Journal of Endocrinological Investigation最新文献

{"title":"Correction: Association between osteocalcin and residual β-cell function in children and adolescents newly diagnosed with type 1 diabetes: a pivotal study.","authors":"M Valenzise, B Bombaci, F Lombardo, S Passanisi, C Lombardo, C Lugarà, F D'Amico, L Grasso, M Aguennouz, A Catalano, G Salzano","doi":"10.1007/s40618-025-02569-6","DOIUrl":"https://doi.org/10.1007/s40618-025-02569-6","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is orbital adipose tissue obesity-privileged? The relationship between small adipocyte size and metabolically healthy state from the view of orbital fat.","authors":"Y Cheng, K Zhang, J Liu, G Liu","doi":"10.1007/s40618-025-02568-7","DOIUrl":"https://doi.org/10.1007/s40618-025-02568-7","url":null,"abstract":"<p><strong>Purpose: </strong>White adipose tissue (WAT) expands by increasing adipocyte size (hypertrophy) and/or number (hyperplasia) to handle excess energy and plays a key homeostatic role in lipid metabolism. Hypertrophic adipocytes have many impaired biological functions. In contrast, hyperplastic adipocytes can reduce the negative metabolic effects of obesity. Thus, understanding the mechanisms of adaptive WAT expansion is essential for optimizing lipid storage and preventing the adverse metabolic consequences of obesity. Hedgehog (Hh) signaling has been shown to improve adipose health and can be a pharmacological target to ameliorate obesity-induced metabolic abnormalities. Clinically, we found that the size of adipocytes in orbital fat (OF) is less affected by obesity, and we hypothesized that OF possesses a relatively metabolically healthy profile.</p><p><strong>Methods: </strong>To verify our hypothesis, we identified multiple hallmarks of healthy adipose tissue in OF using a combination of bioinformatics-based transcriptomics analyses and experimental methods.</p><p><strong>Results: </strong>Our results revealed that compared with abdominal subcutaneous fat (SF), OF had a smaller cell size, more dynamic ability to remodel the adipose extracellular matrix (ECM), higher vascular supply, and less macrophage infiltration. OF also showed promising adipogenic and proliferative capabilities and a healthy adipocytokine secretion pattern. Moreover, the Hh signaling was activated in OF and may influence depot-specific adipose health.</p><p><strong>Conclusion: </strong>These findings collectively support that OF is generally in a naturally metabolically healthy state with high expandability and obesity-free privilege, providing new therapeutic ideas for obesity-related metabolic dysfunctions.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum levels of rapamycin predict the response of Graves' orbitopathy to sirolimus.","authors":"Simone Comi, Giada Cosentino, Elena Sabini, Dalì Antonia Ciampa, Francesca Menconi, Maria Novella Maglionico, Chiara Posarelli, Francesco Latrofa, Roberto Rocchi, Michele Figus, Ferruccio Santini, Michele Marinò","doi":"10.1007/s40618-025-02567-8","DOIUrl":"https://doi.org/10.1007/s40618-025-02567-8","url":null,"abstract":"<p><strong>Objective: </strong>Compared with methylprednisolone, a greater response of Graves' orbitopathy (GO) at 24 weeks was reported in patients treated with sirolimus (rapamycin) for 12 weeks. We investigated whether serum levels of sirolimus at week-12 predict the outcome of GO at week-24.</p><p><strong>Methods: </strong>Retrospective investigation in 30 patients [males: 4; females: 26; age 61.3 (9.62) yr] with moderate-to-severe, active GO, treated with sirolimus (2 mg on day-one, followed by 0.5 mg QD for 12 weeks).</p><p><strong>Primary outcome: </strong>serum sirolimus at week-12 in week-24 GO responders vs nonresponders, assessed by a composite evaluation.</p><p><strong>Secondary outcome: </strong>establishment of a cut-off value of week-12 sirolimus concentrations predictive of response to treatment.</p><p><strong>Results: </strong>At week-24, overall GO responders and nonresponders were 18 (60%) and 12 (40%), respectively. Week-12 serum sirolimus was higher in week-24 responders [4.6 (2.2) ng/mL vs 2.8 (1.6) ng/mL in nonresponders; mean difference 1.7; 95% CI from 0.1 to 3.1; P = 0.034)]. A cut-off value of week-12 serum sirolimus was established at 3.5 ng/mL; levels ≥ 3.5 ng/mL were more frequent in week-24 GO responders than in nonresponders [13/18 (72.2%) vs 3/12 (25%); OR: 7.8; 95% CI from 1.4 to 41.2; P = 0.015], with a positive predictive value of 81.2% (95% CI from 60.9 to 92.3), a sensitivity of 72.2% (95% CI from 46.5 to 90.3), and a specificity of 75% (95% CI from 42.8 to 94.5).