Journal of Veterinary Cardiology最新文献

{"title":"Aorto-left atrial fistula secondary to aortic infective endocarditis in a dog with a bicuspid aortic valve","authors":"A.J. Carrillo ,&nbsp;P. Rivera ,&nbsp;R.T. Walker ,&nbsp;L.L. Farina ,&nbsp;E.J. Benjamin","doi":"10.1016/j.jvc.2024.02.009","DOIUrl":"10.1016/j.jvc.2024.02.009","url":null,"abstract":"<div><p>An 11-year-old male neutered English Bulldog was presented for evaluation of thrombocytopenia, acute onset of ataxia, and vomiting. A new murmur was auscultated on physical examination. Transthoracic echocardiographic examination revealed a bicuspid aortic valve, vegetative lesions on the aortic valve, and continuous shunting from the aortic root to the left atrium through an aorta to left atrial fistula. The dog was euthanized due to guarded prognosis and critical condition. Pathological examination confirmed presence of bicuspid aortic valve, aorto-left atrial fistula, and aortic infective endocarditis. Antemortem blood culture revealed two unusual organisms: <em>Achromobacter xylosoxidans</em> and <em>Fusobacterium mortiferum</em>.</p></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"53 ","pages":"Pages 13-19"},"PeriodicalIF":1.2,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140071703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene-expression profiling of endomyocardial biopsies from dogs with dilated cardiomyopathy phenotype","authors":"A. Di Loria ,&nbsp;C. Ferravante ,&nbsp;Y. D'Agostino ,&nbsp;G. Giurato ,&nbsp;M. Tursi ,&nbsp;E. Grego ,&nbsp;M. Perego ,&nbsp;A. Weisz ,&nbsp;P. Ciaramella ,&nbsp;R. Santilli","doi":"10.1016/j.jvc.2024.02.008","DOIUrl":"10.1016/j.jvc.2024.02.008","url":null,"abstract":"<div><h3>Introduction</h3><p>The employment of advanced molecular biology technologies has expanded the diagnostic investigation of cardiomyopathies in dogs; these technologies have predominantly been performed on postmortem samples, although the recent use of endomyocardial biopsy in living dogs has enabled a better premortem diagnostic approach to study the myocardial injury.</p></div><div><h3>Animals, materials, and methods</h3><p>Endomyocardial biopsies were collected in nine dogs with a dilated cardiomyopathy phenotype (DCM-p) and congestive heart failure and submitted to histologic examination, next-generation sequencing (NGS), and polymerase chain reaction analysis. Data from three healthy dogs (Fastq files) were retrieved from a previously approved study and used as a control group for ribonucleic acid sequencing.</p></div><div><h3>Results</h3><p>Histologic examination revealed endocardial fibrosis in 6 of 9 dogs, whereas lymphocytic interstitial infiltrates were detected in 2 of 9 dogs, and lymphoplasmacytic and macrophage infiltrates were detected in 1 of 9 dogs. On polymerase chain reaction analysis, two dogs tested positive for canine parvovirus 2 and one dog for canine distemper virus. Gene-expression pathways involved in cellular energy metabolism (especially carbohydrates-insulin) and cardiac structural proteins were different in all DCM-p dogs compared to those in the control group. When dogs with lymphocytic interstitial infiltrates were compared to those in the control group, NGS analysis revealed the predominant role of genes related to inflammation and pathogen infection.</p></div><div><h3>Conclusions</h3><p>NGS technology performed on <em>in vivo</em> endomyocardial biopsies has identified different molecular and genetic factors that could play a role in the development and/or progression of DCM-p in dogs.</p></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"52 ","pages":"Pages 78-89"},"PeriodicalIF":1.2,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1760273424000201/pdfft?md5=3b1558ab1181c195b582968d33396a86&pid=1-s2.0-S1760273424000201-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139955513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference intervals for various measurements of canine left atrial size and function obtained using two-dimensional and three-dimensional echocardiography","authors":"J. Treibert ,&nbsp;J. Friederich ,&nbsp;S. Fischer ,&nbsp;H. Küchenhoff ,&nbsp;G. Wess","doi":"10.1016/j.jvc.2024.02.005","DOIUrl":"10.1016/j.jvc.2024.02.005","url":null,"abstract":"<div><h3>Background</h3><p>Many canine cardiac diseases are associated with left atrial (LA) remodeling and decreased function. For accurate assessment of LA indices, large-scale and prospectively determined reference intervals are necessary.