null,"abstract":"<p><strong>Objective: </strong>To assess the utility of shear wave elastography (SWE) for the diagnosis of sarcopenia in individuals with type 2 diabetes (T2D).</p><p><strong>Methods: </strong>In this study, we measured the shear wave velocity (SWV) in the medial gastrocnemius muscle (GCM) in both the relaxed and stretched states via SWE. The study involved 273 T2D patients at Zhongda Hospital Southeast University and was conducted between March 2022 and June 2023. In addition to the SWV, we evaluated the appendicular skeletal muscle mass index (ASMI), muscle strength as measured by handgrip strength, and gait speed as measured by the 6-meter walk test. We analyzed the relationships between conventional sarcopenia indicators and SWV variables and developed diagnostic models based on significant predictors.</p><p><strong>Results: </strong>The age of the patients ranged from 60 to 72 years, with a median age of 66 years, and nearly half (48.0%, n = 131) were female. On the basis of the 2019 criteria set by the Asian Working Group for Sarcopenia (AWGS), the participants were categorized into nonsarcopenia (212, 77.7%) and sarcopenia (61, 22.3%) groups. There was a notable difference in the SWV between those with and without sarcopenia (p < 0.01). A robust positive correlation was identified between traditional sarcopenia indicators and the SWV_bent. A logistic regression model incorporating BMI, ASMI, SWV_straight, and SWV_bent demonstrated high sensitivity (96.7%) and specificity (82.5%), with an AUC of 0.946.</p><p><strong>Conclusion: </strong>Our findings suggest that SWE could be a valuable tool for the objective assessment of sarcopenia in T2D patients. However, additional large-scale, multicenter, and prospective studies are warranted to validate these results.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"2177-2185"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of bone density and microstructure by DXA, TBS and HR-pQCT: an assessment of cortical porosity and its association with vertebral fractures in patients with acromegaly.","authors":"P G Ornellas, Emf Gama, Lmc Mendonça, C Villela-Nogueira, F P Paranhos-Neto, L Kasuki, M R Gadelha, Mlf Farias, M Madeira","doi":"10.1007/s40618-025-02619-z","DOIUrl":"10.1007/s40618-025-02619-z","url":null,"abstract":"<p><strong>Purpose: </strong>Patients with acromegaly are at increased risk of fractures, regardless of areal bone mineral density (BMD). This study aimed to identify whether vertebral fractures (VFs) are related to decreases in bone volumetric density and microstructure via high-resolution peripheral quantitative computed tomography (HR-pQCT) and the trabecular bone score (TBS).</p><p><strong>Methods: </strong>VF was evaluated in 49 patients with acromegaly (22 men and 27 women) via spine X-ray. Areal BMD, volumetric BMD, and bone microstructure were analyzed via dual-energy X-ray absorptiometry (DXA) and HR-pQCT. Lumbar spine trabecular quality was assessed via TBS.</p><p><strong>Results: </strong>Morphometric VFs were identified in 22 patients (11 men and 11 women), accounting for 44.9% of the cohort. Hypogonadism was more common in patients with VFs (59.1% vs. 22.2%; p = 0.017). BMD measured by DXA or HR-pQCT did not differ between patients with and without VFs. The proportion of patients classified as having partially degraded or degraded bone microstructure according to a TBS < 1.310 was 26% (with VF) vs. 32% (without VF; p = 0.749). There was no difference in bone geometry (trabecular and cortical area, cortical perimeter) or microstructure (number, thickness, separation, and trabecular heterogeneity, as well as cortical thickness), except for a trend toward greater cortical porosity at the distal radius in patients with VFs (p = 0.067).</p><p><strong>Conclusions: </strong>VFs were identified in 44.9% of patients with acromegaly, and hypogonadism was more common among those with VFs. There were no significant differences in bone density or microstructure measured by DXA, TBS, or HR-pQCT in patients with or without VFs.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"2087-2095"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between cerebral lesions and the severity of diabetic cardiovascular disease, retinopathy, and nephropathy-new lessons to learn from neuroimaging.","authors":"Moein Ebrahimi, Paul M Thompson, Zeinab Kafashan, Antonio Ceriello, Miriam Kolko, Jakob Grauslund","doi":"10.1007/s40618-025-02600-w","DOIUrl":"10.1007/s40618-025-02600-w","url":null,"abstract":"<p><p>Diabetes is associated with cerebrovascular lesions detectable through neuroimaging. Neuroimaging is traditionally valued for its insights into the structure of the central nervous system. However, the brain is connected with other organs. The vascular system, hormones, and peripheral nerve system connect the brain to other sections of the body bidirectionaly. This interaction between the brain and other parts encourages us to look at the total body, not just its different parts separately. Growing evidence has shown the link between brain injuries and cardiac, retinal, and kidney disorders, suggesting that neuroimaging has the potential to provide valuable information about peripheral organs This is particularly crucial for a systemic disease like diabetes, which affects the entire body. In this review, we aim to first discuss the data that neuroimaging can reveal about the severity of diabetic retinopathy, nephropathy, and cardiovascular disease in diabetic patients. This interdisciplinary approach could guide the design of new randomized controlled trials, screening programs, and an integrated clinical practice. This study explores the mechanisms underlying the association between the brain and other organs in the context of diabetes. Then we will consider their implications for future research and clinical practice.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":"1967-1993"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}