</p><p><strong>Conclusions: </strong>Serum levels of sirolimus at week-12 are predictive of GO response to treatment at week-24, suggesting a dose-dependent relationship with GO outcome.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeat gamma knife radiosurgery for recurrent pituitary adenomas.","authors":"Marco Losa, Luigi Albano, Elena Prandino, Enrico Garbin, Antonella Del Vecchio, Andrei Fodor, Nadia Di Muzio, Lina Raffaella Barzaghi, Pietro Mortini","doi":"10.1007/s40618-025-02564-x","DOIUrl":"https://doi.org/10.1007/s40618-025-02564-x","url":null,"abstract":"<p><strong>Background: </strong>Recurrence of pituitary adenoma after Gamma Knife radiosurgery (GKRS) occurs in around 10% of cases. This study aims to evaluate the effectiveness and safety of repeat GKRS in pituitary adenoma patients who had tumor recurrence after the first GKRS.</p><p><strong>Methods: </strong>This retrospective study included 38 consecutive patients who received a second GKRS treatment for pituitary adenoma at the same institute from 1994 to 2023. The primary study endpoint was tumor growth control. Safety assessment included neurological, visual, and endocrine function.</p><p><strong>Results: </strong>The median radiological follow-up was 71.5 months (IQR, 21.7-124 months). Nine patients (23.7%) had recurrence of disease. The 5-year and 10-year progression-free survival rates were 75.2% (95% CI, 58.4-92.0%) and 61.7% (95% CI, 39.3-84.1%), respectively. Adjusted Cox analysis showed that hormone-secreting adenoma (HR 6.82; 95% CI, 1.42-32.68; P 0.02), having received another surgical procedure before repeat GKRS (HR 10.63; 95% CI, 1.77-63.85; P 0.01), and the interval between the first and the second GKRS (HR 0.97; 95% CI, 0.95-0.99; P 0.01) were independently associated with the risk of tumor recurrence. No serious side effects occurred after repeat GKRS treatment, except one case of transient diplopia and trigeminal neuralgia. New thyroid, gonadal, and adrenal deficit developed in 10.5%, 7.1%, and 18.7% of patients, respectively.</p><p><strong>Conclusion: </strong>Repeat GKRS for regrowth of a pituitary adenoma can stop tumor progression in most patients. No specific safety concerns emerged. Repeat GKRS can be included among the few therapeutic options available after failure of a first GKRS.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension and Cushing's syndrome: hunt for the red flag.","authors":"De Martino M C, L Canu, I Bonaventura, C Vitiello, C Sparano, A Cozzolino","doi":"10.1007/s40618-024-02453-9","DOIUrl":"https://doi.org/10.1007/s40618-024-02453-9","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of secondary hypertension is reported to be 5-15% of people with hypertension. Causes of secondary hypertension include Cushing's syndrome (CS), a rare but serious clinical condition characterized by chronic endogenous hypercortisolism associated with increased morbidity and mortality, especially for cardiovascular complications. The challenge for the clinician is thus to identify the phenotype of hypertensive patients who should be screened for endogenous hypercortisolism.</p><p><strong>Methods: </strong>This study was performed according to the PRISMA statement. The search was last updated in June 2023, and only English language studies were considered. Titles and abstracts have been screened for articles selection, identifying only those that dealt with prevalence of Cushing's syndrome in hypertensive patients. Finally, eight papers were included in the review. Data regarding year of publication, populations' characteristics, inclusion criteria, screening test and cut-off used, and CS prevalence have been extracted.</p><p><strong>Results: </strong>The study search identified eight studies, from 1977 to 2020, including a total number of 11,504 patients, ranging from 80 to 4429 patients for each study. The prevalence of CS reported was variable among the studies, ranging from 0 to 7.7%, having Cushing's disease (CD) a prevalence range of 0-1.2%. The highest prevalence has been found in selected populations of hypertensive patients younger than 40 years (6.2%) or harbouring an adrenal lesion (7.7%). The most used screening test was 1 mg overnight dexamethasone suppression test (1 mg DST), with different cut-off.</p><p><strong>Conclusion: </strong>The most fitting CS profile encompasses younger age (i.e., < 40 years old), rapidly evolving hypertension and the presence of adrenal adenomas, along with subjects with pituitary lesions, who should still be prioritized in the diagnostic pathway. Overall, in the case of hypertensive patients presenting a clinical picture highly suggestive of CS, it is advisable to perform one of the available screening tests (UFC, 1 mg DST, LNSC). LNSC is likely the most discriminatory test and may be preferred, depending on its availability. Conversely, for hypertensive patients with an adrenal incidentaloma, the 1 mg DST is recommended as the screening test to exclude CS.