</p></div><div><h3>Objectives</h3><p>To generate reference intervals of LA size and function using two-dimensional and three-dimensional echocardiography.</p></div><div><h3>Animals</h3><p>Two hundred and one healthy adult dogs.</p></div><div><h3>Methods</h3><p>Left atrial volume was assessed in right parasternal long-axis, left apical 4-chamber and 2-chamber views using monoplane Simpson’s method, two-dimensional and three-dimensional speckle tracking. Additionally, LA diameter was measured in right parasternal short-axis and long-axis views. Furthermore, LA function was determined by measuring strain and calculating LA fractional shortening and ejection fraction. All variables were tested for correlation to heart rate, age, and body weight. For LA diameter and volume, scaling exponents and prediction intervals were generated using allometric scaling. Reference intervals for LA function parameters were calculated using nonparametric methods.</p></div><div><h3>Results</h3><p>Left atrial diameter and volume showed a strong correlation with body weight. The scaling exponent for LA diameter was approximately 1/3 (0.34–0.40) and approximately 1 for volume measurements (0.97–1.26). Parameters of LA function showed no clinically relevant correlation with body weight, except for two variables, which showed a mild negative correlation. No clinically relevant correlations with age or heart rate were found.</p></div><div><h3>Conclusions</h3><p>Reference intervals for linear, two-dimensional and three-dimensional measurements of LA size and function were established. The wide range of measurement methods offers the opportunity to select the appropriate reference values for LA evaluation depending on the available technical possibilities.</p></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"52 ","pages":"Pages 43-60"},"PeriodicalIF":1.2,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1760273424000080/pdfft?md5=831b23c94ff322a45293f0f15c795ca4&pid=1-s2.0-S1760273424000080-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139822712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular images: pacemaker-lead fracture and excessive coiling in a dog","authors":"A.K. McManamey DVM ,&nbsp;M.M. Lake DVM ,&nbsp;T.C. DeFrancesco DVM","doi":"10.1016/j.jvc.2024.02.004","DOIUrl":"10.1016/j.jvc.2024.02.004","url":null,"abstract":"<div><p>A seven-year-old male castrated Labrador Retriever presented emergently due to concern for pacemaker malfunction five years after successful transvenous pacemaker implantation to treat partial atrial standstill. On presentation, the dog's pulse rate was 30–50 beats per minute. An electrocardiogram showed no spontaneous atrial activity or paced ventricular activity. Pacemaker interrogation revealed an increased impedance of 7557 ohms, indicating a lead malfunction. Thoracic radiographs confirmed the lead was fractured and had excessive coiling. The transvenous pacing system was turned off, left in place, and an epicardial pacing system was implanted the following day. The dog was discharged with no perioperative complications. The dog eventually required escalated medical therapy for progressive cardiac disease and was euthanized two years after implantation of the replacement pacemaker. This manuscript illustrates a complete lead fracture and excessive lead coiling, which has not previously been detailed in veterinary medicine.</p></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"52 ","pages":"Pages 68-71"},"PeriodicalIF":1.2,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139891704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous rupture of the right aortic sinus resulting in a sterile aorto-atrial fistula in a pet rabbit (Oryctolagus cuniculus)","authors":"L. Cheung DVM ,&nbsp;B.A. Scansen DVM, MS ,&nbsp;R. Baden DVM ,&nbsp;C.Q. Sloan DVM, MS ,&nbsp;M. Garcia DVM ,&nbsp;S. Han DVM, PhD ,&nbsp;M.J. Sadar DVM","doi":"10.1016/j.jvc.2024.02.006","DOIUrl":"10.1016/j.jvc.2024.02.006","url":null,"abstract":"<div><p>Aortocardiac fistula is a broad term used to describe defects between the aorta and other cardiac chambers that can occur in humans and animals. A 1.5-year-old, 1.7 kg, male castrated Holland lop rabbit (<em>Oryctolagus