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of non-cholesterol sterols and fatty acids in patients with graves' orbitopathy: insights into lipid metabolism in relation to the clinical phenotype of disease.","authors":"Marija Sarić Matutinović, Sandra Vladimirov, Tamara Gojković, Ivana Djuričić, Jasmina Ćirić, Miloš Žarković, Svetlana Ignjatović, George J Kahaly, Biljana Nedeljković-Beleslin","doi":"10.1007/s40618-025-02556-x","DOIUrl":"https://doi.org/10.1007/s40618-025-02556-x","url":null,"abstract":"<p><strong>Purpose: </strong>Graves' orbitopathy (GO) is a complex inflammatory disease of the orbit. A potential link between cholesterol metabolism and the occurrence of GO is possible, but still unexplored. This study aims to investigate patients' lipid status, fatty acid content, and cholesterol homeostasis markers, all in relation to the clinical phenotype of GO.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 89 consecutive patients with GO of varying degrees of activity and severity. Conventional lipid parameters were measured using routine biochemical methods. Concentrations of cholesterol synthesis and cholesterol absorption markers were analyzed by a GC-FID method. The percentage composition of individual fatty acids was determined by GC-FID. Total concentration of thyrotropin-receptor antibodies was measured by a binding immunoassay (Roche Diagnostics), while their stimulating activity (TSAb) was quantified using a cell-based bioassay (Quidelortho).</p><p><strong>Results: </strong>HDL-C concentration was significantly lower in patients with an active GO compared to an inactive form of GO (p = 0.032). The ApoB/ApoA1 ratio was significantly higher in a more severe GO (p = 0.029). Also, a positive correlation between LDL-C and TSAb levels (ρ = 0.255, p = 0.019) was observed. Lathosterol concentration significantly increased in more severe GO cases (p = 0.045). Moreover, the level of cholesterol synthesis-to-absorption index (CSI/CAI) positively correlated with CAS score (ρ = 0.232, p = 0.048). Palmitic acid was significantly associated with active GO (p = 0.012). The levels of desmosterol, lathosterol, CSI/CAI, and oleic acid were significantly associated with TSAb levels.</p><p><strong>Conclusions: </strong>Alterations in patients' lipid profile and the cholesterol homeostasis were associated with a worse clinical phenotype of GO.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of three approaches for adrenal venous sampling in patients with primary aldosteronism.","authors":"Hui Dong, Yujie Zuo, Hongwu Li, Kaiwen Jiang, Yubao Zou, Wentao Ma, Wenjun Ma, Xiongjing Jiang","doi":"10.1007/s40618-025-02551-2","DOIUrl":"https://doi.org/10.1007/s40618-025-02551-2","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the feasibility and safety of three approaches for bilateral adrenal venous sampling (AVS) and their influence on the outcomes of adrenalectomy for dominant lateral primary aldosteronism (PA).</p><p><strong>Methods: </strong>182 PA patients who underwent AVS at Fuwai Hospital between January 2022 and March 2024 were enrolled. According to the puncture access, patients were divided into three groups: simultaneous AVS via antecubital approach group (Group A, N = 48), simultaneous AVS via femoral approach group (Group B, N = 44) and sequential AVS via antecubital approach group (Group C, N = 90). The baseline data, procedure parameters, success rates, complication rates and follow-up data were analyzed.</p><p><strong>Results: </strong>The baseline characteristics did not differ significantly among three groups (all P > 0.05). The procedure time (18.9 ± 7.4 min vs. 25.2 ± 7.5 min; P < 0.001) and fluoroscopy time (7.1 ± 3.8 min vs. 10.8 ± 6.2 min; P < 0.001) were shorter in Group A than in Group C. However, there was no significant difference between Group A and B (all P > 0.05). The bilateral sampling success rates in Groups A, B and C were 93.8%, 93.2% and 91.1%, respectively, which were not significantly different (P = 0.936). One (0.5%) adrenal haematoma was recorded in Group B. The complete clinical success rate (P = 0.894) and complete biochemical success rate (P = 0.954) were not significantly different in patients with dominant lateralization who underwent adrenalectomy.</p><p><strong>Conclusion: </strong>This study revealed that three approaches for AVS are safe and feasible, with similar outcomes after adrenalectomy. Simultaneous AVS via antecubital approach might be a better choice considering its shorter procedure and fluoroscopy time and comfort.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Who and how to screen for endogenous hypercortisolism in a high-risk population: a special issue of the Journal of Endocrinological Investigation.","authors":"Filippo Ceccato, Massimo Terzolo, Carla Scaroni","doi":"10.1007/s40618-024-02484-2","DOIUrl":"https://doi.org/10.1007/s40618-024-02484-2","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of mild traumatic brain injury (mTBI) on sperm genome integrity: insights from a mouse model.","authors":"M Memis, S Taheri, Z Y Sukranlı, E M Duman, B Er, Z Hamurcu, Ahsen Güler, M Rassoulzadegan, Z Karaca, F Tanriverdi, K Unluhizarci, F Kelestimur","doi":"10.1007/s40618-025-02549-w","DOIUrl":"https://doi.org/10.1007/s40618-025-02549-w","url":null,"abstract":"<p><strong>Purpose: </strong>Traumatic Brain Injury (TBI) poses a significant global health burden, with Mild TBI (mTBI) being the most prevalent form. TBI triggers activation of the hypothalamic-pituitary-adrenal (HPA) axis, which in turn affects the hypothalamic-pituitary-gonadal (HPG) axis regulating oogenesis and spermatogenesis. In this study, we investigated the impact of mTBI on sperm genome integrity using a repetitive mTBI (r-mTBI) mouse model.</p><p><strong>Methods: </strong>We assessed sperm telomere length (TL), free TERRA (fTERRA), and DNA/RNA hybrid TERRA (hTERRA) levels, alongside transcriptional changes in genes involved in TERRA regulation and DNA damage response.</p><p><strong>Results: </strong>Our findings reveal that a single mTBI event leads to a significant reduction in sperm TL during the acute phase, followed by an increase in TL during the chronic phase of r-mTBI, reminiscent of aging-associated changes. Moreover, we observed alterations in the transcription levels of Rad51, Exo1, Rb1, RNaseH1, and RNaseH2 genes, particularly in association with fTERRA and hTERRA levels, following mTBI.</p><p><strong>Conclusion: </strong>Understanding the potential non-Mendelian effects of TBI holds promise for elucidating TBI pathogenesis, mechanisms of TBI-induced diseases, and conditions of unknown etiology. Given the risks associated with repeated TBI exposure, especially in sports like football and boxing, consideration of potential paternal transmission of effects to offspring is crucial.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of plasma Irisin levels with executive function in children: the role of weight status.","authors":"Minyan Lan, Shuyue Huang, Xuanqing He, Shaomin Lu, Yajun Chen, Li Cai","doi":"10.1007/s40618-025-02560-1","DOIUrl":"https://doi.org/10.1007/s40618-025-02560-1","url":null,"abstract":"<p><strong>Purpose: </strong>Irisin, an adipokine closely correlated with metabolism, may affect adults' executive function (EF). But little is known about this association in school-aged children, particularly regarding differences across weight status (i.e., thinness, normal-weight, overweight/obesity). Therefore, we aimed to examine the associations of irisin with EFs in school-aged children, and further explore whether weight status modifies these correlations.</p><p><strong>Methods: </strong>Children aged 7-12 years were recruited from five schools in 2017 in Guangzhou, China. Plasma irisin levels were assessed using an enzyme-linked immunosorbent assay. EFs were assessed using the Stroop Color-Word test (inhibitory control), Corsi Block-Tapping task (working memory), and Wisconsin Card Sorting test (cognitive flexibility). Children's weight status was objectively measured and classified into three groups. Multivariable linear regression was performed, with stratified analysis by weight status.</p><p><strong>Results: </strong>A total of 502 children were included. In the overall sample, no significant associations between irisin and EFs in children were found. However, higher irisin levels were significantly associated with better Stroop Color-Word test performance among children with overweight/obesity (response time: β = -0.129, 95%CI: -0.228, -0.030; word interference time: β = -0.088, 95%CI: -0.163, -0.013). Null significant associations in the groups with thinness or normal-weight were found. Weight status significantly modified the associations of irisin with EFs (P_interaction<0.05).</p><p><strong>Conclusions: </strong>Children with overweight/obesity might be more sensitive to the effect of irisin on EFs, especially on inhibitory control. Irisin might be a promising target to promote EF development in overweight/obese children.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}