cuniculus</em>) was presented for a two-week history of a heart murmur with corresponding cardiomegaly on radiographs. Physical examination confirmed a grade-V/VI continuous heart murmur on the right sternal border with a regular rhythm and a gallop sound. Echocardiography revealed an aortic-to-right-atrial fistula causing severe left-sided volume overload. Based on the echocardiographic findings, rupture of the right aortic sinus was suspected. Due to the poor prognosis, euthanasia was elected. On necropsy, a fistula was found connecting the right aortic sinus with the right atrium, without evidence of an inflammatory response nor evidence of an infectious etiology. The sudden onset of a heart murmur supported acquired fistulation from a ruptured aortic sinus (also known as the sinus of Valsalva), though a congenital malformation could not be completely excluded.</p></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"52 ","pages":"Pages 72-77"},"PeriodicalIF":1.2,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139812619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transesophageal echocardiography using a microprobe for determination of transcatheter procedural candidacy, device selection, and procedural monitoring in small dogs with patent ductus arteriosus","authors":"S. Wesselowski,&nbsp;A.B. Saunders","doi":"10.1016/j.jvc.2024.02.007","DOIUrl":"10.1016/j.jvc.2024.02.007","url":null,"abstract":"<div><h3>Introduction</h3><p>Small dogs with patent ductus arteriosus (PDA) may be unable to undergo transesophageal echocardiography (TEE) with traditional probes.</p></div><div><h3>Objectives</h3><p>To report the utility of TEE using a microprobe in dogs weighing less than 4 kg diagnosed with PDA for determination of transcatheter procedural candidacy, device selection, and intraoperative procedural guidance.</p></div><div><h3>Animals</h3><p>Eight dogs weighing less than 4 kg diagnosed with PDA.</p></div><div><h3>Materials and methods</h3><p>All dogs had standard transthoracic echocardiography and microprobe TEE imaging. The quality of TEE images was graded as optimal, adequate, or poor. The ability of TEE to assess PDA anatomy, determine procedural candidacy, provide procedural guidance, detect deployed devices, and assess residual flow was recorded.</p></div><div><h3>Results</h3><p>The median age of included dogs was 6.4 months (range: 3.2–15.7 months) and the median body weight was 2.2 kg (range: 1.4–3.8 kg). Microprobe TEE images were adequate or optimal in all dogs and were integral for guiding procedural candidacy decisions. Transcatheter procedures were not pursued in two dogs based on TEE images. In the other six dogs, TEE procedural guidance was useful during transvenous (n = 5) and transarterial (n = 1) PDA occlusion attempts. Each deployed device (n = 4) was easily detected with the TEE microprobe. Real-time confirmation of adequate device sizing and placement was possible prior to release and residual flow could be monitored after release.</p></div><div><h3>Conclusions</h3><p>Transesophageal echocardiography using a microprobe in dogs weighing less than 4 kg diagnosed with PDA allowed for characterization of PDA anatomy and determination of transcatheter procedural candidacy. Microprobe TEE images were integral for PDA device selection and offered valuable intraoperative procedural guidance.</p></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"52 ","pages":"Pages 35-42"},"PeriodicalIF":1.2,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139812991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of paroxysmal atrial fibrillation preceding persistent atrial fibrillation in a horse using an implantable loop recorder with remote monitoring","authors":"I. Vernemmen DVM ,&nbsp;G. Van Steenkiste DVM, PhD ,&nbsp;A. Decloedt DVM, PhD ,&nbsp;H. Meert MSc ,&nbsp;U. Walser BSc ,&nbsp;G. van Loon DVM, PhD","doi":"10.1016/j.jvc.2024.02.002","DOIUrl":"10.1016/j.jvc.2024.02.002","url":null,"abstract":"<div><p>Implantable loop recorders (ILRs) are increasingly used in equine cardiology to detect arrhythmias in the context of collapse, poor performance or monitoring for recurrence of atrial fibrillation (AF). However to date, the ILR has never been reported to be used with a remote monitoring functionality in horses, therefore the arrhythmia is only discovered when a clinician interrogates the ILR using dedicated equipment, which might delay diagnosis and intervention. This case report describes the use of an ILR with remote monitoring functionality in a horse with recurrent AF. The remote monitoring consisted of a transmission device located in the stable allowing daily transmission of arrhythmia recordings and functioning messages to an online server, available for the clinician to evaluate without specialised equipment. The ILR detected an episode of paroxysmal AF approximately 3 months after implantation. Seven months after implantation, initiation of persistent AF was seen on an episode misclassified by the ILR as bradycardia, and the horse was retired. This report shows the feasibility and benefits of remote monitoring for ILRs in horses, but also the shortcomings of current algorithms to interpret the equine electrocardiogram.</p></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"52 ","pages":"Pages 19-27"},"PeriodicalIF":1.2,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139820761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic and pathologic identification of an aorto-left atrial fistula secondary to infective endocarditis in a canine patient","authors":"K. Iuliani ,&nbsp;A. Lawler ,&nbsp;D. Schrope ,&nbsp;E. Locke","doi":"10.1016/j.jvc.2024.02.003","DOIUrl":"10.1016/j.jvc.2024.02.003","url":null,"abstract":"<div><p>A dog was presented for lameness, fever, and extreme lethargy. On physical exam, a new heart murmur, arrhythmia, and joint effusion were detected. These findings were not detected two months prior. A diagnostic work-up confirmed septic suppurative inflammation in multiple joints. Echocardiogram revealed aortic valvular endocarditis along with a communication, as a consequence of a fistula, that extended from just below the aortic sinotubular junction to the left atrial lumen. Due to a poor prognosis, humane euthanasia was elected. Necropsy and histopathology confirmed infective endocarditis of the aortic valve and an aorto-left atrial fistulous tract extending from the left coronary sinus of the aortic valve to the lumen of left atrium.</p></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"52 ","pages":"Pages 61-67"},"PeriodicalIF":1.2,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139813953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anomalous origin of the right coronary artery from the pulmonary artery in a Staffordshire Bull Terrier","authors":"M. Garncarz PhD ,&nbsp;W. Wtorkowska DVM ,&nbsp;M. Parzeniecka-Jaworska PhD ,&nbsp;M. Krzemiński DVM ,&nbsp;D. Machola DVM ,&nbsp;K. Sienkiewicz MD","doi":"10.1016/j.jvc.2024.02.001","DOIUrl":"10.1016/j.jvc.2024.02.001","url":null,"abstract":"<div><p>An asymptomatic 17-month-old, 18.5-kg, male Staffordshire Bull Terrier was referred due to a heart murmur. Examination revealed a grade 3/6 left apical systolic and right apical 3/6 heart murmur. Echocardiography showed volume overload of the left ventricle and mild systolic dysfunction with a left-right flow over the interventricular septal region. Cardiac gated computed tomography revealed anomalous origin of the right coronary artery from the pulmonary artery, an extensive network of collateral blood vessels connected the right and left coronary arteries, with bronchial and left intercostal arteries also connected to the network of collateral blood vessels, markedly enlarged right and left coronary arteries and left coronary sinus. With varied presentation, coronary anomalies are difficult to recognise and classify and to the best of our knowledge this is the first case of anomalous origin of the right coronary artery from the pulmonary artery diagnosis in the dog.</p></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"52 ","pages":"Pages 28-34"},"PeriodicalIF":1.2,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139881081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journal title page and editorial board","authors":"","doi":"10.1016/S1760-2734(24)00013-4","DOIUrl":"https://doi.org/10.1016/S1760-2734(24)00013-4","url":null,"abstract":"","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"51 ","pages":"Page i"},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1760273424000134/pdfft?md5=05f6b959288268720479927f436ec144&pid=1-s2.0-S1760273424000134-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}